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The map label for this gene is pgl [H]

Identifier: 82702754

GI number: 82702754

Start: 1867229

End: 1867942

Strand: Direct

Name: pgl [H]

Synonym: Nmul_A1628

Alternate gene names: 82702754

Gene position: 1867229-1867942 (Clockwise)

Preceding gene: 82702753

Following gene: 82702756

Centisome position: 58.64

GC content: 54.76

Gene sequence:

>714_bases
ATGGAATCAACCGATCTCCGACAATACAGATGGCATGAATACGCCGACCTGACCGCCCTTCAGGATGCAGCGGTGGCTGC
TATCCTGGATAGCGCCGCCTCTGCCATTCAGGAGCGTGGACGCTTTAATCTCGTTCTTGCCGGGGGTGAATCACCGCGTG
CAATCTATCGGAGATTATGCAGCGCCCCAGCAGATTGGTCTCTCTGGCATATCTATTATGGAGACGAACGCTGCATGCCA
CCCACTCAGGAAGAACTGAATTCCCATATGGTAGAGGAAGCATGGCTTAGCCATGTGCCCATTCCTCCAGTCCAGATTCA
TACCATCCCCAATGGTCCTCGCGCAGATAAAGCTGCGGAAGCGTACGCACAAACACTGCGCGGTGCAGGTTATTTCGACT
TGACGCTGCTCGGGCTCGGTTCGGATGGCCACACCGCAAGCCTGTTCCCGGGTAATGATTGGGGAATGGCGCCGGATTCG
CCCGATACACTGGCAATATTCAATTCCCCCAAGCGGCCCCCACAGCGCGTGTCACTGAGTGCGGCACGTTTAAATCGTTC
GCGAAGGATAATATTTCTGGTAAGCGGTGAATCAAAGCATAAGGCGGTAGCAAGGTGGCGCGCCGGGGAGAATATACCGG
CCAGGGCTATAATGGGAGAAAACGGTGTGGATATACTTGTGGAATCGACGTTACTGTTGCCGTCGAAGGGGTGA

Upstream 100 bases:

>100_bases
CCTGGGTAGCGGAAGATGGGCCGTCCGGCAAGACTGACCAAGCCCCCCATGTCAATGTTCATTATGGTTACACATCAAAA
TAACAAAGGAATCTCTACTG

Downstream 100 bases:

>100_bases
TGGGATTTAAATCAATAAAAAATAAAATAGAAAATAGAGGCAAAAAAAAGGAGTAGAAACTACTCCTTTTTGGATACAAA
CCTGAATCGACATAATTCTC

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MESTDLRQYRWHEYADLTALQDAAVAAILDSAASAIQERGRFNLVLAGGESPRAIYRRLCSAPADWSLWHIYYGDERCMP
PTQEELNSHMVEEAWLSHVPIPPVQIHTIPNGPRADKAAEAYAQTLRGAGYFDLTLLGLGSDGHTASLFPGNDWGMAPDS
PDTLAIFNSPKRPPQRVSLSAARLNRSRRIIFLVSGESKHKAVARWRAGENIPARAIMGENGVDILVESTLLLPSKG

Sequences:

>Translated_237_residues
MESTDLRQYRWHEYADLTALQDAAVAAILDSAASAIQERGRFNLVLAGGESPRAIYRRLCSAPADWSLWHIYYGDERCMP
PTQEELNSHMVEEAWLSHVPIPPVQIHTIPNGPRADKAAEAYAQTLRGAGYFDLTLLGLGSDGHTASLFPGNDWGMAPDS
PDTLAIFNSPKRPPQRVSLSAARLNRSRRIIFLVSGESKHKAVARWRAGENIPARAIMGENGVDILVESTLLLPSKG
>Mature_237_residues
MESTDLRQYRWHEYADLTALQDAAVAAILDSAASAIQERGRFNLVLAGGESPRAIYRRLCSAPADWSLWHIYYGDERCMP
PTQEELNSHMVEEAWLSHVPIPPVQIHTIPNGPRADKAAEAYAQTLRGAGYFDLTLLGLGSDGHTASLFPGNDWGMAPDS
PDTLAIFNSPKRPPQRVSLSAARLNRSRRIIFLVSGESKHKAVARWRAGENIPARAIMGENGVDILVESTLLLPSKG

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=180, Percent_Identity=36.6666666666667, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI6912586, Length=179, Percent_Identity=37.9888268156425, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI115533058, Length=182, Percent_Identity=26.9230769230769, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI115533060, Length=182, Percent_Identity=26.9230769230769, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6321687, Length=178, Percent_Identity=31.4606741573034, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321957, Length=187, Percent_Identity=28.8770053475936, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324362, Length=175, Percent_Identity=29.1428571428571, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24641119, Length=171, Percent_Identity=29.2397660818713, Blast_Score=81, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 26054; Mature: 26054

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESTDLRQYRWHEYADLTALQDAAVAAILDSAASAIQERGRFNLVLAGGESPRAIYRRLC
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHH
SAPADWSLWHIYYGDERCMPPTQEELNSHMVEEAWLSHVPIPPVQIHTIPNGPRADKAAE
CCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHH
AYAQTLRGAGYFDLTLLGLGSDGHTASLFPGNDWGMAPDSPDTLAIFNSPKRPPQRVSLS
HHHHHHCCCCEEEEEEEEECCCCCEEEECCCCCCCCCCCCCCEEEEECCCCCCHHHHHHH
AARLNRSRRIIFLVSGESKHKAVARWRAGENIPARAIMGENGVDILVESTLLLPSKG
HHHCCCCCEEEEEEECCCCHHHHHHHHCCCCCCCEEEECCCCCEEEEEEEEECCCCC
>Mature Secondary Structure
MESTDLRQYRWHEYADLTALQDAAVAAILDSAASAIQERGRFNLVLAGGESPRAIYRRLC
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHH
SAPADWSLWHIYYGDERCMPPTQEELNSHMVEEAWLSHVPIPPVQIHTIPNGPRADKAAE
CCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHH
AYAQTLRGAGYFDLTLLGLGSDGHTASLFPGNDWGMAPDSPDTLAIFNSPKRPPQRVSLS
HHHHHHCCCCEEEEEEEEECCCCCEEEECCCCCCCCCCCCCCEEEEECCCCCCHHHHHHH
AARLNRSRRIIFLVSGESKHKAVARWRAGENIPARAIMGENGVDILVESTLLLPSKG
HHHCCCCCEEEEEEECCCCHHHHHHHHCCCCCCCEEEECCCCCEEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]