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The map label for this gene is ispD

Identifier: 82749960

GI number: 82749960

Start: 242604

End: 243320

Strand: Direct

Name: ispD

Synonym: SAB0194

Alternate gene names: 82749960

Gene position: 242604-243320 (Clockwise)

Preceding gene: 82749959

Following gene: 82749961

Centisome position: 8.85

GC content: 32.5

Gene sequence:

>717_bases
ATGAAATATGCTGGTATTCTAGCTGGAGGTATAGGCTCAAGAATGGGAAACGTACCTTTACCTAAACAATTTTTAGATTT
AGACAACAAACCGATTTTAATCCATACATTAGAAAAATTTATTTTAATTAATGATTTTGAAAAAATTATTATCGCGACGC
CACAACAATGGATGACGCATACGAAAGATACACTTAGAAAATTCAAAATTTCTGATGAAAGAATTGAAGTCATTCAAGGT
GGTAGCGATCGTAACGATACAATTATGAATATCGTTAAACATATTGAATCAACAAATGGTATTAACGATGACGATGTCAT
TGTGACACATGATGCAGTTAGACCATTTTTAACGCATCGTATTATTAAAGAAAATATTCAAGCTGCTTTAGAGTACGGTG
CAGTAGATACAGTGATTGATGCTATAGATACGATTGTTACATCTAAAGATGATCAAACGATTGACGCAATTCCAGTGCGT
AATGAAATGTACCAAGGTCAAACACCTCAATCGTTTAATATTAATTTATTAAAAGAAAGCTATGCACAGTTGAGTGATGA
GCAAAAGAGTATTTTATCTGATGCTTGTAAGATTATTGTGGAAACAAACAAACCGGTTCGACTTGTAAAAGGTGAGTTAT
ATAACATTAAAGTAACAACACCTTACGATTTAAAAGTAGCGAATGCTATTATTCGAGGTGGTATTGCCGATGATTAA

Upstream 100 bases:

>100_bases
AGACATTTAGAGTTTTGATTTTAAAATGAGTTTTCAATTGGAAAATGCAACGAAATTTAAATAATTAAATATAGATATAG
TTGAATGGAGGAAGTATTTT

Downstream 100 bases:

>100_bases
TCAAGTATATCAATTAGTTGCACCTAGACAATTTGAAGTTACGTATAACAACGTAGATATTTACAGTGACTATGTCATTG
TACGTCCTTTATATATGTCA

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase 2; MEP cytidylyltransferase 2; MCT 2

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MKYAGILAGGIGSRMGNVPLPKQFLDLDNKPILIHTLEKFILINDFEKIIIATPQQWMTHTKDTLRKFKISDERIEVIQG
GSDRNDTIMNIVKHIESTNGINDDDVIVTHDAVRPFLTHRIIKENIQAALEYGAVDTVIDAIDTIVTSKDDQTIDAIPVR
NEMYQGQTPQSFNINLLKESYAQLSDEQKSILSDACKIIVETNKPVRLVKGELYNIKVTTPYDLKVANAIIRGGIADD

Sequences:

>Translated_238_residues
MKYAGILAGGIGSRMGNVPLPKQFLDLDNKPILIHTLEKFILINDFEKIIIATPQQWMTHTKDTLRKFKISDERIEVIQG
GSDRNDTIMNIVKHIESTNGINDDDVIVTHDAVRPFLTHRIIKENIQAALEYGAVDTVIDAIDTIVTSKDDQTIDAIPVR
NEMYQGQTPQSFNINLLKESYAQLSDEQKSILSDACKIIVETNKPVRLVKGELYNIKVTTPYDLKVANAIIRGGIADD
>Mature_238_residues
MKYAGILAGGIGSRMGNVPLPKQFLDLDNKPILIHTLEKFILINDFEKIIIATPQQWMTHTKDTLRKFKISDERIEVIQG
GSDRNDTIMNIVKHIESTNGINDDDVIVTHDAVRPFLTHRIIKENIQAALEYGAVDTVIDAIDTIVTSKDDQTIDAIPVR
NEMYQGQTPQSFNINLLKESYAQLSDEQKSILSDACKIIVETNKPVRLVKGELYNIKVTTPYDLKVANAIIRGGIADD

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family

Homologues:

Organism=Homo sapiens, GI157412259, Length=235, Percent_Identity=28.0851063829787, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI157671913, Length=223, Percent_Identity=26.457399103139, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPD2_STAAB (Q2YV73)

Other databases:

- EMBL:   AJ938182
- RefSeq:   YP_415701.1
- ProteinModelPortal:   Q2YV73
- STRING:   Q2YV73
- EnsemblBacteria:   EBSTAT00000011415
- GeneID:   3793578
- GenomeReviews:   AJ938182_GR
- KEGG:   sab:SAB0194
- NMPDR:   fig|273036.3.peg.411
- eggNOG:   COG1211
- GeneTree:   EBGT00050000024510
- HOGENOM:   HBG672839
- OMA:   REQQDFW
- ProtClustDB:   PRK00155
- BioCyc:   SAUR273036:SAB0194-MONOMER
- HAMAP:   MF_00108
- InterPro:   IPR001228
- InterPro:   IPR018294

Pfam domain/function: PF01128 IspD

EC number: =2.7.7.60

Molecular weight: Translated: 26658; Mature: 26658

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYAGILAGGIGSRMGNVPLPKQFLDLDNKPILIHTLEKFILINDFEKIIIATPQQWMTH
CCCCCEEECCHHHHCCCCCCCHHHHCCCCCCEEHHHHHHHHHHCCCCEEEEECCHHHHHH
TKDTLRKFKISDERIEVIQGGSDRNDTIMNIVKHIESTNGINDDDVIVTHDAVRPFLTHR
HHHHHHHHCCCCHHEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHH
IIKENIQAALEYGAVDTVIDAIDTIVTSKDDQTIDAIPVRNEMYQGQTPQSFNINLLKES
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEECCHHHHHCCCCCCCCCHHHHHHH
YAQLSDEQKSILSDACKIIVETNKPVRLVKGELYNIKVTTPYDLKVANAIIRGGIADD
HHHHCHHHHHHHHHHHHEEEECCCCEEEEECEEEEEEECCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKYAGILAGGIGSRMGNVPLPKQFLDLDNKPILIHTLEKFILINDFEKIIIATPQQWMTH
CCCCCEEECCHHHHCCCCCCCHHHHCCCCCCEEHHHHHHHHHHCCCCEEEEECCHHHHHH
TKDTLRKFKISDERIEVIQGGSDRNDTIMNIVKHIESTNGINDDDVIVTHDAVRPFLTHR
HHHHHHHHCCCCHHEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHH
IIKENIQAALEYGAVDTVIDAIDTIVTSKDDQTIDAIPVRNEMYQGQTPQSFNINLLKES
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEECCHHHHHCCCCCCCCCHHHHHHH
YAQLSDEQKSILSDACKIIVETNKPVRLVKGELYNIKVTTPYDLKVANAIIRGGIADD
HHHHCHHHHHHHHHHHHEEEECCCCEEEEECEEEEEEECCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA