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The map label for this gene is rot

Identifier: 82751350

GI number: 82751350

Start: 1768614

End: 1769114

Strand: Reverse

Name: rot

Synonym: SAB1622c

Alternate gene names: 82751350

Gene position: 1769114-1768614 (Counterclockwise)

Preceding gene: 82751351

Following gene: 82751347

Centisome position: 64.51

GC content: 31.94

Gene sequence:

>501_bases
ATGCATAAGTTAGCACATACAAGTTTTGGGATTGTTGGGATGTTTGTTAATACTTGTATGGTGGCTAAATATGTGATTAT
TAATTGGGAGATGTTTAGCATGAAAAAAGTAAATAACGACACTGTATTTGGGATTTTGCAATTAGAAACACTTTTGGGTG
ACATTAACTCAATTTTCAGCGAGATTGAAAGCGAATACAAAATGTCTAGAGAAGAAATTTTAATTTTACTAACTTTATGG
CAAAAAGGTTCTATGACGCTTAAAGAAATGGACAGATTTGTTGAAGTTAAACCGTATAAGCGTACGAGAACGTATAATAA
TTTAGTTGAATTAGAATGGATTTACAAAGAGCGTCCTGTTGACGATGAAAGAACAGTTATTATTCATTTCAATGAAAAGT
TACAACAAGAGAAAGTAGAGTTGTTGAATTTCATCAGTGATGCGATTGCAAGTAGAGCAACAGCAATGCAAAATAGTTTA
AACGCAATTATTGCTGTGTAA

Upstream 100 bases:

>100_bases
CTAAATATTAACTCTATTGATTATTGGTTTTTATACTTATTTAATTTTATTCAACTTTGACAATTGAATAGAAAGCAAGT
TTATTTACACTTGTAGTTTT

Downstream 100 bases:

>100_bases
GTTTAATAGCATAAAAAGAGGTTTTCATTAAGTTGAAAACCTCTTTTTGTTGTTGGTATTAATTTTTCAAATGTTGACTA
CTCAATCCTAAATTATAAAT

Product: repressor of toxins transcriptional regulator

Products: NA

Alternate protein names: Repressor of toxins [H]

Number of amino acids: Translated: 166; Mature: 166

Protein sequence:

>166_residues
MHKLAHTSFGIVGMFVNTCMVAKYVIINWEMFSMKKVNNDTVFGILQLETLLGDINSIFSEIESEYKMSREEILILLTLW
QKGSMTLKEMDRFVEVKPYKRTRTYNNLVELEWIYKERPVDDERTVIIHFNEKLQQEKVELLNFISDAIASRATAMQNSL
NAIIAV

Sequences:

>Translated_166_residues
MHKLAHTSFGIVGMFVNTCMVAKYVIINWEMFSMKKVNNDTVFGILQLETLLGDINSIFSEIESEYKMSREEILILLTLW
QKGSMTLKEMDRFVEVKPYKRTRTYNNLVELEWIYKERPVDDERTVIIHFNEKLQQEKVELLNFISDAIASRATAMQNSL
NAIIAV
>Mature_166_residues
MHKLAHTSFGIVGMFVNTCMVAKYVIINWEMFSMKKVNNDTVFGILQLETLLGDINSIFSEIESEYKMSREEILILLTLW
QKGSMTLKEMDRFVEVKPYKRTRTYNNLVELEWIYKERPVDDERTVIIHFNEKLQQEKVELLNFISDAIASRATAMQNSL
NAIIAV

Specific function: Global regulator with both positive and negative effects that mediates modulation of several genes involved in virulence. Negatively regulates the transcription of several known virulence factors such as lipase (geh), hemolysins (hla and hlb) and protease

COG id: COG1846

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rot family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010166
- InterPro:   IPR000835
- InterPro:   IPR016998
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01047 MarR [H]

EC number: NA

Molecular weight: Translated: 19389; Mature: 19389

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKLAHTSFGIVGMFVNTCMVAKYVIINWEMFSMKKVNNDTVFGILQLETLLGDINSIFS
CCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEHEEEECCCCEEEHHHHHHHHHHHHHHHHH
EIESEYKMSREEILILLTLWQKGSMTLKEMDRFVEVKPYKRTRTYNNLVELEWIYKERPV
HHHHHHHCCHHHEEEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHCCCEEEEEEECCCCC
DDERTVIIHFNEKLQQEKVELLNFISDAIASRATAMQNSLNAIIAV
CCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEC
>Mature Secondary Structure
MHKLAHTSFGIVGMFVNTCMVAKYVIINWEMFSMKKVNNDTVFGILQLETLLGDINSIFS
CCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEHEEEECCCCEEEHHHHHHHHHHHHHHHHH
EIESEYKMSREEILILLTLWQKGSMTLKEMDRFVEVKPYKRTRTYNNLVELEWIYKERPV
HHHHHHHCCHHHEEEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHCCCEEEEEEECCCCC
DDERTVIIHFNEKLQQEKVELLNFISDAIASRATAMQNSLNAIIAV
CCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10809700; 12511508 [H]