Click here to switch to the map view.

The map label for this gene is nhaA

Identifier: 82702666

GI number: 82702666

Start: 1755374

End: 1757248

Strand: Direct

Name: nhaA

Synonym: Nmul_A1537

Alternate gene names: 82702666

Gene position: 1755374-1757248 (Clockwise)

Preceding gene: 82702665

Following gene: 82702667

Centisome position: 55.13

GC content: 55.68

Gene sequence:

>1875_bases
ATGAATCCTGAACTGCCACCCAATCACCTCGATAAACCGGTCGATGATGCGTATGACCATACGTTGGGACCGGCTGATGC
CGAAATTACCCTGGTCGAATACGGTAGTTATGCGGATGCGCCCTCACGCTCGGCACATGAGCGCGTTGCCGAGTTGCGAA
GCCGGTTCGGCAATCGAATGCGTTATGTATTTCGCCATCGCCCGTTGGCAGGAAGCAAAATTGCGCGGCGTGCGGCTGAG
TTGGTGGAATCACACAACAATTCCGGTCGATTCTGGGATCTGCATGTCGCACTGATGAGCCGCTCTGACAAGCTGAGCGC
AGACGATCTGTGCACCATTATTTCTGATTTGAAGCTGGAGGGGAATAAAGAAGCCGGACAGGAAGAAACAGCAGAAAGAG
CAAGAGATCGCGTAGAAGCGGATATAGCCAGCGCAAACGCGAGCGGTGTCATCGTCACCCCGACATTCTTCATCAACGGC
CGTCGTTACGATGGCCCTTGGGATGTGCGTTCACTCTCTGAGGCAATGCTTGGCTCGCTTGGCCACGTTGTGCATGCTGC
CGCACTGGATTTTGCCAAATGGGCGCCTTCGACCGGAATCATGCTGTTGCTTGCGACCGCGCTCGCAGTTGTTCTGAGCA
ACTCTGCGCTTGGCCCGGATTTCAACGAAATGTGGGAGCAGCGTCTGGGGATTACGTTCCAGCATAGCGCTTTTGAACTT
TCATTGCGTCATTGGATAAATGACGGATTGCTGGTGATCTTTTTCCTGGTTGTCGGCCTCGAAATCAAGCGCGAGTTTAC
CGTGGGGCATCTTGCTGAGCGGCAATCCGCCATGTTGCCAATCGCCGCAGCGATTGGAGGCATGGCTGTCCCCGCCTTGC
TTTACCTGATTCTGGTGCCGCCAGGACCGCCAATGGCTCCGGGATCGGACGGAACCGATGGTGCATGGTCATATGGGTGG
GGTGTCCCGATGGCAACGGATACGGCGTTCGCAATTGCGCTGATCGCCATGATGGGTAAACGCGTTCCTGTCGAGCTACG
TGTCTTTCTTACCGCGGCTGCCATTGTCGATGATATTGGAGCAATCATTGTCGTTGCAATTTTTTATTCGGGTGAACTGC
ATATCGCTTATCTGGGCAGCGCGGTCGCGATTGCGGGCTTACTGGCGCTGCTCAATAAGGGCGGCGTGTATCGGGCATCT
CCATATGTGATTCTCGGAATCGTCCTGTGGGTTTTCGTGTATGCCAGCGGGATACATGCCACGCTTGCAGGCATCATTCT
CGCCTTGTTCATTCCTACGCGCCCGCCGCCTAATCTTCGCGCACTCATGCTGCAAGCGGATGCCATTCTGACCGCCGAAA
CCCGGCGCGGGAGGGAGGTCATGCATTACGGCCCTTCCGAACCCGCACTGGAGGCACTGGATGCCATTCATGACCGCTTG
GAATCTCCCGCTGCTCGCATGCTCCGGCATCTGGCGCCAAGATCGAGCTTTCTGGTATTGCCGGTGTTTGCGCTTGCGAA
TGCAGGAGTGGTTGTAGAGACAAGCGTATTCGGCGAGCACATACCGTTAATGCTCGGCACCGCTACGGCCTTGGTCATCG
GCAAGCCCCTCGGGTTTATCACTGCCACCGTAACCGCTGTTCGACTGGGCTTTGCCACCAAGCCAGATGCCTACTCCTGG
CGACAGCTCGGTGGAGCGGGGGCGCTCGCCGGAATCGGTTTTACCATGTCACTTTTCATAGCCAGTCAGGCCTTCCCCGA
GGTAAGCGATTATGCGGCCGCCAAAATCGCAATTTTCGGTGGATCAATCCTATCGGCAATTATCGGCGTCGCGATACTTT
GGAATGCACAGGCAGAAGAAGAAAAAAATCCATGA

Upstream 100 bases:

>100_bases
TCAATCCCAATTCATCCAGCGGGATAGTAGCAAAAAGCAGGAAACTTCCGGCGCGCCATTGCCAGGAGTGAGCGAATATA
TTTGATACGCTCGATCTCTG

Downstream 100 bases:

>100_bases
GCGTGAATAAAAACGCTCCCGGCGGAAATAGCAGGGAAACGCGGTGGCAGCGAAGCGAAGGTAAAAATGAAGCAGATGAT
GGAATTATTTTCCGAAACAC

Product: Na+/H+ antiporter NhaA

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA

Number of amino acids: Translated: 624; Mature: 624

Protein sequence:

>624_residues
MNPELPPNHLDKPVDDAYDHTLGPADAEITLVEYGSYADAPSRSAHERVAELRSRFGNRMRYVFRHRPLAGSKIARRAAE
LVESHNNSGRFWDLHVALMSRSDKLSADDLCTIISDLKLEGNKEAGQEETAERARDRVEADIASANASGVIVTPTFFING
RRYDGPWDVRSLSEAMLGSLGHVVHAAALDFAKWAPSTGIMLLLATALAVVLSNSALGPDFNEMWEQRLGITFQHSAFEL
SLRHWINDGLLVIFFLVVGLEIKREFTVGHLAERQSAMLPIAAAIGGMAVPALLYLILVPPGPPMAPGSDGTDGAWSYGW
GVPMATDTAFAIALIAMMGKRVPVELRVFLTAAAIVDDIGAIIVVAIFYSGELHIAYLGSAVAIAGLLALLNKGGVYRAS
PYVILGIVLWVFVYASGIHATLAGIILALFIPTRPPPNLRALMLQADAILTAETRRGREVMHYGPSEPALEALDAIHDRL
ESPAARMLRHLAPRSSFLVLPVFALANAGVVVETSVFGEHIPLMLGTATALVIGKPLGFITATVTAVRLGFATKPDAYSW
RQLGGAGALAGIGFTMSLFIASQAFPEVSDYAAAKIAIFGGSILSAIIGVAILWNAQAEEEKNP

Sequences:

>Translated_624_residues
MNPELPPNHLDKPVDDAYDHTLGPADAEITLVEYGSYADAPSRSAHERVAELRSRFGNRMRYVFRHRPLAGSKIARRAAE
LVESHNNSGRFWDLHVALMSRSDKLSADDLCTIISDLKLEGNKEAGQEETAERARDRVEADIASANASGVIVTPTFFING
RRYDGPWDVRSLSEAMLGSLGHVVHAAALDFAKWAPSTGIMLLLATALAVVLSNSALGPDFNEMWEQRLGITFQHSAFEL
SLRHWINDGLLVIFFLVVGLEIKREFTVGHLAERQSAMLPIAAAIGGMAVPALLYLILVPPGPPMAPGSDGTDGAWSYGW
GVPMATDTAFAIALIAMMGKRVPVELRVFLTAAAIVDDIGAIIVVAIFYSGELHIAYLGSAVAIAGLLALLNKGGVYRAS
PYVILGIVLWVFVYASGIHATLAGIILALFIPTRPPPNLRALMLQADAILTAETRRGREVMHYGPSEPALEALDAIHDRL
ESPAARMLRHLAPRSSFLVLPVFALANAGVVVETSVFGEHIPLMLGTATALVIGKPLGFITATVTAVRLGFATKPDAYSW
RQLGGAGALAGIGFTMSLFIASQAFPEVSDYAAAKIAIFGGSILSAIIGVAILWNAQAEEEKNP
>Mature_624_residues
MNPELPPNHLDKPVDDAYDHTLGPADAEITLVEYGSYADAPSRSAHERVAELRSRFGNRMRYVFRHRPLAGSKIARRAAE
LVESHNNSGRFWDLHVALMSRSDKLSADDLCTIISDLKLEGNKEAGQEETAERARDRVEADIASANASGVIVTPTFFING
RRYDGPWDVRSLSEAMLGSLGHVVHAAALDFAKWAPSTGIMLLLATALAVVLSNSALGPDFNEMWEQRLGITFQHSAFEL
SLRHWINDGLLVIFFLVVGLEIKREFTVGHLAERQSAMLPIAAAIGGMAVPALLYLILVPPGPPMAPGSDGTDGAWSYGW
GVPMATDTAFAIALIAMMGKRVPVELRVFLTAAAIVDDIGAIIVVAIFYSGELHIAYLGSAVAIAGLLALLNKGGVYRAS
PYVILGIVLWVFVYASGIHATLAGIILALFIPTRPPPNLRALMLQADAILTAETRRGREVMHYGPSEPALEALDAIHDRL
ESPAARMLRHLAPRSSFLVLPVFALANAGVVVETSVFGEHIPLMLGTATALVIGKPLGFITATVTAVRLGFATKPDAYSW
RQLGGAGALAGIGFTMSLFIASQAFPEVSDYAAAKIAIFGGSILSAIIGVAILWNAQAEEEKNP

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=370, Percent_Identity=41.6216216216216, Blast_Score=237, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA_NITMU (Q2Y8T1)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_412232.1
- ProteinModelPortal:   Q2Y8T1
- SMR:   Q2Y8T1
- STRING:   Q2Y8T1
- GeneID:   3785610
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A1537
- eggNOG:   COG3004
- HOGENOM:   HBG665619
- OMA:   HGFGIPM
- PhylomeDB:   Q2Y8T1
- ProtClustDB:   CLSK746316
- BioCyc:   NMUL323848:NMUL_A1537-MONOMER
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- TIGRFAMs:   TIGR00773

Pfam domain/function: PF06965 Na_H_antiport_1; SSF52833 Thiordxn-like_fd

EC number: NA

Molecular weight: Translated: 66847; Mature: 66847

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x131f6698)-; HASH(0x134ee1e4)-; HASH(0x139d16e4)-; HASH(0x13c7cec0)-; HASH(0x13da4d58)-; HASH(0x13aa42bc)-; HASH(0x13daa7a0)-; HASH(0x13db5adc)-; HASH(0x139ba610)-; HASH(0x13db5b6c)-; HASH(0x1373b448)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPELPPNHLDKPVDDAYDHTLGPADAEITLVEYGSYADAPSRSAHERVAELRSRFGNRM
CCCCCCCCCCCCCCHHHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
RYVFRHRPLAGSKIARRAAELVESHNNSGRFWDLHVALMSRSDKLSADDLCTIISDLKLE
HHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCC
GNKEAGQEETAERARDRVEADIASANASGVIVTPTFFINGRRYDGPWDVRSLSEAMLGSL
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCEECCCCCCHHHHHHHHHHHH
GHVVHAAALDFAKWAPSTGIMLLLATALAVVLSNSALGPDFNEMWEQRLGITFQHSAFEL
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEECHHHHH
SLRHWINDGLLVIFFLVVGLEIKREFTVGHLAERQSAMLPIAAAIGGMAVPALLYLILVP
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
PGPPMAPGSDGTDGAWSYGWGVPMATDTAFAIALIAMMGKRVPVELRVFLTAAAIVDDIG
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
AIIVVAIFYSGELHIAYLGSAVAIAGLLALLNKGGVYRASPYVILGIVLWVFVYASGIHA
HHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHCCHHH
TLAGIILALFIPTRPPPNLRALMLQADAILTAETRRGREVMHYGPSEPALEALDAIHDRL
HHHHHHHHHHCCCCCCCCHHEEEEECCHHEEECCCCCCCCEECCCCCHHHHHHHHHHHHH
ESPAARMLRHLAPRSSFLVLPVFALANAGVVVETSVFGEHIPLMLGTATALVIGKPLGFI
CCHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEEHHHCCCCCHHHHHHHHHHHCCCHHHH
TATVTAVRLGFATKPDAYSWRQLGGAGALAGIGFTMSLFIASQAFPEVSDYAAAKIAIFG
HHHHHHHHHCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHEEEEEC
GSILSAIIGVAILWNAQAEEEKNP
HHHHHHHHHHHHHCCCCCCCCCCH
>Mature Secondary Structure
MNPELPPNHLDKPVDDAYDHTLGPADAEITLVEYGSYADAPSRSAHERVAELRSRFGNRM
CCCCCCCCCCCCCCHHHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
RYVFRHRPLAGSKIARRAAELVESHNNSGRFWDLHVALMSRSDKLSADDLCTIISDLKLE
HHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCC
GNKEAGQEETAERARDRVEADIASANASGVIVTPTFFINGRRYDGPWDVRSLSEAMLGSL
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCEECCCCCCHHHHHHHHHHHH
GHVVHAAALDFAKWAPSTGIMLLLATALAVVLSNSALGPDFNEMWEQRLGITFQHSAFEL
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEECHHHHH
SLRHWINDGLLVIFFLVVGLEIKREFTVGHLAERQSAMLPIAAAIGGMAVPALLYLILVP
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
PGPPMAPGSDGTDGAWSYGWGVPMATDTAFAIALIAMMGKRVPVELRVFLTAAAIVDDIG
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
AIIVVAIFYSGELHIAYLGSAVAIAGLLALLNKGGVYRASPYVILGIVLWVFVYASGIHA
HHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHCCHHH
TLAGIILALFIPTRPPPNLRALMLQADAILTAETRRGREVMHYGPSEPALEALDAIHDRL
HHHHHHHHHHCCCCCCCCHHEEEEECCHHEEECCCCCCCCEECCCCCHHHHHHHHHHHHH
ESPAARMLRHLAPRSSFLVLPVFALANAGVVVETSVFGEHIPLMLGTATALVIGKPLGFI
CCHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEEHHHCCCCCHHHHHHHHHHHCCCHHHH
TATVTAVRLGFATKPDAYSWRQLGGAGALAGIGFTMSLFIASQAFPEVSDYAAAKIAIFG
HHHHHHHHHCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHEEEEEC
GSILSAIIGVAILWNAQAEEEKNP
HHHHHHHHHHHHHCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA