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The map label for this gene is menE [H]

Identifier: 82751378

GI number: 82751378

Start: 1794986

End: 1796464

Strand: Reverse

Name: menE [H]

Synonym: SAB1651c

Alternate gene names: 82751378

Gene position: 1796464-1794986 (Counterclockwise)

Preceding gene: 82751384

Following gene: 82751377

Centisome position: 65.5

GC content: 35.5

Gene sequence:

>1479_bases
ATGGACTTTTGGTTATATAAACAAGCACAACAAAATGGACATCATATTGCGATAACAGACGGTCAAGAATCTTATACTTA
TCAAAATTTATACTGTGAAGCGAGTCTATTGGCTAAAAGACTCAAGGCTTATCAACAATCTCGTGTCGGGCTATACATAG
ATAATTCGATTCAATCGATTATTTTAATACATGCATGTTGGTTGGCAAATATTGAAATTGCGATGATTAATACAAGGTTG
ACACCTAATGAGATGAAGAATCAGATGAGATCAATCGATGTACAATTGATTTTTTGCACCTTACCTCTGGAATTGCGAGG
GTTTCAAATTGTATTGTTGGATGATATTGAATTCGCTGGAAGGGATATTACAATGAACGGTTTGTTGGACAACACAATGG
ATATCCAATATGATACATCGAATGAAACTGTGGTGCCGAAAGATTCGCCGTCCAACATATTAAATACATCATTTAATTTA
GATGACATTGCATCGATTATGTTTACATCAGGGACAACTGGCCCTCAAAAAGCGGTGCCACAAACGTTTCGTAATCATTA
TGCCAGTGCAATCGGATGTAAAGAGAGCTTGGGATTTGATCGTGACACTAATTGGCTATCTGTCTTGCCTATTTATCATA
TTTCGGGTCTCAGTGTACTTTTAAGAGCTGTTATTGAAGGGTTTACTGTGCGCATTGTTGATAAATTCAATGCCGAACAA
ATTTTAACGATGATAAAAAATGAACGCATCACACACATTTCGCTTGTGCCACAAACTTTAAATTGGCTTATGCAACAAGG
TTTACATGAACCTTATGATTTACAAAAAATATTACTCGGCGGTGCTAAATTATCTGCCACTATGATAGAGACGGCATTAC
AATATAACCTGCCAATTTATAATTCATTTGGTATGACTGAGACATGTTCGCAATTTTTAACAGCAACACCGCAAATGTTG
CATGCACGTCCTGACACTGTAGGGATGCCAAGTGCCAATGTTGACGTAAAAATTAAAAATCCTAATAAAGAAGGTCATGG
AGAATTAATGATTAAAGGCGCCAATGTGATGAATGGATATTTGTATCCAACAGATTTAACGGGTACGTTTGAAAATGGTT
ATTTTAATACGGGTGACATTGCTGAAATAGATTATGAAGGTTATGTCATGATTTATGACCGACGTAAAGATTTAATTATT
AGTGGCGGTGAAAATATTTATCCATATCAAATTGAAACGGTAGCGAAGCAATTTCCAGGTATCAGTGACGCAGTATGTGT
AGGGCATCCTGATGATACTTGGGGACAAGTACCTAAATTATATTTTGTCAGTGAAAGTGACATTTCAAAGGCACAATTGA
TTGCATATTTATCACAACATTTAGCGAAATATAAAATACCGAAACACTTTGAAAAGGTTGATACTTTACCTTATACATCA
ACAGGTAAATTACAAAGAAATAAGTTGTATAGAGGATGA

Upstream 100 bases:

>100_bases
CATCAATTCGTCTACTTTTTTATATTTTTAAACATAACCACTGCTAGAATGTCATAAAATCGTTATAATTATAAGGTAGA
TGAATTTGGAGGAATAGCGT

Downstream 100 bases:

>100_bases
TTTGATGAAGTTGACAGCTTTGCATTTTTATAAATATAGTGAGCCATTTAAGTCACAAATAGTAACACCGAAAGTCACTT
TAACGCATCGTGATTGTTTG

Product: O-succinylbenzoate-CoA ligase

Products: NA

Alternate protein names: OSB-CoA synthetase; o-succinylbenzoyl-CoA synthetase [H]

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MDFWLYKQAQQNGHHIAITDGQESYTYQNLYCEASLLAKRLKAYQQSRVGLYIDNSIQSIILIHACWLANIEIAMINTRL
TPNEMKNQMRSIDVQLIFCTLPLELRGFQIVLLDDIEFAGRDITMNGLLDNTMDIQYDTSNETVVPKDSPSNILNTSFNL
DDIASIMFTSGTTGPQKAVPQTFRNHYASAIGCKESLGFDRDTNWLSVLPIYHISGLSVLLRAVIEGFTVRIVDKFNAEQ
ILTMIKNERITHISLVPQTLNWLMQQGLHEPYDLQKILLGGAKLSATMIETALQYNLPIYNSFGMTETCSQFLTATPQML
HARPDTVGMPSANVDVKIKNPNKEGHGELMIKGANVMNGYLYPTDLTGTFENGYFNTGDIAEIDYEGYVMIYDRRKDLII
SGGENIYPYQIETVAKQFPGISDAVCVGHPDDTWGQVPKLYFVSESDISKAQLIAYLSQHLAKYKIPKHFEKVDTLPYTS
TGKLQRNKLYRG

Sequences:

>Translated_492_residues
MDFWLYKQAQQNGHHIAITDGQESYTYQNLYCEASLLAKRLKAYQQSRVGLYIDNSIQSIILIHACWLANIEIAMINTRL
TPNEMKNQMRSIDVQLIFCTLPLELRGFQIVLLDDIEFAGRDITMNGLLDNTMDIQYDTSNETVVPKDSPSNILNTSFNL
DDIASIMFTSGTTGPQKAVPQTFRNHYASAIGCKESLGFDRDTNWLSVLPIYHISGLSVLLRAVIEGFTVRIVDKFNAEQ
ILTMIKNERITHISLVPQTLNWLMQQGLHEPYDLQKILLGGAKLSATMIETALQYNLPIYNSFGMTETCSQFLTATPQML
HARPDTVGMPSANVDVKIKNPNKEGHGELMIKGANVMNGYLYPTDLTGTFENGYFNTGDIAEIDYEGYVMIYDRRKDLII
SGGENIYPYQIETVAKQFPGISDAVCVGHPDDTWGQVPKLYFVSESDISKAQLIAYLSQHLAKYKIPKHFEKVDTLPYTS
TGKLQRNKLYRG
>Mature_492_residues
MDFWLYKQAQQNGHHIAITDGQESYTYQNLYCEASLLAKRLKAYQQSRVGLYIDNSIQSIILIHACWLANIEIAMINTRL
TPNEMKNQMRSIDVQLIFCTLPLELRGFQIVLLDDIEFAGRDITMNGLLDNTMDIQYDTSNETVVPKDSPSNILNTSFNL
DDIASIMFTSGTTGPQKAVPQTFRNHYASAIGCKESLGFDRDTNWLSVLPIYHISGLSVLLRAVIEGFTVRIVDKFNAEQ
ILTMIKNERITHISLVPQTLNWLMQQGLHEPYDLQKILLGGAKLSATMIETALQYNLPIYNSFGMTETCSQFLTATPQML
HARPDTVGMPSANVDVKIKNPNKEGHGELMIKGANVMNGYLYPTDLTGTFENGYFNTGDIAEIDYEGYVMIYDRRKDLII
SGGENIYPYQIETVAKQFPGISDAVCVGHPDDTWGQVPKLYFVSESDISKAQLIAYLSQHLAKYKIPKHFEKVDTLPYTS
TGKLQRNKLYRG

Specific function: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA) [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily [H]

Homologues:

Organism=Homo sapiens, GI42544132, Length=362, Percent_Identity=25.9668508287293, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI115511026, Length=380, Percent_Identity=27.1052631578947, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI38505220, Length=369, Percent_Identity=27.3712737127371, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI156151445, Length=354, Percent_Identity=25.7062146892655, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI187761345, Length=380, Percent_Identity=26.3157894736842, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI187761343, Length=380, Percent_Identity=26.3157894736842, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI157311624, Length=362, Percent_Identity=27.3480662983425, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI157311622, Length=362, Percent_Identity=27.3480662983425, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI58082049, Length=361, Percent_Identity=26.8698060941828, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI122937307, Length=268, Percent_Identity=28.3582089552239, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI27477105, Length=158, Percent_Identity=33.5443037974684, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1788107, Length=501, Percent_Identity=25.9481037924152, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI145693145, Length=530, Percent_Identity=25.2830188679245, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1786810, Length=349, Percent_Identity=28.080229226361, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788595, Length=309, Percent_Identity=29.126213592233, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI221142682, Length=467, Percent_Identity=26.1241970021413, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI1789201, Length=489, Percent_Identity=23.1083844580777, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17538037, Length=371, Percent_Identity=28.5714285714286, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17559526, Length=362, Percent_Identity=27.9005524861878, Blast_Score=134, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17557194, Length=373, Percent_Identity=29.2225201072386, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17560308, Length=513, Percent_Identity=25.3411306042885, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI32563687, Length=341, Percent_Identity=28.4457478005865, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17531443, Length=466, Percent_Identity=27.2532188841202, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17558820, Length=474, Percent_Identity=26.3713080168776, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71996755, Length=462, Percent_Identity=24.025974025974, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71994694, Length=348, Percent_Identity=25.8620689655172, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71994690, Length=348, Percent_Identity=25.8620689655172, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71994703, Length=348, Percent_Identity=25.8620689655172, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17560140, Length=527, Percent_Identity=22.2011385199241, Blast_Score=102, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI25141359, Length=471, Percent_Identity=24.416135881104, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71985884, Length=346, Percent_Identity=26.5895953757225, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17556356, Length=260, Percent_Identity=25.3846153846154, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17556552, Length=223, Percent_Identity=27.8026905829596, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319699, Length=338, Percent_Identity=30.4733727810651, Blast_Score=132, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6319264, Length=548, Percent_Identity=19.8905109489051, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21355181, Length=510, Percent_Identity=22.9411764705882, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24581924, Length=517, Percent_Identity=24.9516441005803, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI18859661, Length=513, Percent_Identity=25.3411306042885, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI19922652, Length=507, Percent_Identity=25.2465483234714, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI20130357, Length=475, Percent_Identity=24.6315789473684, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21356947, Length=340, Percent_Identity=25.2941176470588, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24656500, Length=478, Percent_Identity=23.0125523012552, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24648257, Length=451, Percent_Identity=22.6164079822616, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24648260, Length=348, Percent_Identity=25.5747126436782, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17933690, Length=140, Percent_Identity=35, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24653035, Length=344, Percent_Identity=24.7093023255814, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19921316, Length=154, Percent_Identity=33.1168831168831, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21358303, Length=507, Percent_Identity=21.1045364891519, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI161076582, Length=351, Percent_Identity=24.2165242165242, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000873
- InterPro:   IPR010192
- InterPro:   IPR023015 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.26 [H]

Molecular weight: Translated: 55525; Mature: 55525

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFWLYKQAQQNGHHIAITDGQESYTYQNLYCEASLLAKRLKAYQQSRVGLYIDNSIQSI
CCCEEEEHHHCCCCEEEEECCCCCCEEEHEEECHHHHHHHHHHHHHCCCEEEECCCHHHH
ILIHACWLANIEIAMINTRLTPNEMKNQMRSIDVQLIFCTLPLELRGFQIVLLDDIEFAG
HHHHHHHHCCEEEEEEEECCCHHHHHHHHHHCEEEEEEEECCEEECCEEEEEEECCCCCC
RDITMNGLLDNTMDIQYDTSNETVVPKDSPSNILNTSFNLDDIASIMFTSGTTGPQKAVP
CEEEECCCCCCCEEEEECCCCCEECCCCCCCCHHCCCCCHHHHHHHHEECCCCCCHHHHH
QTFRNHYASAIGCKESLGFDRDTNWLSVLPIYHISGLSVLLRAVIEGFTVRIVDKFNAEQ
HHHHHHHHHHCCCHHHCCCCCCCCEEEEEEEHHHHHHHHHHHHHHCCCEEEEEECCCHHH
ILTMIKNERITHISLVPQTLNWLMQQGLHEPYDLQKILLGGAKLSATMIETALQYNLPIY
HHHHHHCCCEEEEEECHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEE
NSFGMTETCSQFLTATPQMLHARPDTVGMPSANVDVKIKNPNKEGHGELMIKGANVMNGY
ECCCCHHHHHHHHHCCCHHHHCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECCEECCE
LYPTDLTGTFENGYFNTGDIAEIDYEGYVMIYDRRKDLIISGGENIYPYQIETVAKQFPG
EEECCCCCCCCCCCCCCCCEEEEECCCEEEEEECCCEEEEECCCEECCCHHHHHHHHCCC
ISDAVCVGHPDDTWGQVPKLYFVSESDISKAQLIAYLSQHLAKYKIPKHFEKVDTLPYTS
CCCEEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCC
TGKLQRNKLYRG
CCCHHCCCCCCC
>Mature Secondary Structure
MDFWLYKQAQQNGHHIAITDGQESYTYQNLYCEASLLAKRLKAYQQSRVGLYIDNSIQSI
CCCEEEEHHHCCCCEEEEECCCCCCEEEHEEECHHHHHHHHHHHHHCCCEEEECCCHHHH
ILIHACWLANIEIAMINTRLTPNEMKNQMRSIDVQLIFCTLPLELRGFQIVLLDDIEFAG
HHHHHHHHCCEEEEEEEECCCHHHHHHHHHHCEEEEEEEECCEEECCEEEEEEECCCCCC
RDITMNGLLDNTMDIQYDTSNETVVPKDSPSNILNTSFNLDDIASIMFTSGTTGPQKAVP
CEEEECCCCCCCEEEEECCCCCEECCCCCCCCHHCCCCCHHHHHHHHEECCCCCCHHHHH
QTFRNHYASAIGCKESLGFDRDTNWLSVLPIYHISGLSVLLRAVIEGFTVRIVDKFNAEQ
HHHHHHHHHHCCCHHHCCCCCCCCEEEEEEEHHHHHHHHHHHHHHCCCEEEEEECCCHHH
ILTMIKNERITHISLVPQTLNWLMQQGLHEPYDLQKILLGGAKLSATMIETALQYNLPIY
HHHHHHCCCEEEEEECHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEE
NSFGMTETCSQFLTATPQMLHARPDTVGMPSANVDVKIKNPNKEGHGELMIKGANVMNGY
ECCCCHHHHHHHHHCCCHHHHCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECCEECCE
LYPTDLTGTFENGYFNTGDIAEIDYEGYVMIYDRRKDLIISGGENIYPYQIETVAKQFPG
EEECCCCCCCCCCCCCCCCEEEEECCCEEEEEECCCEEEEECCCEECCCHHHHHHHHCCC
ISDAVCVGHPDDTWGQVPKLYFVSESDISKAQLIAYLSQHLAKYKIPKHFEKVDTLPYTS
CCCEEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCC
TGKLQRNKLYRG
CCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA