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The map label for this gene is mltA [H]

Identifier: 82703561

GI number: 82703561

Start: 2794097

End: 2795290

Strand: Reverse

Name: mltA [H]

Synonym: Nmul_A2446

Alternate gene names: 82703561

Gene position: 2795290-2794097 (Counterclockwise)

Preceding gene: 82703563

Following gene: 82703558

Centisome position: 87.79

GC content: 55.7

Gene sequence:

>1194_bases
ATGAAAGACCAATTACGCACACTTACTGTTGTCGCGCTACTGTTGCTCGGCGCCTGCAATATCATTCCTACTCCCCGTGT
CACGGAGAAACCGGCCGAACCTCAGCCCAAGCCGGTGCTCAAACCCGCCGGCTGGGATACAGTAGAGGGGTGGAGGGATG
ACGAGATTGTGCCGGCACTGGATGCGTTCCTTCAGAGCTGCACCGTTTTGAAAAAAAAGGCGCTATGGCAGGAAGCCTGC
ATTCAGGCCGATTCCGTGAGAGGACAAGATAGCGATACGGTGCGCCAGTTTTTTGAAAGCTATTTTGTTCCCTATCAGGT
ATTGAATCCTGATGGTACCGAGAACGGCCTCATCACCGGTTATTACGAGCCTCTGCTCAAGGGGAGCCGCACACCTTCCG
CCCGTTACCGCTATCCGCTTTACACAACCCCTGAAGAATTGCTGATAGTGGATTTGAGTTCCGTCTACCCCCAGCTCAAA
AACATGCGGTTGCGGGGACGACTCGAAGGGCGCAAGGTGGTCCCCTTCTACAGCCGGGCTGAAATATCCAGCAATCCCCC
AGCACTACAGGGAAAAGAACTGCTCTGGGTGGATGACGAGGTAGATCTGTTTTTTCTGCAGATTCAGGGGTCCGGGCGGG
TGGAGCTTGAAAATGGCGAGATCGTGAGGGTGGGGTACGCGGATCAAAACGGCCACCCTTACAGATCCATCGGGAAACTG
CTGGTGGATCGCGGCGAATTACCCCTGGAAAGGGCCTCTATGCAGGGAATCAAGGCTTGGGGGCAGAAGAATCCCCGAAA
GCTGCCGAATATTTTGCATCAGAATTCAAGCTTCGTCTTTTTCCGCGAACTGCCGGATACGATATCGGGGCCGCTCGGCT
CCATGGGGGTGCCTCTTACGGCTGGAAGAAGCCTTGCGGTGGATCCGCGGGTGATCCCGCAGGGCGCCCCGGTCTTTCTT
TCCACTACCTGGCCAAATACCGACGAGCAGCTTCAACGGTTGATGGTGGCCCAGGACACCGGCGGAGCAATCAAAGGGAA
TGTGCGGGCAGATTTTTTCTGGGGATTTGGCCCCGACGCAGCAGAAAAGGCAGGGAAGATGAGGCAGACGGGGAGGATGT
GGGTACTCATGCCAGTGGAATATATGCCCCAAGACTTTCCACCCGCCGCGCGAATACTGGGAAGCTCCAAATAA

Upstream 100 bases:

>100_bases
GGATCAACCATGATGTATATTAAGGGGAAGCCTCTGATGCCGCCACGAGCGGGATTGCTCGTTCAGAGATTTCCAAGATG
AAACTTTAACCCAAAACTTC

Downstream 100 bases:

>100_bases
ACCCGCGAATAGGAGGATGCAGGCGCTTCCCAGCGCCTGTCACCGAGTTATCTATTTCGCAGGAGCCGCGTTTAATTTCT
TTTCTATCGTCTCCGCAGGA

Product: MltA

Products: Muramic Acid Residue [C]

Alternate protein names: Mlt38; Murein hydrolase A [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MKDQLRTLTVVALLLLGACNIIPTPRVTEKPAEPQPKPVLKPAGWDTVEGWRDDEIVPALDAFLQSCTVLKKKALWQEAC
IQADSVRGQDSDTVRQFFESYFVPYQVLNPDGTENGLITGYYEPLLKGSRTPSARYRYPLYTTPEELLIVDLSSVYPQLK
NMRLRGRLEGRKVVPFYSRAEISSNPPALQGKELLWVDDEVDLFFLQIQGSGRVELENGEIVRVGYADQNGHPYRSIGKL
LVDRGELPLERASMQGIKAWGQKNPRKLPNILHQNSSFVFFRELPDTISGPLGSMGVPLTAGRSLAVDPRVIPQGAPVFL
STTWPNTDEQLQRLMVAQDTGGAIKGNVRADFFWGFGPDAAEKAGKMRQTGRMWVLMPVEYMPQDFPPAARILGSSK

Sequences:

>Translated_397_residues
MKDQLRTLTVVALLLLGACNIIPTPRVTEKPAEPQPKPVLKPAGWDTVEGWRDDEIVPALDAFLQSCTVLKKKALWQEAC
IQADSVRGQDSDTVRQFFESYFVPYQVLNPDGTENGLITGYYEPLLKGSRTPSARYRYPLYTTPEELLIVDLSSVYPQLK
NMRLRGRLEGRKVVPFYSRAEISSNPPALQGKELLWVDDEVDLFFLQIQGSGRVELENGEIVRVGYADQNGHPYRSIGKL
LVDRGELPLERASMQGIKAWGQKNPRKLPNILHQNSSFVFFRELPDTISGPLGSMGVPLTAGRSLAVDPRVIPQGAPVFL
STTWPNTDEQLQRLMVAQDTGGAIKGNVRADFFWGFGPDAAEKAGKMRQTGRMWVLMPVEYMPQDFPPAARILGSSK
>Mature_397_residues
MKDQLRTLTVVALLLLGACNIIPTPRVTEKPAEPQPKPVLKPAGWDTVEGWRDDEIVPALDAFLQSCTVLKKKALWQEAC
IQADSVRGQDSDTVRQFFESYFVPYQVLNPDGTENGLITGYYEPLLKGSRTPSARYRYPLYTTPEELLIVDLSSVYPQLK
NMRLRGRLEGRKVVPFYSRAEISSNPPALQGKELLWVDDEVDLFFLQIQGSGRVELENGEIVRVGYADQNGHPYRSIGKL
LVDRGELPLERASMQGIKAWGQKNPRKLPNILHQNSSFVFFRELPDTISGPLGSMGVPLTAGRSLAVDPRVIPQGAPVFL
STTWPNTDEQLQRLMVAQDTGGAIKGNVRADFFWGFGPDAAEKAGKMRQTGRMWVLMPVEYMPQDFPPAARILGSSK

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=297, Percent_Identity=35.016835016835, Blast_Score=150, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 44300; Mature: 44300

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDQLRTLTVVALLLLGACNIIPTPRVTEKPAEPQPKPVLKPAGWDTVEGWRDDEIVPAL
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
DAFLQSCTVLKKKALWQEACIQADSVRGQDSDTVRQFFESYFVPYQVLNPDGTENGLITG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCCEEEE
YYEPLLKGSRTPSARYRYPLYTTPEELLIVDLSSVYPQLKNMRLRGRLEGRKVVPFYSRA
EHHHHHCCCCCCCCCEECCCCCCCCCEEEEEHHHHHHHHHCCEEEEECCCCEECCEECCC
EISSNPPALQGKELLWVDDEVDLFFLQIQGSGRVELENGEIVRVGYADQNGHPYRSIGKL
CCCCCCCCCCCCEEEEEECCCEEEEEEEECCCEEEECCCCEEEEEECCCCCCCHHHHHHH
LVDRGELPLERASMQGIKAWGQKNPRKLPNILHQNSSFVFFRELPDTISGPLGSMGVPLT
HHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEECCCHHHCCCCCCCCCCCC
AGRSLAVDPRVIPQGAPVFLSTTWPNTDEQLQRLMVAQDTGGAIKGNVRADFFWGFGPDA
CCCEEECCCEECCCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEECCEEEEEEECCCCHH
AEKAGKMRQTGRMWVLMPVEYMPQDFPPAARILGSSK
HHHHHHHHHCCCEEEEEEHHHCCCCCCHHHHHCCCCC
>Mature Secondary Structure
MKDQLRTLTVVALLLLGACNIIPTPRVTEKPAEPQPKPVLKPAGWDTVEGWRDDEIVPAL
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
DAFLQSCTVLKKKALWQEACIQADSVRGQDSDTVRQFFESYFVPYQVLNPDGTENGLITG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCCEEEE
YYEPLLKGSRTPSARYRYPLYTTPEELLIVDLSSVYPQLKNMRLRGRLEGRKVVPFYSRA
EHHHHHCCCCCCCCCEECCCCCCCCCEEEEEHHHHHHHHHCCEEEEECCCCEECCEECCC
EISSNPPALQGKELLWVDDEVDLFFLQIQGSGRVELENGEIVRVGYADQNGHPYRSIGKL
CCCCCCCCCCCCEEEEEECCCEEEEEEEECCCEEEECCCCEEEEEECCCCCCCHHHHHHH
LVDRGELPLERASMQGIKAWGQKNPRKLPNILHQNSSFVFFRELPDTISGPLGSMGVPLT
HHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEECCCHHHCCCCCCCCCCCC
AGRSLAVDPRVIPQGAPVFLSTTWPNTDEQLQRLMVAQDTGGAIKGNVRADFFWGFGPDA
CCCEEECCCEECCCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEECCEEEEEEECCCCHH
AEKAGKMRQTGRMWVLMPVEYMPQDFPPAARILGSSK
HHHHHHHHHCCCEEEEEEHHHCCCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]