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The map label for this gene is fabI [H]

Identifier: 82703452

GI number: 82703452

Start: 2659842

End: 2660624

Strand: Direct

Name: fabI [H]

Synonym: Nmul_A2335

Alternate gene names: 82703452

Gene position: 2659842-2660624 (Clockwise)

Preceding gene: 82703446

Following gene: 82703463

Centisome position: 83.53

GC content: 53.51

Gene sequence:

>783_bases
ATGACATTTCTCGCCAACAAGCGCATTCTCGTCACGGGCCTTCTGACCAACCGTTCGATTGCATATGGCATCGCAAAGGC
GATGCATCGCGAGGGCGCCCAGCTTGCCTTTACTTATCAAGGGGAAGGTGTGCGTGAACGGGTCGAAAAAGTCATTAAGG
AATTTGACAGCGATTTGCTGTTTCCCTGTGATGTTTCAAAGGATGAGGAAATCGATCGATGTTTCGATGATCTCTCAAAA
CGCTGGGATGGCCTCGATGGCATCGTTCACTCCATTGCCTTTGCTCCACGCGAGGCGCTCAGCGGAGATTATCTTGAAAC
CGTAAACCGGGAGGCTTTTCGTATTGCCCACGATGTCAGTTCCTACAGTTTCGCTGCGCTGGCAAAAGCTGCCCTTCCGC
TCATGCAGGGACGAAATGGCGCGCTTCTGACACTCTCCTATCTGGGTGCAGCAAGGGTGATGCCGAATTACAACGTCATG
GGACTGGCCAAGGCAAGTCTCGAAGCCAACGTCCGCTTCATGGCTTCCAGCCTGGGTCCCAAGGGAATACGGGTCAATGC
GATTTCGGCAGGGCCGATCAAAACCTTGGCTGCCGCGGGAATCGGCAACTTTGGAAAACTGCTGAGCTACACGGAGAAGG
TCGCGCCGCTGCGGCGTAATGTATCGATCATGGATGTGGGCAATGTGGCCGCCTTTCTATGCAGTGATCTGGCAAGCGGC
ATAACAGGCGAAATTACCCATGTCGATGCCGGATTCAACACGATTGCCTTCGATACCCTCTAA

Upstream 100 bases:

>100_bases
AGAGTTCAAGCCGTGCGTGCGACTGCGAGACATCCGGATAAAACAGGGATGCAGTATTTCTATATTTCACATCATTACTC
CAACGCCGCAAGGATATGAC

Downstream 100 bases:

>100_bases
TCCCGGAGCATGCCTATTTCTCGAGGCTTTCACTCCTGACCGATACATCATACCTTTTCTTGATTCCATCCAGATAGGAT
GAAAACTCTTCCTGGGCGAA

Product: Short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MTFLANKRILVTGLLTNRSIAYGIAKAMHREGAQLAFTYQGEGVRERVEKVIKEFDSDLLFPCDVSKDEEIDRCFDDLSK
RWDGLDGIVHSIAFAPREALSGDYLETVNREAFRIAHDVSSYSFAALAKAALPLMQGRNGALLTLSYLGAARVMPNYNVM
GLAKASLEANVRFMASSLGPKGIRVNAISAGPIKTLAAAGIGNFGKLLSYTEKVAPLRRNVSIMDVGNVAAFLCSDLASG
ITGEITHVDAGFNTIAFDTL

Sequences:

>Translated_260_residues
MTFLANKRILVTGLLTNRSIAYGIAKAMHREGAQLAFTYQGEGVRERVEKVIKEFDSDLLFPCDVSKDEEIDRCFDDLSK
RWDGLDGIVHSIAFAPREALSGDYLETVNREAFRIAHDVSSYSFAALAKAALPLMQGRNGALLTLSYLGAARVMPNYNVM
GLAKASLEANVRFMASSLGPKGIRVNAISAGPIKTLAAAGIGNFGKLLSYTEKVAPLRRNVSIMDVGNVAAFLCSDLASG
ITGEITHVDAGFNTIAFDTL
>Mature_259_residues
TFLANKRILVTGLLTNRSIAYGIAKAMHREGAQLAFTYQGEGVRERVEKVIKEFDSDLLFPCDVSKDEEIDRCFDDLSKR
WDGLDGIVHSIAFAPREALSGDYLETVNREAFRIAHDVSSYSFAALAKAALPLMQGRNGALLTLSYLGAARVMPNYNVMG
LAKASLEANVRFMASSLGPKGIRVNAISAGPIKTLAAAGIGNFGKLLSYTEKVAPLRRNVSIMDVGNVAAFLCSDLASGI
TGEITHVDAGFNTIAFDTL

Specific function: Fatty acid biosynthesis pathway; second reduction step. [C]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=260, Percent_Identity=26.9230769230769, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI5031737, Length=262, Percent_Identity=28.2442748091603, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI126723750, Length=260, Percent_Identity=25.7692307692308, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI1787545, Length=260, Percent_Identity=60.7692307692308, Blast_Score=330, Evalue=6e-92,
Organism=Escherichia coli, GI1789378, Length=253, Percent_Identity=26.8774703557312, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1787905, Length=193, Percent_Identity=29.0155440414508, Blast_Score=63, Evalue=2e-11,
Organism=Drosophila melanogaster, GI23397609, Length=252, Percent_Identity=26.1904761904762, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 28029; Mature: 27897

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFLANKRILVTGLLTNRSIAYGIAKAMHREGAQLAFTYQGEGVRERVEKVIKEFDSDLL
CCEECCCEEEEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCE
FPCDVSKDEEIDRCFDDLSKRWDGLDGIVHSIAFAPREALSGDYLETVNREAFRIAHDVS
EECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHCCHHHHHHCHHHHHHHHHHC
SYSFAALAKAALPLMQGRNGALLTLSYLGAARVMPNYNVMGLAKASLEANVRFMASSLGP
HHHHHHHHHHHHHHHCCCCCCEEEEEHHCHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCC
KGIRVNAISAGPIKTLAAAGIGNFGKLLSYTEKVAPLRRNVSIMDVGNVAAFLCSDLASG
CCEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHCC
ITGEITHVDAGFNTIAFDTL
CCCCEEEECCCCCEEEECCC
>Mature Secondary Structure 
TFLANKRILVTGLLTNRSIAYGIAKAMHREGAQLAFTYQGEGVRERVEKVIKEFDSDLL
CEECCCEEEEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCE
FPCDVSKDEEIDRCFDDLSKRWDGLDGIVHSIAFAPREALSGDYLETVNREAFRIAHDVS
EECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHCCHHHHHHCHHHHHHHHHHC
SYSFAALAKAALPLMQGRNGALLTLSYLGAARVMPNYNVMGLAKASLEANVRFMASSLGP
HHHHHHHHHHHHHHHCCCCCCEEEEEHHCHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCC
KGIRVNAISAGPIKTLAAAGIGNFGKLLSYTEKVAPLRRNVSIMDVGNVAAFLCSDLASG
CCEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHCC
ITGEITHVDAGFNTIAFDTL
CCCCEEEECCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10710307 [H]