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The map label for this gene is appC [H]

Identifier: 82703449

GI number: 82703449

Start: 2654781

End: 2656283

Strand: Reverse

Name: appC [H]

Synonym: Nmul_A2332

Alternate gene names: 82703449

Gene position: 2656283-2654781 (Counterclockwise)

Preceding gene: 82703450

Following gene: 82703448

Centisome position: 83.42

GC content: 56.62

Gene sequence:

>1503_bases
ATGTCTTTCAAACCTGTAATCCTGTGGACTGATGCGCTCGTTTACGTTCTGATTGCCGTAATCGTTATCTTTGCCTGGCA
GGTGCGGCGCCATGAACATCTTCTCGCCCCCTGGCGGCGCGTCGGACATAGTGCAAGCGGCATGGCGGCTCTCACCATAC
TGATGTTCTTTATCGTTATCGGGTTGCTCGACACGATACATTTGCGTCCCGCCATCCAAAACGGTAATGGCGGCAGTGAA
GCCGCTTACGGAGTCGAAGTGCTGAGCCTGCTCGACCTGCTTGGCACGCCTCTGCGCACGCAGGTGGAGACAACCTATTC
GGCGCCTTTCGCCACGCATCTCTACGCTCGCGAAACCGTGGAGTTGCCGGATGGAGGGCAGGTACGCGAATTCCCCCGCC
TGAAATTCGGCGGAGCGCACCTGCAGGATCCGGAAGCTCAGCTCGCCGGCGATATTGCCACCAGAGCTGCAGCAGGCACG
GGGTTGGCCCTGCTGCTCTGGTTCTTGATCGCGACATCGGTGATAGCGCTCGTGGCGCACCGCAGGAATGAAAGGTTTTT
ATCCACGTTCTCCGCAATCTGGCGGGGTATTACTCCGGTGCCGTGGAGAGCGGTATTTGTGACGCTTGCCCTGATATTGC
TGCTTGGCGGCGCGGCTCTTGCATTGTGCAGCGATTACCACATTCTTGGCACTGACAAGGTGGGGCAGGACGTATTTTAC
CAGTCCCTCAAGAGTATCCGTACCGGACTGCTCATAGGAACGCTCACGACACTGATGATGCTTCCTTTTGCACTGCTTCT
CGGAGTCGCCGCAGGTTATTTCCGGGGTTGGGTAGATGACTTGATTCAATACCTGTACACCACGCTCAGTTCGATTCCCG
GTGTTCTGCTGATTGCTGCCACGGTGCTGATGATGCAGGTTTACATGGAGACTCATCCTGAGCTCTTCGATACAATCGCT
GCGCGTGCTGATCTCCGCTTGCTGTTTCTCTGCATCATATTGGGGGTTACAAGCTGGACCGGCCTGTGCCGGCTTCTGCG
GGGCGAAACCCTGAAGCTGCGCGAAATGGAATATATCCAGGCAGCCACCGCATTCGGTGTTTCCCACTGGCGCATCATCA
GCCGCCACATTATCCCCAACGTGATGCACATCGTGCTGATCACCACCGTGATGGATTTCAGCGGTCTGGTGCTGGCAGAG
GCTGTACTGTCCTATGTGGGAGTGGGTGTTGATCCCTCAACCATCAGTTTTGGCACCATGATCAACGCCGCGCGCCTGGA
AATGGCGCGGGAACCCATGGTGTGGTGGGCGCTGTTTGCCGCCTTCAGCTTCATGTTTGCGCTGGTCCTGAGCGCAAATC
TCTTTGCCGATGCGGTACAGAATGCGTTCGATCCAAGGATGAAGACTCTAGCCGCACTGGCGCGAACATGGCGCCGTAAA
AAGCATCGGGAAGAACCGGTGACCAAATCCTCTTCTCCCTCGGAGGATTCTCTCCCGTCATGA

Upstream 100 bases:

>100_bases
ATCGTTGCTCTATATCGTCGGACTGATATTGACCGACATTTCCTATACGCTTGTAGATCCGAGGATAAGGCTGGAATGAC
AATATTCCGGCAAGGTTGAC

Downstream 100 bases:

>100_bases
GTTCTGTCCTGCAAATCAAAAATCTAGAGACGGTTTTGCACACCGAGCCGCGACCGGTTTGGGCGGTCGATGGGCTTACG
CTGCAGATCATGAAGGGTGA

Product: binding-protein dependent transport system inner membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MSFKPVILWTDALVYVLIAVIVIFAWQVRRHEHLLAPWRRVGHSASGMAALTILMFFIVIGLLDTIHLRPAIQNGNGGSE
AAYGVEVLSLLDLLGTPLRTQVETTYSAPFATHLYARETVELPDGGQVREFPRLKFGGAHLQDPEAQLAGDIATRAAAGT
GLALLLWFLIATSVIALVAHRRNERFLSTFSAIWRGITPVPWRAVFVTLALILLLGGAALALCSDYHILGTDKVGQDVFY
QSLKSIRTGLLIGTLTTLMMLPFALLLGVAAGYFRGWVDDLIQYLYTTLSSIPGVLLIAATVLMMQVYMETHPELFDTIA
ARADLRLLFLCIILGVTSWTGLCRLLRGETLKLREMEYIQAATAFGVSHWRIISRHIIPNVMHIVLITTVMDFSGLVLAE
AVLSYVGVGVDPSTISFGTMINAARLEMAREPMVWWALFAAFSFMFALVLSANLFADAVQNAFDPRMKTLAALARTWRRK
KHREEPVTKSSSPSEDSLPS

Sequences:

>Translated_500_residues
MSFKPVILWTDALVYVLIAVIVIFAWQVRRHEHLLAPWRRVGHSASGMAALTILMFFIVIGLLDTIHLRPAIQNGNGGSE
AAYGVEVLSLLDLLGTPLRTQVETTYSAPFATHLYARETVELPDGGQVREFPRLKFGGAHLQDPEAQLAGDIATRAAAGT
GLALLLWFLIATSVIALVAHRRNERFLSTFSAIWRGITPVPWRAVFVTLALILLLGGAALALCSDYHILGTDKVGQDVFY
QSLKSIRTGLLIGTLTTLMMLPFALLLGVAAGYFRGWVDDLIQYLYTTLSSIPGVLLIAATVLMMQVYMETHPELFDTIA
ARADLRLLFLCIILGVTSWTGLCRLLRGETLKLREMEYIQAATAFGVSHWRIISRHIIPNVMHIVLITTVMDFSGLVLAE
AVLSYVGVGVDPSTISFGTMINAARLEMAREPMVWWALFAAFSFMFALVLSANLFADAVQNAFDPRMKTLAALARTWRRK
KHREEPVTKSSSPSEDSLPS
>Mature_499_residues
SFKPVILWTDALVYVLIAVIVIFAWQVRRHEHLLAPWRRVGHSASGMAALTILMFFIVIGLLDTIHLRPAIQNGNGGSEA
AYGVEVLSLLDLLGTPLRTQVETTYSAPFATHLYARETVELPDGGQVREFPRLKFGGAHLQDPEAQLAGDIATRAAAGTG
LALLLWFLIATSVIALVAHRRNERFLSTFSAIWRGITPVPWRAVFVTLALILLLGGAALALCSDYHILGTDKVGQDVFYQ
SLKSIRTGLLIGTLTTLMMLPFALLLGVAAGYFRGWVDDLIQYLYTTLSSIPGVLLIAATVLMMQVYMETHPELFDTIAA
RADLRLLFLCIILGVTSWTGLCRLLRGETLKLREMEYIQAATAFGVSHWRIISRHIIPNVMHIVLITTVMDFSGLVLAEA
VLSYVGVGVDPSTISFGTMINAARLEMAREPMVWWALFAAFSFMFALVLSANLFADAVQNAFDPRMKTLAALARTWRRKK
HREEPVTKSSSPSEDSLPS

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787054, Length=242, Percent_Identity=30.1652892561983, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI1787760, Length=246, Percent_Identity=29.2682926829268, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI1787498, Length=240, Percent_Identity=27.9166666666667, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1789964, Length=243, Percent_Identity=27.9835390946502, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788505, Length=244, Percent_Identity=29.5081967213115, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789889, Length=244, Percent_Identity=26.2295081967213, Blast_Score=76, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 55141; Mature: 55009

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFKPVILWTDALVYVLIAVIVIFAWQVRRHEHLLAPWRRVGHSASGMAALTILMFFIVI
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
GLLDTIHLRPAIQNGNGGSEAAYGVEVLSLLDLLGTPLRTQVETTYSAPFATHLYARETV
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHCC
ELPDGGQVREFPRLKFGGAHLQDPEAQLAGDIATRAAAGTGLALLLWFLIATSVIALVAH
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RRNERFLSTFSAIWRGITPVPWRAVFVTLALILLLGGAALALCSDYHILGTDKVGQDVFY
HCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHH
QSLKSIRTGLLIGTLTTLMMLPFALLLGVAAGYFRGWVDDLIQYLYTTLSSIPGVLLIAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
TVLMMQVYMETHPELFDTIAARADLRLLFLCIILGVTSWTGLCRLLRGETLKLREMEYIQ
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AATAFGVSHWRIISRHIIPNVMHIVLITTVMDFSGLVLAEAVLSYVGVGVDPSTISFGTM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
INAARLEMAREPMVWWALFAAFSFMFALVLSANLFADAVQNAFDPRMKTLAALARTWRRK
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KHREEPVTKSSSPSEDSLPS
HHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SFKPVILWTDALVYVLIAVIVIFAWQVRRHEHLLAPWRRVGHSASGMAALTILMFFIVI
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
GLLDTIHLRPAIQNGNGGSEAAYGVEVLSLLDLLGTPLRTQVETTYSAPFATHLYARETV
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHCC
ELPDGGQVREFPRLKFGGAHLQDPEAQLAGDIATRAAAGTGLALLLWFLIATSVIALVAH
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RRNERFLSTFSAIWRGITPVPWRAVFVTLALILLLGGAALALCSDYHILGTDKVGQDVFY
HCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHH
QSLKSIRTGLLIGTLTTLMMLPFALLLGVAAGYFRGWVDDLIQYLYTTLSSIPGVLLIAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
TVLMMQVYMETHPELFDTIAARADLRLLFLCIILGVTSWTGLCRLLRGETLKLREMEYIQ
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AATAFGVSHWRIISRHIIPNVMHIVLITTVMDFSGLVLAEAVLSYVGVGVDPSTISFGTM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
INAARLEMAREPMVWWALFAAFSFMFALVLSANLFADAVQNAFDPRMKTLAALARTWRRK
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KHREEPVTKSSSPSEDSLPS
HHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]