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The map label for this gene is 82702786

Identifier: 82702786

GI number: 82702786

Start: 1899977

End: 1901338

Strand: Direct

Name: 82702786

Synonym: Nmul_A1662

Alternate gene names: NA

Gene position: 1899977-1901338 (Clockwise)

Preceding gene: 82702776

Following gene: 82702787

Centisome position: 59.67

GC content: 52.06

Gene sequence:

>1362_bases
ATGACGCAGCTTCAATTCCTCGGAGCAACCGGAACGGTCACCGGATCTAAGTATCTGCTTCAGCATGAAGCAGCAAATAT
ACTTATTGATTGCGGCCTGTTTCAAGGCTACAAGCAACTTCGCTTGCGTAACTGGAAAGCGTTGCCATTCGATGCCAAAA
AGATCAACGCTGTCGTTCTCACGCATGCGCACATTGATCATAGCGGCTATCTGCCCCTGCTGGCAAAGAACGGGTTTACC
GCTCCGGTTTACTGCACCACTGCTACACGTGACCTATGCGAAATCCTGCTTCCTGATAGTGGCCAATTACAGGAGGAAGA
GGCGGAATATGCGAATCGGCATGGCTTTTCAAAGCATAAACCCGCTGCTCCCTTATATACCCGCGCTGACGCTGAACGTT
GCTTGCGTTTATTCAAGCCCATCGATTTCGATGAAGAAATTGCTGTAGCCGATGATTTGTCGTTGCGTTTGCGCCCTTCC
GGCCATATTCTGGGTGCGGCATTGGCATGCCTTAACACTGCTCGATCGTCGATTGTTTTTTCAGGTGATCTTGGGCGGCA
AAATGATCTGATCATGCCGGCTCCAGCTTCAGTCGGAGGCGCGGATTACCTGGTGGTAGAGTCGACTTACGGTAACCGGT
CCCATAATCCCTCTGATCCGCAGGATATGCTTGCGGATGTAATTAACCGGACGGTGCAACGTGGTGGTGTCGTCGTTATT
CCCACCTTCGCGGTAGGCCGCGCGCAAAGCCTGCTGTATTACCTTTATCTATTGAAAAAGGCAGGCACTATTCCCCCGGA
ATTGCCTGTTTTTCTGAATAGCCCCATGGCAGTAGACGCGACTGAGATATTTCGCAACCACTTGGATGAGCATCGCTTAT
CTACTGCGGAATGCGAAGCGATGTGCCGAATGTCCCACATAATCACCAGTGGATTGGAATCCAAGAGGTTGAATAACCGC
CCAGGTCCCATGGTAATTCTGGCCGGGAGCGGCATGGCCACCGGCGGACGAGTAGTGCACCACCTCAAGGCGTTTGCTCC
GGATCCGCGCAACACCATTTTATTTTCCGGTTTCCAGGCAGGCGGCACGCGCGGTGCGTCCATGCTGCAGGGGGCAGAAC
AGGTGAAGATTCATGGGCAATATGTGCCCATACGAGCGGAAATTGCGCTGATCGATAATATATCCGCACACGCCGACGCA
AATGAGATCATGATTTGGTTAAAACAATTTAAAACAGCACCACAACGGACTTTTGTCACCCATGGGGAACCTGCTGCAGC
GGACGCACTGCGGCTTCGCATACAGGAAGAACTCCAGTGGGATGCGTATGTGCCCGACTACCTGGAGATTGCTCCGTTTT
AA

Upstream 100 bases:

>100_bases
GTAGCGTATTCTTCCATAAACTCTTACTCTTGCTCATCCGCTCTCTCCTGCGAGGCGGGAGCAATATTTCAAAGGGAAAA
CAATTGACAAAAAAACTGGT

Downstream 100 bases:

>100_bases
ACTCAATCTTGGATGCAGCAAGTATTGTTATGCCTTGAATACTAAGCGCCAGGACACAGGTGACAAATCATCTGGGAGGT
AGTGTTTTATTCCAGTCAGG

Product: beta-lactamase-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MTQLQFLGATGTVTGSKYLLQHEAANILIDCGLFQGYKQLRLRNWKALPFDAKKINAVVLTHAHIDHSGYLPLLAKNGFT
APVYCTTATRDLCEILLPDSGQLQEEEAEYANRHGFSKHKPAAPLYTRADAERCLRLFKPIDFDEEIAVADDLSLRLRPS
GHILGAALACLNTARSSIVFSGDLGRQNDLIMPAPASVGGADYLVVESTYGNRSHNPSDPQDMLADVINRTVQRGGVVVI
PTFAVGRAQSLLYYLYLLKKAGTIPPELPVFLNSPMAVDATEIFRNHLDEHRLSTAECEAMCRMSHIITSGLESKRLNNR
PGPMVILAGSGMATGGRVVHHLKAFAPDPRNTILFSGFQAGGTRGASMLQGAEQVKIHGQYVPIRAEIALIDNISAHADA
NEIMIWLKQFKTAPQRTFVTHGEPAAADALRLRIQEELQWDAYVPDYLEIAPF

Sequences:

>Translated_453_residues
MTQLQFLGATGTVTGSKYLLQHEAANILIDCGLFQGYKQLRLRNWKALPFDAKKINAVVLTHAHIDHSGYLPLLAKNGFT
APVYCTTATRDLCEILLPDSGQLQEEEAEYANRHGFSKHKPAAPLYTRADAERCLRLFKPIDFDEEIAVADDLSLRLRPS
GHILGAALACLNTARSSIVFSGDLGRQNDLIMPAPASVGGADYLVVESTYGNRSHNPSDPQDMLADVINRTVQRGGVVVI
PTFAVGRAQSLLYYLYLLKKAGTIPPELPVFLNSPMAVDATEIFRNHLDEHRLSTAECEAMCRMSHIITSGLESKRLNNR
PGPMVILAGSGMATGGRVVHHLKAFAPDPRNTILFSGFQAGGTRGASMLQGAEQVKIHGQYVPIRAEIALIDNISAHADA
NEIMIWLKQFKTAPQRTFVTHGEPAAADALRLRIQEELQWDAYVPDYLEIAPF
>Mature_452_residues
TQLQFLGATGTVTGSKYLLQHEAANILIDCGLFQGYKQLRLRNWKALPFDAKKINAVVLTHAHIDHSGYLPLLAKNGFTA
PVYCTTATRDLCEILLPDSGQLQEEEAEYANRHGFSKHKPAAPLYTRADAERCLRLFKPIDFDEEIAVADDLSLRLRPSG
HILGAALACLNTARSSIVFSGDLGRQNDLIMPAPASVGGADYLVVESTYGNRSHNPSDPQDMLADVINRTVQRGGVVVIP
TFAVGRAQSLLYYLYLLKKAGTIPPELPVFLNSPMAVDATEIFRNHLDEHRLSTAECEAMCRMSHIITSGLESKRLNNRP
GPMVILAGSGMATGGRVVHHLKAFAPDPRNTILFSGFQAGGTRGASMLQGAEQVKIHGQYVPIRAEIALIDNISAHADAN
EIMIWLKQFKTAPQRTFVTHGEPAAADALRLRIQEELQWDAYVPDYLEIAPF

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI33300633, Length=455, Percent_Identity=26.3736263736264, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI7706427, Length=431, Percent_Identity=27.8422273781903, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI32564696, Length=453, Percent_Identity=28.2560706401766, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI32566029, Length=447, Percent_Identity=26.6219239373602, Blast_Score=145, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6323307, Length=434, Percent_Identity=25.3456221198157, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24648013, Length=456, Percent_Identity=28.7280701754386, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI21358523, Length=452, Percent_Identity=28.0973451327434, Blast_Score=166, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 49705; Mature: 49573

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLQFLGATGTVTGSKYLLQHEAANILIDCGLFQGYKQLRLRNWKALPFDAKKINAVVL
CCCEEEECCCCCCCCCHHHHHHCCCEEEEECHHHHHHHHHHHCCCCCCCCCHHHCEEEEE
THAHIDHSGYLPLLAKNGFTAPVYCTTATRDLCEILLPDSGQLQEEEAEYANRHGFSKHK
EEEEECCCCCCEEEECCCCCCCEEEECCHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCC
PAAPLYTRADAERCLRLFKPIDFDEEIAVADDLSLRLRPSGHILGAALACLNTARSSIVF
CCCCCEEHHHHHHHHHHHCCCCCCCCEEEECCCEEEECCCCCHHHHHHHHHHHHHCCEEE
SGDLGRQNDLIMPAPASVGGADYLVVESTYGNRSHNPSDPQDMLADVINRTVQRGGVVVI
ECCCCCCCCEEECCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEE
PTFAVGRAQSLLYYLYLLKKAGTIPPELPVFLNSPMAVDATEIFRNHLDEHRLSTAECEA
ECCCHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCEECHHHHHHHHHHHHCCCHHHHHH
MCRMSHIITSGLESKRLNNRPGPMVILAGSGMATGGRVVHHLKAFAPDPRNTILFSGFQA
HHHHHHHHHCCHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEEECCCC
GGTRGASMLQGAEQVKIHGQYVPIRAEIALIDNISAHADANEIMIWLKQFKTAPQRTFVT
CCCCCHHHHCCCCEEEEECEEEEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEE
HGEPAAADALRLRIQEELQWDAYVPDYLEIAPF
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TQLQFLGATGTVTGSKYLLQHEAANILIDCGLFQGYKQLRLRNWKALPFDAKKINAVVL
CCEEEECCCCCCCCCHHHHHHCCCEEEEECHHHHHHHHHHHCCCCCCCCCHHHCEEEEE
THAHIDHSGYLPLLAKNGFTAPVYCTTATRDLCEILLPDSGQLQEEEAEYANRHGFSKHK
EEEEECCCCCCEEEECCCCCCCEEEECCHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCC
PAAPLYTRADAERCLRLFKPIDFDEEIAVADDLSLRLRPSGHILGAALACLNTARSSIVF
CCCCCEEHHHHHHHHHHHCCCCCCCCEEEECCCEEEECCCCCHHHHHHHHHHHHHCCEEE
SGDLGRQNDLIMPAPASVGGADYLVVESTYGNRSHNPSDPQDMLADVINRTVQRGGVVVI
ECCCCCCCCEEECCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEE
PTFAVGRAQSLLYYLYLLKKAGTIPPELPVFLNSPMAVDATEIFRNHLDEHRLSTAECEA
ECCCHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCEECHHHHHHHHHHHHCCCHHHHHH
MCRMSHIITSGLESKRLNNRPGPMVILAGSGMATGGRVVHHLKAFAPDPRNTILFSGFQA
HHHHHHHHHCCHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEEECCCC
GGTRGASMLQGAEQVKIHGQYVPIRAEIALIDNISAHADANEIMIWLKQFKTAPQRTFVT
CCCCCHHHHCCCCEEEEECEEEEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEE
HGEPAAADALRLRIQEELQWDAYVPDYLEIAPF
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA