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The map label for this gene is apt

Identifier: 82702064

GI number: 82702064

Start: 1082641

End: 1083168

Strand: Direct

Name: apt

Synonym: Nmul_A0935

Alternate gene names: 82702064

Gene position: 1082641-1083168 (Clockwise)

Preceding gene: 82702059

Following gene: 82702065

Centisome position: 34.0

GC content: 57.95

Gene sequence:

>528_bases
ATGCAGATCAAATCCCGCATCCGCACCATCGCGCATTATCCCCATGAAGGCATCATGTTTCGTGATATCACCACTTTGCT
GAAAGACCCGGTGGGGTTGCGCGCGACTATTCAGGAAATCGCCAGCCGCTACAAGAGCATGAAAATCGATAAAGTGGCTG
GAATCGAGTCACGCGGCTTCATCATTGGCGCGCCGGTTGCCTACGAGCTTGGTGTGGGATTTGTGCCGGTGCGCAAGAAG
GGCAAGCTGCCTGCCGAAACGCGGGGGCGCGATTATCAGCTGGAATATGGCAGCGACCGCATCGAGATTCACGTGGATGC
GATTCAGAAGGGCGACCGGGTGCTGCTGGTGGATGATCTGATCGCTACCGGCGGGACGGCGGAGGCTGCCGCTGGCTTGA
TTCATGAGATGGGCGGCGAGGTGGTGGAGTGCAGCTTTGTCATTGATCTGCCGGATATCGGGGGCAGGGCGCGGCTGGAA
GATCAGGGCCTCAAGGTGTTTGCACTGTGCGAGTTTGAGGGGAACTAA

Upstream 100 bases:

>100_bases
GCTATCCCCGGCAACTTTACGGTAGTATAGCCGAAAGCGGCTCATCCGTATCGACGGCCCTTGAATCCTTTGACTCAAAA
AACCAGAAACAGGAAGTAGC

Downstream 100 bases:

>100_bases
ACTCTGCCGGGATGGAGTCTATAATGATTTATATAAACGCATTATCTATGGTTAAGAAGGATACTCATAGTGTGTGTTGT
CCTGTTATTGATCTTCATGC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 175; Mature: 175

Protein sequence:

>175_residues
MQIKSRIRTIAHYPHEGIMFRDITTLLKDPVGLRATIQEIASRYKSMKIDKVAGIESRGFIIGAPVAYELGVGFVPVRKK
GKLPAETRGRDYQLEYGSDRIEIHVDAIQKGDRVLLVDDLIATGGTAEAAAGLIHEMGGEVVECSFVIDLPDIGGRARLE
DQGLKVFALCEFEGN

Sequences:

>Translated_175_residues
MQIKSRIRTIAHYPHEGIMFRDITTLLKDPVGLRATIQEIASRYKSMKIDKVAGIESRGFIIGAPVAYELGVGFVPVRKK
GKLPAETRGRDYQLEYGSDRIEIHVDAIQKGDRVLLVDDLIATGGTAEAAAGLIHEMGGEVVECSFVIDLPDIGGRARLE
DQGLKVFALCEFEGN
>Mature_175_residues
MQIKSRIRTIAHYPHEGIMFRDITTLLKDPVGLRATIQEIASRYKSMKIDKVAGIESRGFIIGAPVAYELGVGFVPVRKK
GKLPAETRGRDYQLEYGSDRIEIHVDAIQKGDRVLLVDDLIATGGTAEAAAGLIHEMGGEVVECSFVIDLPDIGGRARLE
DQGLKVFALCEFEGN

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=174, Percent_Identity=43.1034482758621, Blast_Score=148, Evalue=3e-36,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=47.2, Blast_Score=120, Evalue=6e-28,
Organism=Escherichia coli, GI1786675, Length=173, Percent_Identity=55.4913294797688, Blast_Score=199, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI17509087, Length=165, Percent_Identity=46.0606060606061, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6323619, Length=162, Percent_Identity=40.7407407407407, Blast_Score=118, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6320649, Length=162, Percent_Identity=35.8024691358025, Blast_Score=96, Evalue=4e-21,
Organism=Drosophila melanogaster, GI17136334, Length=173, Percent_Identity=42.1965317919075, Blast_Score=121, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_NITMU (Q2YAI3)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411630.1
- HSSP:   P07741
- ProteinModelPortal:   Q2YAI3
- SMR:   Q2YAI3
- STRING:   Q2YAI3
- GeneID:   3785195
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A0935
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- PhylomeDB:   Q2YAI3
- ProtClustDB:   PRK02304
- BioCyc:   NMUL323848:NMUL_A0935-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19182; Mature: 19182

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIKSRIRTIAHYPHEGIMFRDITTLLKDPVGLRATIQEIASRYKSMKIDKVAGIESRGF
CCHHHHHHHHHHCCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHCCCCCCCE
IIGAPVAYELGVGFVPVRKKGKLPAETRGRDYQLEYGSDRIEIHVDAIQKGDRVLLVDDL
EEECCCHHHCCCCEEEECCCCCCCCCCCCCEEEEEECCCEEEEEEEEECCCCEEEEEECH
IATGGTAEAAAGLIHEMGGEVVECSFVIDLPDIGGRARLEDQGLKVFALCEFEGN
HCCCCCHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCEECCCCCEEEEEEEECCC
>Mature Secondary Structure
MQIKSRIRTIAHYPHEGIMFRDITTLLKDPVGLRATIQEIASRYKSMKIDKVAGIESRGF
CCHHHHHHHHHHCCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHCCCCCCCE
IIGAPVAYELGVGFVPVRKKGKLPAETRGRDYQLEYGSDRIEIHVDAIQKGDRVLLVDDL
EEECCCHHHCCCCEEEECCCCCCCCCCCCCEEEEEECCCEEEEEEEEECCCCEEEEEECH
IATGGTAEAAAGLIHEMGGEVVECSFVIDLPDIGGRARLEDQGLKVFALCEFEGN
HCCCCCHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCEECCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA