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The map label for this gene is gyaR [H]

Identifier: 82751516

GI number: 82751516

Start: 1929288

End: 1930238

Strand: Reverse

Name: gyaR [H]

Synonym: SAB1795c

Alternate gene names: 82751516

Gene position: 1930238-1929288 (Counterclockwise)

Preceding gene: 82751517

Following gene: 82751515

Centisome position: 70.38

GC content: 30.81

Gene sequence:

>951_bases
ATGAGAGTTGTTGGGTTGAATCGTATGCGTGAAGTTGAAACTGAATTACAACAACGCTTTTCAGATGTAGATTTTAAATT
TTATAAAAAAGCATCAGAAATACCTGAGAGTGACTTGGCTGATTTAGATATATTAGTTGGTTATGATGGCGGTATCAATG
AGGCATTTTTACGACGTTGTCCAAATTTAAAATGGATCGCATGGTTTGCAACGGGTGTAAATACATTACCGTTAGATTAT
ATTTCAGATCACGGCATACTTTTAACTAATGGAAAAGGTGTTCAAGCTAAACAATTATCTGAATACATTTTGGCTTTCAT
TTTAGATGATTATAAAAAGATGAAACTATCATATGATAACCAACGACAACATATATATGATTCGAAAATAACTGGTAAAC
GCCTTTCAGGACAAACAGTTTTATTTTTAGGTACAGGTGCAATTGCTACTAGAACTGCGAAGTTAGCAAAGGCTTTTAAT
ATGAATTTAATTGGTCTGAGTAAGTCAGGTCAGAACAAACATGAGTTTGATGAGATATATACTATCGAATCACTTGAAAG
CACATTACCAAATGCTGACATTGTTATAAATGCTTTACCAGAAACGCAAGAAACGATTCATTTACTAAAGAAAAATCATT
TTGAATTAATGAAAGATGAAGCACTTTTTATAAATATAGGACGAGGTAGCATAGTTAAAGAAGCGCTCTTAATAGAAGTA
TTAAAAAGTAGAGTTATTCGACATGCATATTTAGATGTGTTTGAAAATGAACCTTTGAAACCTAATCATGAATTATATGA
ATTGGATAATGTAACTATAACAGCGCATATAACTGGTAATGATTATGAAGCAAAGTATGACTTATTAGATATTTTAAAAA
ACAATCTAGTTAATTTTCTCAATAAGAATGGTCTAATTGAGAATGAAGTCGATGCTAAAAAAGGCTATTAA

Upstream 100 bases:

>100_bases
CTTTTATAATAGATGAACAAGGTAAAGTATTAGATGTTATCGAGAAGGTTAAAGTTAAAACACAAATAGAAGAACTTAAA
AACATTTTGGGGTGACATAT

Downstream 100 bases:

>100_bases
ATGAAATCATTATGTAAATATTGACACGCGCGCAATACTACAGTTATATTTATAGTAAGTAATAATAATTATTATATAAG
AAAGATGGTGATATAGATGA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MRVVGLNRMREVETELQQRFSDVDFKFYKKASEIPESDLADLDILVGYDGGINEAFLRRCPNLKWIAWFATGVNTLPLDY
ISDHGILLTNGKGVQAKQLSEYILAFILDDYKKMKLSYDNQRQHIYDSKITGKRLSGQTVLFLGTGAIATRTAKLAKAFN
MNLIGLSKSGQNKHEFDEIYTIESLESTLPNADIVINALPETQETIHLLKKNHFELMKDEALFINIGRGSIVKEALLIEV
LKSRVIRHAYLDVFENEPLKPNHELYELDNVTITAHITGNDYEAKYDLLDILKNNLVNFLNKNGLIENEVDAKKGY

Sequences:

>Translated_316_residues
MRVVGLNRMREVETELQQRFSDVDFKFYKKASEIPESDLADLDILVGYDGGINEAFLRRCPNLKWIAWFATGVNTLPLDY
ISDHGILLTNGKGVQAKQLSEYILAFILDDYKKMKLSYDNQRQHIYDSKITGKRLSGQTVLFLGTGAIATRTAKLAKAFN
MNLIGLSKSGQNKHEFDEIYTIESLESTLPNADIVINALPETQETIHLLKKNHFELMKDEALFINIGRGSIVKEALLIEV
LKSRVIRHAYLDVFENEPLKPNHELYELDNVTITAHITGNDYEAKYDLLDILKNNLVNFLNKNGLIENEVDAKKGY
>Mature_316_residues
MRVVGLNRMREVETELQQRFSDVDFKFYKKASEIPESDLADLDILVGYDGGINEAFLRRCPNLKWIAWFATGVNTLPLDY
ISDHGILLTNGKGVQAKQLSEYILAFILDDYKKMKLSYDNQRQHIYDSKITGKRLSGQTVLFLGTGAIATRTAKLAKAFN
MNLIGLSKSGQNKHEFDEIYTIESLESTLPNADIVINALPETQETIHLLKKNHFELMKDEALFINIGRGSIVKEALLIEV
LKSRVIRHAYLDVFENEPLKPNHELYELDNVTITAHITGNDYEAKYDLLDILKNNLVNFLNKNGLIENEVDAKKGY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=247, Percent_Identity=27.9352226720648, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI23308577, Length=234, Percent_Identity=26.0683760683761, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI87082289, Length=299, Percent_Identity=27.0903010033445, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI87081824, Length=242, Percent_Identity=24.7933884297521, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1789279, Length=242, Percent_Identity=24.7933884297521, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787645, Length=205, Percent_Identity=24.8780487804878, Blast_Score=75, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=239, Percent_Identity=26.3598326359833, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320925, Length=301, Percent_Identity=25.2491694352159, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322116, Length=307, Percent_Identity=24.1042345276873, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=174, Percent_Identity=29.3103448275862, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324055, Length=169, Percent_Identity=30.7692307692308, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28574286, Length=250, Percent_Identity=26.4, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24585514, Length=253, Percent_Identity=26.0869565217391, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574282, Length=253, Percent_Identity=26.0869565217391, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574284, Length=253, Percent_Identity=26.0869565217391, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45552429, Length=253, Percent_Identity=26.0869565217391, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45551003, Length=253, Percent_Identity=26.0869565217391, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI28571528, Length=178, Percent_Identity=28.0898876404494, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585516, Length=253, Percent_Identity=22.1343873517787, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24646446, Length=231, Percent_Identity=25.1082251082251, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24646448, Length=231, Percent_Identity=25.1082251082251, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24646452, Length=231, Percent_Identity=25.1082251082251, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24646450, Length=231, Percent_Identity=25.1082251082251, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35972; Mature: 35972

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVGLNRMREVETELQQRFSDVDFKFYKKASEIPESDLADLDILVGYDGGINEAFLRRC
CEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHC
PNLKWIAWFATGVNTLPLDYISDHGILLTNGKGVQAKQLSEYILAFILDDYKKMKLSYDN
CCCEEEEEEECCCCCCCHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
QRQHIYDSKITGKRLSGQTVLFLGTGAIATRTAKLAKAFNMNLIGLSKSGQNKHEFDEIY
CHHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHE
TIESLESTLPNADIVINALPETQETIHLLKKNHFELMKDEALFINIGRGSIVKEALLIEV
EHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHH
LKSRVIRHAYLDVFENEPLKPNHELYELDNVTITAHITGNDYEAKYDLLDILKNNLVNFL
HHHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
NKNGLIENEVDAKKGY
HCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRVVGLNRMREVETELQQRFSDVDFKFYKKASEIPESDLADLDILVGYDGGINEAFLRRC
CEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHC
PNLKWIAWFATGVNTLPLDYISDHGILLTNGKGVQAKQLSEYILAFILDDYKKMKLSYDN
CCCEEEEEEECCCCCCCHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
QRQHIYDSKITGKRLSGQTVLFLGTGAIATRTAKLAKAFNMNLIGLSKSGQNKHEFDEIY
CHHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHE
TIESLESTLPNADIVINALPETQETIHLLKKNHFELMKDEALFINIGRGSIVKEALLIEV
EHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHH
LKSRVIRHAYLDVFENEPLKPNHELYELDNVTITAHITGNDYEAKYDLLDILKNNLVNFL
HHHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
NKNGLIENEVDAKKGY
HCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]