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The map label for this gene is fmhB

Identifier: 82751850

GI number: 82751850

Start: 2271060

End: 2272325

Strand: Reverse

Name: fmhB

Synonym: SAB2134c

Alternate gene names: 82751850

Gene position: 2272325-2271060 (Counterclockwise)

Preceding gene: 82751852

Following gene: 82751849

Centisome position: 82.86

GC content: 33.73

Gene sequence:

>1266_bases
ATGGAAAAGATGCATATCACTAATCAGGAACATGACGCATTTGTTAAATCTCACCCAAATGGAGATTTATTACAATTAAC
GAAATGGGCAGAAACAAAGAAATTAACTGGATGGTACGCGCGAAGAATCGCTGTAGGTCGTGATGGTGAAATTCAGGGTG
TTGCGCAGTTACTTTTTAAAAAAGTACCTAAATTACCTTATACGCTATGTTATATTTCACGTGGTTTTGTTGTTGATTAT
AGTAATAAAGAGGCGTTAAATGCATTGTTAGACAGTGCAAAAGAAATTGCTAAAGCTGAGAAAGCTTATGCAATTAAAAT
CGATCCTGATGTTGAAGTCGATAAAGGTACAGATGCTTTGCAAAATTTGAAAGCGCTTGGTTTTAAACATAAAGGATTTA
AAGAAGGTTTATCAAAAGACTACATCCAACCACGTATGACTATGATTACACCAATTGATAAAAATGATGATGAGTTATTA
AATAGTTATGAACGCCGAAATCGTTCAAAAGTGCGCTTGGCATTAAAACGAGGTACGACAGTAGAACGATCTGATAGAGA
AGGTTTAAAAACATTTGCTGAATTAATGAAAATCACTGGGGAACGCGATGGCTTCTTAACGCGTGATATTAGTTACTTTG
AAAATATTTATGATGCGTTGCATGAAGATGGAGATGCTGAACTATTTTTAGTAAAGTTGGATCCAAAAGAAAATATAGCG
AAAGTAAATCAAGAATTGAATGAACTTCATGCCGAAATTGCTAAATGGCAGCAGAAGATGGAAACATCTGAAAAGCAAGC
TAAAAAAGCGCAAAATATGATTAATGATGCGCAAAATAAAATTGCTAAAAATGAAGATTTAAAACGAGACCTAGAAGCTT
TAGAAAAGGAACATCCTGAAGGTATTTATCTTTCTGGTGCACTATTAATGTTTGCTGGCTCAAAATCATATTACTTATAT
GGTGCGTCTTCTAATGAATTTAGAGATTTTTTACCAAATCATCATATGCAGTATACGATGATGAAGTATGCACGTGAACA
TGGTGCAACAACTTACGATTTCGGTGGTACAGATAATGATCCAGATAAAGACTCAGAACATTATGGCTTATGGGCATTTA
AAAAAGTGTGGGGAACATACTTAAGTGAAAAGATTGGTGAATTTGATTATGTATTGAATCAGCCATTGTACCAATTAATT
GAGCAAGTTAAACCGCGTTTAACAAAAGCTAAAATTAAAATATCTCGTAAATTAAAACGAAAATAG

Upstream 100 bases:

>100_bases
AAAATAAGAGTTCAAATCATACACAAGCTCTGAATCGACACTATAAGATACAAACTGTATAATTAAAGGTATTGTTAAAT
AGAAGGAGATATCATAAATC

Downstream 100 bases:

>100_bases
ATTAACGACTGAAATCTGAACGCTCATAAGACTGTCATTTGCGTTCAGATTTTTTTACACAATATAGAATGGTTGAGTAA
AATATTTTTGAATATAGTGA

Product: methicillin resistance factor peptidoglycan pentaglycine interpeptide biosynthetic protein

Products: NA

Alternate protein names: Factor essential for expression of methicillin resistance X [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MEKMHITNQEHDAFVKSHPNGDLLQLTKWAETKKLTGWYARRIAVGRDGEIQGVAQLLFKKVPKLPYTLCYISRGFVVDY
SNKEALNALLDSAKEIAKAEKAYAIKIDPDVEVDKGTDALQNLKALGFKHKGFKEGLSKDYIQPRMTMITPIDKNDDELL
NSYERRNRSKVRLALKRGTTVERSDREGLKTFAELMKITGERDGFLTRDISYFENIYDALHEDGDAELFLVKLDPKENIA
KVNQELNELHAEIAKWQQKMETSEKQAKKAQNMINDAQNKIAKNEDLKRDLEALEKEHPEGIYLSGALLMFAGSKSYYLY
GASSNEFRDFLPNHHMQYTMMKYAREHGATTYDFGGTDNDPDKDSEHYGLWAFKKVWGTYLSEKIGEFDYVLNQPLYQLI
EQVKPRLTKAKIKISRKLKRK

Sequences:

>Translated_421_residues
MEKMHITNQEHDAFVKSHPNGDLLQLTKWAETKKLTGWYARRIAVGRDGEIQGVAQLLFKKVPKLPYTLCYISRGFVVDY
SNKEALNALLDSAKEIAKAEKAYAIKIDPDVEVDKGTDALQNLKALGFKHKGFKEGLSKDYIQPRMTMITPIDKNDDELL
NSYERRNRSKVRLALKRGTTVERSDREGLKTFAELMKITGERDGFLTRDISYFENIYDALHEDGDAELFLVKLDPKENIA
KVNQELNELHAEIAKWQQKMETSEKQAKKAQNMINDAQNKIAKNEDLKRDLEALEKEHPEGIYLSGALLMFAGSKSYYLY
GASSNEFRDFLPNHHMQYTMMKYAREHGATTYDFGGTDNDPDKDSEHYGLWAFKKVWGTYLSEKIGEFDYVLNQPLYQLI
EQVKPRLTKAKIKISRKLKRK
>Mature_421_residues
MEKMHITNQEHDAFVKSHPNGDLLQLTKWAETKKLTGWYARRIAVGRDGEIQGVAQLLFKKVPKLPYTLCYISRGFVVDY
SNKEALNALLDSAKEIAKAEKAYAIKIDPDVEVDKGTDALQNLKALGFKHKGFKEGLSKDYIQPRMTMITPIDKNDDELL
NSYERRNRSKVRLALKRGTTVERSDREGLKTFAELMKITGERDGFLTRDISYFENIYDALHEDGDAELFLVKLDPKENIA
KVNQELNELHAEIAKWQQKMETSEKQAKKAQNMINDAQNKIAKNEDLKRDLEALEKEHPEGIYLSGALLMFAGSKSYYLY
GASSNEFRDFLPNHHMQYTMMKYAREHGATTYDFGGTDNDPDKDSEHYGLWAFKKVWGTYLSEKIGEFDYVLNQPLYQLI
EQVKPRLTKAKIKISRKLKRK

Specific function: Catalyzes the incorporation of the first glycine of the pentaglycine interpeptide bridge, which is characteristic of the S.aureus peptidoglycan. This glycine is added to the epsilon-amino group of the L-lysine of the membrane-bound lipid II intermediate (

COG id: COG2348

COG function: function code V; Uncharacterized protein involved in methicillin resistance

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the femABX family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016181
- InterPro:   IPR003447 [H]

Pfam domain/function: PF02388 FemAB [H]

EC number: NA

Molecular weight: Translated: 48553; Mature: 48553

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKMHITNQEHDAFVKSHPNGDLLQLTKWAETKKLTGWYARRIAVGRDGEIQGVAQLLFK
CCCCCCCCCHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
KVPKLPYTLCYISRGFVVDYSNKEALNALLDSAKEIAKAEKAYAIKIDPDVEVDKGTDAL
HCCCCCEEEEEEECCEEEECCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCHHHH
QNLKALGFKHKGFKEGLSKDYIQPRMTMITPIDKNDDELLNSYERRNRSKVRLALKRGTT
HHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCHHHEEEHHHCCCC
VERSDREGLKTFAELMKITGERDGFLTRDISYFENIYDALHEDGDAELFLVKLDPKENIA
CCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHH
KVNQELNELHAEIAKWQQKMETSEKQAKKAQNMINDAQNKIAKNEDLKRDLEALEKEHPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
GIYLSGALLMFAGSKSYYLYGASSNEFRDFLPNHHMQYTMMKYAREHGATTYDFGGTDND
CEEEECEEEEEECCCCEEEEECCCCHHHHHCCCCCHHHHHHHHHHHCCCEEEECCCCCCC
PDKDSEHYGLWAFKKVWGTYLSEKIGEFDYVLNQPLYQLIEQVKPRLTKAKIKISRKLKR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
K
C
>Mature Secondary Structure
MEKMHITNQEHDAFVKSHPNGDLLQLTKWAETKKLTGWYARRIAVGRDGEIQGVAQLLFK
CCCCCCCCCHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
KVPKLPYTLCYISRGFVVDYSNKEALNALLDSAKEIAKAEKAYAIKIDPDVEVDKGTDAL
HCCCCCEEEEEEECCEEEECCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCHHHH
QNLKALGFKHKGFKEGLSKDYIQPRMTMITPIDKNDDELLNSYERRNRSKVRLALKRGTT
HHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCHHHEEEHHHCCCC
VERSDREGLKTFAELMKITGERDGFLTRDISYFENIYDALHEDGDAELFLVKLDPKENIA
CCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHH
KVNQELNELHAEIAKWQQKMETSEKQAKKAQNMINDAQNKIAKNEDLKRDLEALEKEHPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
GIYLSGALLMFAGSKSYYLYGASSNEFRDFLPNHHMQYTMMKYAREHGATTYDFGGTDND
CEEEECEEEEEECCCCEEEEECCCCHHHHHCCCCCHHHHHHHHHHHCCCEEEECCCCCCC
PDKDSEHYGLWAFKKVWGTYLSEKIGEFDYVLNQPLYQLIEQVKPRLTKAKIKISRKLKR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA