Click here to switch to the map view.

The map label for this gene is fabF [H]

Identifier: 82702205

GI number: 82702205

Start: 1241613

End: 1242860

Strand: Direct

Name: fabF [H]

Synonym: Nmul_A1076

Alternate gene names: 82702205

Gene position: 1241613-1242860 (Clockwise)

Preceding gene: 82702204

Following gene: 82702206

Centisome position: 38.99

GC content: 54.09

Gene sequence:

>1248_bases
TTGTCGAAACGTAGGGTAGTGATCACCGGACTAGGCATAATCTCGCCGGTCGGTAATTCGGTTTCAGATGCCTGGGCCAA
TATTCTTGCCGGAAAATCCGGGGTTACTCGAATCAGCCGTTTCGACTCTTCCCCCTTCGCTTCTCAGATAGCCGGAGAAG
TCAAAGGTTTTGATATCACGAATTATCTTACCGCCAAGGACGCACGTCGAATGGATGTGTTCATTCATTACGGCATGGCT
GCAGGGATTCAGGCGGTAAAGGATGCGGGTATTGGAGACATAGCCGCCAGTAAGCTCGATCCTGAACGAATCGGCGTCAA
TATTGGCTCCGGTATCGGGGGACTGTCCATGATCGAGGGAACGTATGACGCCTATCACGCTGGTGGCGTGCGCAAGATTT
CCCCATTTTTCATTCCCAGCACCATCATCAACATGATCGCAGGTAACCTGTCCATCATGTATGGTTTTCAAGGACCGAAT
CTGGCCATTGTCACCGCTTGCACCACCGCTACCCACTGTGTGGGGGATTCAGCCCGGTTGATAGAATATGGCGATGTGGA
TGTGATGATCGCGGGTGGAGCCGAATCCTGTGTAACGCCCCTGGCGATAGGGGGATTTGCGGCAGCACGGGCGCTTTCCA
CCCGTAATGATGACCCTGCCACTGCCAGTCGGCCATGGGATAAGGGGCGCGATGGTTTTGTCCTGGGCGAGGGAGCCGGT
GTTCTGGTGCTGGAAGAGATGGAGCATGCCCGACGTCGCGGAGCCAGGATTTATGCTGAGCTTGCCGGTTTTGGCATGAG
TGCCGATGCGTACCACATGACTGCACCCTCTGAAGACGGGGAGGGCGCTGCGCGTTGCATGACGAATGCGCTCCGGAATG
CCGGGCTGAACGCAGATGAGGTCGACTATATCAATGCCCATGGTACATCGACGCCATTGGGGGATGTTGCAGAAACCGTT
GCAGTAAAGCGATGCTTTGGAGAGCATGCAAAACAGCTCGTGATGAATTCTACAAAATCCATGACGGGTCATCTGCTCGG
TGCGGCAGGCGGGGTAGAAGCAATATTCAGTGCACTGGCCGTACACCACCAGGTTTCACCTCCCACGATCAATATTTTCG
ATCAGGACCCGGAGTGCGATCTGGATTATGTTCCCAACCATGCGCGAGAAATGAAGATCGATGTGGCAATGTCGAACTCA
TTTGGTTTTGGCGGCACGAATGGCACCTTGATTTTCCGAAGAGCCTGA

Upstream 100 bases:

>100_bases
CGAACAGGCTGAGAAAATAAATACTGTTCAACAGGCAATCGACTATATCAATTCTCACAGCAACTGATTTTGTTTCCAGT
AAATCCATATCGGAGTCATT

Downstream 100 bases:

>100_bases
TTTTTGCTTTGTGGCGAAACTACTGAAGCGCTTCATCCGCGTCATTTTTCTGGGAATGGCGTTCTTTTCCGCATGGGTGG
GGTATAGAGTCAGCAAACCT

Product: beta-ketoacyl synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MSKRRVVITGLGIISPVGNSVSDAWANILAGKSGVTRISRFDSSPFASQIAGEVKGFDITNYLTAKDARRMDVFIHYGMA
AGIQAVKDAGIGDIAASKLDPERIGVNIGSGIGGLSMIEGTYDAYHAGGVRKISPFFIPSTIINMIAGNLSIMYGFQGPN
LAIVTACTTATHCVGDSARLIEYGDVDVMIAGGAESCVTPLAIGGFAAARALSTRNDDPATASRPWDKGRDGFVLGEGAG
VLVLEEMEHARRRGARIYAELAGFGMSADAYHMTAPSEDGEGAARCMTNALRNAGLNADEVDYINAHGTSTPLGDVAETV
AVKRCFGEHAKQLVMNSTKSMTGHLLGAAGGVEAIFSALAVHHQVSPPTINIFDQDPECDLDYVPNHAREMKIDVAMSNS
FGFGGTNGTLIFRRA

Sequences:

>Translated_415_residues
MSKRRVVITGLGIISPVGNSVSDAWANILAGKSGVTRISRFDSSPFASQIAGEVKGFDITNYLTAKDARRMDVFIHYGMA
AGIQAVKDAGIGDIAASKLDPERIGVNIGSGIGGLSMIEGTYDAYHAGGVRKISPFFIPSTIINMIAGNLSIMYGFQGPN
LAIVTACTTATHCVGDSARLIEYGDVDVMIAGGAESCVTPLAIGGFAAARALSTRNDDPATASRPWDKGRDGFVLGEGAG
VLVLEEMEHARRRGARIYAELAGFGMSADAYHMTAPSEDGEGAARCMTNALRNAGLNADEVDYINAHGTSTPLGDVAETV
AVKRCFGEHAKQLVMNSTKSMTGHLLGAAGGVEAIFSALAVHHQVSPPTINIFDQDPECDLDYVPNHAREMKIDVAMSNS
FGFGGTNGTLIFRRA
>Mature_414_residues
SKRRVVITGLGIISPVGNSVSDAWANILAGKSGVTRISRFDSSPFASQIAGEVKGFDITNYLTAKDARRMDVFIHYGMAA
GIQAVKDAGIGDIAASKLDPERIGVNIGSGIGGLSMIEGTYDAYHAGGVRKISPFFIPSTIINMIAGNLSIMYGFQGPNL
AIVTACTTATHCVGDSARLIEYGDVDVMIAGGAESCVTPLAIGGFAAARALSTRNDDPATASRPWDKGRDGFVLGEGAGV
LVLEEMEHARRRGARIYAELAGFGMSADAYHMTAPSEDGEGAARCMTNALRNAGLNADEVDYINAHGTSTPLGDVAETVA
VKRCFGEHAKQLVMNSTKSMTGHLLGAAGGVEAIFSALAVHHQVSPPTINIFDQDPECDLDYVPNHAREMKIDVAMSNSF
GFGGTNGTLIFRRA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=48.0769230769231, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI223972627, Length=145, Percent_Identity=56.551724137931, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI41872631, Length=437, Percent_Identity=24.9427917620137, Blast_Score=102, Evalue=8e-22,
Organism=Escherichia coli, GI1787337, Length=415, Percent_Identity=59.7590361445783, Blast_Score=481, Evalue=1e-137,
Organism=Escherichia coli, GI1788663, Length=413, Percent_Identity=39.7094430992736, Blast_Score=268, Evalue=4e-73,
Organism=Caenorhabditis elegans, GI71983541, Length=415, Percent_Identity=36.6265060240964, Blast_Score=253, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI71983535, Length=255, Percent_Identity=41.5686274509804, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI212642053, Length=431, Percent_Identity=25.5220417633411, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17550940, Length=413, Percent_Identity=23.0024213075061, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=446, Percent_Identity=37.219730941704, Blast_Score=284, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24644341, Length=413, Percent_Identity=43.8256658595642, Blast_Score=351, Evalue=5e-97,
Organism=Drosophila melanogaster, GI19920632, Length=380, Percent_Identity=25.5263157894737, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI221330659, Length=380, Percent_Identity=25.5263157894737, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24581345, Length=427, Percent_Identity=23.4192037470726, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43539; Mature: 43408

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRRVVITGLGIISPVGNSVSDAWANILAGKSGVTRISRFDSSPFASQIAGEVKGFDIT
CCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHCCCCEEH
NYLTAKDARRMDVFIHYGMAAGIQAVKDAGIGDIAASKLDPERIGVNIGSGIGGLSMIEG
HHHCCCCCCEEEEEEEECHHHHHHHHHCCCCCCHHHCCCCHHHHCEECCCCCCCHHHHCC
TYDAYHAGGVRKISPFFIPSTIINMIAGNLSIMYGFQGPNLAIVTACTTATHCVGDSARL
CCHHHHCCCCEECCCEECHHHHHHHHHCCEEEEEECCCCCEEEEEEECHHHHHCCCCCEE
IEYGDVDVMIAGGAESCVTPLAIGGFAAARALSTRNDDPATASRPWDKGRDGFVLGEGAG
EEECCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCC
VLVLEEMEHARRRGARIYAELAGFGMSADAYHMTAPSEDGEGAARCMTNALRNAGLNADE
EEEEHHHHHHHHCCCEEEEHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCC
VDYINAHGTSTPLGDVAETVAVKRCFGEHAKQLVMNSTKSMTGHLLGAAGGVEAIFSALA
CEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHEECCCCHHHHHHHHH
VHHQVSPPTINIFDQDPECDLDYVPNHAREMKIDVAMSNSFGFGGTNGTLIFRRA
HHHCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEEC
>Mature Secondary Structure 
SKRRVVITGLGIISPVGNSVSDAWANILAGKSGVTRISRFDSSPFASQIAGEVKGFDIT
CCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHCCCCEEH
NYLTAKDARRMDVFIHYGMAAGIQAVKDAGIGDIAASKLDPERIGVNIGSGIGGLSMIEG
HHHCCCCCCEEEEEEEECHHHHHHHHHCCCCCCHHHCCCCHHHHCEECCCCCCCHHHHCC
TYDAYHAGGVRKISPFFIPSTIINMIAGNLSIMYGFQGPNLAIVTACTTATHCVGDSARL
CCHHHHCCCCEECCCEECHHHHHHHHHCCEEEEEECCCCCEEEEEEECHHHHHCCCCCEE
IEYGDVDVMIAGGAESCVTPLAIGGFAAARALSTRNDDPATASRPWDKGRDGFVLGEGAG
EEECCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCC
VLVLEEMEHARRRGARIYAELAGFGMSADAYHMTAPSEDGEGAARCMTNALRNAGLNADE
EEEEHHHHHHHHCCCEEEEHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCC
VDYINAHGTSTPLGDVAETVAVKRCFGEHAKQLVMNSTKSMTGHLLGAAGGVEAIFSALA
CEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHEECCCCHHHHHHHHH
VHHQVSPPTINIFDQDPECDLDYVPNHAREMKIDVAMSNSFGFGGTNGTLIFRRA
HHHCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]