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The map label for this gene is apt

Identifier: 82751233

GI number: 82751233

Start: 1622791

End: 1623309

Strand: Reverse

Name: apt

Synonym: SAB1504c

Alternate gene names: 82751233

Gene position: 1623309-1622791 (Counterclockwise)

Preceding gene: 82751234

Following gene: 82751232

Centisome position: 59.19

GC content: 34.87

Gene sequence:

>519_bases
ATGGATTTAAAGCAATACGTATCAGAAGTTCAAGATTGGCCGAAACCAGGTGTTAGTTTCAAGGATATTACTACAATTAT
GGATAATGGTGAAGCATATGGCTATGCAACAAATAAAATTGTAGAATACGCAAAAGACAGAGATGTTGATATCGTCGTAG
GACCTGAAGCGCGTGGCTTTATCATTGGCTGTCCTGTAGCTTATTCAATGGGGATTGGCTTTGCACCTGTTAGAAAAGAA
GGGAAATTACCTCGTGAAGTCATTCGTTATGAGTATGACCTAGAATATGGTACAAATGTTTTAACAATGCACAAAGATGC
AATTAAACCAGGTCAACGTGTGTTAATTACAGATGATTTATTAGCTACTGGTGGTACGATTGAAGCAGCAATAAAATTAG
TCGAAAAATTAGGCGGCATCGTAGTAGGTATTGCATTTATAATTGAATTGAAATATTTAAATGGTATTGAAAAAATTAAA
GATTACGATGTTATGAGTTTAATCTCATACGACGAATAA

Upstream 100 bases:

>100_bases
ACGTATGGATGTTGAAAAGCAATTATTATATCAAGATTTTTCAGAAATAAAAAATTGGATAAAGTCACAATTGTCGTGAG
CAATTTAGGAGGAAATATTA

Downstream 100 bases:

>100_bases
AAAATAATATAATTTTATCAAATGAAATCCTTCATCAAATGTATAAGAACGAATGACTTAATTAAAAAAGTTGTTTAAGT
TTTCTTAACATGAGATGTTA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MDLKQYVSEVQDWPKPGVSFKDITTIMDNGEAYGYATNKIVEYAKDRDVDIVVGPEARGFIIGCPVAYSMGIGFAPVRKE
GKLPREVIRYEYDLEYGTNVLTMHKDAIKPGQRVLITDDLLATGGTIEAAIKLVEKLGGIVVGIAFIIELKYLNGIEKIK
DYDVMSLISYDE

Sequences:

>Translated_172_residues
MDLKQYVSEVQDWPKPGVSFKDITTIMDNGEAYGYATNKIVEYAKDRDVDIVVGPEARGFIIGCPVAYSMGIGFAPVRKE
GKLPREVIRYEYDLEYGTNVLTMHKDAIKPGQRVLITDDLLATGGTIEAAIKLVEKLGGIVVGIAFIIELKYLNGIEKIK
DYDVMSLISYDE
>Mature_172_residues
MDLKQYVSEVQDWPKPGVSFKDITTIMDNGEAYGYATNKIVEYAKDRDVDIVVGPEARGFIIGCPVAYSMGIGFAPVRKE
GKLPREVIRYEYDLEYGTNVLTMHKDAIKPGQRVLITDDLLATGGTIEAAIKLVEKLGGIVVGIAFIIELKYLNGIEKIK
DYDVMSLISYDE

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=172, Percent_Identity=36.6279069767442, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=37.6, Blast_Score=98, Evalue=5e-21,
Organism=Escherichia coli, GI1786675, Length=164, Percent_Identity=51.8292682926829, Blast_Score=177, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17509087, Length=173, Percent_Identity=43.9306358381503, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=172, Percent_Identity=34.8837209302326, Blast_Score=98, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6320649, Length=164, Percent_Identity=30.4878048780488, Blast_Score=76, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17136334, Length=170, Percent_Identity=40, Blast_Score=129, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 19116; Mature: 19116

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKQYVSEVQDWPKPGVSFKDITTIMDNGEAYGYATNKIVEYAKDRDVDIVVGPEARGF
CCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEHHHHHHHHHCCCCCEEEECCCCCCE
IIGCPVAYSMGIGFAPVRKEGKLPREVIRYEYDLEYGTNVLTMHKDAIKPGQRVLITDDL
EEECCHHHHCCCCCCCCCCCCCCCHHHHHEEECCCCCCEEEEEEHHHCCCCCEEEEECCH
LATGGTIEAAIKLVEKLGGIVVGIAFIIELKYLNGIEKIKDYDVMSLISYDE
HHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCC
>Mature Secondary Structure
MDLKQYVSEVQDWPKPGVSFKDITTIMDNGEAYGYATNKIVEYAKDRDVDIVVGPEARGF
CCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEHHHHHHHHHCCCCCEEEECCCCCCE
IIGCPVAYSMGIGFAPVRKEGKLPREVIRYEYDLEYGTNVLTMHKDAIKPGQRVLITDDL
EEECCHHHHCCCCCCCCCCCCCCCHHHHHEEECCCCCCEEEEEEHHHCCCCCEEEEECCH
LATGGTIEAAIKLVEKLGGIVVGIAFIIELKYLNGIEKIKDYDVMSLISYDE
HHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA