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The map label for this gene is lexA [H]

Identifier: 82751478

GI number: 82751478

Start: 1884309

End: 1884977

Strand: Direct

Name: lexA [H]

Synonym: SAB1757

Alternate gene names: 82751478

Gene position: 1884309-1884977 (Clockwise)

Preceding gene: 82751475

Following gene: 82751479

Centisome position: 68.71

GC content: 31.54

Gene sequence:

>669_bases
ATGTTATTATATAGGTACAAATTAGAAATGAGGCAAACAATTATGACTAAAGAAAAAGATTTAAAATATCTTATGGAAAA
GAAATCAGGTAGTGTAAAGGCTTTTTCCGAAGAAATTGGTTTAGCTTATACAACTGTAAGATCTATTTTAGAACGTGGAG
TTTTTAATGCTAAAGTAGAAAACGTCATCAAAATTTGTAATGGTCTAAATATAAGACCAGAAGATATTATGGATATTAAA
CAAACAAAACCTATTGAACCCCAAATTGAAACTTTACCAGTTAAAAAGATTCCGGTCGTTTCAAAAATATCTGCGGGCTT
ACCTATCTATTGTGAAGAAAATTTAGTTGATTACATATACTTTTCTAGGGATAAATTGAACGACGAAAAAGAAGAATTTG
GTCTAAAAGTATCTGGTGATAGTATGAACAAACTTTTTGATGAAGGTGATGTAGTTGTTGTAGAAAAAGATTCTATCGTC
GAAAATGGTCAGTTAGGTGTAGTCATGATAAATGGGTACAACGGTACTGTGAAGCGTATAAGATACAACGGAGACCAAAT
CATATTAATACCTGAATCTAACAACCCTAGTCACTATCCACAAGTATATGGTAAGGACGATGAAGTTAAAATTGTAGGTA
GAGTTGTAGCAAGTGTGAAAACGTATTGA

Upstream 100 bases:

>100_bases
CGTCGATTGCTTAACTAAATATTATACGAATTTTCGTACTATGTCAACACTAAAATTCGTATTTTTTATTTTCTATAATA
CTTGATATACGATTTTTCGC

Downstream 100 bases:

>100_bases
TTAATAGCTCCTTTACGGAGCTTTAATATAAAAAGGAAACAAAGGAGAAACGAAAAATGGCAGGAGATAAATTAACTTTC
AAAGAAATTCTAACAGAAAC

Product: transcriptional repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MLLYRYKLEMRQTIMTKEKDLKYLMEKKSGSVKAFSEEIGLAYTTVRSILERGVFNAKVENVIKICNGLNIRPEDIMDIK
QTKPIEPQIETLPVKKIPVVSKISAGLPIYCEENLVDYIYFSRDKLNDEKEEFGLKVSGDSMNKLFDEGDVVVVEKDSIV
ENGQLGVVMINGYNGTVKRIRYNGDQIILIPESNNPSHYPQVYGKDDEVKIVGRVVASVKTY

Sequences:

>Translated_222_residues
MLLYRYKLEMRQTIMTKEKDLKYLMEKKSGSVKAFSEEIGLAYTTVRSILERGVFNAKVENVIKICNGLNIRPEDIMDIK
QTKPIEPQIETLPVKKIPVVSKISAGLPIYCEENLVDYIYFSRDKLNDEKEEFGLKVSGDSMNKLFDEGDVVVVEKDSIV
ENGQLGVVMINGYNGTVKRIRYNGDQIILIPESNNPSHYPQVYGKDDEVKIVGRVVASVKTY
>Mature_222_residues
MLLYRYKLEMRQTIMTKEKDLKYLMEKKSGSVKAFSEEIGLAYTTVRSILERGVFNAKVENVIKICNGLNIRPEDIMDIK
QTKPIEPQIETLPVKKIPVVSKISAGLPIYCEENLVDYIYFSRDKLNDEKEEFGLKVSGDSMNKLFDEGDVVVVEKDSIV
ENGQLGVVMINGYNGTVKRIRYNGDQIILIPESNNPSHYPQVYGKDDEVKIVGRVVASVKTY

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 25251; Mature: 25251

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS50943 HTH_CROC1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLYRYKLEMRQTIMTKEKDLKYLMEKKSGSVKAFSEEIGLAYTTVRSILERGVFNAKVE
CEEEEEHHHHHHHHHCCHHHHHHHHHHCCCCEEEHHHHHCHHHHHHHHHHHCCCCHHHHH
NVIKICNGLNIRPEDIMDIKQTKPIEPQIETLPVKKIPVVSKISAGLPIYCEENLVDYIY
HHHHHHCCCCCCHHHHHHHHCCCCCCCCHHCCCCCCCCCHHHHCCCCCEEECCCCEEEEE
FSRDKLNDEKEEFGLKVSGDSMNKLFDEGDVVVVEKDSIVENGQLGVVMINGYNGTVKRI
ECCCCCCCCHHHCCCEECCCHHHHHHCCCCEEEEECCCEECCCCEEEEEEECCCCEEEEE
RYNGDQIILIPESNNPSHYPQVYGKDDEVKIVGRVVASVKTY
EECCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MLLYRYKLEMRQTIMTKEKDLKYLMEKKSGSVKAFSEEIGLAYTTVRSILERGVFNAKVE
CEEEEEHHHHHHHHHCCHHHHHHHHHHCCCCEEEHHHHHCHHHHHHHHHHHCCCCHHHHH
NVIKICNGLNIRPEDIMDIKQTKPIEPQIETLPVKKIPVVSKISAGLPIYCEENLVDYIY
HHHHHHCCCCCCHHHHHHHHCCCCCCCCHHCCCCCCCCCHHHHCCCCCEEECCCCEEEEE
FSRDKLNDEKEEFGLKVSGDSMNKLFDEGDVVVVEKDSIVENGQLGVVMINGYNGTVKRI
ECCCCCCCCHHHCCCEECCCHHHHHHCCCCEEEEECCCEECCCCEEEEEEECCCCEEEEE
RYNGDQIILIPESNNPSHYPQVYGKDDEVKIVGRVVASVKTY
EECCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA