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The map label for this gene is glmU

Identifier: 82750206

GI number: 82750206

Start: 493720

End: 495078

Strand: Direct

Name: glmU

Synonym: SAB0448

Alternate gene names: 82750206

Gene position: 493720-495078 (Clockwise)

Preceding gene: 82750205

Following gene: 82750207

Centisome position: 18.0

GC content: 39.07

Gene sequence:

>1359_bases
ATGTTCATGCGAAGACACGCGATAATTTTAGCAGCAGGTAAAGGCACAAGAATGAAATCTAAAAAGTATAAAGTGCTACA
CGAGGTTGCTGGGAAACCTATGGTCGAACATGTATTGGAAAGTGTGAAAGGCTCTGGTGTCGATCAAGTTGTAACCATCG
TAGGACATGGTGCTGAAAGTGTAAAAGGACATTTAGGCGAGCGTTCTTTATACAGTTTTCAAGAGGAACAACTCGGTACT
GCGCATGCAGTGCAAATGGCGAAATCACACTTAGAAGACAAGAAAGGTACGACGATCGTTGTATGTGGTGATACACCGCT
CATCACAAAGGAAACATTAGAAACATTGATTGCGCATCACGAGGATGCTAATGCTCAAGCAACTGTATTATCTGCATCGA
TTCAACAACCATATGGATACGGAAGAATCGTTCGAAATGCGTCAGGTCGTTTAGATCGCATAGTTGAAGAGAAAGATGCA
ACGCAAGCTGAAAAGGATATTAATGAAATTAGTTCAGGTATTTTTGCGTTTAATAATAAAACGTTGTTTGAAAAATTAAC
ACAAGTGAAAAATGATAATGCGCAAGGTGAATATTACCTCCCTGATGTATTGTCGTTAATTTTAAATGATGGCGGCATCG
TAGAAGTCTATCGTACCAATGATGTTGAAGAAATCATGGGTGTAAATGATCGTGTAATGCTTAGTCAGGCTGAGAAGGCG
ATGCAACGTCGTACCAATCATTATCACATGTTAAATGGTGTGACAATCATCGATCCTGACAGCACTTTTATTGGTCCAGA
CGTTATAATTGGTAGTGATACAGTCATTGAACCAGGCGTACGAATTAATGGTCGTACAGAAATTGGCGAAGATGTTGTTA
TTGGTCAGTACTCTGAAATTAACAATAGTACGATTGAAAATGGTGCATGTATTCAACAGTCTGTTGTTAATGATGCTAGC
GTAGGAGCGAATACTAAGGTCGGACCGTTTGCGCAATTGAGACCAGGCGCGCAATTAGGTGCAGATGTTAAGGTTGGAAA
TTTTGTAGAAATTAAAAAAGCAGATCTTAAAGATGGTGCCAAGGTTTCACATTTAAGTTATATTGGTGATGCTGTAATTG
GCGAACGTACTAATATTGGTTGCGGAACGATTACAGTTAACTATGATGGTGAAAATAAATTTATAACTATCGTCGGCAAA
GATTCATTTGTAGGTTGCAATGTTAATTTAGTAGCACCTGTAACAATTGGTGATGATGTATTGGTGGCAGCTGGTTCCAC
AATCACAGATGACGTACCAAATGACAGTTTAGCTGTGGCAAGAGCAAGACAAACAACAAAAGAAGGATATAGGAAATAA

Upstream 100 bases:

>100_bases
TTAAAATTACAACGAATTAAAAACAATGCCTTTTATATGTTGAAAGAGTATTGCAGATTAAATTATAATAATGACGAAGT
GTAAAATTTAATGGGGGTTA

Downstream 100 bases:

>100_bases
TCATTTACGTATTTAAAATGGCTAGGATAAAAGGATAATCCTATGTAATATTAATGTAATCTTTATGATTTAATGATTCG
CATAGTAATGGAGTTACATT

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MFMRRHAIILAAGKGTRMKSKKYKVLHEVAGKPMVEHVLESVKGSGVDQVVTIVGHGAESVKGHLGERSLYSFQEEQLGT
AHAVQMAKSHLEDKKGTTIVVCGDTPLITKETLETLIAHHEDANAQATVLSASIQQPYGYGRIVRNASGRLDRIVEEKDA
TQAEKDINEISSGIFAFNNKTLFEKLTQVKNDNAQGEYYLPDVLSLILNDGGIVEVYRTNDVEEIMGVNDRVMLSQAEKA
MQRRTNHYHMLNGVTIIDPDSTFIGPDVIIGSDTVIEPGVRINGRTEIGEDVVIGQYSEINNSTIENGACIQQSVVNDAS
VGANTKVGPFAQLRPGAQLGADVKVGNFVEIKKADLKDGAKVSHLSYIGDAVIGERTNIGCGTITVNYDGENKFITIVGK
DSFVGCNVNLVAPVTIGDDVLVAAGSTITDDVPNDSLAVARARQTTKEGYRK

Sequences:

>Translated_452_residues
MFMRRHAIILAAGKGTRMKSKKYKVLHEVAGKPMVEHVLESVKGSGVDQVVTIVGHGAESVKGHLGERSLYSFQEEQLGT
AHAVQMAKSHLEDKKGTTIVVCGDTPLITKETLETLIAHHEDANAQATVLSASIQQPYGYGRIVRNASGRLDRIVEEKDA
TQAEKDINEISSGIFAFNNKTLFEKLTQVKNDNAQGEYYLPDVLSLILNDGGIVEVYRTNDVEEIMGVNDRVMLSQAEKA
MQRRTNHYHMLNGVTIIDPDSTFIGPDVIIGSDTVIEPGVRINGRTEIGEDVVIGQYSEINNSTIENGACIQQSVVNDAS
VGANTKVGPFAQLRPGAQLGADVKVGNFVEIKKADLKDGAKVSHLSYIGDAVIGERTNIGCGTITVNYDGENKFITIVGK
DSFVGCNVNLVAPVTIGDDVLVAAGSTITDDVPNDSLAVARARQTTKEGYRK
>Mature_452_residues
MFMRRHAIILAAGKGTRMKSKKYKVLHEVAGKPMVEHVLESVKGSGVDQVVTIVGHGAESVKGHLGERSLYSFQEEQLGT
AHAVQMAKSHLEDKKGTTIVVCGDTPLITKETLETLIAHHEDANAQATVLSASIQQPYGYGRIVRNASGRLDRIVEEKDA
TQAEKDINEISSGIFAFNNKTLFEKLTQVKNDNAQGEYYLPDVLSLILNDGGIVEVYRTNDVEEIMGVNDRVMLSQAEKA
MQRRTNHYHMLNGVTIIDPDSTFIGPDVIIGSDTVIEPGVRINGRTEIGEDVVIGQYSEINNSTIENGACIQQSVVNDAS
VGANTKVGPFAQLRPGAQLGADVKVGNFVEIKKADLKDGAKVSHLSYIGDAVIGERTNIGCGTITVNYDGENKFITIVGK
DSFVGCNVNLVAPVTIGDDVLVAAGSTITDDVPNDSLAVARARQTTKEGYRK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=393, Percent_Identity=22.9007633587786, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI11761619, Length=357, Percent_Identity=21.8487394957983, Blast_Score=80, Evalue=6e-15,
Organism=Escherichia coli, GI1790168, Length=449, Percent_Identity=43.2071269487751, Blast_Score=337, Evalue=8e-94,
Organism=Caenorhabditis elegans, GI133931050, Length=320, Percent_Identity=27.5, Blast_Score=101, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6320148, Length=390, Percent_Identity=25.1282051282051, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355443, Length=370, Percent_Identity=25.6756756756757, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24644084, Length=370, Percent_Identity=25.6756756756757, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 48778; Mature: 48778

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00622 HTH_LUXR_1 ; PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFMRRHAIILAAGKGTRMKSKKYKVLHEVAGKPMVEHVLESVKGSGVDQVVTIVGHGAES
CCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHEEEEECCCHHH
VKGHLGERSLYSFQEEQLGTAHAVQMAKSHLEDKKGTTIVVCGDTPLITKETLETLIAHH
HHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHCC
EDANAQATVLSASIQQPYGYGRIVRNASGRLDRIVEEKDATQAEKDINEISSGIFAFNNK
CCCCCEEEEEEHHHCCCCCCCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCC
TLFEKLTQVKNDNAQGEYYLPDVLSLILNDGGIVEVYRTNDVEEIMGVNDRVMLSQAEKA
HHHHHHHHHCCCCCCCCEEHHHHHHHHHCCCCEEEEEECCCHHHHHCCCCHHHHHHHHHH
MQRRTNHYHMLNGVTIIDPDSTFIGPDVIIGSDTVIEPGVRINGRTEIGEDVVIGQYSEI
HHHHCCCEEEECCEEEECCCCCCCCCEEEECCCCEECCCCEECCCCCCCCCEEEECHHHC
NNSTIENGACIQQSVVNDASVGANTKVGPFAQLRPGAQLGADVKVGNFVEIKKADLKDGA
CCCCCCCCCHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCCCCEECCCEEEEEECCCCCCC
KVSHLSYIGDAVIGERTNIGCGTITVNYDGENKFITIVGKDSFVGCNVNLVAPVTIGDDV
CCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEEEECCCEEECCEEEEEEEEECCCE
LVAAGSTITDDVPNDSLAVARARQTTKEGYRK
EEECCCCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFMRRHAIILAAGKGTRMKSKKYKVLHEVAGKPMVEHVLESVKGSGVDQVVTIVGHGAES
CCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHEEEEECCCHHH
VKGHLGERSLYSFQEEQLGTAHAVQMAKSHLEDKKGTTIVVCGDTPLITKETLETLIAHH
HHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHCC
EDANAQATVLSASIQQPYGYGRIVRNASGRLDRIVEEKDATQAEKDINEISSGIFAFNNK
CCCCCEEEEEEHHHCCCCCCCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCC
TLFEKLTQVKNDNAQGEYYLPDVLSLILNDGGIVEVYRTNDVEEIMGVNDRVMLSQAEKA
HHHHHHHHHCCCCCCCCEEHHHHHHHHHCCCCEEEEEECCCHHHHHCCCCHHHHHHHHHH
MQRRTNHYHMLNGVTIIDPDSTFIGPDVIIGSDTVIEPGVRINGRTEIGEDVVIGQYSEI
HHHHCCCEEEECCEEEECCCCCCCCCEEEECCCCEECCCCEECCCCCCCCCEEEECHHHC
NNSTIENGACIQQSVVNDASVGANTKVGPFAQLRPGAQLGADVKVGNFVEIKKADLKDGA
CCCCCCCCCHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCCCCEECCCEEEEEECCCCCCC
KVSHLSYIGDAVIGERTNIGCGTITVNYDGENKFITIVGKDSFVGCNVNLVAPVTIGDDV
CCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEEEECCCEEECCEEEEEEEEECCCE
LVAAGSTITDDVPNDSLAVARARQTTKEGYRK
EEECCCCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA