Click here to switch to the map view.

The map label for this gene is gyaR [H]

Identifier: 82750545

GI number: 82750545

Start: 862816

End: 863775

Strand: Direct

Name: gyaR [H]

Synonym: SAB0796

Alternate gene names: 82750545

Gene position: 862816-863775 (Clockwise)

Preceding gene: 82750544

Following gene: 82750546

Centisome position: 31.46

GC content: 34.27

Gene sequence:

>960_bases
TTGGTAAAAATAGTTGTTTCGAGGAAAATTCCAGATAAATTTTATCAACAATTAAGTAAACTTGGTGACGTTGTTATGTG
GCAAAAATCATTAGTGCCTATGCCTAAAGATCAATTTGTGACAGCACTTCGTGACGCAGATGCTTGTTTTATCACATTAA
GTGAACAGATCGATGCAGAAATTTTAGCACAATCACCAAATTTAAAAGTAATTGCGAATATGGCTGTAGGATATGACAAC
ATCGATATTGAAAGTGCAACAGAGAACAACGTGGTTGTCACGAATACACCAAATGTACTTACTGAAACAACTGCAGAATT
AGGATTTACATTAATGCTTGCTATAGCACGCCGTATTGTAGAAGCTGAAAAATATGTTGAAGCAGATGCATGGCAAAGCT
GGGGTCCTTATTTATTGTCAGGTAAAGATGTCTTCAATTCAACTATTGGAATATATGGTATGGGAGATATTGGTAAAGCT
TTTGCAAGAAGGTTGCAAGGGTTTAATACTAAAATTCTTTATCATAATCGATCAAGACATAAAGATGCAGAGGCGGACTT
TAATGCAACATATGTTTCTTTTGAAACGTTGTTAGCAGAAAGTGATTTTATCATCTGTACAGCGCCACTTACAAAAGAAA
CACATCATAAATTTAATGCTGAAGCATTTGAGCAAATGAAAAATGATGCAATTTTTATTAATATCGGTAGAGGGCAAATT
GTAGATGAAACAGCATTAATCGATGCACTAGACAATAAAGAAATATTAGCATGTGGTTTAGATGTATTAGCAAATGAACC
AATTGATCATACACATCCATTAATGGGACGTGATAATGTTCTGATTACACCACACATTGGTAGCGCATCAGTAACAACAC
GGGACAATATGATTCAATTATGTATTAATAATATAGAAGCGGTTATGACAAATCAGGTACCACATACTCCAGTAAATTGA

Upstream 100 bases:

>100_bases
ATAAAAATGTGCCACCAACGTATTCTTTTAAAGATTTAAATGAAGCAATAGCTGAATTAGAAAAATAGATATAGTCATTT
TATAAAGTAGGTGAATTGAT

Downstream 100 bases:

>100_bases
AAATAAGTATGGTTTTTAATCATTGGTAAAACAAGCAAAGCAATTGTTAAATATGTTATGCTTGACTTGCGAATGTATAT
ATTTGCGCTGATGATAATTC

Product: glycerate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MVKIVVSRKIPDKFYQQLSKLGDVVMWQKSLVPMPKDQFVTALRDADACFITLSEQIDAEILAQSPNLKVIANMAVGYDN
IDIESATENNVVVTNTPNVLTETTAELGFTLMLAIARRIVEAEKYVEADAWQSWGPYLLSGKDVFNSTIGIYGMGDIGKA
FARRLQGFNTKILYHNRSRHKDAEADFNATYVSFETLLAESDFIICTAPLTKETHHKFNAEAFEQMKNDAIFINIGRGQI
VDETALIDALDNKEILACGLDVLANEPIDHTHPLMGRDNVLITPHIGSASVTTRDNMIQLCINNIEAVMTNQVPHTPVN

Sequences:

>Translated_319_residues
MVKIVVSRKIPDKFYQQLSKLGDVVMWQKSLVPMPKDQFVTALRDADACFITLSEQIDAEILAQSPNLKVIANMAVGYDN
IDIESATENNVVVTNTPNVLTETTAELGFTLMLAIARRIVEAEKYVEADAWQSWGPYLLSGKDVFNSTIGIYGMGDIGKA
FARRLQGFNTKILYHNRSRHKDAEADFNATYVSFETLLAESDFIICTAPLTKETHHKFNAEAFEQMKNDAIFINIGRGQI
VDETALIDALDNKEILACGLDVLANEPIDHTHPLMGRDNVLITPHIGSASVTTRDNMIQLCINNIEAVMTNQVPHTPVN
>Mature_319_residues
MVKIVVSRKIPDKFYQQLSKLGDVVMWQKSLVPMPKDQFVTALRDADACFITLSEQIDAEILAQSPNLKVIANMAVGYDN
IDIESATENNVVVTNTPNVLTETTAELGFTLMLAIARRIVEAEKYVEADAWQSWGPYLLSGKDVFNSTIGIYGMGDIGKA
FARRLQGFNTKILYHNRSRHKDAEADFNATYVSFETLLAESDFIICTAPLTKETHHKFNAEAFEQMKNDAIFINIGRGQI
VDETALIDALDNKEILACGLDVLANEPIDHTHPLMGRDNVLITPHIGSASVTTRDNMIQLCINNIEAVMTNQVPHTPVN

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=315, Percent_Identity=39.0476190476191, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI23308577, Length=257, Percent_Identity=28.7937743190661, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI4557497, Length=253, Percent_Identity=30.0395256916996, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI61743967, Length=253, Percent_Identity=30.0395256916996, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI145580578, Length=259, Percent_Identity=27.7992277992278, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI4557499, Length=259, Percent_Identity=27.7992277992278, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI145580575, Length=271, Percent_Identity=28.4132841328413, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI87082289, Length=318, Percent_Identity=41.8238993710692, Blast_Score=238, Evalue=4e-64,
Organism=Escherichia coli, GI1787645, Length=200, Percent_Identity=35, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1789279, Length=271, Percent_Identity=27.3062730627306, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI87081824, Length=250, Percent_Identity=26, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788660, Length=272, Percent_Identity=26.1029411764706, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=279, Percent_Identity=30.8243727598566, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI25147481, Length=255, Percent_Identity=28.6274509803922, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324055, Length=314, Percent_Identity=30.8917197452229, Blast_Score=155, Evalue=7e-39,
Organism=Saccharomyces cerevisiae, GI6320925, Length=270, Percent_Identity=27.037037037037, Blast_Score=106, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6322116, Length=282, Percent_Identity=27.6595744680851, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324964, Length=307, Percent_Identity=24.7557003257329, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6325144, Length=174, Percent_Identity=32.183908045977, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6321253, Length=173, Percent_Identity=33.5260115606936, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45551003, Length=305, Percent_Identity=38.3606557377049, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI45552429, Length=305, Percent_Identity=38.3606557377049, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI28574284, Length=305, Percent_Identity=38.3606557377049, Blast_Score=218, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24585514, Length=305, Percent_Identity=38.3606557377049, Blast_Score=218, Evalue=3e-57,
Organism=Drosophila melanogaster, GI28574282, Length=305, Percent_Identity=38.3606557377049, Blast_Score=218, Evalue=3e-57,
Organism=Drosophila melanogaster, GI28571528, Length=312, Percent_Identity=40.3846153846154, Blast_Score=218, Evalue=3e-57,
Organism=Drosophila melanogaster, GI28574286, Length=276, Percent_Identity=40.2173913043478, Blast_Score=209, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24585516, Length=276, Percent_Identity=37.3188405797101, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI19921140, Length=291, Percent_Identity=26.8041237113402, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24646446, Length=266, Percent_Identity=26.6917293233083, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24646448, Length=266, Percent_Identity=26.6917293233083, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24646452, Length=266, Percent_Identity=26.6917293233083, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24646450, Length=266, Percent_Identity=26.6917293233083, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI62472511, Length=258, Percent_Identity=26.7441860465116, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35444; Mature: 35444

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKIVVSRKIPDKFYQQLSKLGDVVMWQKSLVPMPKDQFVTALRDADACFITLSEQIDAE
CEEEEEECCCCHHHHHHHHHHHHEEEHHHHCCCCCHHHHHHHHHCCCEEEEEECCCCCHH
ILAQSPNLKVIANMAVGYDNIDIESATENNVVVTNTPNVLTETTAELGFTLMLAIARRIV
HEECCCCEEEEEEEEECCCCCEECCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
EAEKYVEADAWQSWGPYLLSGKDVFNSTIGIYGMGDIGKAFARRLQGFNTKILYHNRSRH
HHHHHHHHHCCCCCCCEEEECHHHHCCCCCEEECCHHHHHHHHHHCCCCEEEEEECCCCC
KDAEADFNATYVSFETLLAESDFIICTAPLTKETHHKFNAEAFEQMKNDAIFINIGRGQI
CCCCCCCCEEEEEHHHHHCCCCEEEEECCCCCHHHHCCCHHHHHHHCCCEEEEECCCCCE
VDETALIDALDNKEILACGLDVLANEPIDHTHPLMGRDNVLITPHIGSASVTTRDNMIQL
ECHHHHHHHCCCCEEEEECHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCEECHHHHHHH
CINNIEAVMTNQVPHTPVN
HHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MVKIVVSRKIPDKFYQQLSKLGDVVMWQKSLVPMPKDQFVTALRDADACFITLSEQIDAE
CEEEEEECCCCHHHHHHHHHHHHEEEHHHHCCCCCHHHHHHHHHCCCEEEEEECCCCCHH
ILAQSPNLKVIANMAVGYDNIDIESATENNVVVTNTPNVLTETTAELGFTLMLAIARRIV
HEECCCCEEEEEEEEECCCCCEECCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
EAEKYVEADAWQSWGPYLLSGKDVFNSTIGIYGMGDIGKAFARRLQGFNTKILYHNRSRH
HHHHHHHHHCCCCCCCEEEECHHHHCCCCCEEECCHHHHHHHHHHCCCCEEEEEECCCCC
KDAEADFNATYVSFETLLAESDFIICTAPLTKETHHKFNAEAFEQMKNDAIFINIGRGQI
CCCCCCCCEEEEEHHHHHCCCCEEEEECCCCCHHHHCCCHHHHHHHCCCEEEEECCCCCE
VDETALIDALDNKEILACGLDVLANEPIDHTHPLMGRDNVLITPHIGSASVTTRDNMIQL
ECHHHHHHHCCCCEEEEECHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCEECHHHHHHH
CINNIEAVMTNQVPHTPVN
HHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA