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The map label for this gene is nupC [H]

Identifier: 82750013

GI number: 82750013

Start: 301386

End: 302606

Strand: Direct

Name: nupC [H]

Synonym: SAB0250

Alternate gene names: 82750013

Gene position: 301386-302606 (Clockwise)

Preceding gene: 82750012

Following gene: 82750016

Centisome position: 10.99

GC content: 33.09

Gene sequence:

>1221_bases
ATGAATATTTTATTCGCTATCACAGGGATAGCATTTGCACTATTTGTTGCGTTTTTATTCAGTTTTGATCGTAAAAACAT
AGACTTCAAAAAGACGTTAATAATGATATTTATTCAAGTGTTGATTGTGTTATTTATGATGAACACAACGATTGGTTTAA
CAATCTTAACTGCATTAGGTTCATTTTTTGAAGGGTTAATAAATGTTAGTAAAGCAGGTATAAACTTTGTTTTTGGAGAT
ATACAAAATAAAAATGGCTTTACATTCTTTTTAAATGTGTTGCTGCCATTAGTGTTCATTTCTGTATTAATAGGCATTTT
TAATTATATTAAGGTATTACCATTTATTATCAAATATGTAGGTATTACTATTAATAAAATAACGAGAATGGGGCGTTTAG
AAAGTTACTTTGCTATTTCGACAGCGATGTTTGGACAGCCAGAAGTGTATTTAACTATAAAAGACATCATACCAAAGTTG
TCTAGAGCAAAATTATATACAATTGCGACATCTGGTATGAGTGCTGTTAGTATGGCAATGTTGGGTTCATATATGCAGAT
GATTGAGCCTAAGTTCGTAGTTACAGCAGTAATGTTAAATATTTTTAGTGCGCTTATCATCGCCAGTGTAATCAATCCCT
ATAAATCTGATGATACTGATGTTGAAATTGATAACCTAACGAAATCCACAGAAACTAAAACATTGAATGGAAAAACAGGA
AAACCTAAGAAAGTTGCCTTTTTCCAAATGATTGGTGATAGTGCAATGGATGGGTTTAAAATCGCTGTTGTAGTAGCCGT
AATGTTGTTAGCATTTATTTCACTAATGGAAGCAATTAATATCATGTTTGGTAGTGTTGGTTTGAACTTTAAACAGCTTA
TTGGCTATGTGTTTGCACCAATCGCATTCTTAATGGGGATTCCATGGAGCGAAGCAGTTCCAGCTGGCTCTTTAATGGCG
ACTAAATTAATTACAAATGAGTTTGTAGCAATGCTTGATTTTAAAAATGTCCTGGGTGATGTATCTGCTCGAACACAAGG
TATCATTTCAGTTTACTTAGTAAGCTTCGCTAATTTTGGTACGGTTGGTATCATCGTAGGTTCAATTAAAGGCATTAGTG
ATAAACAAGGAGAAAAAGTTGCATCCTTTGCAATGAGGCTGTTACTTGGTTCAACTCTAGCTTCAATCATTTCAGGATCA
ATCATTGGCCTAGTATTGTAA

Upstream 100 bases:

>100_bases
GGTAAAAGTTTAGCAGCAAATATAAAACTTGTTGAAAACAATGCGGCGTTGGGTGCTAAAATTGCTGTCGCTGTTAATAA
ATTATTGTAGGTGATGATAC

Downstream 100 bases:

>100_bases
ATTAATCGAAGTATCTAAATTAAATTCATGGCAAAGCTAAACCCCATCACCAAGTTGGCGCAACAGCGCATCATAACTTA
GTGATGGGGTTTTATCATAA

Product: nucleoside transporter permease

Products: uridine [Cytoplasm]; thymidine [Cytoplasm]; inosine [Cytoplasm]; Deoxyuridine [Cytoplasm]; deoxyinosine [Cytoplasm]; deoxycytidine [Cytoplasm]; deoxyadenosine [Cytoplasm]; cytidine [Cytoplasm]; Proton [Cytoplasm]; adenosine [Cytoplasm] [C]

Alternate protein names: Nucleoside-transport system protein nupC [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MNILFAITGIAFALFVAFLFSFDRKNIDFKKTLIMIFIQVLIVLFMMNTTIGLTILTALGSFFEGLINVSKAGINFVFGD
IQNKNGFTFFLNVLLPLVFISVLIGIFNYIKVLPFIIKYVGITINKITRMGRLESYFAISTAMFGQPEVYLTIKDIIPKL
SRAKLYTIATSGMSAVSMAMLGSYMQMIEPKFVVTAVMLNIFSALIIASVINPYKSDDTDVEIDNLTKSTETKTLNGKTG
KPKKVAFFQMIGDSAMDGFKIAVVVAVMLLAFISLMEAINIMFGSVGLNFKQLIGYVFAPIAFLMGIPWSEAVPAGSLMA
TKLITNEFVAMLDFKNVLGDVSARTQGIISVYLVSFANFGTVGIIVGSIKGISDKQGEKVASFAMRLLLGSTLASIISGS
IIGLVL

Sequences:

>Translated_406_residues
MNILFAITGIAFALFVAFLFSFDRKNIDFKKTLIMIFIQVLIVLFMMNTTIGLTILTALGSFFEGLINVSKAGINFVFGD
IQNKNGFTFFLNVLLPLVFISVLIGIFNYIKVLPFIIKYVGITINKITRMGRLESYFAISTAMFGQPEVYLTIKDIIPKL
SRAKLYTIATSGMSAVSMAMLGSYMQMIEPKFVVTAVMLNIFSALIIASVINPYKSDDTDVEIDNLTKSTETKTLNGKTG
KPKKVAFFQMIGDSAMDGFKIAVVVAVMLLAFISLMEAINIMFGSVGLNFKQLIGYVFAPIAFLMGIPWSEAVPAGSLMA
TKLITNEFVAMLDFKNVLGDVSARTQGIISVYLVSFANFGTVGIIVGSIKGISDKQGEKVASFAMRLLLGSTLASIISGS
IIGLVL
>Mature_406_residues
MNILFAITGIAFALFVAFLFSFDRKNIDFKKTLIMIFIQVLIVLFMMNTTIGLTILTALGSFFEGLINVSKAGINFVFGD
IQNKNGFTFFLNVLLPLVFISVLIGIFNYIKVLPFIIKYVGITINKITRMGRLESYFAISTAMFGQPEVYLTIKDIIPKL
SRAKLYTIATSGMSAVSMAMLGSYMQMIEPKFVVTAVMLNIFSALIIASVINPYKSDDTDVEIDNLTKSTETKTLNGKTG
KPKKVAFFQMIGDSAMDGFKIAVVVAVMLLAFISLMEAINIMFGSVGLNFKQLIGYVFAPIAFLMGIPWSEAVPAGSLMA
TKLITNEFVAMLDFKNVLGDVSARTQGIISVYLVSFANFGTVGIIVGSIKGISDKQGEKVASFAMRLLLGSTLASIISGS
IIGLVL

Specific function: Transports nucleosides with a high affinity except guanosine and deoxyguanosine. Driven by a proton motive force [H]

COG id: COG1972

COG function: function code F; Nucleoside permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family [H]

Homologues:

Organism=Homo sapiens, GI11545853, Length=411, Percent_Identity=25.7907542579075, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI42542381, Length=422, Percent_Identity=22.5118483412322, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI227116277, Length=426, Percent_Identity=23.0046948356808, Blast_Score=105, Evalue=1e-22,
Organism=Escherichia coli, GI1788737, Length=413, Percent_Identity=42.6150121065375, Blast_Score=352, Evalue=2e-98,
Organism=Escherichia coli, GI1788485, Length=422, Percent_Identity=29.6208530805687, Blast_Score=184, Evalue=7e-48,
Organism=Escherichia coli, GI1788488, Length=424, Percent_Identity=30.188679245283, Blast_Score=184, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI17560276, Length=403, Percent_Identity=20.5955334987593, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71991794, Length=406, Percent_Identity=22.1674876847291, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI45552519, Length=415, Percent_Identity=24.8192771084337, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45552517, Length=415, Percent_Identity=24.8192771084337, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI19921868, Length=415, Percent_Identity=24.8192771084337, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI281360430, Length=362, Percent_Identity=24.8618784530387, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008276
- InterPro:   IPR018270
- InterPro:   IPR011657
- InterPro:   IPR002668 [H]

Pfam domain/function: PF07662 Nucleos_tra2_C; PF01773 Nucleos_tra2_N [H]

EC number: NA

Molecular weight: Translated: 44196; Mature: 44196

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILFAITGIAFALFVAFLFSFDRKNIDFKKTLIMIFIQVLIVLFMMNTTIGLTILTALG
CCEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFFEGLINVSKAGINFVFGDIQNKNGFTFFLNVLLPLVFISVLIGIFNYIKVLPFIIKYV
HHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GITINKITRMGRLESYFAISTAMFGQPEVYLTIKDIIPKLSRAKLYTIATSGMSAVSMAM
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCHHHCEEEEEECCCHHHHHHHH
LGSYMQMIEPKFVVTAVMLNIFSALIIASVINPYKSDDTDVEIDNLTKSTETKTLNGKTG
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHCCCCCCCCCCCCCCCC
KPKKVAFFQMIGDSAMDGFKIAVVVAVMLLAFISLMEAINIMFGSVGLNFKQLIGYVFAP
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
IAFLMGIPWSEAVPAGSLMATKLITNEFVAMLDFKNVLGDVSARTQGIISVYLVSFANFG
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TVGIIVGSIKGISDKQGEKVASFAMRLLLGSTLASIISGSIIGLVL
HHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCC
>Mature Secondary Structure
MNILFAITGIAFALFVAFLFSFDRKNIDFKKTLIMIFIQVLIVLFMMNTTIGLTILTALG
CCEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFFEGLINVSKAGINFVFGDIQNKNGFTFFLNVLLPLVFISVLIGIFNYIKVLPFIIKYV
HHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GITINKITRMGRLESYFAISTAMFGQPEVYLTIKDIIPKLSRAKLYTIATSGMSAVSMAM
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCHHHCEEEEEECCCHHHHHHHH
LGSYMQMIEPKFVVTAVMLNIFSALIIASVINPYKSDDTDVEIDNLTKSTETKTLNGKTG
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHCCCCCCCCCCCCCCCC
KPKKVAFFQMIGDSAMDGFKIAVVVAVMLLAFISLMEAINIMFGSVGLNFKQLIGYVFAP
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
IAFLMGIPWSEAVPAGSLMATKLITNEFVAMLDFKNVLGDVSARTQGIISVYLVSFANFG
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TVGIIVGSIKGISDKQGEKVASFAMRLLLGSTLASIISGSIIGLVL
HHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: uridine [Periplasm]; thymidine [Periplasm]; inosine [Periplasm]; Deoxyuridine [Periplasm]; deoxyinosine [Periplasm]; deoxycytidine [Periplasm]; deoxyadenosine [Periplasm]; cytidine [Periplasm]; Proton [Periplasm]; adenosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uridine [Periplasm] = Proton [Cytoplasm] + uridine [Cytoplasm] Proton [Periplasm] + thymidine [Periplasm] = Proton [Cytoplasm] + thymidine [Cytoplasm] Proton [Periplasm] + inosine [Periplasm] = Proton [Cytoplasm] + inosine [Cytoplasm]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]