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The map label for this gene is folK [H]

Identifier: 82702010

GI number: 82702010

Start: 1001609

End: 1002121

Strand: Reverse

Name: folK [H]

Synonym: Nmul_A0881

Alternate gene names: 82702010

Gene position: 1002121-1001609 (Counterclockwise)

Preceding gene: 82702011

Following gene: 82702009

Centisome position: 31.47

GC content: 56.92

Gene sequence:

>513_bases
ATGAACGGGGCTGACGACGTTCGAATCGCCTCGCATGCGTATATCGGATTGGGTAGTAATCTGGATGAACCTGTAGCGCA
TGTGCAAAAAGCGTTTGAAGAACTGGGTGAGCTTCCTTTTACGCGCTTGCAGGCGCGTTCTTCGCTCTACCGCAGCGCCC
CGATGGGACGCCTGGACCAGCCTGATTTCATCAACGCAGTCGCGCATATCGAAACCGCCCTGCCACCCCGGGATCTGCTG
AAAGCCCTGCTCGGGATCGAGCAAAAGCACGGGCGGATGCGCGAGTATCTCAATGCGCCGCGCACACTCGATCTCGACTT
GCTGCTGTACGATGACCTGCAACTGAATGAGGATAGCCTGATTCTGCCTCATCCGAGGATGCACGAACGGGCATTCGTAT
TGCAGCCCCTGCTCGAAATTGCGTCGATCAGCAGCATACCGGGACACGACAACATAAGGGAATTGCTTGCTGCCTGTAAG
GGACAGCGGCTGGAACGCGAGCTGGACACGTGA

Upstream 100 bases:

>100_bases
AGAAGAGACGCAGGAGAAACCGTGGCCGTAAAAAATCGGGCATTCTCCCTGCAGGCGAGAGCGACCGCGGAGTATCCGGG
AAGCAGGATGGTTCTGCCCC

Downstream 100 bases:

>100_bases
AACTTGAGGAATATCGCCACATCGCGGTGGAAGGCCCCATCGGCGTGGGAAAAACCAGCCTGGCGCGACGAATGGCGGAG
TATGCGGGTGGACAGCTCCT

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MNGADDVRIASHAYIGLGSNLDEPVAHVQKAFEELGELPFTRLQARSSLYRSAPMGRLDQPDFINAVAHIETALPPRDLL
KALLGIEQKHGRMREYLNAPRTLDLDLLLYDDLQLNEDSLILPHPRMHERAFVLQPLLEIASISSIPGHDNIRELLAACK
GQRLERELDT

Sequences:

>Translated_170_residues
MNGADDVRIASHAYIGLGSNLDEPVAHVQKAFEELGELPFTRLQARSSLYRSAPMGRLDQPDFINAVAHIETALPPRDLL
KALLGIEQKHGRMREYLNAPRTLDLDLLLYDDLQLNEDSLILPHPRMHERAFVLQPLLEIASISSIPGHDNIRELLAACK
GQRLERELDT
>Mature_170_residues
MNGADDVRIASHAYIGLGSNLDEPVAHVQKAFEELGELPFTRLQARSSLYRSAPMGRLDQPDFINAVAHIETALPPRDLL
KALLGIEQKHGRMREYLNAPRTLDLDLLLYDDLQLNEDSLILPHPRMHERAFVLQPLLEIASISSIPGHDNIRELLAACK
GQRLERELDT

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=155, Percent_Identity=39.3548387096774, Blast_Score=114, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324073, Length=155, Percent_Identity=36.1290322580645, Blast_Score=101, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19119; Mature: 19119

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGADDVRIASHAYIGLGSNLDEPVAHVQKAFEELGELPFTRLQARSSLYRSAPMGRLDQ
CCCCCCCEEHHHEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCC
PDFINAVAHIETALPPRDLLKALLGIEQKHGRMREYLNAPRTLDLDLLLYDDLQLNEDSL
CHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEECCCEECCCCE
ILPHPRMHERAFVLQPLLEIASISSIPGHDNIRELLAACKGQRLERELDT
ECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHCCC
>Mature Secondary Structure
MNGADDVRIASHAYIGLGSNLDEPVAHVQKAFEELGELPFTRLQARSSLYRSAPMGRLDQ
CCCCCCCEEHHHEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCC
PDFINAVAHIETALPPRDLLKALLGIEQKHGRMREYLNAPRTLDLDLLLYDDLQLNEDSL
CHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEECCCEECCCCE
ILPHPRMHERAFVLQPLLEIASISSIPGHDNIRELLAACKGQRLERELDT
ECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10080886 [H]