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The map label for this gene is csrD [H]

Identifier: 82702688

GI number: 82702688

Start: 1789508

End: 1791619

Strand: Direct

Name: csrD [H]

Synonym: Nmul_A1559

Alternate gene names: 82702688

Gene position: 1789508-1791619 (Clockwise)

Preceding gene: 82702683

Following gene: 82702689

Centisome position: 56.2

GC content: 53.31

Gene sequence:

>2112_bases
ATGTCTCTCTTTCGACAACTATGGTTAGCCGTTATCCTGGTGACCATCACAAGTTTTACCGGTAGTCTTTTTGTAAGTCT
GCTCGGCACACGAAGCTATCTGGAGCAACAGCTTCACCGTAAAAACATCGATAGCGCGAATTCTCTCGCATATTCGATTT
CCCAACTGCGCAAGGACCCTATCACCATTGGTCTTCAAATCGCTGCATTTTTTGATAGTGGCCAATACCAGGCAATCTCC
ATCACCTCCGCCGATGGCAAGTTGATCACAGAACGCGTGCAGAACAAGATAGAAACGACTGTTCCAGGATGGTTCACTCG
TCTCTTTCCAATCAGTGCAGCACCGGGTCAAGCCCAGATATCGGACGCCTTACTGCATTTTGGAGTGATCAAGGTGGTCA
GCCAGGCTCAACTCGCGTATCAGGCACTTTGGGAGCAGGCGAAAACCCTGATGCTCTGGTTTCTGGGGGCAGCGATGGTA
TGCGTGCTGATCGGGGCGATGATATTGCAGCGTATCCACAAACCGCTTGCGGAAATGGTCGAGCAGGCCGATGAGATCAT
AGAACGCCGCTTTCTTACCATTTCAGAACCCCGCATACCGGAACTGCGCAGTCTGGCGCGTGCCACCAATGACATGATCA
GACGCCTGCATAACCGCGGCATCGAAGAAACCAAGCGCCTGGAAGCTTTGCACAAGCGAATAAATTTCGACCCGGTCACA
GGCTTGGCCCGGCGGGAGCACTTCATGAACCAGCTTAGCCAGATTTTGCTTGGGAGGGAAGAAGGCGATGAAATAGAACA
GAAATCCGCGACTGCCAGCGAAGCAGCGCGGGAGACGGTCCAGGATGAGGCCAGAGGGGGAGAATTTCGCCCTACGGGTG
AACACGGCAAGGTTTTCCTGCACGAGGAAAAGGCTTTCGCTTCGACTGCAACCGATGCAGATACGGCCACGGGAAAGGTA
CAAGGCACACGGGGAATTTTTTTTCTTATACGCCTCAATAATCTGGAAGAAATCAACCGCAAACTCGGCAGAGCTGGCGC
AAACGAACTGCTTCATCGGGTTGGCTCACTGATCGCCGGCATCACGGGGGAATTCGAGGAAATCACATCTTCTCCGCCGC
TTGCTGCACGCCTGAATGGCTCGGATTTCGCCCTACTTGCTCCTGATATCAGGAATGCGGCAAAATTTGCCAGGCGCTTG
TCTGAGGAGCTGGCAGCGCTCCCCCTGCGTGACGGTGACAAGATCGCTGATTTCTGTCATATCGGAGCAGTGCCCTATCG
ACGGGGTGATACCCTCAGCGAGCTTCTTTCCAGAGCAGACGCAGCCTTGGCCACGGCGGAGCAGACCGGGGCAAACGCTT
GGCATCTCGCGGCCCCGTCATCGGGACAGACTTCTCCAGTCTCCCTCAATATCTCCGACTGGCGCCACATTTTCAGTGAT
GCTTTGACTGCCAACCGCTTCATGCTGGCTTTCCACCCTGTTATCGATCCCACTGGCGCAGTCCTGCATCAGGAAAGCGT
TGCACGCATGCAAGCTCAACCGGAAGGCGGGTGGCTGGAGGCATCCGACTTTATCAGCATCGCCGCTCGTCTGAATATTA
CCGGCCCCATTGACGTAGCAGTATTGCGTCACGCACTGGAATTCCTCCAATCGAATACCGGCGAGGTCGCGGTTGATTTA
TCGATCGAAACAGTCGCTAACTATCGTTTCCGCAATAAACTTGACGCACTGCTGCACCCCCATCCCGAACTGTGCCGCCG
ACTCTGGATCGAAGTGTCGGAGTATGGCGCTTTTCGCAAGTTTGAAGCCTTCCGCGATTTTTGCCACATTTTTAGGCAGT
TGGGCTGTCACGTTGGTATCAGGGATTTCGGACGTCATCTCGACAGCATTCAAAGTCTCGCCGGGGCAGGGCTAAGCTAT
CTTAAAGTAACCGACAGGTTCATTCACCGCATTAACCAGAATAAAACCAACCAGAAATTCCTGAAAAATCTGTGCGAACA
GGCTCATGCCTTGGGTATGAAAGTGATCGCGCTCGGTGTCCAAAATGAAGTCGAGCGAAAGGCATTGATAAAACTGGGTT
TCGACGGTCTGGCCGGCAAGGGCATAAAATAG

Upstream 100 bases:

>100_bases
CTCAGGAATCCACCCCAGGTTGATAATTCCGTGACGCGCCGCCATCGCACCTGCGCAGGACATTTTCCTGAAGACGCTGT
CTAAAACAATAAGGCGTTCA

Downstream 100 bases:

>100_bases
CTTTTTGATTCAAAAGTACGGCGTTGTGAACGGGGACATTGGGTTTGCGCGTCCAATCGGAACGTGACCCTTTTCCCGGA
GCGGGGTTATACCTGCAGTC

Product: diguanylate cyclase/phosphodiesterase

Products: NA

Alternate protein names: Regulator of CsrB and CsrC decay CsrD [H]

Number of amino acids: Translated: 703; Mature: 702

Protein sequence:

>703_residues
MSLFRQLWLAVILVTITSFTGSLFVSLLGTRSYLEQQLHRKNIDSANSLAYSISQLRKDPITIGLQIAAFFDSGQYQAIS
ITSADGKLITERVQNKIETTVPGWFTRLFPISAAPGQAQISDALLHFGVIKVVSQAQLAYQALWEQAKTLMLWFLGAAMV
CVLIGAMILQRIHKPLAEMVEQADEIIERRFLTISEPRIPELRSLARATNDMIRRLHNRGIEETKRLEALHKRINFDPVT
GLARREHFMNQLSQILLGREEGDEIEQKSATASEAARETVQDEARGGEFRPTGEHGKVFLHEEKAFASTATDADTATGKV
QGTRGIFFLIRLNNLEEINRKLGRAGANELLHRVGSLIAGITGEFEEITSSPPLAARLNGSDFALLAPDIRNAAKFARRL
SEELAALPLRDGDKIADFCHIGAVPYRRGDTLSELLSRADAALATAEQTGANAWHLAAPSSGQTSPVSLNISDWRHIFSD
ALTANRFMLAFHPVIDPTGAVLHQESVARMQAQPEGGWLEASDFISIAARLNITGPIDVAVLRHALEFLQSNTGEVAVDL
SIETVANYRFRNKLDALLHPHPELCRRLWIEVSEYGAFRKFEAFRDFCHIFRQLGCHVGIRDFGRHLDSIQSLAGAGLSY
LKVTDRFIHRINQNKTNQKFLKNLCEQAHALGMKVIALGVQNEVERKALIKLGFDGLAGKGIK

Sequences:

>Translated_703_residues
MSLFRQLWLAVILVTITSFTGSLFVSLLGTRSYLEQQLHRKNIDSANSLAYSISQLRKDPITIGLQIAAFFDSGQYQAIS
ITSADGKLITERVQNKIETTVPGWFTRLFPISAAPGQAQISDALLHFGVIKVVSQAQLAYQALWEQAKTLMLWFLGAAMV
CVLIGAMILQRIHKPLAEMVEQADEIIERRFLTISEPRIPELRSLARATNDMIRRLHNRGIEETKRLEALHKRINFDPVT
GLARREHFMNQLSQILLGREEGDEIEQKSATASEAARETVQDEARGGEFRPTGEHGKVFLHEEKAFASTATDADTATGKV
QGTRGIFFLIRLNNLEEINRKLGRAGANELLHRVGSLIAGITGEFEEITSSPPLAARLNGSDFALLAPDIRNAAKFARRL
SEELAALPLRDGDKIADFCHIGAVPYRRGDTLSELLSRADAALATAEQTGANAWHLAAPSSGQTSPVSLNISDWRHIFSD
ALTANRFMLAFHPVIDPTGAVLHQESVARMQAQPEGGWLEASDFISIAARLNITGPIDVAVLRHALEFLQSNTGEVAVDL
SIETVANYRFRNKLDALLHPHPELCRRLWIEVSEYGAFRKFEAFRDFCHIFRQLGCHVGIRDFGRHLDSIQSLAGAGLSY
LKVTDRFIHRINQNKTNQKFLKNLCEQAHALGMKVIALGVQNEVERKALIKLGFDGLAGKGIK
>Mature_702_residues
SLFRQLWLAVILVTITSFTGSLFVSLLGTRSYLEQQLHRKNIDSANSLAYSISQLRKDPITIGLQIAAFFDSGQYQAISI
TSADGKLITERVQNKIETTVPGWFTRLFPISAAPGQAQISDALLHFGVIKVVSQAQLAYQALWEQAKTLMLWFLGAAMVC
VLIGAMILQRIHKPLAEMVEQADEIIERRFLTISEPRIPELRSLARATNDMIRRLHNRGIEETKRLEALHKRINFDPVTG
LARREHFMNQLSQILLGREEGDEIEQKSATASEAARETVQDEARGGEFRPTGEHGKVFLHEEKAFASTATDADTATGKVQ
GTRGIFFLIRLNNLEEINRKLGRAGANELLHRVGSLIAGITGEFEEITSSPPLAARLNGSDFALLAPDIRNAAKFARRLS
EELAALPLRDGDKIADFCHIGAVPYRRGDTLSELLSRADAALATAEQTGANAWHLAAPSSGQTSPVSLNISDWRHIFSDA
LTANRFMLAFHPVIDPTGAVLHQESVARMQAQPEGGWLEASDFISIAARLNITGPIDVAVLRHALEFLQSNTGEVAVDLS
IETVANYRFRNKLDALLHPHPELCRRLWIEVSEYGAFRKFEAFRDFCHIFRQLGCHVGIRDFGRHLDSIQSLAGAGLSYL
KVTDRFIHRINQNKTNQKFLKNLCEQAHALGMKVIALGVQNEVERKALIKLGFDGLAGKGIK

Specific function: Serves as a specificity factor required for RNase E- mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di- GMP, despite its domain composition. Positively modulates motility ge

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI1789650, Length=385, Percent_Identity=22.3376623376623, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788849, Length=228, Percent_Identity=28.0701754385965, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1787541, Length=386, Percent_Identity=25.3886010362694, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI87081921, Length=376, Percent_Identity=21.5425531914894, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790496, Length=225, Percent_Identity=25.3333333333333, Blast_Score=66, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF [H]

EC number: NA

Molecular weight: Translated: 77983; Mature: 77852

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS50885 HAMP ; PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFRQLWLAVILVTITSFTGSLFVSLLGTRSYLEQQLHRKNIDSANSLAYSISQLRKDP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCC
ITIGLQIAAFFDSGQYQAISITSADGKLITERVQNKIETTVPGWFTRLFPISAAPGQAQI
CEEEEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHH
SDALLHFGVIKVVSQAQLAYQALWEQAKTLMLWFLGAAMVCVLIGAMILQRIHKPLAEMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQADEIIERRFLTISEPRIPELRSLARATNDMIRRLHNRGIEETKRLEALHKRINFDPVT
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHH
GLARREHFMNQLSQILLGREEGDEIEQKSATASEAARETVQDEARGGEFRPTGEHGKVFL
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
HEEKAFASTATDADTATGKVQGTRGIFFLIRLNNLEEINRKLGRAGANELLHRVGSLIAG
EECHHHHHCCCCCCCCCCCEECCCCEEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHH
ITGEFEEITSSPPLAARLNGSDFALLAPDIRNAAKFARRLSEELAALPLRDGDKIADFCH
CCCCHHHHCCCCCCEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
IGAVPYRRGDTLSELLSRADAALATAEQTGANAWHLAAPSSGQTSPVSLNISDWRHIFSD
HCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEHHHHHHHHHH
ALTANRFMLAFHPVIDPTGAVLHQESVARMQAQPEGGWLEASDFISIAARLNITGPIDVA
HHHHCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHH
VLRHALEFLQSNTGEVAVDLSIETVANYRFRNKLDALLHPHPELCRRLWIEVSEYGAFRK
HHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHH
FEAFRDFCHIFRQLGCHVGIRDFGRHLDSIQSLAGAGLSYLKVTDRFIHRINQNKTNQKF
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHH
LKNLCEQAHALGMKVIALGVQNEVERKALIKLGFDGLAGKGIK
HHHHHHHHHHCCHHHEEECCHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SLFRQLWLAVILVTITSFTGSLFVSLLGTRSYLEQQLHRKNIDSANSLAYSISQLRKDP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCC
ITIGLQIAAFFDSGQYQAISITSADGKLITERVQNKIETTVPGWFTRLFPISAAPGQAQI
CEEEEEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHH
SDALLHFGVIKVVSQAQLAYQALWEQAKTLMLWFLGAAMVCVLIGAMILQRIHKPLAEMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQADEIIERRFLTISEPRIPELRSLARATNDMIRRLHNRGIEETKRLEALHKRINFDPVT
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHH
GLARREHFMNQLSQILLGREEGDEIEQKSATASEAARETVQDEARGGEFRPTGEHGKVFL
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
HEEKAFASTATDADTATGKVQGTRGIFFLIRLNNLEEINRKLGRAGANELLHRVGSLIAG
EECHHHHHCCCCCCCCCCCEECCCCEEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHH
ITGEFEEITSSPPLAARLNGSDFALLAPDIRNAAKFARRLSEELAALPLRDGDKIADFCH
CCCCHHHHCCCCCCEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
IGAVPYRRGDTLSELLSRADAALATAEQTGANAWHLAAPSSGQTSPVSLNISDWRHIFSD
HCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEHHHHHHHHHH
ALTANRFMLAFHPVIDPTGAVLHQESVARMQAQPEGGWLEASDFISIAARLNITGPIDVA
HHHHCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHH
VLRHALEFLQSNTGEVAVDLSIETVANYRFRNKLDALLHPHPELCRRLWIEVSEYGAFRK
HHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHH
FEAFRDFCHIFRQLGCHVGIRDFGRHLDSIQSLAGAGLSYLKVTDRFIHRINQNKTNQKF
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHH
LKNLCEQAHALGMKVIALGVQNEVERKALIKLGFDGLAGKGIK
HHHHHHHHHHCCHHHEEECCHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 3049542 [H]