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The map label for this gene is phoR [H]

Identifier: 82703350

GI number: 82703350

Start: 2535510

End: 2536811

Strand: Direct

Name: phoR [H]

Synonym: Nmul_A2232

Alternate gene names: 82703350

Gene position: 2535510-2536811 (Clockwise)

Preceding gene: 82703349

Following gene: 82703351

Centisome position: 79.63

GC content: 56.07

Gene sequence:

>1302_bases
GTGTCCGGTTTCTGGGGGCATTTTGCCAATCTCGTACTGATTGCCGTTGTAAGCGGAGTACTGATGACTGTGTCCGGCGC
AGCCGCGGCGCTGACATTTTATGTCGTTGTTCTGTTCCTGCTGGTCCTGCGCCACTCGCACAATCTGAAGCGCCTGGACC
GCTGGCTTCGTAGTGAAGAAGCTGTGCTACCCGACAGCTCCGGCAGATGGGGAGATGTATTCGCGCGCCTGGCCCGGCTC
ATGCGCGATCAAAAACAAACCCACCAAAACCTCAGTTCCGCTCTGGAGCGCCTGCGGAGCGCCACCTCAGCCATGCCCGA
GGGAGTGGTCATCCTCGATGAAATGGACCGCATCGAATGGTGCAATCCAGTGGCCGAAAAACATCTGGGCATCAATGCCA
GTCTCGATACCGGGCAGCATATCACGCATCTGATGCGTCAAACCCAGTTCGCGGAATATCTTGCCGCGCGGAATTACAAG
GAACCCCTGGTGATCAAACAACCGCGGCAGCACGAGTTGACGCTCTCGCTGCAGTTCGTTCCTTATGGCGACAAGCAGAA
ACTGCTCCTCAGCCGTGATATAACCAAGCTTGAAAGAATCCAGACCATGCGCCGCGATTTTGTCGCCAACGTCTCGCATG
AACTGCGCACGCCTTTGACCGTCATCGGTGGGTTTCTCGAAACGCTGTCGGACGATAATCAACCCGATCCCGATACCCGC
AAATGGGCATTGGAATTGATGAGCGAGCAGACGCGACGCATGCAAAGCCTGGTGGAGGATCTGTTGACTCTGTCGAGGCT
CGAGAATACGGAAAACCAGGTGCGCGAGGAGCACGTCAACATACCGGAAATGTTGCGAACGCTGTATGAGGAAGCGAAAT
CCCTGAGTGGAGGACACCATCGCATCACGCTCGAGCTCGATACAACCACAAAACTCCTGGGCAACCTGTTTGACCTGCGC
AGCGCCTTCATCAATCTGATCAGCAATGCCATACGCTATACTCCTGATGGAGGGAATATAACGCTGCGCTGGGCAATTCA
GGACGGGAAAGGTGTATTTTCGGTGCAGGACACGGGGATAGGGATTGAACCCGAACATATCTCGCGCCTGACGGAGCGTT
TTTATCGCGTCGACCGTGGCCGATCGCGTGAAACCGGAGGCACCGGCCTCGGTCTTGCCATTGTCAAGCACGTGCTCAGC
GGTCACCAGGCGAAGCTGGAAATTACCAGCGAACCGGGCAAAGGCAGTCGCTTCAGCGCAGTGTTTCCGGCTACCCGGCT
TCTGATACAGCAAGGTGAGTAA

Upstream 100 bases:

>100_bases
CAGACAGTGCGGGGCTCCGGCTATCGCCTTTCGGCAGGTCAAGCAGTGAACGCGGGATGAAAGCGGGAATGATCTGTTGT
AATCGTTCCAACTGACGTTC

Downstream 100 bases:

>100_bases
ATAGTAGCCTGCTGCGCGCGGTATAATCGGCTGAATACCATTTCCCCGGAAAGCGGATAACGGATGCAACGAGCAGTGGA
ACAAACAGATCCCGCCGCGG

Product: PAS/PAC sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MSGFWGHFANLVLIAVVSGVLMTVSGAAAALTFYVVVLFLLVLRHSHNLKRLDRWLRSEEAVLPDSSGRWGDVFARLARL
MRDQKQTHQNLSSALERLRSATSAMPEGVVILDEMDRIEWCNPVAEKHLGINASLDTGQHITHLMRQTQFAEYLAARNYK
EPLVIKQPRQHELTLSLQFVPYGDKQKLLLSRDITKLERIQTMRRDFVANVSHELRTPLTVIGGFLETLSDDNQPDPDTR
KWALELMSEQTRRMQSLVEDLLTLSRLENTENQVREEHVNIPEMLRTLYEEAKSLSGGHHRITLELDTTTKLLGNLFDLR
SAFINLISNAIRYTPDGGNITLRWAIQDGKGVFSVQDTGIGIEPEHISRLTERFYRVDRGRSRETGGTGLGLAIVKHVLS
GHQAKLEITSEPGKGSRFSAVFPATRLLIQQGE

Sequences:

>Translated_433_residues
MSGFWGHFANLVLIAVVSGVLMTVSGAAAALTFYVVVLFLLVLRHSHNLKRLDRWLRSEEAVLPDSSGRWGDVFARLARL
MRDQKQTHQNLSSALERLRSATSAMPEGVVILDEMDRIEWCNPVAEKHLGINASLDTGQHITHLMRQTQFAEYLAARNYK
EPLVIKQPRQHELTLSLQFVPYGDKQKLLLSRDITKLERIQTMRRDFVANVSHELRTPLTVIGGFLETLSDDNQPDPDTR
KWALELMSEQTRRMQSLVEDLLTLSRLENTENQVREEHVNIPEMLRTLYEEAKSLSGGHHRITLELDTTTKLLGNLFDLR
SAFINLISNAIRYTPDGGNITLRWAIQDGKGVFSVQDTGIGIEPEHISRLTERFYRVDRGRSRETGGTGLGLAIVKHVLS
GHQAKLEITSEPGKGSRFSAVFPATRLLIQQGE
>Mature_432_residues
SGFWGHFANLVLIAVVSGVLMTVSGAAAALTFYVVVLFLLVLRHSHNLKRLDRWLRSEEAVLPDSSGRWGDVFARLARLM
RDQKQTHQNLSSALERLRSATSAMPEGVVILDEMDRIEWCNPVAEKHLGINASLDTGQHITHLMRQTQFAEYLAARNYKE
PLVIKQPRQHELTLSLQFVPYGDKQKLLLSRDITKLERIQTMRRDFVANVSHELRTPLTVIGGFLETLSDDNQPDPDTRK
WALELMSEQTRRMQSLVEDLLTLSRLENTENQVREEHVNIPEMLRTLYEEAKSLSGGHHRITLELDTTTKLLGNLFDLRS
AFINLISNAIRYTPDGGNITLRWAIQDGKGVFSVQDTGIGIEPEHISRLTERFYRVDRGRSRETGGTGLGLAIVKHVLSG
HQAKLEITSEPGKGSRFSAVFPATRLLIQQGE

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=387, Percent_Identity=43.4108527131783, Blast_Score=311, Evalue=5e-86,
Organism=Escherichia coli, GI1786783, Length=255, Percent_Identity=30.9803921568627, Blast_Score=121, Evalue=9e-29,
Organism=Escherichia coli, GI1788393, Length=246, Percent_Identity=29.6747967479675, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI145693157, Length=334, Percent_Identity=26.9461077844311, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI48994928, Length=405, Percent_Identity=25.4320987654321, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790346, Length=236, Percent_Identity=29.6610169491525, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789149, Length=229, Percent_Identity=33.6244541484716, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790861, Length=193, Percent_Identity=34.7150259067358, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI87082128, Length=233, Percent_Identity=27.8969957081545, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788713, Length=230, Percent_Identity=28.2608695652174, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788549, Length=387, Percent_Identity=24.8062015503876, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87081816, Length=231, Percent_Identity=29.4372294372294, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787894, Length=223, Percent_Identity=27.3542600896861, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1789403, Length=210, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790551, Length=205, Percent_Identity=32.1951219512195, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790436, Length=243, Percent_Identity=25.5144032921811, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790300, Length=352, Percent_Identity=25.8522727272727, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786912, Length=228, Percent_Identity=26.3157894736842, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789808, Length=230, Percent_Identity=29.1304347826087, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48931; Mature: 48800

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGFWGHFANLVLIAVVSGVLMTVSGAAAALTFYVVVLFLLVLRHSHNLKRLDRWLRSEE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
AVLPDSSGRWGDVFARLARLMRDQKQTHQNLSSALERLRSATSAMPEGVVILDEMDRIEW
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHH
CNPVAEKHLGINASLDTGQHITHLMRQTQFAEYLAARNYKEPLVIKQPRQHELTLSLQFV
CCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCEEEEEEEEE
PYGDKQKLLLSRDITKLERIQTMRRDFVANVSHELRTPLTVIGGFLETLSDDNQPDPDTR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCHHH
KWALELMSEQTRRMQSLVEDLLTLSRLENTENQVREEHVNIPEMLRTLYEEAKSLSGGHH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCE
RITLELDTTTKLLGNLFDLRSAFINLISNAIRYTPDGGNITLRWAIQDGKGVFSVQDTGI
EEEEEECHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEEECCCEEEEEECCCC
GIEPEHISRLTERFYRVDRGRSRETGGTGLGLAIVKHVLSGHQAKLEITSEPGKGSRFSA
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCEEH
VFPATRLLIQQGE
HHHHHHHHHHCCC
>Mature Secondary Structure 
SGFWGHFANLVLIAVVSGVLMTVSGAAAALTFYVVVLFLLVLRHSHNLKRLDRWLRSEE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
AVLPDSSGRWGDVFARLARLMRDQKQTHQNLSSALERLRSATSAMPEGVVILDEMDRIEW
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHH
CNPVAEKHLGINASLDTGQHITHLMRQTQFAEYLAARNYKEPLVIKQPRQHELTLSLQFV
CCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCEEEEEEEEE
PYGDKQKLLLSRDITKLERIQTMRRDFVANVSHELRTPLTVIGGFLETLSDDNQPDPDTR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCHHH
KWALELMSEQTRRMQSLVEDLLTLSRLENTENQVREEHVNIPEMLRTLYEEAKSLSGGHH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCE
RITLELDTTTKLLGNLFDLRSAFINLISNAIRYTPDGGNITLRWAIQDGKGVFSVQDTGI
EEEEEECHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEEECCCEEEEEECCCC
GIEPEHISRLTERFYRVDRGRSRETGGTGLGLAIVKHVLSGHQAKLEITSEPGKGSRFSA
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCEEH
VFPATRLLIQQGE
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043; 2115874 [H]