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The map label for this gene is lytR

Identifier: 82749966

GI number: 82749966

Start: 250623

End: 251363

Strand: Direct

Name: lytR

Synonym: SAB0200

Alternate gene names: 82749966

Gene position: 250623-251363 (Clockwise)

Preceding gene: 82749965

Following gene: 82749967

Centisome position: 9.14

GC content: 31.31

Gene sequence:

>741_bases
ATGAAAGCATTAATCATAGATGATGAGCCATTAGCACGTAATGAATTAACATATTTATTAAATGAAATTGGTGGTTTTGA
AGAAATTAATGAGGCAGAAAATGTAAAAGAAACATTGGAAGCACTACTGATAAATCAATATGACATTATATTTTTAGATG
TCAATTTAATGGATGAAAATGGTATCGAATTAGGAGCTAAAATTCAAAAGATGAAAGAGCCACCTGCGATTATTTTTGCA
ACTGCACATGACCAATACGCAGTACAGGCATTTGAATTAAATGCGACAGACTATATTTTGAAACCGTTTGGTCAAAAACG
TATTGAACAAGCAGTCAATAAAGTTCGTGCGACTAAAGCCAAAGATGATAATAGCGCAAATGCAATTGTGAATGATATGT
CGGCGAATTTTGATCAAAGTTTACCTGTTGAAATTGACGATAAAATTCACATGTTAAAGCAACAAAATATTATTGGGATT
GGTACACATAATGGTATTACAACCATACATACAACGAATCATAAATACGAAACAACAGAGCCATTGAATCGTTATGAAAA
ACGATTGAATCCCACTTATTTTATACGTATTCATCGTTCATATATTATTAACACTAAACACATTAAAGAAGTGCAACAAT
GGTTTAACTACACTTATATGGTAATATTGACAAATGGTGTCAAGATGCAAGTTGGACGTTCATTTATGAAAGATTTTAAA
GCGTCGATAGGATTACTTTAA

Upstream 100 bases:

>100_bases
GATTATTTGGAAAATCCGCAGCATTACAATTTGAATCGACATCGAGCGGTACCACTTTTTGGTGTGTACTTCCTTATGAA
AGACAAGAGGAGGAATAAAT

Downstream 100 bases:

>100_bases
CAGTAATCCTTTTTTTTATGCATTTTACCTATGATATTTTGTATTTCGGACTAAAATTCACGCAAATCGAAGTGAGCCAT
CTATACTTTAGTTAAATCAA

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MKALIIDDEPLARNELTYLLNEIGGFEEINEAENVKETLEALLINQYDIIFLDVNLMDENGIELGAKIQKMKEPPAIIFA
TAHDQYAVQAFELNATDYILKPFGQKRIEQAVNKVRATKAKDDNSANAIVNDMSANFDQSLPVEIDDKIHMLKQQNIIGI
GTHNGITTIHTTNHKYETTEPLNRYEKRLNPTYFIRIHRSYIINTKHIKEVQQWFNYTYMVILTNGVKMQVGRSFMKDFK
ASIGLL

Sequences:

>Translated_246_residues
MKALIIDDEPLARNELTYLLNEIGGFEEINEAENVKETLEALLINQYDIIFLDVNLMDENGIELGAKIQKMKEPPAIIFA
TAHDQYAVQAFELNATDYILKPFGQKRIEQAVNKVRATKAKDDNSANAIVNDMSANFDQSLPVEIDDKIHMLKQQNIIGI
GTHNGITTIHTTNHKYETTEPLNRYEKRLNPTYFIRIHRSYIINTKHIKEVQQWFNYTYMVILTNGVKMQVGRSFMKDFK
ASIGLL
>Mature_246_residues
MKALIIDDEPLARNELTYLLNEIGGFEEINEAENVKETLEALLINQYDIIFLDVNLMDENGIELGAKIQKMKEPPAIIFA
TAHDQYAVQAFELNATDYILKPFGQKRIEQAVNKVRATKAKDDNSANAIVNDMSANFDQSLPVEIDDKIHMLKQQNIIGI
GTHNGITTIHTTNHKYETTEPLNRYEKRLNPTYFIRIHRSYIINTKHIKEVQQWFNYTYMVILTNGVKMQVGRSFMKDFK
ASIGLL

Specific function: Member of the two-component regulatory system lytR/lytS that regulates genes involved in autolysis and cell wall metabolism. Regulates the activity of the cell wall-associated murein hydrolase through regulation of lrgA and lrgB [H]

COG id: COG3279

COG function: function code KT; Response regulator of the LytR/AlgR family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788724, Length=246, Percent_Identity=31.3008130081301, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI87082052, Length=248, Percent_Identity=31.4516129032258, Blast_Score=129, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR007492
- InterPro:   IPR001789 [H]

Pfam domain/function: PF04397 LytTR; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 28250; Mature: 28250

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50930 HTH_LYTTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALIIDDEPLARNELTYLLNEIGGFEEINEAENVKETLEALLINQYDIIFLDVNLMDEN
CCEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCC
GIELGAKIQKMKEPPAIIFATAHDQYAVQAFELNATDYILKPFGQKRIEQAVNKVRATKA
CCCHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCHHHHCCCCHHHHHHHHHHHHHHCC
KDDNSANAIVNDMSANFDQSLPVEIDDKIHMLKQQNIIGIGTHNGITTIHTTNHKYETTE
CCCCCCHHEEECCCCCCCCCCCEEECHHHHHHHHCCEEEEECCCCEEEEEECCCCCCCCC
PLNRYEKRLNPTYFIRIHRSYIINTKHIKEVQQWFNYTYMVILTNGVKMQVGRSFMKDFK
HHHHHHHHCCCEEEEEEEEHEEECHHHHHHHHHHHCEEEEEEEECCCEEHHHHHHHHHHH
ASIGLL
HHHCCC
>Mature Secondary Structure
MKALIIDDEPLARNELTYLLNEIGGFEEINEAENVKETLEALLINQYDIIFLDVNLMDEN
CCEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCC
GIELGAKIQKMKEPPAIIFATAHDQYAVQAFELNATDYILKPFGQKRIEQAVNKVRATKA
CCCHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCHHHHCCCCHHHHHHHHHHHHHHCC
KDDNSANAIVNDMSANFDQSLPVEIDDKIHMLKQQNIIGIGTHNGITTIHTTNHKYETTE
CCCCCCHHEEECCCCCCCCCCCEEECHHHHHHHHCCEEEEECCCCEEEEEECCCCCCCCC
PLNRYEKRLNPTYFIRIHRSYIINTKHIKEVQQWFNYTYMVILTNGVKMQVGRSFMKDFK
HHHHHHHHCCCEEEEEEEEHEEECHHHHHHHHHHHCEEEEEEEECCCEEHHHHHHHHHHH
ASIGLL
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA