Click here to switch to the map view.

The map label for this gene is hemE

Identifier: 82701838

GI number: 82701838

Start: 811376

End: 812473

Strand: Direct

Name: hemE

Synonym: Nmul_A0705

Alternate gene names: 82701838

Gene position: 811376-812473 (Clockwise)

Preceding gene: 82701837

Following gene: 82701839

Centisome position: 25.48

GC content: 56.1

Gene sequence:

>1098_bases
ATGACAAGATTGAAGAACGATACCCTGCTCAGGGCCCTGCTGAGGCAACCTACTGAATACACGCCGGTTTGGCTCATGCG
GCAGGCAGGACGTTATCTCTCCGAATATAATCAGACGAGGGCTCGTGCGGGCAATTTTCTCGCGCTCTGCAAGAATCCCG
ACTTCGCCACCGAAGTTACGATGCAGCCTCTAGCCCGATTTCCTTTGGATGCTGCCATACTGTTTTCGGATATTCTGACG
ATTCCTGATGCGATGGGATTGGGATTATATTTTGCGGAAGGAGAGGGTCCCAGGTTCGAGCGCCCCTTGCGCGAAGAGTG
GGAGATCCGGGCCCTTACCGTCCCGGATCCTGCTGTTCATTTGCGCTATGTCATGGACGCGGTTTCACAGATACGCAAGA
CTCTGGATAATCGGGTTCCGCTGATCGGATTCTCCGGCAGTCCGTTTACGCTTGCCTGCTATATGGTGGAAGGAGCCGGC
GGGACTGATTTCCGGCAAATAAAAACCATGCTGTACCGCCGTCCTGATCTGTTGCATCATATTCTCGATATCAATGCGCA
GGCTGTCACCGCTTATCTGAACGCTCAAATCGAGTCCGGCGCGCAGGCAGTAATGATTTTTGATACCTGGGGTGGCGCCC
TTTCCCATGCCGCTTATCAGCAGTTTTCGCTGCGCTACATGACCCAGGTGCTGGCCGGGTTGAGGCGGTATCAGGGGGCT
GAGCGTATTCCGAGCATTGTTTTCACCAAGGGCGGGGGGCTATGGCTCGAGAGTATCGCGGACAGCGGGTGTGATGCAGT
GGGACTGGACTGGACGGTTAATATCGGAGACGCCCGGCGACGTGTGGGCCACAAAGTGGCCTTGCAGGGCAACCTGGATC
CTGCCGTACTATTCGCCGAGCCGGGGGTAATTGCTGCCGAGGTGGAGCAGATCCTTGCGAGTTTTGGCGAAGGCAGTGGG
CACATCTTCAACCTGGGACATGGCATATCGCAGTTTACGCCGCCCGAAAATGCGCTTACGCTGGTCGAGGCGGTTCACAG
CCTCAGCCGCAGATTTCATCGTGCGGATGCAGAGGGAAACAACAGTTTCGGCAGCTAG

Upstream 100 bases:

>100_bases
AGTTCCAAGACATACATTTCCACGGGTAGCTCTACGGGTAGTTTGAGCATCCGGCTTTTACTGATCGGCTTTACTGATTT
TTGCGATTGATTGGGTCTGA

Downstream 100 bases:

>100_bases
CGGATAAACAGAATTTTTCACCTCGAATCTACATGATATTTTGATATTTCTGCAGGTCTGATTGTTTGGAACTCTTCACG
TGCGCATACTTATTATTGAA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MTRLKNDTLLRALLRQPTEYTPVWLMRQAGRYLSEYNQTRARAGNFLALCKNPDFATEVTMQPLARFPLDAAILFSDILT
IPDAMGLGLYFAEGEGPRFERPLREEWEIRALTVPDPAVHLRYVMDAVSQIRKTLDNRVPLIGFSGSPFTLACYMVEGAG
GTDFRQIKTMLYRRPDLLHHILDINAQAVTAYLNAQIESGAQAVMIFDTWGGALSHAAYQQFSLRYMTQVLAGLRRYQGA
ERIPSIVFTKGGGLWLESIADSGCDAVGLDWTVNIGDARRRVGHKVALQGNLDPAVLFAEPGVIAAEVEQILASFGEGSG
HIFNLGHGISQFTPPENALTLVEAVHSLSRRFHRADAEGNNSFGS

Sequences:

>Translated_365_residues
MTRLKNDTLLRALLRQPTEYTPVWLMRQAGRYLSEYNQTRARAGNFLALCKNPDFATEVTMQPLARFPLDAAILFSDILT
IPDAMGLGLYFAEGEGPRFERPLREEWEIRALTVPDPAVHLRYVMDAVSQIRKTLDNRVPLIGFSGSPFTLACYMVEGAG
GTDFRQIKTMLYRRPDLLHHILDINAQAVTAYLNAQIESGAQAVMIFDTWGGALSHAAYQQFSLRYMTQVLAGLRRYQGA
ERIPSIVFTKGGGLWLESIADSGCDAVGLDWTVNIGDARRRVGHKVALQGNLDPAVLFAEPGVIAAEVEQILASFGEGSG
HIFNLGHGISQFTPPENALTLVEAVHSLSRRFHRADAEGNNSFGS
>Mature_364_residues
TRLKNDTLLRALLRQPTEYTPVWLMRQAGRYLSEYNQTRARAGNFLALCKNPDFATEVTMQPLARFPLDAAILFSDILTI
PDAMGLGLYFAEGEGPRFERPLREEWEIRALTVPDPAVHLRYVMDAVSQIRKTLDNRVPLIGFSGSPFTLACYMVEGAGG
TDFRQIKTMLYRRPDLLHHILDINAQAVTAYLNAQIESGAQAVMIFDTWGGALSHAAYQQFSLRYMTQVLAGLRRYQGAE
RIPSIVFTKGGGLWLESIADSGCDAVGLDWTVNIGDARRRVGHKVALQGNLDPAVLFAEPGVIAAEVEQILASFGEGSGH
IFNLGHGISQFTPPENALTLVEAVHSLSRRFHRADAEGNNSFGS

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=351, Percent_Identity=46.1538461538462, Blast_Score=299, Evalue=3e-81,
Organism=Escherichia coli, GI2367337, Length=354, Percent_Identity=63.2768361581921, Blast_Score=469, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6320252, Length=358, Percent_Identity=39.1061452513966, Blast_Score=253, Evalue=3e-68,
Organism=Drosophila melanogaster, GI221330099, Length=348, Percent_Identity=40.5172413793103, Blast_Score=257, Evalue=7e-69,
Organism=Drosophila melanogaster, GI19921920, Length=348, Percent_Identity=40.5172413793103, Blast_Score=257, Evalue=7e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_NITMU (Q2YB59)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411404.1
- ProteinModelPortal:   Q2YB59
- SMR:   Q2YB59
- STRING:   Q2YB59
- GeneID:   3786167
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A0705
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   Q2YB59
- ProtClustDB:   PRK00115
- BioCyc:   NMUL323848:NMUL_A0705-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 40326; Mature: 40194

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 77-77 BINDING 154-154 BINDING 209-209 BINDING 327-327

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRLKNDTLLRALLRQPTEYTPVWLMRQAGRYLSEYNQTRARAGNFLALCKNPDFATEVT
CCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHH
MQPLARFPLDAAILFSDILTIPDAMGLGLYFAEGEGPRFERPLREEWEIRALTVPDPAVH
HHHHHHCCCHHHHHHHHHHHCCCHHCCCEEEECCCCCCCCCCCCCCCCEEEEECCCHHHH
LRYVMDAVSQIRKTLDNRVPLIGFSGSPFTLACYMVEGAGGTDFRQIKTMLYRRPDLLHH
HHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHHCHHHHHH
ILDINAQAVTAYLNAQIESGAQAVMIFDTWGGALSHAAYQQFSLRYMTQVLAGLRRYQGA
HHHCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCH
ERIPSIVFTKGGGLWLESIADSGCDAVGLDWTVNIGDARRRVGHKVALQGNLDPAVLFAE
HHCCCEEEECCCCCHHHHHHCCCCCEECCEEEEECCHHHHHCCCEEEEECCCCCEEEEEC
PGVIAAEVEQILASFGEGSGHIFNLGHGISQFTPPENALTLVEAVHSLSRRFHRADAEGN
CCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
NSFGS
CCCCC
>Mature Secondary Structure 
TRLKNDTLLRALLRQPTEYTPVWLMRQAGRYLSEYNQTRARAGNFLALCKNPDFATEVT
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHH
MQPLARFPLDAAILFSDILTIPDAMGLGLYFAEGEGPRFERPLREEWEIRALTVPDPAVH
HHHHHHCCCHHHHHHHHHHHCCCHHCCCEEEECCCCCCCCCCCCCCCCEEEEECCCHHHH
LRYVMDAVSQIRKTLDNRVPLIGFSGSPFTLACYMVEGAGGTDFRQIKTMLYRRPDLLHH
HHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEEEECCCCCHHHHHHHHHHHCHHHHHH
ILDINAQAVTAYLNAQIESGAQAVMIFDTWGGALSHAAYQQFSLRYMTQVLAGLRRYQGA
HHHCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCH
ERIPSIVFTKGGGLWLESIADSGCDAVGLDWTVNIGDARRRVGHKVALQGNLDPAVLFAE
HHCCCEEEECCCCCHHHHHHCCCCCEECCEEEEECCHHHHHCCCEEEEECCCCCEEEEEC
PGVIAAEVEQILASFGEGSGHIFNLGHGISQFTPPENALTLVEAVHSLSRRFHRADAEGN
CCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
NSFGS
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA