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The map label for this gene is comA [H]

Identifier: 82703621

GI number: 82703621

Start: 2863682

End: 2865982

Strand: Reverse

Name: comA [H]

Synonym: Nmul_A2506

Alternate gene names: 82703621

Gene position: 2865982-2863682 (Counterclockwise)

Preceding gene: 82703623

Following gene: 82703620

Centisome position: 90.01

GC content: 57.84

Gene sequence:

>2301_bases
ATGGCGTGTGGAATTCTGCTGCTTTCCTGCCGTGCCCCTGTTTTTGCTCGGATCGGCAAAATGCTTTGGGTTTGCCTTTT
CCTGGGAGCAGGTTTTTACTGGGCGACTGCTTTTGCGCAATGGCGCTTGAACGATGCGCTCCTGCCCGAGTGGGAAGGGA
GAGATATCCAGGTAATTGGCGTGGTTGCGGAGTTGCCGCAAACCGGCAGGACCAGTGTGCGCTTTACTTTCGATGTTGAG
CAGGTGTTGACGGAAGGTGCAATCGTGCCTGCCCGTCTTTCTCTTTCCTGGTATAAGGAGCGCGGAAGCGGCTTTATGCC
AGGACCTTCAACACCTCCCCTCAATGCCGGGGAACGCTGGCGGCTTACTGCACGGCTCAAGCGCCCCCATGGAACCGCCA
ATCCGCATGCTTCCGATTTCGAGCAGTGGGCGCTGGAGCGCAACATTGGGGCCACAGGCTATGTGCGCAAGGATGACGAA
AATATACGCCTGGAGAAAGTGGTGGGACGTCCCGCTTATCAGGTCGAGCGTCTGCGCCAGGATATCCGCGATAATTTCCT
TGCCGCGCTGCCCTATCAGGCTTATGCCGGTACCCTCGTTGCGCTGGCGGTGGGGGATCAACGGGCGATTCCACACGAGC
AGTGGCAGGTATTCACGCGGACGGGGATAAACCATCTCGTCAGCATATCCGGCCTTCATATCACCATGCTGTCGGGGCTT
GTGTTTACGATGGCATACTGGCTATGGCGCAGAAGCTATCATTTGACGCTGCGGTTGCCAGCCAGGAAAGCCGCAGTCAT
AGCCGGGCTGGTGGCCGCGCTCGGTTATACGCTGCTGGCCGGTTTTGCGATTCCGGCACAACGCACGCTCTATATGCTCA
CCGCGGTCGCCGTTACCCTATGGCTTGATCGTTCCATTGCCATGACCACAGTCCTGGCCTGGGCATTGCTTGCAGTGGTG
GCTCTCGATCCATGGGCAGTGCTTTCACCCGGCTTCTGGTTATCCTTTGGCGCCATCGCGGTCATCATGCTGGTATCTGT
CGGCCGCGTTGGCAGGCCGCATTGGCTGAGTAGTTGGACAACGGTGCAGTGGGCCATAACCCTGGGCCTGATACCTCTTT
TATTGGCGATGTTTCAGCAAATATCGCTGGTTTCCCCAATCGCCAATGCGGTGGCGATTCCACTGGTGAGTCTTGTCGTG
GTGCCGCTGGCCCTGCTCGCAACCCTGCCGCCCCTCGATTTTCTGTTGGTACCGGCACATGCAGCGCTGGATGGTTGCAT
GACCGTAATGGAATGGCTGAGCAATGCGCCTCAGGCCGTCTGGAGCCAGCAGGCGCCGCCTTTCTGGGCAGTAGCCGTGG
GGACGGCGGGCATTTTCTGGACGCTGTTGCCTGGGAAATGGGGTTGGCAGCTCGGCCTTGGTACCGGTTTCCCTGCTCGT
TGGCTTGGTCTCGTCGCGTTGCTGCCGCTGTTTCTGCTGCCTCTCCCAAAACCGGAGCAGGGAGAGTTGTGGCTGACCGT
GCTGGATGTTGGGCAGGGACTGGCGGTCCTGGCGCGTACGGAAAATCACACGCTGCTCTACGATACGGGCCCTGCCTTTA
CGTCCGAAGCCGATAGCGGCAGCCGCACCATCGTTCCATTTCTCCGCGGGGAAGGGATAAGGCATCTCGATGCAATGATC
GTCACACACGCCGATTCGGATCATAGCGGCGGAGGGTTGTCCGTGCTGCAAGCAGTACCCGTCGAATGGCTCGTCTCGTC
GTTGGGCGAGGATCATCCCATACAACAGGCTGCTCTCAACAAGCGCCGGTGCAAGGCGGGGCAGTCGTGGGAATGGGATG
GCGTTCGCTTCGACATGCTTCATCCCCTGGAAGAGAGCTACAATGATCTTCGCCTCAAGAGTAACGCCTTGAGTTGCGTG
TTGAAAATTACCACATGGCACGGAAGCGTGCTTCTGCCGGGGGATATCGAGAAAAAATCCGAATATCAATTGCTCAAGCG
TTATGGGGAGGCGCTTTCCTCAACGGTATTGATCGCTCCTCATCATGGCAGCAAAACTTCTTCCACCGAGGAGTTCGTGC
GGAAGGTGAATCCGCGGTGGGTAGTATTTACCGTAGGTTATCGCAACCGTTTTGGCCATCCAAAAGAGGAAGTTGCGGAG
CGGTATCGAGCGGTGGGAAGCAGATTGTTGCGCAGCGATATCGATGGTGCCATATTGCTGCGCTTTGGCGGTAACGACCT
TGCCGTGGAGCGGTGGCGCGTTCGGCGGATGCGTTATTGGCACGATTCAGCAACGCTTTAA

Upstream 100 bases:

>100_bases
GATGCGACTTTGTATTCTGGCATTTGTTGCCGGGGTGGTGCTGCTGCAACAGCAGCCAGTGCTGCCAGCGCTTGCAGGTG
CGTGGGCTCTCTTCCCCGGC

Downstream 100 bases:

>100_bases
CCGGAAATAAAGCAATTATGAAAGGACATGAGTAACATGGGGGCTCAATTGAAAAAGGCCGTTCCAATACTCACTACACC
CGTTCCATGAGCGCTCCCTC

Product: DNA internalization-related competence protein ComEC/Rec2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 766; Mature: 765

Protein sequence:

>766_residues
MACGILLLSCRAPVFARIGKMLWVCLFLGAGFYWATAFAQWRLNDALLPEWEGRDIQVIGVVAELPQTGRTSVRFTFDVE
QVLTEGAIVPARLSLSWYKERGSGFMPGPSTPPLNAGERWRLTARLKRPHGTANPHASDFEQWALERNIGATGYVRKDDE
NIRLEKVVGRPAYQVERLRQDIRDNFLAALPYQAYAGTLVALAVGDQRAIPHEQWQVFTRTGINHLVSISGLHITMLSGL
VFTMAYWLWRRSYHLTLRLPARKAAVIAGLVAALGYTLLAGFAIPAQRTLYMLTAVAVTLWLDRSIAMTTVLAWALLAVV
ALDPWAVLSPGFWLSFGAIAVIMLVSVGRVGRPHWLSSWTTVQWAITLGLIPLLLAMFQQISLVSPIANAVAIPLVSLVV
VPLALLATLPPLDFLLVPAHAALDGCMTVMEWLSNAPQAVWSQQAPPFWAVAVGTAGIFWTLLPGKWGWQLGLGTGFPAR
WLGLVALLPLFLLPLPKPEQGELWLTVLDVGQGLAVLARTENHTLLYDTGPAFTSEADSGSRTIVPFLRGEGIRHLDAMI
VTHADSDHSGGGLSVLQAVPVEWLVSSLGEDHPIQQAALNKRRCKAGQSWEWDGVRFDMLHPLEESYNDLRLKSNALSCV
LKITTWHGSVLLPGDIEKKSEYQLLKRYGEALSSTVLIAPHHGSKTSSTEEFVRKVNPRWVVFTVGYRNRFGHPKEEVAE
RYRAVGSRLLRSDIDGAILLRFGGNDLAVERWRVRRMRYWHDSATL

Sequences:

>Translated_766_residues
MACGILLLSCRAPVFARIGKMLWVCLFLGAGFYWATAFAQWRLNDALLPEWEGRDIQVIGVVAELPQTGRTSVRFTFDVE
QVLTEGAIVPARLSLSWYKERGSGFMPGPSTPPLNAGERWRLTARLKRPHGTANPHASDFEQWALERNIGATGYVRKDDE
NIRLEKVVGRPAYQVERLRQDIRDNFLAALPYQAYAGTLVALAVGDQRAIPHEQWQVFTRTGINHLVSISGLHITMLSGL
VFTMAYWLWRRSYHLTLRLPARKAAVIAGLVAALGYTLLAGFAIPAQRTLYMLTAVAVTLWLDRSIAMTTVLAWALLAVV
ALDPWAVLSPGFWLSFGAIAVIMLVSVGRVGRPHWLSSWTTVQWAITLGLIPLLLAMFQQISLVSPIANAVAIPLVSLVV
VPLALLATLPPLDFLLVPAHAALDGCMTVMEWLSNAPQAVWSQQAPPFWAVAVGTAGIFWTLLPGKWGWQLGLGTGFPAR
WLGLVALLPLFLLPLPKPEQGELWLTVLDVGQGLAVLARTENHTLLYDTGPAFTSEADSGSRTIVPFLRGEGIRHLDAMI
VTHADSDHSGGGLSVLQAVPVEWLVSSLGEDHPIQQAALNKRRCKAGQSWEWDGVRFDMLHPLEESYNDLRLKSNALSCV
LKITTWHGSVLLPGDIEKKSEYQLLKRYGEALSSTVLIAPHHGSKTSSTEEFVRKVNPRWVVFTVGYRNRFGHPKEEVAE
RYRAVGSRLLRSDIDGAILLRFGGNDLAVERWRVRRMRYWHDSATL
>Mature_765_residues
ACGILLLSCRAPVFARIGKMLWVCLFLGAGFYWATAFAQWRLNDALLPEWEGRDIQVIGVVAELPQTGRTSVRFTFDVEQ
VLTEGAIVPARLSLSWYKERGSGFMPGPSTPPLNAGERWRLTARLKRPHGTANPHASDFEQWALERNIGATGYVRKDDEN
IRLEKVVGRPAYQVERLRQDIRDNFLAALPYQAYAGTLVALAVGDQRAIPHEQWQVFTRTGINHLVSISGLHITMLSGLV
FTMAYWLWRRSYHLTLRLPARKAAVIAGLVAALGYTLLAGFAIPAQRTLYMLTAVAVTLWLDRSIAMTTVLAWALLAVVA
LDPWAVLSPGFWLSFGAIAVIMLVSVGRVGRPHWLSSWTTVQWAITLGLIPLLLAMFQQISLVSPIANAVAIPLVSLVVV
PLALLATLPPLDFLLVPAHAALDGCMTVMEWLSNAPQAVWSQQAPPFWAVAVGTAGIFWTLLPGKWGWQLGLGTGFPARW
LGLVALLPLFLLPLPKPEQGELWLTVLDVGQGLAVLARTENHTLLYDTGPAFTSEADSGSRTIVPFLRGEGIRHLDAMIV
THADSDHSGGGLSVLQAVPVEWLVSSLGEDHPIQQAALNKRRCKAGQSWEWDGVRFDMLHPLEESYNDLRLKSNALSCVL
KITTWHGSVLLPGDIEKKSEYQLLKRYGEALSSTVLIAPHHGSKTSSTEEFVRKVNPRWVVFTVGYRNRFGHPKEEVAER
YRAVGSRLLRSDIDGAILLRFGGNDLAVERWRVRRMRYWHDSATL

Specific function: Essential for natural transformation. Could be a transporter involved in DNA uptake [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis ComEC, H.influenzae REC2, and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=671, Percent_Identity=29.6572280178838, Blast_Score=225, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 84891; Mature: 84759

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MACGILLLSCRAPVFARIGKMLWVCLFLGAGFYWATAFAQWRLNDALLPEWEGRDIQVIG
CCCCEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
VVAELPQTGRTSVRFTFDVEQVLTEGAIVPARLSLSWYKERGSGFMPGPSTPPLNAGERW
EEECCCCCCCCEEEEEEEHHHHHHCCCEEEEEEHHHHHHHCCCCCCCCCCCCCCCCCCCE
RLTARLKRPHGTANPHASDFEQWALERNIGATGYVRKDDENIRLEKVVGRPAYQVERLRQ
EEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCEECCCCCCEEHHHHCCCHHHHHHHHH
DIRDNFLAALPYQAYAGTLVALAVGDQRAIPHEQWQVFTRTGINHLVSISGLHITMLSGL
HHHHHHHHHCCCHHHHCEEEEEEECCCCCCCHHHHHHHHHHCHHHHEEECCHHHHHHHHH
VFTMAYWLWRRSYHLTLRLPARKAAVIAGLVAALGYTLLAGFAIPAQRTLYMLTAVAVTL
HHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
WLDRSIAMTTVLAWALLAVVALDPWAVLSPGFWLSFGAIAVIMLVSVGRVGRPHWLSSWT
HHCCHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
TVQWAITLGLIPLLLAMFQQISLVSPIANAVAIPLVSLVVVPLALLATLPPLDFLLVPAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHH
AALDGCMTVMEWLSNAPQAVWSQQAPPFWAVAVGTAGIFWTLLPGKWGWQLGLGTGFPAR
HHHHHHHHHHHHHCCCCHHHHCCCCCCEEEEEECCCCEEEEECCCCCCEEECCCCCCHHH
WLGLVALLPLFLLPLPKPEQGELWLTVLDVGQGLAVLARTENHTLLYDTGPAFTSEADSG
HHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEECCCCEEEEECCCCCCCCCCCC
SRTIVPFLRGEGIRHLDAMIVTHADSDHSGGGLSVLQAVPVEWLVSSLGEDHPIQQAALN
CCEEEEECCCCCCCEEEEEEEEECCCCCCCCCHHHHHHCCHHHHHHHCCCCCCHHHHHHH
KRRCKAGQSWEWDGVRFDMLHPLEESYNDLRLKSNALSCVLKITTWHGSVLLPGDIEKKS
HHHHCCCCCCCCCCEEEECCCCHHHCHHHHEECCCCEEEEEEEEECCCCEEECCCCCCHH
EYQLLKRYGEALSSTVLIAPHHGSKTSSTEEFVRKVNPRWVVFTVGYRNRFGHPKEEVAE
HHHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHH
RYRAVGSRLLRSDIDGAILLRFGGNDLAVERWRVRRMRYWHDSATL
HHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
ACGILLLSCRAPVFARIGKMLWVCLFLGAGFYWATAFAQWRLNDALLPEWEGRDIQVIG
CCCEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
VVAELPQTGRTSVRFTFDVEQVLTEGAIVPARLSLSWYKERGSGFMPGPSTPPLNAGERW
EEECCCCCCCCEEEEEEEHHHHHHCCCEEEEEEHHHHHHHCCCCCCCCCCCCCCCCCCCE
RLTARLKRPHGTANPHASDFEQWALERNIGATGYVRKDDENIRLEKVVGRPAYQVERLRQ
EEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCEECCCCCCEEHHHHCCCHHHHHHHHH
DIRDNFLAALPYQAYAGTLVALAVGDQRAIPHEQWQVFTRTGINHLVSISGLHITMLSGL
HHHHHHHHHCCCHHHHCEEEEEEECCCCCCCHHHHHHHHHHCHHHHEEECCHHHHHHHHH
VFTMAYWLWRRSYHLTLRLPARKAAVIAGLVAALGYTLLAGFAIPAQRTLYMLTAVAVTL
HHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
WLDRSIAMTTVLAWALLAVVALDPWAVLSPGFWLSFGAIAVIMLVSVGRVGRPHWLSSWT
HHCCHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
TVQWAITLGLIPLLLAMFQQISLVSPIANAVAIPLVSLVVVPLALLATLPPLDFLLVPAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHH
AALDGCMTVMEWLSNAPQAVWSQQAPPFWAVAVGTAGIFWTLLPGKWGWQLGLGTGFPAR
HHHHHHHHHHHHHCCCCHHHHCCCCCCEEEEEECCCCEEEEECCCCCCEEECCCCCCHHH
WLGLVALLPLFLLPLPKPEQGELWLTVLDVGQGLAVLARTENHTLLYDTGPAFTSEADSG
HHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEECCCCEEEEECCCCCCCCCCCC
SRTIVPFLRGEGIRHLDAMIVTHADSDHSGGGLSVLQAVPVEWLVSSLGEDHPIQQAALN
CCEEEEECCCCCCCEEEEEEEEECCCCCCCCCHHHHHHCCHHHHHHHCCCCCCHHHHHHH
KRRCKAGQSWEWDGVRFDMLHPLEESYNDLRLKSNALSCVLKITTWHGSVLLPGDIEKKS
HHHHCCCCCCCCCCEEEECCCCHHHCHHHHEECCCCEEEEEEEEECCCCEEECCCCCCHH
EYQLLKRYGEALSSTVLIAPHHGSKTSSTEEFVRKVNPRWVVFTVGYRNRFGHPKEEVAE
HHHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHH
RYRAVGSRLLRSDIDGAILLRFGGNDLAVERWRVRRMRYWHDSATL
HHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934834; 8830266 [H]