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The map label for this gene is ahcY [H]

Identifier: 82703655

GI number: 82703655

Start: 2908432

End: 2909871

Strand: Reverse

Name: ahcY [H]

Synonym: Nmul_A2540

Alternate gene names: 82703655

Gene position: 2909871-2908432 (Counterclockwise)

Preceding gene: 82703656

Following gene: 82703654

Centisome position: 91.38

GC content: 53.82

Gene sequence:

>1440_bases
ATGAACGCTGTGCTCAGTCCTGCTTCCGCGGGTTTCACCGACTATAAAGTTGCCGATATGTCCCTGGCGGAATGGGGGCG
CAAGGAAATTGCCATTGCCGAGACGGAGATGCCGGGTCTGATGGCGCTACGGGAAGAGCATGCCGGTGCCAAGCCTCTTG
CAGGGGCACGCATTGCCGGTTCCCTCCACATGACCATTCAGACCGCGGTACTGATCGAAACGCTCACCAAGCTAGGAGCT
CAAGTACGATGGGCTTCGTGCAACATTTTCTCGACCCAGGACCATGCCGCCGCGGCCATTGCTGCAGAAGGCATTCCCGT
ATTTGCCCATAAGGGCGAATCTCTGGATGAATATTGGGAATATACCCACCGTATCTTTGAATGGCGAGGGGATACCCCGG
AGGGGAATGACAGTCCCAATATGATTCTGGATGATGGCGGCGACGCCACCTTGCTCATTCTCCTCGGCAGCAGGGCGGAA
GAAGATCCGTCTGTCATCGCCAGTCCTGCCAACGAAGAAGAGCAGGCCTTGTTTGCTGCCATTCGCAAGCGCTTGAGCGT
CAGCCCGAACTGGTACTCCACCCGGCGCGCCAGTATCAGGGGGGTGACGGAGGAAACAACTACCGGCGTCCATCGTCTGT
ATGAAATGCAAAAGAAAGGCGAGTTGCCGTTTCCGGCATTCAACGTGAATGATTCCGTCACCAAATCCAAATTCGACAAT
CTATACGGTTGCCGCGAGTCTCTGGTTGACGGGATCAAGCGGGCGACCGATGTCATGATTGCCGGAAAGATCGCCATAGT
GTGTGGTTACGGGGATGTCGGCAAAGGCTGCGCTCAATCCCTGCGCGGCCTTGGAGCCACCGTATGGATAACGGAAATTG
ATCCCATTTGCGCACTGCAAGCGGCAATGGAAGGTTATCGTGTCGTTACCCTAGATGAAGCCTGCGATCAGGCCGACATT
TTCGTGACTGCCACCGGTAATCTGCGAGTCATCACCCATGATCACATGGTGCGAATGAAAGACCAGGCAATCGTCTGTAA
TATTGGCCACTTCGATTCCGAAATCGATATTGCTTCGGTTCAGAAGTACCAATGGGAGAATATCAAGCCGCAGGTCGATC
ACGTCATTTTTCCTACCGGCCGCCGTATCATTGTGCTGGCAAAGGGACGACTGGTGAATCTTGGCTGTGCAACAGGACAC
CCTTCCTTTGTCATGTCGACTTCATTCACCAATCAGGTTCTGGCACAAATTGAGCTTTGGCAGAATGGCGCCAGCTACCA
GAAAAACGTCTACGTGCTGCCCAAGCATCTGGATGAAAAAGTAGCGCGATTACATCTCAAAAAGCTTGGCGCCAAACTTA
CGCGACTGACGGAGGAACAGGCGAGCTACCTGAATCTGGACATTGACGGGCCGTATAAGCCGACAATGTACCGTTATTGA

Upstream 100 bases:

>100_bases
CCCTTCCAGACCGAGGAGCGCTGCAACGGGCATTGTCCCGCGAGGCTCGGCAAGGAAGGATCGCTACAACGGCGCTCGTT
CATTTTCAGGAGAAAATATT

Downstream 100 bases:

>100_bases
TTTTTTTCAGGTCTGGATTAGCGCGGTGAAGGAAAGAGGGGATTAGAACACCATCTTTTTACCCTCTCCGCGCTTTTCCG
CTTTGCCATGGAATCTCAAA

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MNAVLSPASAGFTDYKVADMSLAEWGRKEIAIAETEMPGLMALREEHAGAKPLAGARIAGSLHMTIQTAVLIETLTKLGA
QVRWASCNIFSTQDHAAAAIAAEGIPVFAHKGESLDEYWEYTHRIFEWRGDTPEGNDSPNMILDDGGDATLLILLGSRAE
EDPSVIASPANEEEQALFAAIRKRLSVSPNWYSTRRASIRGVTEETTTGVHRLYEMQKKGELPFPAFNVNDSVTKSKFDN
LYGCRESLVDGIKRATDVMIAGKIAIVCGYGDVGKGCAQSLRGLGATVWITEIDPICALQAAMEGYRVVTLDEACDQADI
FVTATGNLRVITHDHMVRMKDQAIVCNIGHFDSEIDIASVQKYQWENIKPQVDHVIFPTGRRIIVLAKGRLVNLGCATGH
PSFVMSTSFTNQVLAQIELWQNGASYQKNVYVLPKHLDEKVARLHLKKLGAKLTRLTEEQASYLNLDIDGPYKPTMYRY

Sequences:

>Translated_479_residues
MNAVLSPASAGFTDYKVADMSLAEWGRKEIAIAETEMPGLMALREEHAGAKPLAGARIAGSLHMTIQTAVLIETLTKLGA
QVRWASCNIFSTQDHAAAAIAAEGIPVFAHKGESLDEYWEYTHRIFEWRGDTPEGNDSPNMILDDGGDATLLILLGSRAE
EDPSVIASPANEEEQALFAAIRKRLSVSPNWYSTRRASIRGVTEETTTGVHRLYEMQKKGELPFPAFNVNDSVTKSKFDN
LYGCRESLVDGIKRATDVMIAGKIAIVCGYGDVGKGCAQSLRGLGATVWITEIDPICALQAAMEGYRVVTLDEACDQADI
FVTATGNLRVITHDHMVRMKDQAIVCNIGHFDSEIDIASVQKYQWENIKPQVDHVIFPTGRRIIVLAKGRLVNLGCATGH
PSFVMSTSFTNQVLAQIELWQNGASYQKNVYVLPKHLDEKVARLHLKKLGAKLTRLTEEQASYLNLDIDGPYKPTMYRY
>Mature_479_residues
MNAVLSPASAGFTDYKVADMSLAEWGRKEIAIAETEMPGLMALREEHAGAKPLAGARIAGSLHMTIQTAVLIETLTKLGA
QVRWASCNIFSTQDHAAAAIAAEGIPVFAHKGESLDEYWEYTHRIFEWRGDTPEGNDSPNMILDDGGDATLLILLGSRAE
EDPSVIASPANEEEQALFAAIRKRLSVSPNWYSTRRASIRGVTEETTTGVHRLYEMQKKGELPFPAFNVNDSVTKSKFDN
LYGCRESLVDGIKRATDVMIAGKIAIVCGYGDVGKGCAQSLRGLGATVWITEIDPICALQAAMEGYRVVTLDEACDQADI
FVTATGNLRVITHDHMVRMKDQAIVCNIGHFDSEIDIASVQKYQWENIKPQVDHVIFPTGRRIIVLAKGRLVNLGCATGH
PSFVMSTSFTNQVLAQIELWQNGASYQKNVYVLPKHLDEKVARLHLKKLGAKLTRLTEEQASYLNLDIDGPYKPTMYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=468, Percent_Identity=60.4700854700855, Blast_Score=534, Evalue=1e-152,
Organism=Homo sapiens, GI239937451, Length=446, Percent_Identity=60.0896860986547, Blast_Score=504, Evalue=1e-143,
Organism=Homo sapiens, GI24308043, Length=474, Percent_Identity=51.2658227848101, Blast_Score=483, Evalue=1e-136,
Organism=Homo sapiens, GI298286489, Length=474, Percent_Identity=51.2658227848101, Blast_Score=482, Evalue=1e-136,
Organism=Homo sapiens, GI195539337, Length=474, Percent_Identity=51.2658227848101, Blast_Score=482, Evalue=1e-136,
Organism=Homo sapiens, GI195539349, Length=474, Percent_Identity=51.2658227848101, Blast_Score=481, Evalue=1e-136,
Organism=Homo sapiens, GI21361647, Length=474, Percent_Identity=50.210970464135, Blast_Score=457, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17506425, Length=470, Percent_Identity=57.6595744680851, Blast_Score=519, Evalue=1e-147,
Organism=Saccharomyces cerevisiae, GI6320882, Length=488, Percent_Identity=55.327868852459, Blast_Score=502, Evalue=1e-143,
Organism=Drosophila melanogaster, GI24642172, Length=467, Percent_Identity=59.9571734475375, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24656245, Length=475, Percent_Identity=49.4736842105263, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI45553387, Length=475, Percent_Identity=49.8947368421053, Blast_Score=450, Evalue=1e-126,
Organism=Drosophila melanogaster, GI45553385, Length=474, Percent_Identity=49.789029535865, Blast_Score=447, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 52749; Mature: 52749

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAVLSPASAGFTDYKVADMSLAEWGRKEIAIAETEMPGLMALREEHAGAKPLAGARIAG
CCCCCCCCCCCCCCEEEECCCHHHCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCEEEC
SLHMTIQTAVLIETLTKLGAQVRWASCNIFSTQDHAAAAIAAEGIPVFAHKGESLDEYWE
EEEEHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCHHHHHECCCCEEEEECCCCHHHHHH
YTHRIFEWRGDTPEGNDSPNMILDDGGDATLLILLGSRAEEDPSVIASPANEEEQALFAA
HHHHHHEECCCCCCCCCCCCEEEECCCCEEEEEEECCCCCCCCCEEECCCCHHHHHHHHH
IRKRLSVSPNWYSTRRASIRGVTEETTTGVHRLYEMQKKGELPFPAFNVNDSVTKSKFDN
HHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHH
LYGCRESLVDGIKRATDVMIAGKIAIVCGYGDVGKGCAQSLRGLGATVWITEIDPICALQ
HHHHHHHHHHHHHHHHHEEEECEEEEEECCCCCCHHHHHHHHHCCEEEEEEECCHHHHHH
AAMEGYRVVTLDEACDQADIFVTATGNLRVITHDHMVRMKDQAIVCNIGHFDSEIDIASV
HHHCCCEEEEECCCCCCCCEEEEECCCEEEEECCCEEEECCCEEEEECCCCCCCCCHHHH
QKYQWENIKPQVDHVIFPTGRRIIVLAKGRLVNLGCATGHPSFVMSTSFTNQVLAQIELW
HHHHCCCCCCCCCEEEECCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHHHHHHHH
QNGASYQKNVYVLPKHLDEKVARLHLKKLGAKLTRLTEEQASYLNLDIDGPYKPTMYRY
CCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MNAVLSPASAGFTDYKVADMSLAEWGRKEIAIAETEMPGLMALREEHAGAKPLAGARIAG
CCCCCCCCCCCCCCEEEECCCHHHCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCEEEC
SLHMTIQTAVLIETLTKLGAQVRWASCNIFSTQDHAAAAIAAEGIPVFAHKGESLDEYWE
EEEEHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCHHHHHECCCCEEEEECCCCHHHHHH
YTHRIFEWRGDTPEGNDSPNMILDDGGDATLLILLGSRAEEDPSVIASPANEEEQALFAA
HHHHHHEECCCCCCCCCCCCEEEECCCCEEEEEEECCCCCCCCCEEECCCCHHHHHHHHH
IRKRLSVSPNWYSTRRASIRGVTEETTTGVHRLYEMQKKGELPFPAFNVNDSVTKSKFDN
HHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHH
LYGCRESLVDGIKRATDVMIAGKIAIVCGYGDVGKGCAQSLRGLGATVWITEIDPICALQ
HHHHHHHHHHHHHHHHHEEEECEEEEEECCCCCCHHHHHHHHHCCEEEEEEECCHHHHHH
AAMEGYRVVTLDEACDQADIFVTATGNLRVITHDHMVRMKDQAIVCNIGHFDSEIDIASV
HHHCCCEEEEECCCCCCCCEEEEECCCEEEEECCCEEEECCCEEEEECCCCCCCCCHHHH
QKYQWENIKPQVDHVIFPTGRRIIVLAKGRLVNLGCATGHPSFVMSTSFTNQVLAQIELW
HHHHCCCCCCCCCEEEECCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHHHHHHHH
QNGASYQKNVYVLPKHLDEKVARLHLKKLGAKLTRLTEEQASYLNLDIDGPYKPTMYRY
CCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA