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The map label for this gene is dnaX

Identifier: 82750185

GI number: 82750185

Start: 469593

End: 471290

Strand: Direct

Name: dnaX

Synonym: SAB0427

Alternate gene names: 82750185

Gene position: 469593-471290 (Clockwise)

Preceding gene: 82750184

Following gene: 82750186

Centisome position: 17.12

GC content: 36.22

Gene sequence:

>1698_bases
TTGAATTATCAAGCCTTATATCGTATGTACAGACCCCAAAGTTTCGAGGATGTCGTCGGACAAGAACATGTCACGAAGAC
ATTGCGCAATGCGATTTCGAAAGAAAAACAGTCGCATGCATATATTTTTAGTGGTCCGAGAGGTACGGGGAAAACGAGTA
TTGCCAAAGTGTTTGCTAAAGCAATCAACTGTTTAAATAGCGCTGATGGAGAACCTTGTAATGAATGTCATATTTGTAAA
GGCATTACGCAGGGGACTAATTCAGATGTGATAGAAATTGATGCTGCTAGTAATAATGGTGTTGATGAAATAAGAAATAT
TAGAGACAAAGTTAAATATGCACCAAGTGAATCGAAATATAAAGTTTATATTATAGATGAGGTGCACATGCTAACAACAG
GTGCTTTTAATGCCCTTTTAAAGACGTTAGAAGAACCTCCAGCACACGCTATTTTTATATTGGCAACGACAGAACCACAT
AAAATCCCTCCAACAATCATTTCTAGGGCACAACGTTTTGATTTTAAAGCAATTAGCCTAGATCAAATTGTTGAACGTTT
AAAATTTGTAGCAGATGCACAACAAATTGAATGTGAAGATGCAGCCTTGGCATTTATCGCTAAAGCGTCTGAAGGGGGTA
TGCGTGATGCATTAAGTATTATGGATCAGGCTATTGCTTTTGGCGATGGCACATTGACATTACAAGATGCCCTAAATGTT
ACGGGTAGCGTTCATGATGAAGCGTTGGATCACTTGTTTGATGATATTGTACAAGGTGACGTACAAGCATCTTTTAAAAA
ATACCATCAGTTTATAACAGAAGGTAAAGAAGTGAATCGCCTAATAAATGATATGATTTATTTTGTCAGAGATACGATTA
TGAATAAAACATCTGAGAAAGATACTGAGTATCGAGCGCTGATGAACTTAGAATTAGATATGTTATACCAAATGATTGAT
CTTATTAATGATACATTAGTGTCGATTCGTTTTAGTGTGAATCAAAACGTTCATTTTGAAGTGTTGTTAGTAAAATTAGC
TGAGCAGATTAAGGGTCAACCACAAGTGATTGCGAATGTAGCTGAACCAGCACAAATTGCTTCATCGCCAAACACAGATG
TATTGTTGCAACGTATGGAACAGTTAGAGCAAGAACTAAAAACACTAAAAGTACAAGGAGTGAGTGTCGCTCCTGTTCAA
AAATCTTCGAAAAAGCCTGCGAGAGGTATACAAAAATCTAAAAATGCATTTTCAATGCAACAAATTGCAAAAGTGCTAGA
TAAAGCGAATAAGGCAGATATCAAATTGTTGAAAGATCATTGGCAAGAAGTGATTGATCATGCCAAAAACAATGATAAAA
AATCACTCGTTAGTTTATTGCAAAATTCGGAACCTGTGGCGGCAAGTGAAGATCACGTACTTGTGAAATTTGAGGAAGAG
ATTCATTGTGAAATCGTCAATAAAGACGACGAGAAACGTAGTAGTATAGAAAGTGTTGTATGTAATATCGTTAATAAAAA
CGTTAAAGTTGTTGGTGTACCATCAGATCAATGGCAAAGAGTTCGAACGGAGTATTTACAAAATCGTAAAAACGAAGGCG
ATGATATGCCAAAGCAACAAGCACAACAAACAGATATTGCTCAAAAAGCAAAAGATCTTTTCGGTGAAGAAACTGTACAT
GTGATAGATGAAGAGTGA

Upstream 100 bases:

>100_bases
GAATCGTAAAATTTCCAGAACATTTTTATTAATTGTTCATTTAAGAAGTAAAGGTATTATCATGCTATAATGAAAGGTAA
TTGTTTATGGAGGTGCTAAC

Downstream 100 bases:

>100_bases
TACATGACAAGCGATATAATCGTATGTATAATGAAAGAAACATCATTTTATTGATAAATATTTATTGGTTTTCAAGGAGG
AAATGGAATATGCGCGGTGG

Product: DNA polymerase III gamma and tau subunits

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MNYQALYRMYRPQSFEDVVGQEHVTKTLRNAISKEKQSHAYIFSGPRGTGKTSIAKVFAKAINCLNSADGEPCNECHICK
GITQGTNSDVIEIDAASNNGVDEIRNIRDKVKYAPSESKYKVYIIDEVHMLTTGAFNALLKTLEEPPAHAIFILATTEPH
KIPPTIISRAQRFDFKAISLDQIVERLKFVADAQQIECEDAALAFIAKASEGGMRDALSIMDQAIAFGDGTLTLQDALNV
TGSVHDEALDHLFDDIVQGDVQASFKKYHQFITEGKEVNRLINDMIYFVRDTIMNKTSEKDTEYRALMNLELDMLYQMID
LINDTLVSIRFSVNQNVHFEVLLVKLAEQIKGQPQVIANVAEPAQIASSPNTDVLLQRMEQLEQELKTLKVQGVSVAPVQ
KSSKKPARGIQKSKNAFSMQQIAKVLDKANKADIKLLKDHWQEVIDHAKNNDKKSLVSLLQNSEPVAASEDHVLVKFEEE
IHCEIVNKDDEKRSSIESVVCNIVNKNVKVVGVPSDQWQRVRTEYLQNRKNEGDDMPKQQAQQTDIAQKAKDLFGEETVH
VIDEE

Sequences:

>Translated_565_residues
MNYQALYRMYRPQSFEDVVGQEHVTKTLRNAISKEKQSHAYIFSGPRGTGKTSIAKVFAKAINCLNSADGEPCNECHICK
GITQGTNSDVIEIDAASNNGVDEIRNIRDKVKYAPSESKYKVYIIDEVHMLTTGAFNALLKTLEEPPAHAIFILATTEPH
KIPPTIISRAQRFDFKAISLDQIVERLKFVADAQQIECEDAALAFIAKASEGGMRDALSIMDQAIAFGDGTLTLQDALNV
TGSVHDEALDHLFDDIVQGDVQASFKKYHQFITEGKEVNRLINDMIYFVRDTIMNKTSEKDTEYRALMNLELDMLYQMID
LINDTLVSIRFSVNQNVHFEVLLVKLAEQIKGQPQVIANVAEPAQIASSPNTDVLLQRMEQLEQELKTLKVQGVSVAPVQ
KSSKKPARGIQKSKNAFSMQQIAKVLDKANKADIKLLKDHWQEVIDHAKNNDKKSLVSLLQNSEPVAASEDHVLVKFEEE
IHCEIVNKDDEKRSSIESVVCNIVNKNVKVVGVPSDQWQRVRTEYLQNRKNEGDDMPKQQAQQTDIAQKAKDLFGEETVH
VIDEE
>Mature_565_residues
MNYQALYRMYRPQSFEDVVGQEHVTKTLRNAISKEKQSHAYIFSGPRGTGKTSIAKVFAKAINCLNSADGEPCNECHICK
GITQGTNSDVIEIDAASNNGVDEIRNIRDKVKYAPSESKYKVYIIDEVHMLTTGAFNALLKTLEEPPAHAIFILATTEPH
KIPPTIISRAQRFDFKAISLDQIVERLKFVADAQQIECEDAALAFIAKASEGGMRDALSIMDQAIAFGDGTLTLQDALNV
TGSVHDEALDHLFDDIVQGDVQASFKKYHQFITEGKEVNRLINDMIYFVRDTIMNKTSEKDTEYRALMNLELDMLYQMID
LINDTLVSIRFSVNQNVHFEVLLVKLAEQIKGQPQVIANVAEPAQIASSPNTDVLLQRMEQLEQELKTLKVQGVSVAPVQ
KSSKKPARGIQKSKNAFSMQQIAKVLDKANKADIKLLKDHWQEVIDHAKNNDKKSLVSLLQNSEPVAASEDHVLVKFEEE
IHCEIVNKDDEKRSSIESVVCNIVNKNVKVVGVPSDQWQRVRTEYLQNRKNEGDDMPKQQAQQTDIAQKAKDLFGEETVH
VIDEE

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=308, Percent_Identity=25, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI194306571, Length=308, Percent_Identity=25, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI194306567, Length=308, Percent_Identity=25, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI4506491, Length=287, Percent_Identity=24.7386759581882, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI31881687, Length=287, Percent_Identity=24.7386759581882, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI31563534, Length=260, Percent_Identity=24.6153846153846, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI194306569, Length=228, Percent_Identity=24.5614035087719, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786676, Length=298, Percent_Identity=44.6308724832215, Blast_Score=275, Evalue=7e-75,
Organism=Escherichia coli, GI1787119, Length=233, Percent_Identity=27.0386266094421, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17541988, Length=290, Percent_Identity=26.2068965517241, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17554730, Length=224, Percent_Identity=28.125, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71986063, Length=230, Percent_Identity=26.5217391304348, Blast_Score=75, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6322528, Length=302, Percent_Identity=23.5099337748344, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6324039, Length=222, Percent_Identity=28.8288288288288, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324478, Length=241, Percent_Identity=26.1410788381743, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI18859927, Length=336, Percent_Identity=22.6190476190476, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17647857, Length=260, Percent_Identity=25, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19921076, Length=221, Percent_Identity=27.6018099547511, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 63440; Mature: 63440

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00214 FABP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYQALYRMYRPQSFEDVVGQEHVTKTLRNAISKEKQSHAYIFSGPRGTGKTSIAKVFAK
CCHHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHH
AINCLNSADGEPCNECHICKGITQGTNSDVIEIDAASNNGVDEIRNIRDKVKYAPSESKY
HHHHHHCCCCCCCCCHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCE
KVYIIDEVHMLTTGAFNALLKTLEEPPAHAIFILATTEPHKIPPTIISRAQRFDFKAISL
EEEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCEECH
DQIVERLKFVADAQQIECEDAALAFIAKASEGGMRDALSIMDQAIAFGDGTLTLQDALNV
HHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEHHHHHCC
TGSVHDEALDHLFDDIVQGDVQASFKKYHQFITEGKEVNRLINDMIYFVRDTIMNKTSEK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCC
DTEYRALMNLELDMLYQMIDLINDTLVSIRFSVNQNVHFEVLLVKLAEQIKGQPQVIANV
HHHHHHHHHCCHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHH
AEPAQIASSPNTDVLLQRMEQLEQELKTLKVQGVSVAPVQKSSKKPARGIQKSKNAFSMQ
HCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHHHHHCHHHHHH
QIAKVLDKANKADIKLLKDHWQEVIDHAKNNDKKSLVSLLQNSEPVAASEDHVLVKFEEE
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCC
IHCEIVNKDDEKRSSIESVVCNIVNKNVKVVGVPSDQWQRVRTEYLQNRKNEGDDMPKQQ
EEEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHH
AQQTDIAQKAKDLFGEETVHVIDEE
HHHHHHHHHHHHHCCCCCEEEECCC
>Mature Secondary Structure
MNYQALYRMYRPQSFEDVVGQEHVTKTLRNAISKEKQSHAYIFSGPRGTGKTSIAKVFAK
CCHHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHH
AINCLNSADGEPCNECHICKGITQGTNSDVIEIDAASNNGVDEIRNIRDKVKYAPSESKY
HHHHHHCCCCCCCCCHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCE
KVYIIDEVHMLTTGAFNALLKTLEEPPAHAIFILATTEPHKIPPTIISRAQRFDFKAISL
EEEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCEECH
DQIVERLKFVADAQQIECEDAALAFIAKASEGGMRDALSIMDQAIAFGDGTLTLQDALNV
HHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEHHHHHCC
TGSVHDEALDHLFDDIVQGDVQASFKKYHQFITEGKEVNRLINDMIYFVRDTIMNKTSEK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCC
DTEYRALMNLELDMLYQMIDLINDTLVSIRFSVNQNVHFEVLLVKLAEQIKGQPQVIANV
HHHHHHHHHCCHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHH
AEPAQIASSPNTDVLLQRMEQLEQELKTLKVQGVSVAPVQKSSKKPARGIQKSKNAFSMQ
HCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHHHHHCHHHHHH
QIAKVLDKANKADIKLLKDHWQEVIDHAKNNDKKSLVSLLQNSEPVAASEDHVLVKFEEE
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCC
IHCEIVNKDDEKRSSIESVVCNIVNKNVKVVGVPSDQWQRVRTEYLQNRKNEGDDMPKQQ
EEEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHH
AQQTDIAQKAKDLFGEETVHVIDEE
HHHHHHHHHHHHHCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]