BacMap

Definition	Staphylococcus aureus RF122, complete genome.
Accession	NC_007622
Length	2,742,531

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The map label for this gene is gmk

Identifier: 82750814

GI number: 82750814

Start: 1158635

End: 1159258

Strand: Direct

Name: gmk

Synonym: SAB1073

Alternate gene names: 82750814

Gene position: 1158635-1159258 (Clockwise)

Preceding gene: 82750812

Following gene: 82750815

Centisome position: 42.25

GC content: 33.33

Gene sequence:

>624_bases
ATGGATAATGAAAAAGGATTGTTAATCGTTTTATCAGGACCATCTGGAGTAGGTAAAGGTACTGTTAGAAAACGAATATT
TGAAGATCCAAGTACATCATATAAGTATTCTATTTCAATGACAACACGTCAAATGCGTGAAGGTGAAGTTGATGGCGTAG
ATTACTTTTTTAAAACTAGGGATGCGTTTGAAGCTTTAATTAAAGATGACCAATTTATAGAATATGCTGAATATGTAGGC
AACTATTATGGTACACCAGTTCAATATGTTAAAGATACAATGGACGAAGGTCATGATGTATTTTTAGAAATTGAAGTAGA
AGGTGCAAAGCAAGTTAGAAAGAAATTTCCAGATGCGTTATTTATTTTCTTAGCACCTCCAAGTTTAGATCACTTGAGAG
AGCGATTAGTAGGTAGAGGAACAGAATCTGATGAGAAAATACAAAGTCGCATTAACGAAGCACGTAAAGAAGTCGAAATG
ATGAATTTATACGATTACGTTGTAGTTAATGATGAAGTAGAACTTGCGAAGAATAGAATTCAATGTATTGTAGAAGCTGA
GCACTTAAAAAGAGAGCGCGTAGAAGCTAAGTATAGAAAAATGATTTTGGAGGCTAAAAAATAA

Upstream 100 bases:

>100_bases
AGAAATTATGGCATGCAATTTCAAATATGCTATACAATATAAAGAACAATGTGATATCATATTTAAATAATAGAAGATTA
GCTTAGAGAGGTCGTAAGGC

Downstream 100 bases:

>100_bases
TGTTAAATCCACCATTAAACCAATTAACGTCACAAATTAAATCAAAGTATTTAATTGCAACAACTGCAGCGAAAAGAGCG
CGTGAAATTGATGAACAACC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MDNEKGLLIVLSGPSGVGKGTVRKRIFEDPSTSYKYSISMTTRQMREGEVDGVDYFFKTRDAFEALIKDDQFIEYAEYVG
NYYGTPVQYVKDTMDEGHDVFLEIEVEGAKQVRKKFPDALFIFLAPPSLDHLRERLVGRGTESDEKIQSRINEARKEVEM
MNLYDYVVVNDEVELAKNRIQCIVEAEHLKRERVEAKYRKMILEAKK

Sequences:

>Translated_207_residues
MDNEKGLLIVLSGPSGVGKGTVRKRIFEDPSTSYKYSISMTTRQMREGEVDGVDYFFKTRDAFEALIKDDQFIEYAEYVG
NYYGTPVQYVKDTMDEGHDVFLEIEVEGAKQVRKKFPDALFIFLAPPSLDHLRERLVGRGTESDEKIQSRINEARKEVEM
MNLYDYVVVNDEVELAKNRIQCIVEAEHLKRERVEAKYRKMILEAKK
>Mature_207_residues
MDNEKGLLIVLSGPSGVGKGTVRKRIFEDPSTSYKYSISMTTRQMREGEVDGVDYFFKTRDAFEALIKDDQFIEYAEYVG
NYYGTPVQYVKDTMDEGHDVFLEIEVEGAKQVRKKFPDALFIFLAPPSLDHLRERLVGRGTESDEKIQSRINEARKEVEM
MNLYDYVVVNDEVELAKNRIQCIVEAEHLKRERVEAKYRKMILEAKK

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=191, Percent_Identity=34.5549738219895, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI226874833, Length=191, Percent_Identity=34.5549738219895, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI4504221, Length=191, Percent_Identity=34.5549738219895, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI38570142, Length=170, Percent_Identity=32.3529411764706, Blast_Score=97, Evalue=8e-21,
Organism=Homo sapiens, GI14780902, Length=206, Percent_Identity=27.1844660194175, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI111154074, Length=173, Percent_Identity=29.4797687861272, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI21361598, Length=198, Percent_Identity=26.7676767676768, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI21536464, Length=192, Percent_Identity=23.4375, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI4505237, Length=173, Percent_Identity=24.8554913294798, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI262118255, Length=173, Percent_Identity=24.8554913294798, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI262118263, Length=173, Percent_Identity=24.8554913294798, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI262118259, Length=173, Percent_Identity=24.8554913294798, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI119943108, Length=171, Percent_Identity=28.0701754385965, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI261862237, Length=171, Percent_Identity=28.0701754385965, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI119943106, Length=171, Percent_Identity=28.0701754385965, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI186700627, Length=171, Percent_Identity=22.8070175438596, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI186972120, Length=171, Percent_Identity=22.8070175438596, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI186700629, Length=171, Percent_Identity=22.8070175438596, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI21389483, Length=181, Percent_Identity=22.6519337016575, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI192447426, Length=179, Percent_Identity=26.8156424581006, Blast_Score=64, Evalue=7e-11,
Organism=Homo sapiens, GI4557529, Length=179, Percent_Identity=26.8156424581006, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1790080, Length=199, Percent_Identity=40.2010050251256, Blast_Score=156, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17508835, Length=172, Percent_Identity=37.7906976744186, Blast_Score=131, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI193203132, Length=172, Percent_Identity=37.7906976744186, Blast_Score=130, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17557440, Length=169, Percent_Identity=28.9940828402367, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71988041, Length=178, Percent_Identity=24.1573033707865, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71988048, Length=178, Percent_Identity=24.1573033707865, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17556244, Length=142, Percent_Identity=29.5774647887324, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=42.6229508196721, Blast_Score=153, Evalue=2e-38,
Organism=Drosophila melanogaster, GI21356141, Length=151, Percent_Identity=42.3841059602649, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI161077626, Length=186, Percent_Identity=34.9462365591398, Blast_Score=111, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24640542, Length=186, Percent_Identity=34.9462365591398, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI45554481, Length=186, Percent_Identity=34.9462365591398, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI45554489, Length=186, Percent_Identity=34.9462365591398, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI85724806, Length=186, Percent_Identity=34.9462365591398, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI116007136, Length=186, Percent_Identity=34.9462365591398, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI221330164, Length=146, Percent_Identity=32.1917808219178, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221330162, Length=146, Percent_Identity=32.1917808219178, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221330166, Length=146, Percent_Identity=32.1917808219178, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI85816106, Length=126, Percent_Identity=31.7460317460317, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45551002, Length=126, Percent_Identity=31.7460317460317, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI85816281, Length=126, Percent_Identity=31.7460317460317, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24648808, Length=195, Percent_Identity=22.5641025641026, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281362230, Length=195, Percent_Identity=22.5641025641026, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161078487, Length=195, Percent_Identity=22.5641025641026, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24641280, Length=175, Percent_Identity=30.8571428571429, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45554804, Length=175, Percent_Identity=30.8571428571429, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI281360700, Length=175, Percent_Identity=30.8571428571429, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24641282, Length=175, Percent_Identity=30.8571428571429, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45554818, Length=175, Percent_Identity=30.8571428571429, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI161078485, Length=195, Percent_Identity=22.5641025641026, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24648810, Length=195, Percent_Identity=22.5641025641026, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI281362232, Length=195, Percent_Identity=22.5641025641026, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 24024; Mature: 24024

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNEKGLLIVLSGPSGVGKGTVRKRIFEDPSTSYKYSISMTTRQMREGEVDGVDYFFKTR
CCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEEHHHHHHCCCCCCHHHHHHHH
DAFEALIKDDQFIEYAEYVGNYYGTPVQYVKDTMDEGHDVFLEIEVEGAKQVRKKFPDAL
HHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEEECCHHHHHHHCCCEE
FIFLAPPSLDHLRERLVGRGTESDEKIQSRINEARKEVEMMNLYDYVVVNDEVELAKNRI
EEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHH
QCIVEAEHLKRERVEAKYRKMILEAKK
HHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDNEKGLLIVLSGPSGVGKGTVRKRIFEDPSTSYKYSISMTTRQMREGEVDGVDYFFKTR
CCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEEHHHHHHCCCCCCHHHHHHHH
DAFEALIKDDQFIEYAEYVGNYYGTPVQYVKDTMDEGHDVFLEIEVEGAKQVRKKFPDAL
HHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEEECCHHHHHHHCCCEE
FIFLAPPSLDHLRERLVGRGTESDEKIQSRINEARKEVEMMNLYDYVVVNDEVELAKNRI
EEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHH
QCIVEAEHLKRERVEAKYRKMILEAKK
HHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA