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The map label for this gene is lspA [H]

Identifier: 82703768

GI number: 82703768

Start: 3047583

End: 3048065

Strand: Direct

Name: lspA [H]

Synonym: Nmul_A2655

Alternate gene names: 82703768

Gene position: 3047583-3048065 (Clockwise)

Preceding gene: 82703767

Following gene: 82703791

Centisome position: 95.71

GC content: 54.04

Gene sequence:

>483_bases
ATGAAGCTGTGGGTAAGCCTGGTTATTGCGCTGATTGTAGTGGTGCTCGATTTCGTCACGAAGCGCTGGATAGAGGGCGT
ATTGGATTATGGCGAGCATGTGCCGCTGACCGGTTTTTTCAATCTGGTGCTGGCATATAACGCGGGAGCCGCGTTCAGCT
TCCTGAGTGATGCGGGAGGGTGGCAGCGCTGGTTTTTCACGACCGTTTCCGCAGGCGCTTCTGTATTAATCGTTTTTTTG
CTGTACAGGCATGCGGCAGATAAACTTTTCTGCATCGCTTTGAGCCTGATCCTCGGAGGTGCCCTGGGGAACTTATGGGA
CCGGGCTACCCTGGGTCATGTCGTCGATTTTCTGGATTTCCATGTAGCGGGCTATCACTGGCCCGCCTTCAACGTCGCGG
ATTCAGCGATTTCGCTTGGAGCCGTATTGCTGGTGATCGACGGTTTTCGGCGAAAGGATGCCGATATCGCAAAGAGCAGG
TGA

Upstream 100 bases:

>100_bases
GGAGCACCCGACCATTTGCGGGCGATGCGTATCCAACCTGTATGGGGCGGGCGAGGCTAGACGATATGCTTGAACAAGTT
TCTTGGGAGGACAGGCTTAT

Downstream 100 bases:

>100_bases
TTCCAGCGCAAGAAGAGGTTTCAGACGGCGGTCTTGCCGGGCTGCCACATCACGTCTTCCACACCTTGCTGCCGATTCAG
GAAGCGGCATAATACGAACA

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II [H]

Number of amino acids: Translated: 160; Mature: 160

Protein sequence:

>160_residues
MKLWVSLVIALIVVVLDFVTKRWIEGVLDYGEHVPLTGFFNLVLAYNAGAAFSFLSDAGGWQRWFFTTVSAGASVLIVFL
LYRHAADKLFCIALSLILGGALGNLWDRATLGHVVDFLDFHVAGYHWPAFNVADSAISLGAVLLVIDGFRRKDADIAKSR

Sequences:

>Translated_160_residues
MKLWVSLVIALIVVVLDFVTKRWIEGVLDYGEHVPLTGFFNLVLAYNAGAAFSFLSDAGGWQRWFFTTVSAGASVLIVFL
LYRHAADKLFCIALSLILGGALGNLWDRATLGHVVDFLDFHVAGYHWPAFNVADSAISLGAVLLVIDGFRRKDADIAKSR
>Mature_160_residues
MKLWVSLVIALIVVVLDFVTKRWIEGVLDYGEHVPLTGFFNLVLAYNAGAAFSFLSDAGGWQRWFFTTVSAGASVLIVFL
LYRHAADKLFCIALSLILGGALGNLWDRATLGHVVDFLDFHVAGYHWPAFNVADSAISLGAVLLVIDGFRRKDADIAKSR

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins [H]

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family [H]

Homologues:

Organism=Escherichia coli, GI1786210, Length=153, Percent_Identity=47.7124183006536, Blast_Score=129, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001872 [H]

Pfam domain/function: PF01252 Peptidase_A8 [H]

EC number: =3.4.23.36 [H]

Molecular weight: Translated: 17574; Mature: 17574

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLWVSLVIALIVVVLDFVTKRWIEGVLDYGEHVPLTGFFNLVLAYNAGAAFSFLSDAGG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCC
WQRWFFTTVSAGASVLIVFLLYRHAADKLFCIALSLILGGALGNLWDRATLGHVVDFLDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HVAGYHWPAFNVADSAISLGAVLLVIDGFRRKDADIAKSR
HHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCC
>Mature Secondary Structure
MKLWVSLVIALIVVVLDFVTKRWIEGVLDYGEHVPLTGFFNLVLAYNAGAAFSFLSDAGG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCC
WQRWFFTTVSAGASVLIVFLLYRHAADKLFCIALSLILGGALGNLWDRATLGHVVDFLDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HVAGYHWPAFNVADSAISLGAVLLVIDGFRRKDADIAKSR
HHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]