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The map label for this gene is pdhA

Identifier: 82750703

GI number: 82750703

Start: 1039710

End: 1040822

Strand: Direct

Name: pdhA

Synonym: SAB0959

Alternate gene names: 82750703

Gene position: 1039710-1040822 (Clockwise)

Preceding gene: 82750702

Following gene: 82750704

Centisome position: 37.91

GC content: 37.2

Gene sequence:

>1113_bases
ATGGCTCCTAAGTTACAAGCCCAATTCGATGCAGTAAAAGTTTTAAATGATACTCAATCGAAATTTGAAATGGTTCAAAT
TTTGGATGAGAATGGTAACGTCGTAAATGAAGACTTAGTACCTGATCTTACGGATGAACAATTAGTAGAATTAATGGAAA
GAATGGTATGGACTCGTATCCTTGATCAACGTTCTATCTCATTAAACAGACAAGGACGTTTAGGTTTCTATGCACCAACT
GCTGGTCAAGAAGCATCACAATTAGCGTCACAATACGCTTTAGAAAAAGAAGATTACATTTTACCGGGATACAGAGATGT
TCCTCAAATTATTTGGCATGGTTTACCATTAACTGAAGCTTTCTTATTCTCAAGAGGTCACTTCAAAGGAAATCAATTCC
CTGAAGGCGTTAATGCATTAAGCCCACAAATTATTATCGGTGCACAATACATTCAAGCTGCTGGTGTTGCATTTGCACTT
AAAAAACGTGGTAAATATGCAGTTGCAATCACTTACACTGGTGACGGTGGTTCTTCACAAGGTGATTTCTACGAAGGTAT
TAACTTTGCAGCAGCTTATAAAGCACCTGCAATTTTCGTTATTCAAAACAATAACTATGCAATTTCAACACCAAGAAGCA
AGCAAACTGCTGCTGAAACATTAGCTCAAAAAGCAATCGCTGTAGGTATTCCTGGTATCCAAGTTGATGGTATGGATGCG
TTAGCTGTATATCAAGCAACTAAAGAAGCACGTGACCGCGCAGTTGCAGGTGAAGGTCCAACATTAATTGAAACTATGAC
ATATCGTTATGGTCCTCATACAATGGCTGGTGACGATCCAACTCGTTACAGAACTTCAGACGAAGATGCTGAATGGGAGA
AAAAAGACCCATTAGTACGTTTCCGTAAATTCCTTGAAAACAAAGGTTTATGGAATGAAGACAAAGAAAATGAAGTTATT
GAACGTGCAAAAGCTGATATTAAAGCAGCAATTAAAGAGGCTGATAACACTGAAAAACAAACTGTTACTTCTCTAATGGA
AATTATGTATGAAGATATGCCTCAAAACTTAGTAGAACAATATGAAATTTACAAAGAGAAGGAGTCGAAGTAA

Upstream 100 bases:

>100_bases
GAACTTTTTCAAATGGTTTAACAGTCCCATTTATTTGTGGTACAATTAGTAAGGATAAAATGAATTTCTATACAATTATG
GGAAAGGTATGGTGAATTGA

Downstream 100 bases:

>100_bases
GCCATGGCACAAATGACAATGGTTCAAGCGATTAATGATGCGCTTAAAACTGAACTTAAAAATGACCAAGATGTTTTAAT
TTTTGGTGAAGACGTTGGTG

Product: pyruvate dehydrogenase E1 component alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MAPKLQAQFDAVKVLNDTQSKFEMVQILDENGNVVNEDLVPDLTDEQLVELMERMVWTRILDQRSISLNRQGRLGFYAPT
AGQEASQLASQYALEKEDYILPGYRDVPQIIWHGLPLTEAFLFSRGHFKGNQFPEGVNALSPQIIIGAQYIQAAGVAFAL
KKRGKYAVAITYTGDGGSSQGDFYEGINFAAAYKAPAIFVIQNNNYAISTPRSKQTAAETLAQKAIAVGIPGIQVDGMDA
LAVYQATKEARDRAVAGEGPTLIETMTYRYGPHTMAGDDPTRYRTSDEDAEWEKKDPLVRFRKFLENKGLWNEDKENEVI
ERAKADIKAAIKEADNTEKQTVTSLMEIMYEDMPQNLVEQYEIYKEKESK

Sequences:

>Translated_370_residues
MAPKLQAQFDAVKVLNDTQSKFEMVQILDENGNVVNEDLVPDLTDEQLVELMERMVWTRILDQRSISLNRQGRLGFYAPT
AGQEASQLASQYALEKEDYILPGYRDVPQIIWHGLPLTEAFLFSRGHFKGNQFPEGVNALSPQIIIGAQYIQAAGVAFAL
KKRGKYAVAITYTGDGGSSQGDFYEGINFAAAYKAPAIFVIQNNNYAISTPRSKQTAAETLAQKAIAVGIPGIQVDGMDA
LAVYQATKEARDRAVAGEGPTLIETMTYRYGPHTMAGDDPTRYRTSDEDAEWEKKDPLVRFRKFLENKGLWNEDKENEVI
ERAKADIKAAIKEADNTEKQTVTSLMEIMYEDMPQNLVEQYEIYKEKESK
>Mature_369_residues
APKLQAQFDAVKVLNDTQSKFEMVQILDENGNVVNEDLVPDLTDEQLVELMERMVWTRILDQRSISLNRQGRLGFYAPTA
GQEASQLASQYALEKEDYILPGYRDVPQIIWHGLPLTEAFLFSRGHFKGNQFPEGVNALSPQIIIGAQYIQAAGVAFALK
KRGKYAVAITYTGDGGSSQGDFYEGINFAAAYKAPAIFVIQNNNYAISTPRSKQTAAETLAQKAIAVGIPGIQVDGMDAL
AVYQATKEARDRAVAGEGPTLIETMTYRYGPHTMAGDDPTRYRTSDEDAEWEKKDPLVRFRKFLENKGLWNEDKENEVIE
RAKADIKAAIKEADNTEKQTVTSLMEIMYEDMPQNLVEQYEIYKEKESK

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=353, Percent_Identity=34.5609065155807, Blast_Score=204, Evalue=8e-53,
Organism=Homo sapiens, GI258645172, Length=353, Percent_Identity=34.5609065155807, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI4505685, Length=309, Percent_Identity=29.126213592233, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4885543, Length=294, Percent_Identity=29.5918367346939, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI291084742, Length=309, Percent_Identity=29.126213592233, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI291084744, Length=268, Percent_Identity=29.8507462686567, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI291084757, Length=292, Percent_Identity=28.7671232876712, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI86563357, Length=361, Percent_Identity=34.9030470914127, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI86563355, Length=361, Percent_Identity=34.9030470914127, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI32564172, Length=288, Percent_Identity=31.5972222222222, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17536047, Length=288, Percent_Identity=31.5972222222222, Blast_Score=136, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321026, Length=326, Percent_Identity=30.6748466257669, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI21355903, Length=349, Percent_Identity=30.945558739255, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24639740, Length=319, Percent_Identity=30.0940438871473, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24639744, Length=319, Percent_Identity=30.0940438871473, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI28571106, Length=319, Percent_Identity=30.0940438871473, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24639746, Length=286, Percent_Identity=31.1188811188811, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24639748, Length=274, Percent_Identity=31.3868613138686, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 41460; Mature: 41329

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPKLQAQFDAVKVLNDTQSKFEMVQILDENGNVVNEDLVPDLTDEQLVELMERMVWTRI
CCCCCHHHHHHHHHHHCHHHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHH
LDQRSISLNRQGRLGFYAPTAGQEASQLASQYALEKEDYILPGYRDVPQIIWHGLPLTEA
HHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCEECCCCCHHHHHHHCCCCHHHH
FLFSRGHFKGNQFPEGVNALSPQIIIGAQYIQAAGVAFALKKRGKYAVAITYTGDGGSSQ
HHHHCCCCCCCCCCCCHHHCCCEEEEEHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCC
GDFYEGINFAAAYKAPAIFVIQNNNYAISTPRSKQTAAETLAQKAIAVGIPGIQVDGMDA
CCHHHCCCCEEECCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEECCCHH
LAVYQATKEARDRAVAGEGPTLIETMTYRYGPHTMAGDDPTRYRTSDEDAEWEKKDPLVR
HHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
FRKFLENKGLWNEDKENEVIERAKADIKAAIKEADNTEKQTVTSLMEIMYEDMPQNLVEQ
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
YEIYKEKESK
HHHHHHHCCC
>Mature Secondary Structure 
APKLQAQFDAVKVLNDTQSKFEMVQILDENGNVVNEDLVPDLTDEQLVELMERMVWTRI
CCCCHHHHHHHHHHHCHHHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHH
LDQRSISLNRQGRLGFYAPTAGQEASQLASQYALEKEDYILPGYRDVPQIIWHGLPLTEA
HHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCEECCCCCHHHHHHHCCCCHHHH
FLFSRGHFKGNQFPEGVNALSPQIIIGAQYIQAAGVAFALKKRGKYAVAITYTGDGGSSQ
HHHHCCCCCCCCCCCCHHHCCCEEEEEHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCC
GDFYEGINFAAAYKAPAIFVIQNNNYAISTPRSKQTAAETLAQKAIAVGIPGIQVDGMDA
CCHHHCCCCEEECCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEECCCHH
LAVYQATKEARDRAVAGEGPTLIETMTYRYGPHTMAGDDPTRYRTSDEDAEWEKKDPLVR
HHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
FRKFLENKGLWNEDKENEVIERAKADIKAAIKEADNTEKQTVTSLMEIMYEDMPQNLVEQ
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
YEIYKEKESK
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA