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The map label for this gene is obgE

Identifier: 82702940

GI number: 82702940

Start: 2076810

End: 2077874

Strand: Direct

Name: obgE

Synonym: Nmul_A1817

Alternate gene names: 82702940

Gene position: 2076810-2077874 (Clockwise)

Preceding gene: 82702939

Following gene: 82702941

Centisome position: 65.22

GC content: 55.77

Gene sequence:

>1065_bases
ATGAAATACATTGACGAAGCGATTATCCATGTAATCGCTGGAAAAGGTGGAGATGGCGTCGCAGCCTTCCGCAGGGAGAA
ATACATTCCCAAAGGCGGCCCATCCGGTGGTGATGGCGGACGCGGAGGCAGCATTTATGCGATGGCCGACCGCAACATCA
ATACCTTGGTGGATTACCGGTTTGCCCGCATCCACCGGGCAAAAAACGGCGAAAACGGACAAGGTTCGGATCGCTACGGA
AAAAGCGCCCACGATATCGTGTTGCGTATGCCCGTTGGCACCGTTATCACCAACGAGGCGACAGGAGAACGGGTGGCCGA
CCTGGTCCAGCATGATCAGAAAATCCTGCTCGCGAAAGGTGGCACGGGGGGACTGGGCAATCTGCACTTCAAATCCAGCA
CAAATCGCACGCCTCGGCAATTCACGCTGGGTGAACCGGGAGAAGAAGCCGACCTCAAGCTGGAACTCAAGGTTCTTGCG
GACGTGGGACTGCTCGGCATGCCAAACGCGGGCAAGTCGACCCTGATTCGCGCAATTTCAGCGGCACGCCCAAAAGTAGC
TGATTATCCTTTCACCACCATGCACCCTGCTCTGGGTGTGGTGCGCGTGGATCAGAACCGCAGTTTCGTAATGGCTGATA
TTCCGGGGCTGATCGAAGGCGCAGCGGAAGGCGCGGGACTTGGACACCGCTTCCTGAAGCATCTGGCACGTACCCGCCTG
TTGCTGCATGTGGTCGACATTGCGCCGCTCGATGAAGCGATTGATCCCGTGTATGAGGCCAAGGCTATTCTCGAAGAACT
GAGGAAGTATGACGAAGCACTCTACCGCAAGCCGCGCTGGCTGGTGCTCAACAAGGTGGATCTGCTGCCGGAAAATGAGC
GCGAAAAAATATGCAAGAAATTCATCCGCAGCCTTCGCTGGAAAGACAAGAACTTTGCCATCTCAGCCATGACCGGGGAT
GGCTGCAAGGAACTGACCTACGCGATCATGGAATTTCTGGAGCGGGAATCGATGGACGAAAATCAGGAGCGGGCAACATT
TGCGGAACCGGATACATCCGATTGA

Upstream 100 bases:

>100_bases
AAGACAGTAAGCATTATCCCGGCTTAATTTATTTTATTTCCCAGGAAAGCCCTATCAGCCCGATAGGGCTTTTTTGTTTG
CATCCCGGTAAGCTGATTCC

Downstream 100 bases:

>100_bases
TTTCCCACAGGCTCCATTAACAGGAACCCTCCATTGCCCCCTTTCATTCCTTTAGTTGTACTACACTTAACCAGATTTCC
AGAGAAAGCCCTACTGCGCT

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MKYIDEAIIHVIAGKGGDGVAAFRREKYIPKGGPSGGDGGRGGSIYAMADRNINTLVDYRFARIHRAKNGENGQGSDRYG
KSAHDIVLRMPVGTVITNEATGERVADLVQHDQKILLAKGGTGGLGNLHFKSSTNRTPRQFTLGEPGEEADLKLELKVLA
DVGLLGMPNAGKSTLIRAISAARPKVADYPFTTMHPALGVVRVDQNRSFVMADIPGLIEGAAEGAGLGHRFLKHLARTRL
LLHVVDIAPLDEAIDPVYEAKAILEELRKYDEALYRKPRWLVLNKVDLLPENEREKICKKFIRSLRWKDKNFAISAMTGD
GCKELTYAIMEFLERESMDENQERATFAEPDTSD

Sequences:

>Translated_354_residues
MKYIDEAIIHVIAGKGGDGVAAFRREKYIPKGGPSGGDGGRGGSIYAMADRNINTLVDYRFARIHRAKNGENGQGSDRYG
KSAHDIVLRMPVGTVITNEATGERVADLVQHDQKILLAKGGTGGLGNLHFKSSTNRTPRQFTLGEPGEEADLKLELKVLA
DVGLLGMPNAGKSTLIRAISAARPKVADYPFTTMHPALGVVRVDQNRSFVMADIPGLIEGAAEGAGLGHRFLKHLARTRL
LLHVVDIAPLDEAIDPVYEAKAILEELRKYDEALYRKPRWLVLNKVDLLPENEREKICKKFIRSLRWKDKNFAISAMTGD
GCKELTYAIMEFLERESMDENQERATFAEPDTSD
>Mature_354_residues
MKYIDEAIIHVIAGKGGDGVAAFRREKYIPKGGPSGGDGGRGGSIYAMADRNINTLVDYRFARIHRAKNGENGQGSDRYG
KSAHDIVLRMPVGTVITNEATGERVADLVQHDQKILLAKGGTGGLGNLHFKSSTNRTPRQFTLGEPGEEADLKLELKVLA
DVGLLGMPNAGKSTLIRAISAARPKVADYPFTTMHPALGVVRVDQNRSFVMADIPGLIEGAAEGAGLGHRFLKHLARTRL
LLHVVDIAPLDEAIDPVYEAKAILEELRKYDEALYRKPRWLVLNKVDLLPENEREKICKKFIRSLRWKDKNFAISAMTGD
GCKELTYAIMEFLERESMDENQERATFAEPDTSD

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=325, Percent_Identity=38.1538461538462, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI111955139, Length=293, Percent_Identity=35.8361774744027, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI111955063, Length=262, Percent_Identity=32.4427480916031, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI58761500, Length=135, Percent_Identity=29.6296296296296, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1789574, Length=333, Percent_Identity=59.1591591591592, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI1787454, Length=100, Percent_Identity=39, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790615, Length=211, Percent_Identity=32.2274881516588, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17508313, Length=302, Percent_Identity=40.0662251655629, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17552324, Length=326, Percent_Identity=31.9018404907975, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17509631, Length=150, Percent_Identity=31.3333333333333, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321962, Length=188, Percent_Identity=37.2340425531915, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319281, Length=127, Percent_Identity=29.9212598425197, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI20129375, Length=344, Percent_Identity=37.5, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24585318, Length=240, Percent_Identity=41.25, Blast_Score=160, Evalue=9e-40,
Organism=Drosophila melanogaster, GI24640873, Length=133, Percent_Identity=33.8345864661654, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24640877, Length=133, Percent_Identity=33.8345864661654, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24640875, Length=133, Percent_Identity=33.8345864661654, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_NITMU (Q2Y807)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_412506.1
- HSSP:   Q5SJ29
- ProteinModelPortal:   Q2Y807
- SMR:   Q2Y807
- STRING:   Q2Y807
- GeneID:   3784912
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A1817
- eggNOG:   COG0536
- HOGENOM:   HBG716038
- OMA:   LIDYRFN
- PhylomeDB:   Q2Y807
- ProtClustDB:   PRK12299
- BioCyc:   NMUL323848:NMUL_A1817-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 38995; Mature: 38995

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYIDEAIIHVIAGKGGDGVAAFRREKYIPKGGPSGGDGGRGGSIYAMADRNINTLVDYR
CCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHH
FARIHRAKNGENGQGSDRYGKSAHDIVLRMPVGTVITNEATGERVADLVQHDQKILLAKG
HHHHHHHCCCCCCCCCCCCCCCHHCEEEEECCCEEEECCCCHHHHHHHHHCCCEEEEEEC
GTGGLGNLHFKSSTNRTPRQFTLGEPGEEADLKLELKVLADVGLLGMPNAGKSTLIRAIS
CCCCCCCEEECCCCCCCCCEEECCCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHH
AARPKVADYPFTTMHPALGVVRVDQNRSFVMADIPGLIEGAAEGAGLGHRFLKHLARTRL
HCCCCCCCCCCHHHCCCCEEEEECCCCCEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHH
LLHVVDIAPLDEAIDPVYEAKAILEELRKYDEALYRKPRWLVLNKVDLLPENEREKICKK
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHH
FIRSLRWKDKNFAISAMTGDGCKELTYAIMEFLERESMDENQERATFAEPDTSD
HHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHCEECCCCCCC
>Mature Secondary Structure
MKYIDEAIIHVIAGKGGDGVAAFRREKYIPKGGPSGGDGGRGGSIYAMADRNINTLVDYR
CCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHH
FARIHRAKNGENGQGSDRYGKSAHDIVLRMPVGTVITNEATGERVADLVQHDQKILLAKG
HHHHHHHCCCCCCCCCCCCCCCHHCEEEEECCCEEEECCCCHHHHHHHHHCCCEEEEEEC
GTGGLGNLHFKSSTNRTPRQFTLGEPGEEADLKLELKVLADVGLLGMPNAGKSTLIRAIS
CCCCCCCEEECCCCCCCCCEEECCCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHH
AARPKVADYPFTTMHPALGVVRVDQNRSFVMADIPGLIEGAAEGAGLGHRFLKHLARTRL
HCCCCCCCCCCHHHCCCCEEEEECCCCCEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHH
LLHVVDIAPLDEAIDPVYEAKAILEELRKYDEALYRKPRWLVLNKVDLLPENEREKICKK
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHH
FIRSLRWKDKNFAISAMTGDGCKELTYAIMEFLERESMDENQERATFAEPDTSD
HHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA