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The map label for this gene is ald [H]

Identifier: 82702284

GI number: 82702284

Start: 1332292

End: 1333413

Strand: Direct

Name: ald [H]

Synonym: Nmul_A1155

Alternate gene names: 82702284

Gene position: 1332292-1333413 (Clockwise)

Preceding gene: 82702283

Following gene: 82702285

Centisome position: 41.84

GC content: 55.88

Gene sequence:

>1122_bases
ATGCCCATGCTGATCGGATTGCCCAAAGAAACGAAAGACCATGAAAACAGAGTAGGCATGACTCCGAGCAATGTCAAAGG
GTTGACGCGACGTGGTCACCGCGTGCTGGTACAAAGCGGAGCAGGAGAAGGAAGTTTTCTTTCGGACGACGAATATCGCT
TGGCAGGGGCTACGATTGTCCCCCGGGCGGAAGATGCGTGGGCAGCGCAGCTCGTGGTCAAGGTCAAGGAACCGACTCCT
GCGGAATACGGTTACCTGCATCGGGACATGATGCTTTTCACTTATCTTCATCTGGCCTCGGACCGCCCTCTTGTCGAGGC
TTTGCTCTCGAGCGGGGTTACAGCTGTGGCTTACGAAACGGTGCAAACCGCAGATGGGAAATTGCCACTGCTGGCGCCCA
TGAGCGAGGTGGCAGGACGCATGGCTACTCAAATCGGGGCGACCTATCTGCAAAAAACACAAGGGGGGCGAGGCGTGTTG
ATGGGAGGTGTCCCTGGTGTGGCCGCGGCCAACGTCGCCATTCTCGGCGCGGGCATCGTGGGAACGAACGCCGCCCGTGT
GGCTGCGGGATGTGGCGCTCAGGTCACCGTGCTGGATGTGAGCCACGACCGTCTGAAATACCTGGATGACATATATCGGG
GGCAATTGCAGACGCGCTTCAGCGATGAATACAATATCGAGGAAGCGGTCTACGACGCCGATCTTGTCATCGGTGCGGTT
TTGATCCCGGGGGGACGAACTCCCTGGCTGGTAACGACGGATATGTTGCCGAAAATGCGAAGAGGATCGGTCATCGTCGA
TGTGGCGGTGGATCAGGGGGGATGCATTGAAACAAGCCGACCTACTACTCATAGCAATCCAACCTATGAGATCGACGGAG
TGGTGCATTATTGTGTTGCGAACATGCCGAGCGCCGTTCCTCGTACCAGTACCTTTGCGCTGAGTATTCAGACGGCGATC
TACGTCGTGCAGCTGGCGGATGAAGGTGTGAATGCGGTCAGAAAAAATCCGGCATTGAAATTCGGAATGAACACGCATCG
CGGAGCGGTCACTTATCCCGCTATTGCACAGGAATTTGATATGCAATATGTCGATCCCTTGCAGGCATTGGGTAATGCCT
GA

Upstream 100 bases:

>100_bases
CGGCTTCCCGGCAACATTTGCGCGCTGTCCCTGCTAATTCTCCAGACTCAGTCATACACAAAAAAACGTTTTCCTCATTC
CCCTGTTACCCCAGTTATAT

Downstream 100 bases:

>100_bases
TCAAAATCCTGACATTGGAAATATCGGGAGAGCAAGATGAAGTTACCCTACTCGACATTTCTCGTCATGCTGTTCGCCCC
GTTGTTCCTGGCAAGCCAGA

Product: alanine dehydrogenase

Products: NA

Alternate protein names: 40 kDa antigen; TB43 [H]

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MPMLIGLPKETKDHENRVGMTPSNVKGLTRRGHRVLVQSGAGEGSFLSDDEYRLAGATIVPRAEDAWAAQLVVKVKEPTP
AEYGYLHRDMMLFTYLHLASDRPLVEALLSSGVTAVAYETVQTADGKLPLLAPMSEVAGRMATQIGATYLQKTQGGRGVL
MGGVPGVAAANVAILGAGIVGTNAARVAAGCGAQVTVLDVSHDRLKYLDDIYRGQLQTRFSDEYNIEEAVYDADLVIGAV
LIPGGRTPWLVTTDMLPKMRRGSVIVDVAVDQGGCIETSRPTTHSNPTYEIDGVVHYCVANMPSAVPRTSTFALSIQTAI
YVVQLADEGVNAVRKNPALKFGMNTHRGAVTYPAIAQEFDMQYVDPLQALGNA

Sequences:

>Translated_373_residues
MPMLIGLPKETKDHENRVGMTPSNVKGLTRRGHRVLVQSGAGEGSFLSDDEYRLAGATIVPRAEDAWAAQLVVKVKEPTP
AEYGYLHRDMMLFTYLHLASDRPLVEALLSSGVTAVAYETVQTADGKLPLLAPMSEVAGRMATQIGATYLQKTQGGRGVL
MGGVPGVAAANVAILGAGIVGTNAARVAAGCGAQVTVLDVSHDRLKYLDDIYRGQLQTRFSDEYNIEEAVYDADLVIGAV
LIPGGRTPWLVTTDMLPKMRRGSVIVDVAVDQGGCIETSRPTTHSNPTYEIDGVVHYCVANMPSAVPRTSTFALSIQTAI
YVVQLADEGVNAVRKNPALKFGMNTHRGAVTYPAIAQEFDMQYVDPLQALGNA
>Mature_372_residues
PMLIGLPKETKDHENRVGMTPSNVKGLTRRGHRVLVQSGAGEGSFLSDDEYRLAGATIVPRAEDAWAAQLVVKVKEPTPA
EYGYLHRDMMLFTYLHLASDRPLVEALLSSGVTAVAYETVQTADGKLPLLAPMSEVAGRMATQIGATYLQKTQGGRGVLM
GGVPGVAAANVAILGAGIVGTNAARVAAGCGAQVTVLDVSHDRLKYLDDIYRGQLQTRFSDEYNIEEAVYDADLVIGAVL
IPGGRTPWLVTTDMLPKMRRGSVIVDVAVDQGGCIETSRPTTHSNPTYEIDGVVHYCVANMPSAVPRTSTFALSIQTAIY
VVQLADEGVNAVRKNPALKFGMNTHRGAVTYPAIAQEFDMQYVDPLQALGNA

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=330, Percent_Identity=30, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI122939153, Length=330, Percent_Identity=30, Blast_Score=130, Evalue=3e-30,
Organism=Escherichia coli, GI1787887, Length=301, Percent_Identity=29.2358803986711, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17550456, Length=350, Percent_Identity=27.1428571428571, Blast_Score=122, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 39885; Mature: 39754

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMLIGLPKETKDHENRVGMTPSNVKGLTRRGHRVLVQSGAGEGSFLSDDEYRLAGATIV
CCCEECCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEEECCCCCCCCCCCCCEEEECCEEE
PRAEDAWAAQLVVKVKEPTPAEYGYLHRDMMLFTYLHLASDRPLVEALLSSGVTAVAYET
CCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEEH
VQTADGKLPLLAPMSEVAGRMATQIGATYLQKTQGGRGVLMGGVPGVAAANVAILGAGIV
HHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHCCEEEEECCEE
GTNAARVAAGCGAQVTVLDVSHDRLKYLDDIYRGQLQTRFSDEYNIEEAVYDADLVIGAV
CCCCHHHHHCCCCEEEEEECCHHHHHHHHHHHHCHHHCCCCCCCCHHHHHHHHHEEEEEE
LIPGGRTPWLVTTDMLPKMRRGSVIVDVAVDQGGCIETSRPTTHSNPTYEIDGVVHYCVA
EECCCCCCEEEEHHHCCHHCCCCEEEEEEECCCCCEECCCCCCCCCCCEEECCHHHHHHH
NMPSAVPRTSTFALSIQTAIYVVQLADEGVNAVRKNPALKFGMNTHRGAVTYPAIAQEFD
CCCCCCCCCCEEEEEEEEEEEEEEECCCCHHHHHCCCCEEECCCCCCCCEECHHHHHHHC
MQYVDPLQALGNA
CHHHHHHHHHCCC
>Mature Secondary Structure 
PMLIGLPKETKDHENRVGMTPSNVKGLTRRGHRVLVQSGAGEGSFLSDDEYRLAGATIV
CCEECCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEEECCCCCCCCCCCCCEEEECCEEE
PRAEDAWAAQLVVKVKEPTPAEYGYLHRDMMLFTYLHLASDRPLVEALLSSGVTAVAYET
CCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEEH
VQTADGKLPLLAPMSEVAGRMATQIGATYLQKTQGGRGVLMGGVPGVAAANVAILGAGIV
HHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHCCEEEEECCEE
GTNAARVAAGCGAQVTVLDVSHDRLKYLDDIYRGQLQTRFSDEYNIEEAVYDADLVIGAV
CCCCHHHHHCCCCEEEEEECCHHHHHHHHHHHHCHHHCCCCCCCCHHHHHHHHHEEEEEE
LIPGGRTPWLVTTDMLPKMRRGSVIVDVAVDQGGCIETSRPTTHSNPTYEIDGVVHYCVA
EECCCCCCEEEEHHHCCHHCCCCEEEEEEECCCCCEECCCCCCCCCCCEEECCHHHHHHH
NMPSAVPRTSTFALSIQTAIYVVQLADEGVNAVRKNPALKFGMNTHRGAVTYPAIAQEFD
CCCCCCCCCCEEEEEEEEEEEEEEECCCCHHHHHCCCCEEECCCCCCCCEECHHHHHHHC
MQYVDPLQALGNA
CHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1587598; 9634230; 12218036; 7822223 [H]