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The map label for this gene is dltA

Identifier: 82750547

GI number: 82750547

Start: 864355

End: 865812

Strand: Direct

Name: dltA

Synonym: SAB0798

Alternate gene names: 82750547

Gene position: 864355-865812 (Clockwise)

Preceding gene: 82750546

Following gene: 82750548

Centisome position: 31.52

GC content: 34.29

Gene sequence:

>1458_bases
ATGACAGATATTATTAACAAGCTGCAAGCGTTTGCGGATGCAAATCCACAAAGCATTGCTGTTAGACACACAACTGATGA
ATTAACTTATCAACAGTTAATGGATGAGTCTAGTAAATTAGCACATCGATTACAAGGTAGTAAGAAACCGATGATTTTAT
TCGGTCACATGTCACCATATATGATTGTTGGGATGATTGGTGCCATTAAAGCAGGATGTGGATATGTACCTGTAGACACT
TCAATTCCTGAAGACCGTATTAAAATGATTATTAACAAGGTTCAACCAGAGTTTGTATTTAATACGACTGATGAATCATT
TGAAAGTTTAGAAGGCGAAGTATTTACAATAGAAGATATTAAAACATCTCAAGACCCAGTAATTTTTGATAGTCAGATTA
AAGATAACGACACAGTATACACAATCTTTACATCTGGTTCTACTGGGGAACCTAAAGGTGTTCAAATTGAATATGCAAGT
TTAGTTCAATTTACTGAGTGGATGTTAGAACTTAATAAATCAGGAAATGAACAACAATGGCTTAACCAAGCGCCATTTTC
ATTTGATTTATCTGTAATGGCTATTTATCCATGTTTAGCATCAGGCGGTACATTAAATCTTGTAGATAAAAACATGATTA
ATAAACCTAAATTATTAAATGAAATGCTAACATCAATACCGATTAACATTTGGGTATCAACACCATCATTTATGGAAATG
TGTTTATTATTACCAACGCTTAATGAAGAACAGTATGGTAGTCTTAACGAATTCTTCTTCTGTGGTGAAATTCTACCTCA
CAGAGCAGCAAAAGCGTTAGTAAGCCGTTTCCCAAGTGCGACGATTTACAACACATATGGTCCAACTGAAGCTACGGTAG
CAGTTACAAGTATTCAAATTACACAAGAAATCTTAGATCAATATCCGACATTACCTGTTGGCGTCGAAAGACCAGGCGCA
AGATTATCTACGACAGATGAAGGTGAACTTGTTATCGAAGGTCAAAGTGTAAGTTTAGGATACTTAAAAAATGACCAAAA
AACAGCTGAAGTATTTAATTTCGATGACGGTATTCGTACTTATCACACTGGTGATAAAGCGAAGTTTGAAAATGGTCAAT
GGTTCATTCAAGGTCGTATTGATTTCCAAATCAAATTGAATGGCTACAGAATGGAATTAGAAGAAATTGAAACACAATTA
CGCCAGTCTGAGTTCGTAAAAGAAGCGATTGTTGTACCTGTATATAAAAATGATAAAGTTATTCATTTAATTGGTGCAAT
TGTGCCAACGACTGAAGTTACGGACAATGCAGAAATGACTAAAAATATTAAAAATGACTTGAAATCACGCTTACCAGAGT
ATATGATTCCTAGAAAGTTTGAATGGATGGAACAATTGCCATTAACTTCAAATGGTAAAATTGACAGAAAGAAAATTGCA
GAGGTAATTAACGGATGA

Upstream 100 bases:

>100_bases
ATTGTATTTGGCAATATTTATTACTTTATATTTAATTTATGGCAGTGGCGACACACACAATAACTTCATTTATAATGAGT
TCTAATGAGGGAGACTTAAT

Downstream 100 bases:

>100_bases
TTCCATATGGTGATTTTACATTCTTCTTAATTGCTTTAATTGCATTATTACCAGTCATTATACTTGGATTTTTAGGTAAG
CGAAGTTACATTTATAATGG

Product: D-alanine--poly(phosphoribitol) ligase subunit 1

Products: NA

Alternate protein names: D-alanine-D-alanyl carrier protein ligase; DCL; D-alanine-activating enzyme; DAE [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MTDIINKLQAFADANPQSIAVRHTTDELTYQQLMDESSKLAHRLQGSKKPMILFGHMSPYMIVGMIGAIKAGCGYVPVDT
SIPEDRIKMIINKVQPEFVFNTTDESFESLEGEVFTIEDIKTSQDPVIFDSQIKDNDTVYTIFTSGSTGEPKGVQIEYAS
LVQFTEWMLELNKSGNEQQWLNQAPFSFDLSVMAIYPCLASGGTLNLVDKNMINKPKLLNEMLTSIPINIWVSTPSFMEM
CLLLPTLNEEQYGSLNEFFFCGEILPHRAAKALVSRFPSATIYNTYGPTEATVAVTSIQITQEILDQYPTLPVGVERPGA
RLSTTDEGELVIEGQSVSLGYLKNDQKTAEVFNFDDGIRTYHTGDKAKFENGQWFIQGRIDFQIKLNGYRMELEEIETQL
RQSEFVKEAIVVPVYKNDKVIHLIGAIVPTTEVTDNAEMTKNIKNDLKSRLPEYMIPRKFEWMEQLPLTSNGKIDRKKIA
EVING

Sequences:

>Translated_485_residues
MTDIINKLQAFADANPQSIAVRHTTDELTYQQLMDESSKLAHRLQGSKKPMILFGHMSPYMIVGMIGAIKAGCGYVPVDT
SIPEDRIKMIINKVQPEFVFNTTDESFESLEGEVFTIEDIKTSQDPVIFDSQIKDNDTVYTIFTSGSTGEPKGVQIEYAS
LVQFTEWMLELNKSGNEQQWLNQAPFSFDLSVMAIYPCLASGGTLNLVDKNMINKPKLLNEMLTSIPINIWVSTPSFMEM
CLLLPTLNEEQYGSLNEFFFCGEILPHRAAKALVSRFPSATIYNTYGPTEATVAVTSIQITQEILDQYPTLPVGVERPGA
RLSTTDEGELVIEGQSVSLGYLKNDQKTAEVFNFDDGIRTYHTGDKAKFENGQWFIQGRIDFQIKLNGYRMELEEIETQL
RQSEFVKEAIVVPVYKNDKVIHLIGAIVPTTEVTDNAEMTKNIKNDLKSRLPEYMIPRKFEWMEQLPLTSNGKIDRKKIA
EVING
>Mature_484_residues
TDIINKLQAFADANPQSIAVRHTTDELTYQQLMDESSKLAHRLQGSKKPMILFGHMSPYMIVGMIGAIKAGCGYVPVDTS
IPEDRIKMIINKVQPEFVFNTTDESFESLEGEVFTIEDIKTSQDPVIFDSQIKDNDTVYTIFTSGSTGEPKGVQIEYASL
VQFTEWMLELNKSGNEQQWLNQAPFSFDLSVMAIYPCLASGGTLNLVDKNMINKPKLLNEMLTSIPINIWVSTPSFMEMC
LLLPTLNEEQYGSLNEFFFCGEILPHRAAKALVSRFPSATIYNTYGPTEATVAVTSIQITQEILDQYPTLPVGVERPGAR
LSTTDEGELVIEGQSVSLGYLKNDQKTAEVFNFDDGIRTYHTGDKAKFENGQWFIQGRIDFQIKLNGYRMELEEIETQLR
QSEFVKEAIVVPVYKNDKVIHLIGAIVPTTEVTDNAEMTKNIKNDLKSRLPEYMIPRKFEWMEQLPLTSNGKIDRKKIAE
VING

Specific function: Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp [H]

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=358, Percent_Identity=25.6983240223464, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI156151445, Length=393, Percent_Identity=26.972010178117, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI38505220, Length=527, Percent_Identity=21.4421252371917, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI115511026, Length=368, Percent_Identity=24.4565217391304, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786801, Length=451, Percent_Identity=27.0509977827051, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1790505, Length=466, Percent_Identity=20.6008583690987, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17556356, Length=501, Percent_Identity=26.1477045908184, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI32563687, Length=420, Percent_Identity=23.3333333333333, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17558820, Length=434, Percent_Identity=22.3502304147465, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17550940, Length=477, Percent_Identity=22.8511530398323, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17531443, Length=364, Percent_Identity=25, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17557194, Length=369, Percent_Identity=24.1192411924119, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319591, Length=582, Percent_Identity=23.1958762886598, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6319699, Length=378, Percent_Identity=24.0740740740741, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24648676, Length=455, Percent_Identity=25.4945054945055, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI18859661, Length=535, Percent_Identity=22.803738317757, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24581924, Length=533, Percent_Identity=22.1388367729831, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR000873
- InterPro:   IPR010072 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.1.1.13 [H]

Molecular weight: Translated: 54672; Mature: 54541

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIINKLQAFADANPQSIAVRHTTDELTYQQLMDESSKLAHRLQGSKKPMILFGHMSPY
CHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCHHHHHHHHHCCCCCCEEEEECCCHH
MIVGMIGAIKAGCGYVPVDTSIPEDRIKMIINKVQPEFVFNTTDESFESLEGEVFTIEDI
HHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHCCCCEEEECCCHHHHHCCCCEEEEECC
KTSQDPVIFDSQIKDNDTVYTIFTSGSTGEPKGVQIEYASLVQFTEWMLELNKSGNEQQW
CCCCCCEEEECCCCCCCEEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCHHHH
LNQAPFSFDLSVMAIYPCLASGGTLNLVDKNMINKPKLLNEMLTSIPINIWVSTPSFMEM
HHCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCEEEEECCHHHHHH
CLLLPTLNEEQYGSLNEFFFCGEILPHRAAKALVSRFPSATIYNTYGPTEATVAVTSIQI
HHHCCCCCCHHCCCCHHEEEEHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEHHHH
TQEILDQYPTLPVGVERPGARLSTTDEGELVIEGQSVSLGYLKNDQKTAEVFNFDDGIRT
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEEECCCCHHHHEECCCCCCCE
YHTGDKAKFENGQWFIQGRIDFQIKLNGYRMELEEIETQLRQSEFVKEAIVVPVYKNDKV
EECCCCCEECCCCEEEEEEEEEEEEECCEEEEHHHHHHHHHHHHHHHHHEEEEEECCCCE
IHLIGAIVPTTEVTDNAEMTKNIKNDLKSRLPEYMIPRKFEWMEQLPLTSNGKIDRKKIA
EEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCHHCCCCHHHHHHHCCCCCCCCCCHHHHH
EVING
HHHCC
>Mature Secondary Structure 
TDIINKLQAFADANPQSIAVRHTTDELTYQQLMDESSKLAHRLQGSKKPMILFGHMSPY
HHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCHHHHHHHHHCCCCCCEEEEECCCHH
MIVGMIGAIKAGCGYVPVDTSIPEDRIKMIINKVQPEFVFNTTDESFESLEGEVFTIEDI
HHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHCCCCEEEECCCHHHHHCCCCEEEEECC
KTSQDPVIFDSQIKDNDTVYTIFTSGSTGEPKGVQIEYASLVQFTEWMLELNKSGNEQQW
CCCCCCEEEECCCCCCCEEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCHHHH
LNQAPFSFDLSVMAIYPCLASGGTLNLVDKNMINKPKLLNEMLTSIPINIWVSTPSFMEM
HHCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCEEEEECCHHHHHH
CLLLPTLNEEQYGSLNEFFFCGEILPHRAAKALVSRFPSATIYNTYGPTEATVAVTSIQI
HHHCCCCCCHHCCCCHHEEEEHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEHHHH
TQEILDQYPTLPVGVERPGARLSTTDEGELVIEGQSVSLGYLKNDQKTAEVFNFDDGIRT
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEEECCCCHHHHEECCCCCCCE
YHTGDKAKFENGQWFIQGRIDFQIKLNGYRMELEEIETQLRQSEFVKEAIVVPVYKNDKV
EECCCCCEECCCCEEEEEEEEEEEEECCEEEEHHHHHHHHHHHHHHHHHEEEEEECCCCE
IHLIGAIVPTTEVTDNAEMTKNIKNDLKSRLPEYMIPRKFEWMEQLPLTSNGKIDRKKIA
EEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCHHCCCCHHHHHHHCCCCCCCCCCHHHHH
EVING
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA