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The map label for this gene is nhaA [H]

Identifier: 82702195

GI number: 82702195

Start: 1233764

End: 1234714

Strand: Direct

Name: nhaA [H]

Synonym: Nmul_A1066

Alternate gene names: 82702195

Gene position: 1233764-1234714 (Clockwise)

Preceding gene: 82702194

Following gene: 82702198

Centisome position: 38.75

GC content: 53.1

Gene sequence:

>951_bases
ATGTCTGATTCACAGAATCGAAACGAAGGTTGGGACAGGCAGGTGCTGGAAAAGCTGGTGTTCTCCACCTTGCAGGAACA
GCGCCGCACGCGGCAGTGGGGGGTGTTTTTCAAGTCCCTTACTTTTATCTGGCTGTTTATCCTCCTGTTTTTCGGTCTTG
GCTGGTTTGGAGACAGCAGTATGTCCATTTCCGGCAAGCATACCGCTCTCGTCGATTTGCGCGGTGTAATCTCTCCCGAT
AGCATCAGCAGCGCGGAAAACATCACTGCCGGCCTGCAGCAGGCATTCAAGGACGCAAAAACGCAGGGGGTGATCCTGCG
CATCAACAGTCCCGGGGGGAGTCCCGTTCAGGCAGGATACATCAACGATGAGATACGCCGCCTGCGTGCAGAATATCCTG
AAATACCCCTCTACGCTGTCGTGGAAGATATCTGCGCTTCGGGCGGCTATTATGTAGCGGTTGCCGCCGACAAGATATAT
GTGGACAAGGCAAGTATCATTGGTTCCATCGGCGTCCTGATAAACGGGTTCGGTTTTACAAAAGCAATGGAAAAACTTGG
CATCGAAAGGCGCTTGATCACGGCAGGAGAAAACAAGGCTTTTCTCGATCCATTTTCTCCCAACAATCGCGAGCAGGAGG
AATATGCCAAGAAAATGCTGGGTGATATCCATGAGCAATTCATTCAGGTAGTTCAGCAAGGCCGGGGCGAACGCCTGAAG
GAAAAGCCGGAAATATTCAGCGGCAAGGTGTGGACAGGTCAAAAAAGTGTCGAACTGGGACTTGCTGACGGAATGGGCAG
CGCGGAATACGTGGCGCGGGAAATTATCAAGGCGGAACACATCGTCGACTATACGACCCGGGAGGGAGTTGCCGAGCGCC
TCGCCAAACGCTTTGGAGGAGTCCTGGCGGAAACGCTGAGTGGTTTGGGAATGAGTGCGGAACTCCACTAA

Upstream 100 bases:

>100_bases
TGTAGCCGGAGGCGGAAACAACGAGCAGTTTTGGCAGTTTCATATTTTGGCCTGTCGCTGCGGCAGGGCGCTTTATTTGA
CTTGAAGGATCAAAATAATC

Downstream 100 bases:

>100_bases
CCCGGATATTTCGCCGGAGCACCCTCGGGGCGACCGTGGCGGGTGGAGCAGTAGCTTCCGAAGGAAGATTCGATCCCGAA
ACGGGAAACTGCAAGGCGAC

Product: peptidase S49

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MSDSQNRNEGWDRQVLEKLVFSTLQEQRRTRQWGVFFKSLTFIWLFILLFFGLGWFGDSSMSISGKHTALVDLRGVISPD
SISSAENITAGLQQAFKDAKTQGVILRINSPGGSPVQAGYINDEIRRLRAEYPEIPLYAVVEDICASGGYYVAVAADKIY
VDKASIIGSIGVLINGFGFTKAMEKLGIERRLITAGENKAFLDPFSPNNREQEEYAKKMLGDIHEQFIQVVQQGRGERLK
EKPEIFSGKVWTGQKSVELGLADGMGSAEYVAREIIKAEHIVDYTTREGVAERLAKRFGGVLAETLSGLGMSAELH

Sequences:

>Translated_316_residues
MSDSQNRNEGWDRQVLEKLVFSTLQEQRRTRQWGVFFKSLTFIWLFILLFFGLGWFGDSSMSISGKHTALVDLRGVISPD
SISSAENITAGLQQAFKDAKTQGVILRINSPGGSPVQAGYINDEIRRLRAEYPEIPLYAVVEDICASGGYYVAVAADKIY
VDKASIIGSIGVLINGFGFTKAMEKLGIERRLITAGENKAFLDPFSPNNREQEEYAKKMLGDIHEQFIQVVQQGRGERLK
EKPEIFSGKVWTGQKSVELGLADGMGSAEYVAREIIKAEHIVDYTTREGVAERLAKRFGGVLAETLSGLGMSAELH
>Mature_315_residues
SDSQNRNEGWDRQVLEKLVFSTLQEQRRTRQWGVFFKSLTFIWLFILLFFGLGWFGDSSMSISGKHTALVDLRGVISPDS
ISSAENITAGLQQAFKDAKTQGVILRINSPGGSPVQAGYINDEIRRLRAEYPEIPLYAVVEDICASGGYYVAVAADKIYV
DKASIIGSIGVLINGFGFTKAMEKLGIERRLITAGENKAFLDPFSPNNREQEEYAKKMLGDIHEQFIQVVQQGRGERLKE
KPEIFSGKVWTGQKSVELGLADGMGSAEYVAREIIKAEHIVDYTTREGVAERLAKRFGGVLAETLSGLGMSAELH

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=243, Percent_Identity=32.9218106995885, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788064, Length=184, Percent_Identity=27.7173913043478, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 35022; Mature: 34891

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSQNRNEGWDRQVLEKLVFSTLQEQRRTRQWGVFFKSLTFIWLFILLFFGLGWFGDSS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
MSISGKHTALVDLRGVISPDSISSAENITAGLQQAFKDAKTQGVILRINSPGGSPVQAGY
CEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
INDEIRRLRAEYPEIPLYAVVEDICASGGYYVAVAADKIYVDKASIIGSIGVLINGFGFT
CHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEECEEEEHHHHHHHHHHHHHCCCCHH
KAMEKLGIERRLITAGENKAFLDPFSPNNREQEEYAKKMLGDIHEQFIQVVQQGRGERLK
HHHHHHCCHHEEEECCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
EKPEIFSGKVWTGQKSVELGLADGMGSAEYVAREIIKAEHIVDYTTREGVAERLAKRFGG
CCCCHHCCCEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLAETLSGLGMSAELH
HHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SDSQNRNEGWDRQVLEKLVFSTLQEQRRTRQWGVFFKSLTFIWLFILLFFGLGWFGDSS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
MSISGKHTALVDLRGVISPDSISSAENITAGLQQAFKDAKTQGVILRINSPGGSPVQAGY
CEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
INDEIRRLRAEYPEIPLYAVVEDICASGGYYVAVAADKIYVDKASIIGSIGVLINGFGFT
CHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEECEEEEHHHHHHHHHHHHHCCCCHH
KAMEKLGIERRLITAGENKAFLDPFSPNNREQEEYAKKMLGDIHEQFIQVVQQGRGERLK
HHHHHHCCHHEEEECCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
EKPEIFSGKVWTGQKSVELGLADGMGSAEYVAREIIKAEHIVDYTTREGVAERLAKRFGG
CCCCHHCCCEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLAETLSGLGMSAELH
HHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA