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The map label for this gene is purE [H]

Identifier: 82701743

GI number: 82701743

Start: 691245

End: 691748

Strand: Direct

Name: purE [H]

Synonym: Nmul_A0610

Alternate gene names: 82701743

Gene position: 691245-691748 (Clockwise)

Preceding gene: 82701742

Following gene: 82701744

Centisome position: 21.71

GC content: 59.52

Gene sequence:

>504_bases
ATGGAAGGCCAAATCAACAAGCCCCAAGTGGGTGTCATCATGGGCAGCAGCAGCGATTGGGAGGTCATGAAGCATGCTGT
GGAAGTATTGAAGAAATTCCATGTGCCTTACGAAGCGGAGGTGGTTTCCGCTCATCGAACCCCTGATCGCATGTTCGAAT
ATGCGGAAACTGCCGGCGGGCGGGGGCTGAAATGCATCATTGCCGGTGCAGGCGGGGCAGCGCATCTTCCGGGAATGGTC
GCCGCGAAAACGCTCCTGCCCGTGCTGGGCGTGCCGGTTACTTCCCGGCAGCTTCAAGGGCTGGATTCGCTTTTGTCCAT
AGTACAAATGCCGAGGGGGATACCGGTTGCCACCTTCGCCATAGGCGAGGCGGGCGCGGCTAACGCGGGGTTGTTTGCCG
TTGCGCTGCTGGCGATGGAAGATGCGGGCCTGGCCAGGCAGCTTGCCGAGTTTCGGGAAACCCAGATGGCGACGGTGGCT
TCCATGACTTTACCCCTCTCATGA

Upstream 100 bases:

>100_bases
GTCATCCGTTACGGGCACGTGCGCTATCCTTACGTGGAAGATCTGGAGGAACTGACAGAGGCGGCTTCCAAGGAAAGAGA
ACAAAAAATTCGCGATTGAT

Downstream 100 bases:

>100_bases
GTACGCGGCCTGGGGCGATGCTGGGGTTGCTGGGCGGCGGCCAGCTCGGCAGGATGTTCACCATGGCGGCCCAAAGCCTG
GGTTACAGCGTGACCGTTCT

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 167; Mature: 167

Protein sequence:

>167_residues
MEGQINKPQVGVIMGSSSDWEVMKHAVEVLKKFHVPYEAEVVSAHRTPDRMFEYAETAGGRGLKCIIAGAGGAAHLPGMV
AAKTLLPVLGVPVTSRQLQGLDSLLSIVQMPRGIPVATFAIGEAGAANAGLFAVALLAMEDAGLARQLAEFRETQMATVA
SMTLPLS

Sequences:

>Translated_167_residues
MEGQINKPQVGVIMGSSSDWEVMKHAVEVLKKFHVPYEAEVVSAHRTPDRMFEYAETAGGRGLKCIIAGAGGAAHLPGMV
AAKTLLPVLGVPVTSRQLQGLDSLLSIVQMPRGIPVATFAIGEAGAANAGLFAVALLAMEDAGLARQLAEFRETQMATVA
SMTLPLS
>Mature_167_residues
MEGQINKPQVGVIMGSSSDWEVMKHAVEVLKKFHVPYEAEVVSAHRTPDRMFEYAETAGGRGLKCIIAGAGGAAHLPGMV
AAKTLLPVLGVPVTSRQLQGLDSLLSIVQMPRGIPVATFAIGEAGAANAGLFAVALLAMEDAGLARQLAEFRETQMATVA
SMTLPLS

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=159, Percent_Identity=57.8616352201258, Blast_Score=160, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6324702, Length=145, Percent_Identity=60.6896551724138, Blast_Score=166, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17483; Mature: 17483

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGQINKPQVGVIMGSSSDWEVMKHAVEVLKKFHVPYEAEVVSAHRTPDRMFEYAETAGG
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHCCC
RGLKCIIAGAGGAAHLPGMVAAKTLLPVLGVPVTSRQLQGLDSLLSIVQMPRGIPVATFA
CCEEEEEECCCCCHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEE
IGEAGAANAGLFAVALLAMEDAGLARQLAEFRETQMATVASMTLPLS
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEGQINKPQVGVIMGSSSDWEVMKHAVEVLKKFHVPYEAEVVSAHRTPDRMFEYAETAGG
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHCCC
RGLKCIIAGAGGAAHLPGMVAAKTLLPVLGVPVTSRQLQGLDSLLSIVQMPRGIPVATFA
CCEEEEEECCCCCHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEE
IGEAGAANAGLFAVALLAMEDAGLARQLAEFRETQMATVASMTLPLS
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]