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The map label for this gene is yqeC [H]

Identifier: 82702750

GI number: 82702750

Start: 1862756

End: 1863661

Strand: Direct

Name: yqeC [H]

Synonym: Nmul_A1623

Alternate gene names: 82702750

Gene position: 1862756-1863661 (Clockwise)

Preceding gene: 82702749

Following gene: 82702751

Centisome position: 58.5

GC content: 55.74

Gene sequence:

>906_bases
ATGGAACTGGGAATGATTGGATTGGGGCGAATGGGAGGCGCGATGTCGCAACGGCTGCTGCAGGCGGGACACCAGGTGTC
GGGTTACGCCCGCAGCACTGATACCATGAAGCAGTTGGAAGAAAAAGGCCTCGTCGCCGCCTCCTCGGTGGAGGATCTGG
TTAGCAAATTGAAGCCACAACGCATCATCTGGCTGATGATTCCGTCAGGAAAACCGGTGGATGAAACCATCGGCATCTTG
ATGCCGCTGCTGGAGGCTGATGACGTTATCATCGATGGCGGAAACTCGGATTACAAGGATACTCTGCGCCGGGCGGAAAC
GCTCAGGGCACGTCAGATTCACTATGTAGACGTGGGCACCAGCGGCGGTGTCTGGGGCCTTGAAAACGGCTACAGTATGA
TGGTGGGCGGCGACGATGGCGTGGTGTCACACCTGGAACCCCTCTTTGAAACTCTTGCTCCCGGCCCAAATAAAGGATGG
GGTCACGTTGGTCCGTGCGGGGCCGGTCATTTTACCAAAATGATCCACAATGGCATCGAGTACGGAATAATGCAGGCCTA
CGGCGAAGGTTTTGCGATCATGCACCATAAGGAAGAATTCAAGCTGGACTTGCATCAGGTTGCGGAAATCTGGCGCTACG
GCAGCGTGATTCAATCCTGGCTGCTCGATCTGACCGCTGCTGCCCTGGAAAAAAACCCGGGTCTTGAAGGCATTGCACCC
TATGTTGCCGATTCCGGAGAGGGACGCTGGACGGTAGCCGAGGCGATAGACCTGAACGTCGCCGCGCCTGTCATTACCTT
GTCGTTGTTGCAACGATTGCAATCACGGGATTCTGATTCGTTCTCCGACAAGCTGCTATCGGCGCTCCGCAATCAATTCG
GCGGACATGCGATGAAGAAGGAGTAG

Upstream 100 bases:

>100_bases
TGAGGAAAAAGCGCCAGGAAATTCTCACTACCAGCGACCAGACAGCCTGAACCGGTCCAAGATTATTATTCAACAGAGAA
CAATTGCCAAGGGAGGGATC

Downstream 100 bases:

>100_bases
CCGTACGATCAAACCCTTAGACTCCGAAATCTAAAGTTTTCCGAGTAGTTCAACCTTATAAAGCCTCATTTTCCCTTGTC
CCATGGGGTTCCCCAAGTGG

Product: 6-phosphogluconate dehydrogenase-like protein

Products: CO2; Nicotinamide adenine dinucleotide phosphate - reduced; D-Ribulose 5-phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MELGMIGLGRMGGAMSQRLLQAGHQVSGYARSTDTMKQLEEKGLVAASSVEDLVSKLKPQRIIWLMIPSGKPVDETIGIL
MPLLEADDVIIDGGNSDYKDTLRRAETLRARQIHYVDVGTSGGVWGLENGYSMMVGGDDGVVSHLEPLFETLAPGPNKGW
GHVGPCGAGHFTKMIHNGIEYGIMQAYGEGFAIMHHKEEFKLDLHQVAEIWRYGSVIQSWLLDLTAAALEKNPGLEGIAP
YVADSGEGRWTVAEAIDLNVAAPVITLSLLQRLQSRDSDSFSDKLLSALRNQFGGHAMKKE

Sequences:

>Translated_301_residues
MELGMIGLGRMGGAMSQRLLQAGHQVSGYARSTDTMKQLEEKGLVAASSVEDLVSKLKPQRIIWLMIPSGKPVDETIGIL
MPLLEADDVIIDGGNSDYKDTLRRAETLRARQIHYVDVGTSGGVWGLENGYSMMVGGDDGVVSHLEPLFETLAPGPNKGW
GHVGPCGAGHFTKMIHNGIEYGIMQAYGEGFAIMHHKEEFKLDLHQVAEIWRYGSVIQSWLLDLTAAALEKNPGLEGIAP
YVADSGEGRWTVAEAIDLNVAAPVITLSLLQRLQSRDSDSFSDKLLSALRNQFGGHAMKKE
>Mature_301_residues
MELGMIGLGRMGGAMSQRLLQAGHQVSGYARSTDTMKQLEEKGLVAASSVEDLVSKLKPQRIIWLMIPSGKPVDETIGIL
MPLLEADDVIIDGGNSDYKDTLRRAETLRARQIHYVDVGTSGGVWGLENGYSMMVGGDDGVVSHLEPLFETLAPGPNKGW
GHVGPCGAGHFTKMIHNGIEYGIMQAYGEGFAIMHHKEEFKLDLHQVAEIWRYGSVIQSWLLDLTAAALEKNPGLEGIAP
YVADSGEGRWTVAEAIDLNVAAPVITLSLLQRLQSRDSDSFSDKLLSALRNQFGGHAMKKE

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=313, Percent_Identity=35.1437699680511, Blast_Score=144, Evalue=1e-34,
Organism=Escherichia coli, GI1788341, Length=309, Percent_Identity=31.7152103559871, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1786719, Length=198, Percent_Identity=31.8181818181818, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17542558, Length=295, Percent_Identity=35.2542372881356, Blast_Score=158, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6321695, Length=303, Percent_Identity=36.6336633663366, Blast_Score=166, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6321977, Length=306, Percent_Identity=35.2941176470588, Blast_Score=153, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24639279, Length=293, Percent_Identity=35.4948805460751, Blast_Score=144, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44 [C]

Molecular weight: Translated: 32713; Mature: 32713

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELGMIGLGRMGGAMSQRLLQAGHQVSGYARSTDTMKQLEEKGLVAASSVEDLVSKLKPQ
CCCCCCCCCCCCHHHHHHHHHCCCHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCC
RIIWLMIPSGKPVDETIGILMPLLEADDVIIDGGNSDYKDTLRRAETLRARQIHYVDVGT
EEEEEEECCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHEEEEEEECC
SGGVWGLENGYSMMVGGDDGVVSHLEPLFETLAPGPNKGWGHVGPCGAGHFTKMIHNGIE
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
YGIMQAYGEGFAIMHHKEEFKLDLHQVAEIWRYGSVIQSWLLDLTAAALEKNPGLEGIAP
HHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
YVADSGEGRWTVAEAIDLNVAAPVITLSLLQRLQSRDSDSFSDKLLSALRNQFGGHAMKK
HHCCCCCCCEEEHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCC
E
C
>Mature Secondary Structure
MELGMIGLGRMGGAMSQRLLQAGHQVSGYARSTDTMKQLEEKGLVAASSVEDLVSKLKPQ
CCCCCCCCCCCCHHHHHHHHHCCCHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCC
RIIWLMIPSGKPVDETIGILMPLLEADDVIIDGGNSDYKDTLRRAETLRARQIHYVDVGT
EEEEEEECCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHEEEEEEECC
SGGVWGLENGYSMMVGGDDGVVSHLEPLFETLAPGPNKGWGHVGPCGAGHFTKMIHNGIE
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
YGIMQAYGEGFAIMHHKEEFKLDLHQVAEIWRYGSVIQSWLLDLTAAALEKNPGLEGIAP
HHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
YVADSGEGRWTVAEAIDLNVAAPVITLSLLQRLQSRDSDSFSDKLLSALRNQFGGHAMKK
HHCCCCCCCEEEHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-Phospho-D-gluconate; Nicotinamide adenine dinucleotide phosphate [C]

Specific reaction: 6-Phospho-D-gluconate + Nicotinamide adenine dinucleotide phosphate --> CO2 + Nicotinamide adenine dinucleotide phosphate - reduced + D-Ribulose 5-phosphate [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]