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The map label for this gene is hoxH [H]

Identifier: 82702797

GI number: 82702797

Start: 1912154

End: 1913635

Strand: Direct

Name: hoxH [H]

Synonym: Nmul_A1673

Alternate gene names: 82702797

Gene position: 1912154-1913635 (Clockwise)

Preceding gene: 82702796

Following gene: 82702798

Centisome position: 60.05

GC content: 56.01

Gene sequence:

>1482_bases
ATGACATCTGAACTGGAAACTGCCGCGAATCCAGAGAAGCTTAAGCGGATCGTAATCGAACCGGTCACCCGCGTGGAAGG
TCATGGCAAAGTGACCCTCCTGCTGGATGAGGATAACCGGGTGCAGCAGGCGCGCTTTCACATCGTCGAATTTCGCGGCT
TCGAGAAATTCATTCAGGGACGTCCCTATACGGAAGTACCGGTATTGGTGCAGCGCCTCTGCGGCATTTGCCCGGTGAGT
CACAATCTTGCCGCTTCCAAGGCGATGGATGTGATCGTGGGGGCAGCGCCTCCCCCCGCGGCCGACAAGCTGCGCCGCCT
GATGCACATGGGGCAAATGCTGCAATCGCACGCGCTGCATTTTTTCCATCTCTCCTCTCCCGACCTGCTCTTCGGCTTCG
ATGCGGAAGTGGGGAAACGCAACATCGCCGGTCTTGCCATGCAATTCCCCGATATCGCCAGGCAAGGGGTCGGATTGCGC
AAGTTTGGCCAGGAAGTCATCCGCATGACGAGCGGCAAGCGCGTACACGGCACAGGCGTGATTCCAGGCGGCATGAGCAA
AAATTTATCTCGCGAAGATCGGGATTGGCTGCTCGCCGAGATAGACCAGGTTGTGCGCTGGAGCCAGCAAGCAGTGAACC
TTATCAAGCGTCTTTATGGCGAGCATAAGGATTTTTACAACAACTTTGGCTATTACCGCTCGAGTTTCATGAGCCTCGTG
CGTGAAGACGGGGCCATGGACCTGTATCACGGGAACCTCCGGGCTATAGATGACAAGGGCCAGACCATTTTCGACCACGT
GGATTACAGCCACTACGGGGATTACATCCACGAAGAAGTGAAGTCATGGTCTTACATGAAATTTCCGTTCATACGTTCCC
AAGGCAGGGAGGAAGGCTGGTACAGGGTGGGGCCGCTGGCGCGCGTCAACAACTGCGATTTCATCCCTACTCCTCTGGCG
GAGGCCGAGCGCAAAATTTTCAAGGAATATGACGGGGGGCGTGCGTCCCATGCCACGCTCTCCTTTCACTGGGCGCGCAT
GATCGAAATGCTCCACTCTGCGGAGGCGATACGGGAGCTATTGCACGATGACGATTTGCTGAGCGACGACCTGGTGAACA
TCGGGGAACGACAGCTGCGTGGCGTAGGCGTAATCGAGGCGCCGCGAGGAACATTGATCCACCACTATCGGATCAACGAA
GACGAGCAGATCGTGCGCGCCAATCTGATTGTAGCCACTACGCATAATAATCAGGCGATGAACGAAGCCATACGCCAAGT
GTCGTTGCAATACCTCGACGGGCAGCAGCTTACCGAAGGCTTGCTCAATTATATCGAGGTAGCGATCCGCGCGTTCGACC
CCTGTCTTTCCTGCGCGACTCACGCCTTGGGAAAAATGCCGCTGGAAGTGGAGCTGGTGGATGCGGAAGGAGCAAGAGTA
AAGAGAATAATTAAGGATTCCGATGGGGGGTACCGCGCTTAA

Upstream 100 bases:

>100_bases
CGGAGATCGGTTATGAATCGCTCCGGTACGATTAGGATATTCCCCTTGTGCTGTCCCTTGCCTGCACCAATAGCGGTCGG
AAGGAATATGGGAGTAGCGG

Downstream 100 bases:

>100_bases
CTATCTACTATCGATCTGGAAATGGGATTCCCACTTAAAACAACATTAAGGCGATCGCAATGTTTTTATCCCTCATTGGA
ACTGCTCGGAATAACTAACG

Product: nickel-dependent hydrogenase, large subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 492

Protein sequence:

>493_residues
MTSELETAANPEKLKRIVIEPVTRVEGHGKVTLLLDEDNRVQQARFHIVEFRGFEKFIQGRPYTEVPVLVQRLCGICPVS
HNLAASKAMDVIVGAAPPPAADKLRRLMHMGQMLQSHALHFFHLSSPDLLFGFDAEVGKRNIAGLAMQFPDIARQGVGLR
KFGQEVIRMTSGKRVHGTGVIPGGMSKNLSREDRDWLLAEIDQVVRWSQQAVNLIKRLYGEHKDFYNNFGYYRSSFMSLV
REDGAMDLYHGNLRAIDDKGQTIFDHVDYSHYGDYIHEEVKSWSYMKFPFIRSQGREEGWYRVGPLARVNNCDFIPTPLA
EAERKIFKEYDGGRASHATLSFHWARMIEMLHSAEAIRELLHDDDLLSDDLVNIGERQLRGVGVIEAPRGTLIHHYRINE
DEQIVRANLIVATTHNNQAMNEAIRQVSLQYLDGQQLTEGLLNYIEVAIRAFDPCLSCATHALGKMPLEVELVDAEGARV
KRIIKDSDGGYRA

Sequences:

>Translated_493_residues
MTSELETAANPEKLKRIVIEPVTRVEGHGKVTLLLDEDNRVQQARFHIVEFRGFEKFIQGRPYTEVPVLVQRLCGICPVS
HNLAASKAMDVIVGAAPPPAADKLRRLMHMGQMLQSHALHFFHLSSPDLLFGFDAEVGKRNIAGLAMQFPDIARQGVGLR
KFGQEVIRMTSGKRVHGTGVIPGGMSKNLSREDRDWLLAEIDQVVRWSQQAVNLIKRLYGEHKDFYNNFGYYRSSFMSLV
REDGAMDLYHGNLRAIDDKGQTIFDHVDYSHYGDYIHEEVKSWSYMKFPFIRSQGREEGWYRVGPLARVNNCDFIPTPLA
EAERKIFKEYDGGRASHATLSFHWARMIEMLHSAEAIRELLHDDDLLSDDLVNIGERQLRGVGVIEAPRGTLIHHYRINE
DEQIVRANLIVATTHNNQAMNEAIRQVSLQYLDGQQLTEGLLNYIEVAIRAFDPCLSCATHALGKMPLEVELVDAEGARV
KRIIKDSDGGYRA
>Mature_492_residues
TSELETAANPEKLKRIVIEPVTRVEGHGKVTLLLDEDNRVQQARFHIVEFRGFEKFIQGRPYTEVPVLVQRLCGICPVSH
NLAASKAMDVIVGAAPPPAADKLRRLMHMGQMLQSHALHFFHLSSPDLLFGFDAEVGKRNIAGLAMQFPDIARQGVGLRK
FGQEVIRMTSGKRVHGTGVIPGGMSKNLSREDRDWLLAEIDQVVRWSQQAVNLIKRLYGEHKDFYNNFGYYRSSFMSLVR
EDGAMDLYHGNLRAIDDKGQTIFDHVDYSHYGDYIHEEVKSWSYMKFPFIRSQGREEGWYRVGPLARVNNCDFIPTPLAE
AERKIFKEYDGGRASHATLSFHWARMIEMLHSAEAIRELLHDDDLLSDDLVNIGERQLRGVGVIEAPRGTLIHHYRINED
EQIVRANLIVATTHNNQAMNEAIRQVSLQYLDGQQLTEGLLNYIEVAIRAFDPCLSCATHALGKMPLEVELVDAEGARVK
RIIKDSDGGYRA

Specific function: This Is One Of Three E.Coli Hydrogenases Synthesized In Response To Different Physiological Conditions. Hyd1 Is Believed To Have A Role In Hydrogen Cycling During Fermentative Growth. [C]

COG id: COG3259

COG function: function code C; Coenzyme F420-reducing hydrogenase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family [H]

Homologues:

Organism=Escherichia coli, GI1787207, Length=145, Percent_Identity=28.9655172413793, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1789368, Length=116, Percent_Identity=30.1724137931034, Blast_Score=72, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001501
- InterPro:   IPR018194 [H]

Pfam domain/function: PF00374 NiFeSe_Hases [H]

EC number: =1.12.1.2 [H]

Molecular weight: Translated: 55889; Mature: 55757

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00507 NI_HGENASE_L_1 ; PS00508 NI_HGENASE_L_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSELETAANPEKLKRIVIEPVTRVEGHGKVTLLLDEDNRVQQARFHIVEFRGFEKFIQG
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
RPYTEVPVLVQRLCGICPVSHNLAASKAMDVIVGAAPPPAADKLRRLMHMGQMLQSHALH
CCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHCCEE
FFHLSSPDLLFGFDAEVGKRNIAGLAMQFPDIARQGVGLRKFGQEVIRMTSGKRVHGTGV
EEECCCCCEEEECCCHHCCCHHHHHHHHCHHHHHHCCCHHHHHHHHHHHCCCCEEECCCC
IPGGMSKNLSREDRDWLLAEIDQVVRWSQQAVNLIKRLYGEHKDFYNNFGYYRSSFMSLV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REDGAMDLYHGNLRAIDDKGQTIFDHVDYSHYGDYIHEEVKSWSYMKFPFIRSQGREEGW
HHCCCEEEECCCEEEECCCCCEEHHHCCHHHHHHHHHHHHHCCCEEECHHHHCCCCCCCC
YRVGPLARVNNCDFIPTPLAEAERKIFKEYDGGRASHATLSFHWARMIEMLHSAEAIREL
EEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LHDDDLLSDDLVNIGERQLRGVGVIEAPRGTLIHHYRINEDEQIVRANLIVATTHNNQAM
HCCCCCCHHHHHHCCHHHHCCCCEEECCCCCEEEEEECCCCHHEEEEEEEEEECCCCHHH
NEAIRQVSLQYLDGQQLTEGLLNYIEVAIRAFDPCLSCATHALGKMPLEVELVDAEGARV
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHH
KRIIKDSDGGYRA
HHHHHCCCCCCCC
>Mature Secondary Structure 
TSELETAANPEKLKRIVIEPVTRVEGHGKVTLLLDEDNRVQQARFHIVEFRGFEKFIQG
CCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
RPYTEVPVLVQRLCGICPVSHNLAASKAMDVIVGAAPPPAADKLRRLMHMGQMLQSHALH
CCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHCCEE
FFHLSSPDLLFGFDAEVGKRNIAGLAMQFPDIARQGVGLRKFGQEVIRMTSGKRVHGTGV
EEECCCCCEEEECCCHHCCCHHHHHHHHCHHHHHHCCCHHHHHHHHHHHCCCCEEECCCC
IPGGMSKNLSREDRDWLLAEIDQVVRWSQQAVNLIKRLYGEHKDFYNNFGYYRSSFMSLV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REDGAMDLYHGNLRAIDDKGQTIFDHVDYSHYGDYIHEEVKSWSYMKFPFIRSQGREEGW
HHCCCEEEECCCEEEECCCCCEEHHHCCHHHHHHHHHHHHHCCCEEECHHHHCCCCCCCC
YRVGPLARVNNCDFIPTPLAEAERKIFKEYDGGRASHATLSFHWARMIEMLHSAEAIREL
EEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LHDDDLLSDDLVNIGERQLRGVGVIEAPRGTLIHHYRINEDEQIVRANLIVATTHNNQAM
HCCCCCCHHHHHHCCHHHHCCCCEEECCCCCEEEEEECCCCHHEEEEEEEEEECCCCHHH
NEAIRQVSLQYLDGQQLTEGLLNYIEVAIRAFDPCLSCATHALGKMPLEVELVDAEGARV
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHH
KRIIKDSDGGYRA
HHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2188945; 12948488; 2496982 [H]