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The map label for this gene is hemY

Identifier: 82751484

GI number: 82751484

Start: 1889449

End: 1890849

Strand: Reverse

Name: hemY

Synonym: SAB1763c

Alternate gene names: 82751484

Gene position: 1890849-1889449 (Counterclockwise)

Preceding gene: 82751485

Following gene: 82751483

Centisome position: 68.95

GC content: 35.47

Gene sequence:

>1401_bases
GTGACTAAATCAGTGGCTATTATAGGAGCGGGGATAACAGGTTTATCAAGTGCATATTTTTTAAAACAGCAAGATCCTAA
CATTGATGTAACCATCTTTGAAGCATCGAATCGTCCGGGGGGAAAGATTCAATCGTATCGTAAAGATGGTTATATGATTG
AACTAGGGCCTGAATCTTATTTAGGTAGAAAAACGATCATGACAGAATTAGCGAAAGATATTGGATTAGAACAAGATATT
GTTACAAATACGACTGGACAATCTTATATTTTTGCGAAAAACAAATTGTATCCTATTCCAGGTGGATCAATTATGGGAAT
TCCGACAGATATCAAACCGTTTGTGACAACTAAATTAATTTCACCACTTGGAAAGTTAAGAGCAGGGTTAGATTTACTTA
AAAAACCTACTCAAATGCAGGATGGTGACATTTCTGTTGGTGCATTTTTCAGAGCAAGATTAGGTAATGAGGTACTTGAG
AATTTAATTGAGCCTTTAATGGGTGGTATTTATGGTACCGATATTGATAAATTAAGTTTGATGAGTACGTTTCCTAATTT
TAAAGAAAAAGAAGAGGCATTCGGAAGTCTGATAAAAGGTATGAAGGATGAGAAAAATAAGCGTCTGAAACAAAGACAAT
TATATCCTGGCGCACCAAAAGGACAATTCAAACAATTTAAGCATGGTTTAAGCTCATTTATTGAAGCATTAGAACAAGAT
GTGAAAAATAAAGGTGTGACAATACGCTACAATACGTCAGTGGATGATATTATTACATCTCAAAAGCAATATAAAATTGT
TTACAGTAATCAACAAGAAGATGTATTCGATGGAATATTAGTGACAACACCGCATCAAGTCTTTTTGAATTGGTTCGGAC
AAGATCCAGCATTTGATTACTTTAAAACGATGGATAGTACGACTGTTGCAACTGTTGTATTGGCATTTGATGAAAAAGAC
ATTGAAAATACTTATGATGGTACTGGCTTCGTGATTGCGAGAACGAGTGATACTGACATTACCGCATGTACTTGGACATC
GAAAAAATGGCCATTTACTACACCGGAAGGTAAGGTTTTGATTCGTGCGTATGTAGGTAAACCAGGTGATACTGTGGTTG
ATGATCATACAGATAATGAATTAGTATCGATTGTACGTAGAGATTTAAGTCAAATGATGACATTTAAAGGTGATCCTGAA
TTTACAATTGTCAATCGTTTGCCGAAAAGTATGCCACAGTACCATGTTGGTCACATTCAACAAATTAGACAGATTCAAGC
ACATATTAAACAAACATATCCACGACTTAGAGTAACTGGTGCATCTTTTGAAGCGGTTGGACTACCTGATTGTATTACAC
AAGGTAAAGTTGCTGCTGAAGAAGTAATCGCAGAGTTGTAA

Upstream 100 bases:

>100_bases
ATTATCGTCCAAAAATGCCGAATACACATCCATTATTTATCGGTGCAATTGTTGATGAAATCAAGTCTATATTTTAATGA
CGAAAGAAGCGTGAAACGTT

Downstream 100 bases:

>100_bases
GTTAATTGTTGGATGGAGTTGGTGTAGGTGCGACGCCTTTAGATCATGTTTGATGAAATATAGTCATTTTTAAGTTATAT
AATGGTGGAAGTAATGTGTA

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MTKSVAIIGAGITGLSSAYFLKQQDPNIDVTIFEASNRPGGKIQSYRKDGYMIELGPESYLGRKTIMTELAKDIGLEQDI
VTNTTGQSYIFAKNKLYPIPGGSIMGIPTDIKPFVTTKLISPLGKLRAGLDLLKKPTQMQDGDISVGAFFRARLGNEVLE
NLIEPLMGGIYGTDIDKLSLMSTFPNFKEKEEAFGSLIKGMKDEKNKRLKQRQLYPGAPKGQFKQFKHGLSSFIEALEQD
VKNKGVTIRYNTSVDDIITSQKQYKIVYSNQQEDVFDGILVTTPHQVFLNWFGQDPAFDYFKTMDSTTVATVVLAFDEKD
IENTYDGTGFVIARTSDTDITACTWTSKKWPFTTPEGKVLIRAYVGKPGDTVVDDHTDNELVSIVRRDLSQMMTFKGDPE
FTIVNRLPKSMPQYHVGHIQQIRQIQAHIKQTYPRLRVTGASFEAVGLPDCITQGKVAAEEVIAEL

Sequences:

>Translated_466_residues
MTKSVAIIGAGITGLSSAYFLKQQDPNIDVTIFEASNRPGGKIQSYRKDGYMIELGPESYLGRKTIMTELAKDIGLEQDI
VTNTTGQSYIFAKNKLYPIPGGSIMGIPTDIKPFVTTKLISPLGKLRAGLDLLKKPTQMQDGDISVGAFFRARLGNEVLE
NLIEPLMGGIYGTDIDKLSLMSTFPNFKEKEEAFGSLIKGMKDEKNKRLKQRQLYPGAPKGQFKQFKHGLSSFIEALEQD
VKNKGVTIRYNTSVDDIITSQKQYKIVYSNQQEDVFDGILVTTPHQVFLNWFGQDPAFDYFKTMDSTTVATVVLAFDEKD
IENTYDGTGFVIARTSDTDITACTWTSKKWPFTTPEGKVLIRAYVGKPGDTVVDDHTDNELVSIVRRDLSQMMTFKGDPE
FTIVNRLPKSMPQYHVGHIQQIRQIQAHIKQTYPRLRVTGASFEAVGLPDCITQGKVAAEEVIAEL
>Mature_465_residues
TKSVAIIGAGITGLSSAYFLKQQDPNIDVTIFEASNRPGGKIQSYRKDGYMIELGPESYLGRKTIMTELAKDIGLEQDIV
TNTTGQSYIFAKNKLYPIPGGSIMGIPTDIKPFVTTKLISPLGKLRAGLDLLKKPTQMQDGDISVGAFFRARLGNEVLEN
LIEPLMGGIYGTDIDKLSLMSTFPNFKEKEEAFGSLIKGMKDEKNKRLKQRQLYPGAPKGQFKQFKHGLSSFIEALEQDV
KNKGVTIRYNTSVDDIITSQKQYKIVYSNQQEDVFDGILVTTPHQVFLNWFGQDPAFDYFKTMDSTTVATVVLAFDEKDI
ENTYDGTGFVIARTSDTDITACTWTSKKWPFTTPEGKVLIRAYVGKPGDTVVDDHTDNELVSIVRRDLSQMMTFKGDPEF
TIVNRLPKSMPQYHVGHIQQIRQIQAHIKQTYPRLRVTGASFEAVGLPDCITQGKVAAEEVIAEL

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Also oxidizes the pathway intermediate coproporphyrinogen-III [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=488, Percent_Identity=23.3606557377049, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI4506001, Length=488, Percent_Identity=23.3606557377049, Blast_Score=119, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6320851, Length=210, Percent_Identity=31.4285714285714, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24649745, Length=460, Percent_Identity=24.1304347826087, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 51947; Mature: 51816

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKSVAIIGAGITGLSSAYFLKQQDPNIDVTIFEASNRPGGKIQSYRKDGYMIELGPESY
CCCCEEEEECCHHHCCCEEEEECCCCCEEEEEEECCCCCCCCHHHHCCCCEEEEECCHHH
LGRKTIMTELAKDIGLEQDIVTNTTGQSYIFAKNKLYPIPGGSIMGIPTDIKPFVTTKLI
HHHHHHHHHHHHHCCCCCHHEECCCCCEEEEECCEEEECCCCCEECCCCCCCHHHHHHHH
SPLGKLRAGLDLLKKPTQMQDGDISVGAFFRARLGNEVLENLIEPLMGGIYGTDIDKLSL
HHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
MSTFPNFKEKEEAFGSLIKGMKDEKNKRLKQRQLYPGAPKGQFKQFKHGLSSFIEALEQD
HHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VKNKGVTIRYNTSVDDIITSQKQYKIVYSNQQEDVFDGILVTTPHQVFLNWFGQDPAFDY
HHHCCEEEEECCCHHHHHCCCCEEEEEECCCCHHHHCCEEEECCHHHHHHHCCCCCCHHH
FKTMDSTTVATVVLAFDEKDIENTYDGTGFVIARTSDTDITACTWTSKKWPFTTPEGKVL
HHHCCCCEEEEEEEEECCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCEE
IRAYVGKPGDTVVDDHTDNELVSIVRRDLSQMMTFKGDPEFTIVNRLPKSMPQYHVGHIQ
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCHHHHHHHH
QIRQIQAHIKQTYPRLRVTGASFEAVGLPDCITQGKVAAEEVIAEL
HHHHHHHHHHHHCCCEEEECCCEEECCCCHHHHCCCHHHHHHHHCC
>Mature Secondary Structure 
TKSVAIIGAGITGLSSAYFLKQQDPNIDVTIFEASNRPGGKIQSYRKDGYMIELGPESY
CCCEEEEECCHHHCCCEEEEECCCCCEEEEEEECCCCCCCCHHHHCCCCEEEEECCHHH
LGRKTIMTELAKDIGLEQDIVTNTTGQSYIFAKNKLYPIPGGSIMGIPTDIKPFVTTKLI
HHHHHHHHHHHHHCCCCCHHEECCCCCEEEEECCEEEECCCCCEECCCCCCCHHHHHHHH
SPLGKLRAGLDLLKKPTQMQDGDISVGAFFRARLGNEVLENLIEPLMGGIYGTDIDKLSL
HHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
MSTFPNFKEKEEAFGSLIKGMKDEKNKRLKQRQLYPGAPKGQFKQFKHGLSSFIEALEQD
HHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VKNKGVTIRYNTSVDDIITSQKQYKIVYSNQQEDVFDGILVTTPHQVFLNWFGQDPAFDY
HHHCCEEEEECCCHHHHHCCCCEEEEEECCCCHHHHCCEEEECCHHHHHHHCCCCCCHHH
FKTMDSTTVATVVLAFDEKDIENTYDGTGFVIARTSDTDITACTWTSKKWPFTTPEGKVL
HHHCCCCEEEEEEEEECCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCEE
IRAYVGKPGDTVVDDHTDNELVSIVRRDLSQMMTFKGDPEFTIVNRLPKSMPQYHVGHIQ
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCHHHHHHHH
QIRQIQAHIKQTYPRLRVTGASFEAVGLPDCITQGKVAAEEVIAEL
HHHHHHHHHHHHCCCEEEECCCEEECCCCHHHHCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1459957; 9579061; 9384377; 8288631 [H]