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The map label for this gene is hutH

Identifier: 82749785

GI number: 82749785

Start: 10890

End: 12404

Strand: Direct

Name: hutH

Synonym: SAB0008

Alternate gene names: 82749785

Gene position: 10890-12404 (Clockwise)

Preceding gene: 82749783

Following gene: 82749786

Centisome position: 0.4

GC content: 37.1

Gene sequence:

>1515_bases
ATGACTTTATATTTAGATGGTGAAACACTAACAATTGAGGATATTAAATCATTTTTACAACAACAATCAAAGGTTGAAAT
TATTGATGATGCGTTAGAACGTGTCAAAAAAAGCAGAGCGGTAGTTGAACGTATTATTGAAAATGAGGAAACGGTTTACG
GTATTACTACAGGTTTTGGATTATTTAGTGATGTACGTATAGACCCGACGCAATATAATGAATTACAAGTGAATCTGATA
CGCTCACATGCCTGTGGACTAGGTGAGCCATTTTCAAAAGAAGTAGCATTAGTCATGATGATTTTACGATTGAATACATT
ATTAAAAGGTCATTCAGGTGCCACTTTAGAATTAGTGAGACAATTACAATTTTTTATAAATGAACGTATTATACCGATAA
TCCCACAGCAAGGCTCTCTCGGTGCATCAGGAGATTTAGCGCCATTATCACATTTAGCATTAGCATTAATTGGTGAAGGG
AAAGTATTGCACAGAGGGGAAGAAAAGGATAGTGACGATGTATTAAGAGAATTAAATAGACAACCTTTGAACCTTCAGGC
TAAAGAAGGTTTAGCATTGATTAATGGTACGCAAGCTATGACAGCTCAAGGTGTCATTAGTTATATAGAAGCAGAAGATT
TAGGTTACCAATCTGAATGGATTGCTGCATTAACGCATCAGTCTCTTAATGGCATTATAGATGCATATCGACATGATGTG
CACGCTGTTCGTAATTTTCAAGAACAGATTAATGTGGCAGCGCGTATGCGTGATTGGTTAGAAGGATCAACATTAACGAC
GCGACAAGCAGAAATACGTGTACAAGATGCATATACGTTGCGTTGTATACCACAAATCCATGGCGCGAGTTTTCAAGTAT
TCAATTATGTTAAACAGCAATTAGAATTTGAAATGAATGCGGCTAATGATAATCCACTTATATTTGAGGAAGTAAATGAA
ACGTTTGTTATTTCAGGTGGTAACTTCCATGGACAACCTATTGCTTTTGCATTAGATCATCTTAAATTAGGTGTAAGTGA
ATTAGCAAACGTATCGGAACGTCGTCTAGAGCGACTAGTAAATCCTCAATTAAATGGTGATTTACCAGCATTTCTTAGTC
CAGAGCCAGGATTGCAAAGTGGCGCGATGATTATGCAATATGCTGCTGCAAGTCTCGTTTCTGAAAATAAAACTTTAGCG
CATCCAGCGAGTGTTGATTCTATCACTTCATCTGCGAACCAAGAAGATCACGTATCTATGGGAACTACAGCTGCTAGACA
TGGTTATCAAATTATTGAAAATACAAGACGTGTGTTGGCAATCGAATGTGTTATTGCATTACAAGCAACAGAGTTGAAAG
GTGTCGAAGGATTATCACCAAAAACACGTCGCAAGTATGATGAGTTTCGAAGTATCGTGCCATCCATTACACATGACCGT
CAATTTCATAGAGATATTGAAGCGGTTGCACAGTATTTAAAGCAATCAATTTATCAAACGACTGCATGTCACTAA

Upstream 100 bases:

>100_bases
TAATAGGTTATAAATGTACGTAAAACCATTGTTTCAATAAAAATGAAAACGTATACTTCAAGAAGGATGGGTTACTTAAT
ATAAACAAGGGGGTACATAT

Downstream 100 bases:

>100_bases
ATCGACATGAGTGATGTTTGAAATCGTTACTTGAAAAAGCAAATATAGTTTGCTATATTAAAAATAACTTAATAAGACAT
TGTTCGTAGGACAAGTAATA

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MTLYLDGETLTIEDIKSFLQQQSKVEIIDDALERVKKSRAVVERIIENEETVYGITTGFGLFSDVRIDPTQYNELQVNLI
RSHACGLGEPFSKEVALVMMILRLNTLLKGHSGATLELVRQLQFFINERIIPIIPQQGSLGASGDLAPLSHLALALIGEG
KVLHRGEEKDSDDVLRELNRQPLNLQAKEGLALINGTQAMTAQGVISYIEAEDLGYQSEWIAALTHQSLNGIIDAYRHDV
HAVRNFQEQINVAARMRDWLEGSTLTTRQAEIRVQDAYTLRCIPQIHGASFQVFNYVKQQLEFEMNAANDNPLIFEEVNE
TFVISGGNFHGQPIAFALDHLKLGVSELANVSERRLERLVNPQLNGDLPAFLSPEPGLQSGAMIMQYAAASLVSENKTLA
HPASVDSITSSANQEDHVSMGTTAARHGYQIIENTRRVLAIECVIALQATELKGVEGLSPKTRRKYDEFRSIVPSITHDR
QFHRDIEAVAQYLKQSIYQTTACH

Sequences:

>Translated_504_residues
MTLYLDGETLTIEDIKSFLQQQSKVEIIDDALERVKKSRAVVERIIENEETVYGITTGFGLFSDVRIDPTQYNELQVNLI
RSHACGLGEPFSKEVALVMMILRLNTLLKGHSGATLELVRQLQFFINERIIPIIPQQGSLGASGDLAPLSHLALALIGEG
KVLHRGEEKDSDDVLRELNRQPLNLQAKEGLALINGTQAMTAQGVISYIEAEDLGYQSEWIAALTHQSLNGIIDAYRHDV
HAVRNFQEQINVAARMRDWLEGSTLTTRQAEIRVQDAYTLRCIPQIHGASFQVFNYVKQQLEFEMNAANDNPLIFEEVNE
TFVISGGNFHGQPIAFALDHLKLGVSELANVSERRLERLVNPQLNGDLPAFLSPEPGLQSGAMIMQYAAASLVSENKTLA
HPASVDSITSSANQEDHVSMGTTAARHGYQIIENTRRVLAIECVIALQATELKGVEGLSPKTRRKYDEFRSIVPSITHDR
QFHRDIEAVAQYLKQSIYQTTACH
>Mature_503_residues
TLYLDGETLTIEDIKSFLQQQSKVEIIDDALERVKKSRAVVERIIENEETVYGITTGFGLFSDVRIDPTQYNELQVNLIR
SHACGLGEPFSKEVALVMMILRLNTLLKGHSGATLELVRQLQFFINERIIPIIPQQGSLGASGDLAPLSHLALALIGEGK
VLHRGEEKDSDDVLRELNRQPLNLQAKEGLALINGTQAMTAQGVISYIEAEDLGYQSEWIAALTHQSLNGIIDAYRHDVH
AVRNFQEQINVAARMRDWLEGSTLTTRQAEIRVQDAYTLRCIPQIHGASFQVFNYVKQQLEFEMNAANDNPLIFEEVNET
FVISGGNFHGQPIAFALDHLKLGVSELANVSERRLERLVNPQLNGDLPAFLSPEPGLQSGAMIMQYAAASLVSENKTLAH
PASVDSITSSANQEDHVSMGTTAARHGYQIIENTRRVLAIECVIALQATELKGVEGLSPKTRRKYDEFRSIVPSITHDRQ
FHRDIEAVAQYLKQSIYQTTACH

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=506, Percent_Identity=45.8498023715415, Blast_Score=418, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17567831, Length=510, Percent_Identity=44.5098039215686, Blast_Score=389, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 56136; Mature: 56005

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLYLDGETLTIEDIKSFLQQQSKVEIIDDALERVKKSRAVVERIIENEETVYGITTGFG
CEEEECCCEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
LFSDVRIDPTQYNELQVNLIRSHACGLGEPFSKEVALVMMILRLNTLLKGHSGATLELVR
CCCCCEECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
QLQFFINERIIPIIPQQGSLGASGDLAPLSHLALALIGEGKVLHRGEEKDSDDVLRELNR
HHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHCC
QPLNLQAKEGLALINGTQAMTAQGVISYIEAEDLGYQSEWIAALTHQSLNGIIDAYRHDV
CCCCEECCCCEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
HAVRNFQEQINVAARMRDWLEGSTLTTRQAEIRVQDAYTLRCIPQIHGASFQVFNYVKQQ
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCEEEEEEHHHCCCHHHHHHHHHHH
LEFEMNAANDNPLIFEEVNETFVISGGNFHGQPIAFALDHLKLGVSELANVSERRLERLV
HHEEECCCCCCCEEEEECCCEEEEECCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHC
NPQLNGDLPAFLSPEPGLQSGAMIMQYAAASLVSENKTLAHPASVDSITSSANQEDHVSM
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCC
GTTAARHGYQIIENTRRVLAIECVIALQATELKGVEGLSPKTRRKYDEFRSIVPSITHDR
CCHHHHHHHHHHHCCHHEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHCHH
QFHRDIEAVAQYLKQSIYQTTACH
HHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TLYLDGETLTIEDIKSFLQQQSKVEIIDDALERVKKSRAVVERIIENEETVYGITTGFG
EEEECCCEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
LFSDVRIDPTQYNELQVNLIRSHACGLGEPFSKEVALVMMILRLNTLLKGHSGATLELVR
CCCCCEECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
QLQFFINERIIPIIPQQGSLGASGDLAPLSHLALALIGEGKVLHRGEEKDSDDVLRELNR
HHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHCC
QPLNLQAKEGLALINGTQAMTAQGVISYIEAEDLGYQSEWIAALTHQSLNGIIDAYRHDV
CCCCEECCCCEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
HAVRNFQEQINVAARMRDWLEGSTLTTRQAEIRVQDAYTLRCIPQIHGASFQVFNYVKQQ
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCEEEEEEHHHCCCHHHHHHHHHHH
LEFEMNAANDNPLIFEEVNETFVISGGNFHGQPIAFALDHLKLGVSELANVSERRLERLV
HHEEECCCCCCCEEEEECCCEEEEECCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHC
NPQLNGDLPAFLSPEPGLQSGAMIMQYAAASLVSENKTLAHPASVDSITSSANQEDHVSM
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCC
GTTAARHGYQIIENTRRVLAIECVIALQATELKGVEGLSPKTRRKYDEFRSIVPSITHDR
CCHHHHHHHHHHHCCHHEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHCHH
QFHRDIEAVAQYLKQSIYQTTACH
HHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA