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The map label for this gene is ubiB [H]

Identifier: 82702117

GI number: 82702117

Start: 1146418

End: 1147932

Strand: Reverse

Name: ubiB [H]

Synonym: Nmul_A0988

Alternate gene names: 82702117

Gene position: 1147932-1146418 (Counterclockwise)

Preceding gene: 82702118

Following gene: 82702114

Centisome position: 36.05

GC content: 56.17

Gene sequence:

>1515_bases
ATGCGTTTCTTCCGTCTTCTCAAAATACTCGCCGTCTCATTCCGTTTCGGCCTCGACGAATTCTTCCTGAGCCACGAACG
TCTGCGCCTACTGCGGCCTGTCGTCAGAACGGCAACGTTCTGGCGTAAACTGGATCGTGCGCGGGGCGAACGTCTCCGCC
TCGCCCTGGAGGCTCTGGGTCCCATCTTCGTCAAGTTCGGCCAGATGCTCTCTACCCGGCGGGATCTTCTGCCGCCCGAT
ATCGCCGACGAACTGGCGAAACTACAGGATCAGGTTCCACCATTTCCCTCCAGCATTGCCCTCAAGACACTGGAAGAGGT
CTACGGAAAACCCGTCAACGAAGTTTTTCTGCTGTTCGATGTGGAGCCGGTAGCAAGCGCGTCCATTGCCCAGGTTCATC
TGGCAGTGCTGCATGATGGTACGGAAGTCGCAGTCAAGGTGCTGCGTCCCGGCATCGCGCCTGTGATCGCCCATGATATC
GCGCTGATGGACACAGGCGCTCTTTTGCTCGAAATAGTCTGGCCGGATGCCAAGCGGCTCAAGGTACGGGAAGTTGTGAC
TGAATTCGCCCGTCATCTCGATGACGAACTGGATCTCATGCGCGAAGCCTCCAATTGCAGCCAGTTGCGGCGCAATTTCC
TGGATTCTCCCCTGCTTCTGGTTCCGGAAGTCTACTGGGATTACTGCTATTCGAGCGTCATGGTGATGCAGCGCGTCAAA
GGCACGCCCATCAGTCATGTCACAGCCTTGCGGGAGCAGGGCGTGGATATTCCGCGACTTGCCCGCGTCGGCGTGGAAAT
CTTTTTCACCCAGGTATTCCGCGATGGCTATTTTCATGCCGACATGCATCCGGGAAACATCTTTGTCGGCAAGGACGGCC
GGTATATCGCTGTCGACTTCGGCATAATGGGAACCCTTACCGACGAAGACAAGAATTATCTCGCGCAGAATTTCCTGGCT
TTCTTCCGCCGTGACTACAAGCGTGTGGCGGAAGCGCACGTGGAGGCGGGATGGGCGCCGAAAAACACGCGAGTCAATGA
TTTCGAAACCGCTATCCGGGCAGTATGCGAACCTATTTTCGACAAGCCCTTGAGCGAGATTTCATTTGGGCGGGTATTGC
TGCGGCTGTTTCAAACGTCGCGCCAGTTCAATGTCGAAATCCAGCCGCAGCTCGTGATGCTGCAAAAAACCCTGCTCAAT
ATCGAGGGGCTGGGGCGGGACCTCGACCCTAATCTCGACCTGTGGACGACAGCCAAGCCGTACCTGGAAAACTGGATGGC
GGAGCAGTTGGGCTGGAGAGGGCTCAGCCGCCGCCTGCGCAAGGAAGCCACGAGTTGGGCGGTAATCATGCCCCAGTTTC
CCCGCCTGATGCATCATGCCCTGACGGAAATACGTACCAGCGCTCTGGAAGAAAAGATGGACCAGTTCATCCTGGAGAAA
AAACGTGAGACCCGGCGCCTCACCATCTTCATCGTATTACTGATCATAGTGATACTGTGGCATCTGGGAAAATAA

Upstream 100 bases:

>100_bases
TGCGCGTGGAAGGCCTCATAAACAAGTCCTTATAAGTGAACTGAGAAGAAGGAATATCTGGGCAAATCCCTGAGCGAATC
GGGGTAGCAGAATAGAATAA

Downstream 100 bases:

>100_bases
GGGCGGTTTTTGCATACTCGCGAGAGCATGAACACCCCTTATTGAAAATGGAAGAATCGCAGTCCGGGAACCTCCCGGTC
AGGGCGTAATAGAAGGTGTC

Product: putative ubiquinone biosynthesis protein UbiB

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MRFFRLLKILAVSFRFGLDEFFLSHERLRLLRPVVRTATFWRKLDRARGERLRLALEALGPIFVKFGQMLSTRRDLLPPD
IADELAKLQDQVPPFPSSIALKTLEEVYGKPVNEVFLLFDVEPVASASIAQVHLAVLHDGTEVAVKVLRPGIAPVIAHDI
ALMDTGALLLEIVWPDAKRLKVREVVTEFARHLDDELDLMREASNCSQLRRNFLDSPLLLVPEVYWDYCYSSVMVMQRVK
GTPISHVTALREQGVDIPRLARVGVEIFFTQVFRDGYFHADMHPGNIFVGKDGRYIAVDFGIMGTLTDEDKNYLAQNFLA
FFRRDYKRVAEAHVEAGWAPKNTRVNDFETAIRAVCEPIFDKPLSEISFGRVLLRLFQTSRQFNVEIQPQLVMLQKTLLN
IEGLGRDLDPNLDLWTTAKPYLENWMAEQLGWRGLSRRLRKEATSWAVIMPQFPRLMHHALTEIRTSALEEKMDQFILEK
KRETRRLTIFIVLLIIVILWHLGK

Sequences:

>Translated_504_residues
MRFFRLLKILAVSFRFGLDEFFLSHERLRLLRPVVRTATFWRKLDRARGERLRLALEALGPIFVKFGQMLSTRRDLLPPD
IADELAKLQDQVPPFPSSIALKTLEEVYGKPVNEVFLLFDVEPVASASIAQVHLAVLHDGTEVAVKVLRPGIAPVIAHDI
ALMDTGALLLEIVWPDAKRLKVREVVTEFARHLDDELDLMREASNCSQLRRNFLDSPLLLVPEVYWDYCYSSVMVMQRVK
GTPISHVTALREQGVDIPRLARVGVEIFFTQVFRDGYFHADMHPGNIFVGKDGRYIAVDFGIMGTLTDEDKNYLAQNFLA
FFRRDYKRVAEAHVEAGWAPKNTRVNDFETAIRAVCEPIFDKPLSEISFGRVLLRLFQTSRQFNVEIQPQLVMLQKTLLN
IEGLGRDLDPNLDLWTTAKPYLENWMAEQLGWRGLSRRLRKEATSWAVIMPQFPRLMHHALTEIRTSALEEKMDQFILEK
KRETRRLTIFIVLLIIVILWHLGK
>Mature_504_residues
MRFFRLLKILAVSFRFGLDEFFLSHERLRLLRPVVRTATFWRKLDRARGERLRLALEALGPIFVKFGQMLSTRRDLLPPD
IADELAKLQDQVPPFPSSIALKTLEEVYGKPVNEVFLLFDVEPVASASIAQVHLAVLHDGTEVAVKVLRPGIAPVIAHDI
ALMDTGALLLEIVWPDAKRLKVREVVTEFARHLDDELDLMREASNCSQLRRNFLDSPLLLVPEVYWDYCYSSVMVMQRVK
GTPISHVTALREQGVDIPRLARVGVEIFFTQVFRDGYFHADMHPGNIFVGKDGRYIAVDFGIMGTLTDEDKNYLAQNFLA
FFRRDYKRVAEAHVEAGWAPKNTRVNDFETAIRAVCEPIFDKPLSEISFGRVLLRLFQTSRQFNVEIQPQLVMLQKTLLN
IEGLGRDLDPNLDLWTTAKPYLENWMAEQLGWRGLSRRLRKEATSWAVIMPQFPRLMHHALTEIRTSALEEKMDQFILEK
KRETRRLTIFIVLLIIVILWHLGK

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=277, Percent_Identity=31.0469314079422, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI41393593, Length=332, Percent_Identity=31.0240963855422, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI217035081, Length=228, Percent_Identity=31.140350877193, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI32261307, Length=385, Percent_Identity=27.012987012987, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI34147522, Length=252, Percent_Identity=28.968253968254, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI27363457, Length=210, Percent_Identity=29.0476190476191, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI217416386, Length=186, Percent_Identity=27.9569892473118, Blast_Score=76, Evalue=8e-14,
Organism=Escherichia coli, GI2367309, Length=468, Percent_Identity=53.4188034188034, Blast_Score=491, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17559152, Length=283, Percent_Identity=26.1484098939929, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI32565180, Length=319, Percent_Identity=26.6457680250784, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17555620, Length=482, Percent_Identity=22.1991701244813, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325148, Length=437, Percent_Identity=25.629290617849, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323282, Length=254, Percent_Identity=27.1653543307087, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321319, Length=301, Percent_Identity=24.9169435215947, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI22024280, Length=282, Percent_Identity=29.0780141843972, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24662575, Length=299, Percent_Identity=28.4280936454849, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI18859849, Length=202, Percent_Identity=30.1980198019802, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 58130; Mature: 58130

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFFRLLKILAVSFRFGLDEFFLSHERLRLLRPVVRTATFWRKLDRARGERLRLALEALG
CHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
PIFVKFGQMLSTRRDLLPPDIADELAKLQDQVPPFPSSIALKTLEEVYGKPVNEVFLLFD
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHEEEEEE
VEPVASASIAQVHLAVLHDGTEVAVKVLRPGIAPVIAHDIALMDTGALLLEIVWPDAKRL
CCHHHCHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHEEECCCHHHH
KVREVVTEFARHLDDELDLMREASNCSQLRRNFLDSPLLLVPEVYWDYCYSSVMVMQRVK
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHC
GTPISHVTALREQGVDIPRLARVGVEIFFTQVFRDGYFHADMHPGNIFVGKDGRYIAVDF
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEECCCCCEEEEEC
GIMGTLTDEDKNYLAQNFLAFFRRDYKRVAEAHVEAGWAPKNTRVNDFETAIRAVCEPIF
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
DKPLSEISFGRVLLRLFQTSRQFNVEIQPQLVMLQKTLLNIEGLGRDLDPNLDLWTTAKP
CCCHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHCCCCCCCCCCEECCCHH
YLENWMAEQLGWRGLSRRLRKEATSWAVIMPQFPRLMHHALTEIRTSALEEKMDQFILEK
HHHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRETRRLTIFIVLLIIVILWHLGK
HHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRFFRLLKILAVSFRFGLDEFFLSHERLRLLRPVVRTATFWRKLDRARGERLRLALEALG
CHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
PIFVKFGQMLSTRRDLLPPDIADELAKLQDQVPPFPSSIALKTLEEVYGKPVNEVFLLFD
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHEEEEEE
VEPVASASIAQVHLAVLHDGTEVAVKVLRPGIAPVIAHDIALMDTGALLLEIVWPDAKRL
CCHHHCHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHEEECCCHHHH
KVREVVTEFARHLDDELDLMREASNCSQLRRNFLDSPLLLVPEVYWDYCYSSVMVMQRVK
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHC
GTPISHVTALREQGVDIPRLARVGVEIFFTQVFRDGYFHADMHPGNIFVGKDGRYIAVDF
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEECCCCCEEEEEC
GIMGTLTDEDKNYLAQNFLAFFRRDYKRVAEAHVEAGWAPKNTRVNDFETAIRAVCEPIF
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
DKPLSEISFGRVLLRLFQTSRQFNVEIQPQLVMLQKTLLNIEGLGRDLDPNLDLWTTAKP
CCCHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHCCCCCCCCCCEECCCHH
YLENWMAEQLGWRGLSRRLRKEATSWAVIMPQFPRLMHHALTEIRTSALEEKMDQFILEK
HHHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRETRRLTIFIVLLIIVILWHLGK
HHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA