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The map label for this gene is serA [C]

Identifier: 82749888

GI number: 82749888

Start: 138873

End: 140000

Strand: Direct

Name: serA [C]

Synonym: SAB0117

Alternate gene names: 82749888

Gene position: 138873-140000 (Clockwise)

Preceding gene: 82749887

Following gene: 82749889

Centisome position: 5.06

GC content: 34.93

Gene sequence:

>1128_bases
GTGGTATGTCAAACGGTGCCGTTTTTTGTCATATTTTTAAAACAAGCAACATGCAACACGTACTTTAAGGAAGTCAAAAT
TTATCATTTAGGAGAGATGGATATGAAAATTGTAGCGTTATTTCCAGAAGCAGTACAAGGTCAAGACAATCAATTACTTA
ATACTAAAAAAGCATTAGGATTAAAAACATTTTTAGAGGAAAGAGGACATGAGTTCATTATATTAGCAGATAATGGTGAA
GACTTAGATAAACATTTACCAGATATGGATGTGATTATTAGTGCGCCATTTTATCCTGCATATATGACTCGTGAACGTAT
TGAAAAAGCACCGAACTTGAAATTAGCAATTACAGCAGGTGTAGGATCTGACCATGTAGATTTAGCGGCAGCAAGTGAAC
ACAACATTGGTGTCGTTGAAGTTACAGGAAGTAATACAGTTAGTGTGGCAGAACATGCGGTTATGGATTTATTAATACTA
CTTAGAAACTATGAAGAAGGTCATCGTCAATCAGTAGAAGGTGAATGGAACTTGTCTCAAGTAGGTAATCATGCGCATGA
ATTACAACACAAAACAATTGGTATTTTTGGATTTGGACGAATTGGACAACTTGTTGCTGAAAGATTAGCGCCATTTAATG
TAACATTACAACACTATGATCCAATCAATCAACAAGATCATAAATTGTCTAAATTTGTAAGCTTTGATGAACTTGTTTCA
ACAAGTGATGCGATTACAATTCATGCACCATTAACACCAGAAACTGATAACTTATTTGATAAAGATGTTTTAAGTCGTAT
GAAAAAACACAGTTATTTAGTGAATACTGCACGTGGTAAAATTGTAAATCGCGATGCGTTAGTTGAAGCGTTAGCACCTG
AGCATTTACAAGGATATGCTGGTGATGTTTGGTATCCACAACCTGCACCTGCTGATCATCCATGGAGAACAATGCCTAGA
AATGCTATGACAGTTCACTATTCAGGTATGACTTTAGAAGCACAAAAACGTATTGAAGATGGAGTTAAAGATATTTTAGA
GCGTTTCTTCAATCATGAACCTTTCCAAGATAAAGATATTATTGTTGCAAGTGGTCGTATTGCTAGTAAAAGTTATACAG
CTAAATAG

Upstream 100 bases:

>100_bases
AATATTTGTTTTCGATAAGTCAATAGAATAAGTGTTGCTGGTGTAAGGTACGCGGTGCTGTTTGCTAACTTCGCTTTGAG
TTTAACAATAATTCAAGGGG

Downstream 100 bases:

>100_bases
AATAAGGATGCTGGGCTAGCGATTAACGCTTTCAATTTTATATAAATGAATCATATAAGTACTACTGCTGTTGTAAAGAT
GGCAGTAGTTTTTTATGATT

Product: formate dehydrogenase

Products: NA

Alternate protein names: NAD-dependent formate dehydrogenase; FDH [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MVCQTVPFFVIFLKQATCNTYFKEVKIYHLGEMDMKIVALFPEAVQGQDNQLLNTKKALGLKTFLEERGHEFIILADNGE
DLDKHLPDMDVIISAPFYPAYMTRERIEKAPNLKLAITAGVGSDHVDLAAASEHNIGVVEVTGSNTVSVAEHAVMDLLIL
LRNYEEGHRQSVEGEWNLSQVGNHAHELQHKTIGIFGFGRIGQLVAERLAPFNVTLQHYDPINQQDHKLSKFVSFDELVS
TSDAITIHAPLTPETDNLFDKDVLSRMKKHSYLVNTARGKIVNRDALVEALAPEHLQGYAGDVWYPQPAPADHPWRTMPR
NAMTVHYSGMTLEAQKRIEDGVKDILERFFNHEPFQDKDIIVASGRIASKSYTAK

Sequences:

>Translated_375_residues
MVCQTVPFFVIFLKQATCNTYFKEVKIYHLGEMDMKIVALFPEAVQGQDNQLLNTKKALGLKTFLEERGHEFIILADNGE
DLDKHLPDMDVIISAPFYPAYMTRERIEKAPNLKLAITAGVGSDHVDLAAASEHNIGVVEVTGSNTVSVAEHAVMDLLIL
LRNYEEGHRQSVEGEWNLSQVGNHAHELQHKTIGIFGFGRIGQLVAERLAPFNVTLQHYDPINQQDHKLSKFVSFDELVS
TSDAITIHAPLTPETDNLFDKDVLSRMKKHSYLVNTARGKIVNRDALVEALAPEHLQGYAGDVWYPQPAPADHPWRTMPR
NAMTVHYSGMTLEAQKRIEDGVKDILERFFNHEPFQDKDIIVASGRIASKSYTAK
>Mature_375_residues
MVCQTVPFFVIFLKQATCNTYFKEVKIYHLGEMDMKIVALFPEAVQGQDNQLLNTKKALGLKTFLEERGHEFIILADNGE
DLDKHLPDMDVIISAPFYPAYMTRERIEKAPNLKLAITAGVGSDHVDLAAASEHNIGVVEVTGSNTVSVAEHAVMDLLIL
LRNYEEGHRQSVEGEWNLSQVGNHAHELQHKTIGIFGFGRIGQLVAERLAPFNVTLQHYDPINQQDHKLSKFVSFDELVS
TSDAITIHAPLTPETDNLFDKDVLSRMKKHSYLVNTARGKIVNRDALVEALAPEHLQGYAGDVWYPQPAPADHPWRTMPR
NAMTVHYSGMTLEAQKRIEDGVKDILERFFNHEPFQDKDIIVASGRIASKSYTAK

Specific function: Serine biosynthesis; first step. [C]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=264, Percent_Identity=32.1969696969697, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI6912396, Length=225, Percent_Identity=34.2222222222222, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI145580578, Length=265, Percent_Identity=28.6792452830189, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI4557499, Length=265, Percent_Identity=28.6792452830189, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI4557497, Length=279, Percent_Identity=27.5985663082437, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI61743967, Length=279, Percent_Identity=27.5985663082437, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI145580575, Length=260, Percent_Identity=29.2307692307692, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI1789279, Length=243, Percent_Identity=32.9218106995885, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI87082289, Length=237, Percent_Identity=28.2700421940928, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787645, Length=185, Percent_Identity=31.3513513513514, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1788660, Length=262, Percent_Identity=27.0992366412214, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87081824, Length=229, Percent_Identity=28.82096069869, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=287, Percent_Identity=31.7073170731707, Blast_Score=124, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI25147481, Length=218, Percent_Identity=28.8990825688073, Blast_Score=95, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6324964, Length=356, Percent_Identity=43.8202247191011, Blast_Score=299, Evalue=4e-82,
Organism=Saccharomyces cerevisiae, GI6324980, Length=214, Percent_Identity=41.1214953271028, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6324979, Length=126, Percent_Identity=50, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6320925, Length=304, Percent_Identity=28.2894736842105, Blast_Score=115, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6322116, Length=263, Percent_Identity=28.8973384030418, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=228, Percent_Identity=27.6315789473684, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI19921140, Length=245, Percent_Identity=30.2040816326531, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI28574286, Length=223, Percent_Identity=32.7354260089686, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI28571528, Length=234, Percent_Identity=31.1965811965812, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24585516, Length=278, Percent_Identity=28.0575539568345, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI45552429, Length=211, Percent_Identity=33.175355450237, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24585514, Length=211, Percent_Identity=33.175355450237, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI28574282, Length=211, Percent_Identity=33.175355450237, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI28574284, Length=211, Percent_Identity=33.175355450237, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI45551003, Length=211, Percent_Identity=33.175355450237, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24646446, Length=278, Percent_Identity=26.978417266187, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24646448, Length=278, Percent_Identity=26.978417266187, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24646452, Length=278, Percent_Identity=26.978417266187, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24646450, Length=278, Percent_Identity=26.978417266187, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI62472511, Length=278, Percent_Identity=26.978417266187, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 42140; Mature: 42140

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVCQTVPFFVIFLKQATCNTYFKEVKIYHLGEMDMKIVALFPEAVQGQDNQLLNTKKALG
CCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEEECCHHHCCCCCHHHHHHHHHH
LKTFLEERGHEFIILADNGEDLDKHLPDMDVIISAPFYPAYMTRERIEKAPNLKLAITAG
HHHHHHHCCCEEEEEECCCCCHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEEEEC
VGSDHVDLAAASEHNIGVVEVTGSNTVSVAEHAVMDLLILLRNYEEGHRQSVEGEWNLSQ
CCCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHH
VGNHAHELQHKTIGIFGFGRIGQLVAERLAPFNVTLQHYDPINQQDHKLSKFVSFDELVS
HCCHHHHHHHCEEEEEECHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHC
TSDAITIHAPLTPETDNLFDKDVLSRMKKHSYLVNTARGKIVNRDALVEALAPEHLQGYA
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHEEECCCCCEECHHHHHHHHCHHHHCCCC
GDVWYPQPAPADHPWRTMPRNAMTVHYSGMTLEAQKRIEDGVKDILERFFNHEPFQDKDI
CCCCCCCCCCCCCCCCCCCCCEEEEEECCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCE
IVASGRIASKSYTAK
EEECCCEECCCCCCC
>Mature Secondary Structure
MVCQTVPFFVIFLKQATCNTYFKEVKIYHLGEMDMKIVALFPEAVQGQDNQLLNTKKALG
CCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEEECCHHHCCCCCHHHHHHHHHH
LKTFLEERGHEFIILADNGEDLDKHLPDMDVIISAPFYPAYMTRERIEKAPNLKLAITAG
HHHHHHHCCCEEEEEECCCCCHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEEEEC
VGSDHVDLAAASEHNIGVVEVTGSNTVSVAEHAVMDLLILLRNYEEGHRQSVEGEWNLSQ
CCCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHH
VGNHAHELQHKTIGIFGFGRIGQLVAERLAPFNVTLQHYDPINQQDHKLSKFVSFDELVS
HCCHHHHHHHCEEEEEECHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHC
TSDAITIHAPLTPETDNLFDKDVLSRMKKHSYLVNTARGKIVNRDALVEALAPEHLQGYA
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHEEECCCCCEECHHHHHHHHCHHHHCCCC
GDVWYPQPAPADHPWRTMPRNAMTVHYSGMTLEAQKRIEDGVKDILERFFNHEPFQDKDI
CCCCCCCCCCCCCCCCCCCCCEEEEEECCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCE
IVASGRIASKSYTAK
EEECCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1954846; 2357236; 1597184; 8484798 [H]