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The map label for this gene is norG [H]

Identifier: 82749823

GI number: 82749823

Start: 61429

End: 62826

Strand: Direct

Name: norG [H]

Synonym: SAB0047

Alternate gene names: 82749823

Gene position: 61429-62826 (Clockwise)

Preceding gene: 82749819

Following gene: 82749824

Centisome position: 2.24

GC content: 29.83

Gene sequence:

>1398_bases
ATGACGAAATATAAAGATATTGCTAGTGACATCAGAGATAAAATAATCGCAGGGGATTGGTTTTATGGAATGAAGATACC
TTCACAGAGGCAGTTGGCGATACAATACAACGTAAATAGAGTGACGATTATTAAAAGTATTGAGTTATTAGAGGCTGAAG
GATTTATCTATACTAAAGTGGGGAGTGGAACATATGTTAATGACTATTTGAACGAAGCACATATTACAAATAAATGGTCT
GAAATGATGTTATGGTCCTCTCGACAAAGAAGTCAGTATACGGTGCAATTAATTAATAAAATTGAGACAGATGCCTCGTA
TATACATATAAGTAAAGGTGAATTGGGTCAACCATTAATGCCACATATTCAATTGAAAAAAGCCATGTCTAATACAGCCA
GTCATATTGAAGACTTATCTTTTGGTTATAATAATGGCTATGGTTATATCAAGTTAAGAGATATCATCGTTGAACGAATG
TCAAAGCAAGGTATAAATGTAGGTAGAGAAAATGTAATGATCACTTCAGGCGCTTTACATGCCATTCAACTTTTATCTAT
TGGGTTTTTAGGTCAAGATGCCATAATAATTTCAAATACACCATCATATATTCACTCTACAAATGTTTTTGAGCAATTGA
ATTTTAGACATATTGATGCTCCTTATAATCAAATTAATGAAATTAATACCATCATTGATAGATTTATTAATTTTAAAAAT
AAAGCGCTTTATATAGAACCTAGGTTTAATAACCCGACAGGTTGTTCTTTAACGAATGAGCAAAAGCAAAATATAATTAC
TTATAGCGAAAGACATAATATACCTATCATTGAAGATGATATCTTTAGAGATATTTTCTTTAGCGATCCAACACCTGCTA
TCAAAACTTTTGATAAATTGGGAAAAGTTATACATATAAGCAGTTTTTCAAAAACGATTGCACCAGCAATAAGAATAGGT
TGGATTGTTGCTTCTGAAAAAATAATAGAGCAATTGGCAGATGTAAGAATGCAAATTGACTATGGATCCAGTATTTTGTC
ACAAATGGTTGTATATGAGATGTTGAAAAATAAGTCTTATGATAAACACTTAGTAAAGTTAAGGTATGTTTTAAAAGATA
AACGAGACTTTATGTTAAATATCCTCAATAATTTATTTAAGGATATAGCACATTGGGAAGTTTCAAGTGGAGGTTATTTT
GTATGGTTAGTCTTTAAAATAGATATAGATATTAAATATTTATTCTACGAATTGTTAAGTAAAGAAAAAATATTAATCAA
TCCGGGTTACATTTATGGCAGTAAAGAAAAGAGTATAAGGCTATCTTTTGCCTTTGAATCAAATGAAAATATTAAGCATG
CGCTCTATAAAATTTATACATATGTGAAAAAGGTTTAA

Upstream 100 bases:

>100_bases
CCTTTAATTGTGTGTTTCTATATTAAAAAATATGATTTAAAATGAGTACAACCAATTTTGATTAGATTTACCTATCCAAT
TTATAAAAAGGGGGGAGAAG

Downstream 100 bases:

>100_bases
TTAAAACAATAATTCGAATCATTATGTGGCATGTTAAACAGCTAAATATAAGCTATGCACATTTAACAAGCGGATACTCC
TGACGCAATTATAGTATCAT

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MTKYKDIASDIRDKIIAGDWFYGMKIPSQRQLAIQYNVNRVTIIKSIELLEAEGFIYTKVGSGTYVNDYLNEAHITNKWS
EMMLWSSRQRSQYTVQLINKIETDASYIHISKGELGQPLMPHIQLKKAMSNTASHIEDLSFGYNNGYGYIKLRDIIVERM
SKQGINVGRENVMITSGALHAIQLLSIGFLGQDAIIISNTPSYIHSTNVFEQLNFRHIDAPYNQINEINTIIDRFINFKN
KALYIEPRFNNPTGCSLTNEQKQNIITYSERHNIPIIEDDIFRDIFFSDPTPAIKTFDKLGKVIHISSFSKTIAPAIRIG
WIVASEKIIEQLADVRMQIDYGSSILSQMVVYEMLKNKSYDKHLVKLRYVLKDKRDFMLNILNNLFKDIAHWEVSSGGYF
VWLVFKIDIDIKYLFYELLSKEKILINPGYIYGSKEKSIRLSFAFESNENIKHALYKIYTYVKKV

Sequences:

>Translated_465_residues
MTKYKDIASDIRDKIIAGDWFYGMKIPSQRQLAIQYNVNRVTIIKSIELLEAEGFIYTKVGSGTYVNDYLNEAHITNKWS
EMMLWSSRQRSQYTVQLINKIETDASYIHISKGELGQPLMPHIQLKKAMSNTASHIEDLSFGYNNGYGYIKLRDIIVERM
SKQGINVGRENVMITSGALHAIQLLSIGFLGQDAIIISNTPSYIHSTNVFEQLNFRHIDAPYNQINEINTIIDRFINFKN
KALYIEPRFNNPTGCSLTNEQKQNIITYSERHNIPIIEDDIFRDIFFSDPTPAIKTFDKLGKVIHISSFSKTIAPAIRIG
WIVASEKIIEQLADVRMQIDYGSSILSQMVVYEMLKNKSYDKHLVKLRYVLKDKRDFMLNILNNLFKDIAHWEVSSGGYF
VWLVFKIDIDIKYLFYELLSKEKILINPGYIYGSKEKSIRLSFAFESNENIKHALYKIYTYVKKV
>Mature_464_residues
TKYKDIASDIRDKIIAGDWFYGMKIPSQRQLAIQYNVNRVTIIKSIELLEAEGFIYTKVGSGTYVNDYLNEAHITNKWSE
MMLWSSRQRSQYTVQLINKIETDASYIHISKGELGQPLMPHIQLKKAMSNTASHIEDLSFGYNNGYGYIKLRDIIVERMS
KQGINVGRENVMITSGALHAIQLLSIGFLGQDAIIISNTPSYIHSTNVFEQLNFRHIDAPYNQINEINTIIDRFINFKNK
ALYIEPRFNNPTGCSLTNEQKQNIITYSERHNIPIIEDDIFRDIFFSDPTPAIKTFDKLGKVIHISSFSKTIAPAIRIGW
IVASEKIIEQLADVRMQIDYGSSILSQMVVYEMLKNKSYDKHLVKLRYVLKDKRDFMLNILNNLFKDIAHWEVSSGGYFV
WLVFKIDIDIKYLFYELLSKEKILINPGYIYGSKEKSIRLSFAFESNENIKHALYKIYTYVKKV

Specific function: Positively regulates the expression of the NorB efflux pump and negatively regulates the expression of the AbcA efflux pump. Binds specifically to the promoters of norA, norB and norC and abcA genes. Could also have an aminotransferase activity [H]

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=329, Percent_Identity=27.355623100304, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI33469970, Length=329, Percent_Identity=27.355623100304, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1787710, Length=485, Percent_Identity=24.9484536082474, Blast_Score=158, Evalue=7e-40,
Organism=Escherichia coli, GI1790797, Length=475, Percent_Identity=23.5789473684211, Blast_Score=139, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6321236, Length=175, Percent_Identity=27.4285714285714, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000524
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00155 Aminotran_1_2; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 53869; Mature: 53738

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: PS50949 HTH_GNTR ; PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKYKDIASDIRDKIIAGDWFYGMKIPSQRQLAIQYNVNRVTIIKSIELLEAEGFIYTKV
CCCHHHHHHHHHHHEEECCEEEECCCCCCCEEEEEECCCEEEEEEEEEEEECCCEEEEEE
GSGTYVNDYLNEAHITNKWSEMMLWSSRQRSQYTVQLINKIETDASYIHISKGELGQPLM
CCCCCHHHHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCC
PHIQLKKAMSNTASHIEDLSFGYNNGYGYIKLRDIIVERMSKQGINVGRENVMITSGALH
CHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCEEEECCHHH
AIQLLSIGFLGQDAIIISNTPSYIHSTNVFEQLNFRHIDAPYNQINEINTIIDRFINFKN
HHHHHHHCCCCCCEEEEECCCCHHCCCCHHHHCCCEECCCCHHHHHHHHHHHHHHHCCCC
KALYIEPRFNNPTGCSLTNEQKQNIITYSERHNIPIIEDDIFRDIFFSDPTPAIKTFDKL
CEEEEEECCCCCCCCCCCCHHHCCEEEEECCCCCCEECHHHHHHHHCCCCCHHHHHHHHC
GKVIHISSFSKTIAPAIRIGWIVASEKIIEQLADVRMQIDYGSSILSQMVVYEMLKNKSY
CCEEEEECHHHHHHHHHHHHHEEHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHCCCC
DKHLVKLRYVLKDKRDFMLNILNNLFKDIAHWEVSSGGYFVWLVFKIDIDIKYLFYELLS
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCEEECCCCEEEEEEEEEECCHHHHHHHHHC
KEKILINPGYIYGSKEKSIRLSFAFESNENIKHALYKIYTYVKKV
CCEEEECCCEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TKYKDIASDIRDKIIAGDWFYGMKIPSQRQLAIQYNVNRVTIIKSIELLEAEGFIYTKV
CCHHHHHHHHHHHEEECCEEEECCCCCCCEEEEEECCCEEEEEEEEEEEECCCEEEEEE
GSGTYVNDYLNEAHITNKWSEMMLWSSRQRSQYTVQLINKIETDASYIHISKGELGQPLM
CCCCCHHHHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCC
PHIQLKKAMSNTASHIEDLSFGYNNGYGYIKLRDIIVERMSKQGINVGRENVMITSGALH
CHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCEEEECCHHH
AIQLLSIGFLGQDAIIISNTPSYIHSTNVFEQLNFRHIDAPYNQINEINTIIDRFINFKN
HHHHHHHCCCCCCEEEEECCCCHHCCCCHHHHCCCEECCCCHHHHHHHHHHHHHHHCCCC
KALYIEPRFNNPTGCSLTNEQKQNIITYSERHNIPIIEDDIFRDIFFSDPTPAIKTFDKL
CEEEEEECCCCCCCCCCCCHHHCCEEEEECCCCCCEECHHHHHHHHCCCCCHHHHHHHHC
GKVIHISSFSKTIAPAIRIGWIVASEKIIEQLADVRMQIDYGSSILSQMVVYEMLKNKSY
CCEEEEECHHHHHHHHHHHHHEEHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHCCCC
DKHLVKLRYVLKDKRDFMLNILNNLFKDIAHWEVSSGGYFVWLVFKIDIDIKYLFYELLS
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCEEECCCCEEEEEEEEEECCHHHHHHHHHC
KEKILINPGYIYGSKEKSIRLSFAFESNENIKHALYKIYTYVKKV
CCEEEECCCEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA