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The map label for this gene is trpC

Identifier: 82750961

GI number: 82750961

Start: 1341176

End: 1341958

Strand: Direct

Name: trpC

Synonym: SAB1225

Alternate gene names: 82750961

Gene position: 1341176-1341958 (Clockwise)

Preceding gene: 82750960

Following gene: 82750962

Centisome position: 48.9

GC content: 31.29

Gene sequence:

>783_bases
ATGACGATTTTAGCAGAAATTGTTAAATATAAACAGTCACTTTTACAAAATGGGTATTATCAAGACAAACTTAATACCTT
GAAAAGTGTGAAGATTCAGAATAAAAAATCTTTTATAAACGCAATTGAGAAAGAACGAAAGCTAGCAATTATTGCAGAAA
TCAAATCGAAGAGTCCTACAGTTAATGACTTACCTGAACGAGATTTATCACAACAAATCTCAGATTATGAAAAGTATGGT
GCAAATGCCGTGTCCATTTTAACTGATGAAAAGTACTTTGGTGGTAGTTTTGAAAGATTACAAGCATTGACAACAAAAAC
AACATTACCCGTATTATGCAAAGATTTTATTATAGATCCGCTTCAAATTGATGTTGCTAAACAAGCTGGTGCATCTATGA
TTTTATTGATCGTTAACATCTTATCGGATAAACAATTGAAAGATTTATATAACTACGCTATATCGCAAAATTTAGAAGTG
TTAGTTGAAGTACATGATCGCCATGAATTAGAACGTGTCTATAAGGTTAATGCTAAATTGATTGGTGTAAATAACAGGGA
CTTAAAACGATTTGTCACAAATGTGGAACATACAAATACTATTTTAGAAAATAAAAAACCAAATCATTATTATATTTCTG
AAAGTGGTATTCACGATGCATCTGATGTAAGAAAAATCTTGCATAGTGGTATCGATGGCTTACTAATAGGTGAGGCGCTT
ATGCGTTGTGACAATCTATCTGAATTTTTACCACAACTAAAAATGCAAAAGGTGAAGTCATGA

Upstream 100 bases:

>100_bases
GAGAAAGTGGATACCATCGCAGAAGGCATAGAACTTGCAACTACATTGATTGATAATGGTGAAGCATTGAAAAAATATTA
TCGAATGAGAGGTGAATAAT

Downstream 100 bases:

>100_bases
TGAAATTGAAATTTTGTGGCTTTACATCAATCGAGGATGTTACAGCGGCCAGTCAATTACCTATTGATGCGATAGGTTTC
ATTCATTATGAAAAAAGTAA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MTILAEIVKYKQSLLQNGYYQDKLNTLKSVKIQNKKSFINAIEKERKLAIIAEIKSKSPTVNDLPERDLSQQISDYEKYG
ANAVSILTDEKYFGGSFERLQALTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQNLEV
LVEVHDRHELERVYKVNAKLIGVNNRDLKRFVTNVEHTNTILENKKPNHYYISESGIHDASDVRKILHSGIDGLLIGEAL
MRCDNLSEFLPQLKMQKVKS

Sequences:

>Translated_260_residues
MTILAEIVKYKQSLLQNGYYQDKLNTLKSVKIQNKKSFINAIEKERKLAIIAEIKSKSPTVNDLPERDLSQQISDYEKYG
ANAVSILTDEKYFGGSFERLQALTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQNLEV
LVEVHDRHELERVYKVNAKLIGVNNRDLKRFVTNVEHTNTILENKKPNHYYISESGIHDASDVRKILHSGIDGLLIGEAL
MRCDNLSEFLPQLKMQKVKS
>Mature_259_residues
TILAEIVKYKQSLLQNGYYQDKLNTLKSVKIQNKKSFINAIEKERKLAIIAEIKSKSPTVNDLPERDLSQQISDYEKYGA
NAVSILTDEKYFGGSFERLQALTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQNLEVL
VEVHDRHELERVYKVNAKLIGVNNRDLKRFVTNVEHTNTILENKKPNHYYISESGIHDASDVRKILHSGIDGLLIGEALM
RCDNLSEFLPQLKMQKVKS

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=245, Percent_Identity=36.734693877551, Blast_Score=142, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6322638, Length=217, Percent_Identity=35.4838709677419, Blast_Score=129, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 29609; Mature: 29477

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILAEIVKYKQSLLQNGYYQDKLNTLKSVKIQNKKSFINAIEKERKLAIIAEIKSKSPT
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHEEECCCCCCC
VNDLPERDLSQQISDYEKYGANAVSILTDEKYFGGSFERLQALTTKTTLPVLCKDFIIDP
CCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
LQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQNLEVLVEVHDRHELERVYKVNAKL
HHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCEE
IGVNNRDLKRFVTNVEHTNTILENKKPNHYYISESGIHDASDVRKILHSGIDGLLIGEAL
EECCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHH
MRCDNLSEFLPQLKMQKVKS
HHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TILAEIVKYKQSLLQNGYYQDKLNTLKSVKIQNKKSFINAIEKERKLAIIAEIKSKSPT
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHEEECCCCCCC
VNDLPERDLSQQISDYEKYGANAVSILTDEKYFGGSFERLQALTTKTTLPVLCKDFIIDP
CCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
LQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQNLEVLVEVHDRHELERVYKVNAKL
HHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCEE
IGVNNRDLKRFVTNVEHTNTILENKKPNHYYISESGIHDASDVRKILHSGIDGLLIGEAL
EECCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHH
MRCDNLSEFLPQLKMQKVKS
HHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA