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The map label for this gene is ywlC [H]

Identifier: 82701740

GI number: 82701740

Start: 688740

End: 689834

Strand: Direct

Name: ywlC [H]

Synonym: Nmul_A0607

Alternate gene names: 82701740

Gene position: 688740-689834 (Clockwise)

Preceding gene: 82701739

Following gene: 82701741

Centisome position: 21.63

GC content: 60.0

Gene sequence:

>1095_bases
ATGCCTCCTGCATTGCACAGCGAGATCGACGCGGCCGCTGCCCTCCTGAAAAAAGGAGGCGTTGTCGCTTTCCCGACAGA
AACCGTTTATGGCCTCGGGGCTGAGGTTTCCAGCCCTTCTGCAGTCGCGCGCATATTTGAAATCAAGAAGCGTCCCCTGG
ATCATCCTCTCATTGTCCATTTTGCCGATGCCTCCCGGTTATCGCATTGGGCGCGGGAGGTGCCGCAGCAGGCATGGCGG
CTGGCTGAGTGCTTCTGGCCGGGCCCTTTGACCCTGATACTGCCACGTAGTCGTCATGTGCCGGAAAAGGTGACCGGCGG
TCAGGATACAGTGGGATTGCGCGTTCCTGATCATCCCGTAGCGCTTGCCTTGCTGAGGGAACTGGGGCCGGACAGAGCGC
TTGCCGCCCCGTCGGCCAATCGTTTCGGTCATGTCAGCCCGACAACGGCAGCACATGTGCGTGAGGAGTTTGGCGACGAG
CTGGACATGGTTCTGGATGGCGGGCCGTGCCAGGTGGGTCTGGAAAGCACCATTGTGGGTTTTGAAGGCCAAACTGCGGT
TATATTGCGGCCAGGTGGCATCCAGTTGGCAGCGCTGGCGGAAGTGTTGGATGGAAATGTGATGCTTTCCCAAGAGGCAG
AACGTTCTGTACGCGTGCCGGGCGCCCTCCCTTCGCATTATGCCCCCTCAACGCCGCTCGAGCTCCTGCCGGCGGATCCC
TTATGGGCGCGCGCTTTGGAGCTGGAAGCAAAAGGTATGCGGGTAGCAGTCATGGGTTGGCGGCGGCGAGAGCATTCTCT
ACCCAGGCATCATCCGGAAAATGAACCGGTCGTATTTTCCGCGATGCCTGAAGAACCCGAGGAATATGCGCGTCAGTTGT
ATGCTACCTTGCGCCGGTTCGATCGGGGACATTTCGATCGGTTGTTGGTGGAGAAGCCGCCTGAGACGGCCGCCTGGGTG
GCAATCGCGGACCGCCTGCGGCGGGCGAGCAGCAGGACACACCCCGGCGCGAATGCAGTGCTAAGGGGCGAGCAAAGCAG
TTCGTCCCTGACGCGGGAGGATGAGAATGAAACAATTTATGGGCAAACTGGATAA

Upstream 100 bases:

>100_bases
TGCGGGGTTTTCATATCGAGAAGGCGCAAGTGCACCAGGGGCACCCCTGGTCCAAGATCTCCGATCACGCAGTCCTCTCG
GCGCAGATGATCCTCAGATA

Downstream 100 bases:

>100_bases
ATAACGATTTTATGGATAGCAAAGTTCGCGCAGTACTGTTTGATGTGGATGGTACGCTGGCTGACACGGAGCGTGATGGT
CATCGCCCCGCTTTTAATGC

Product: Sua5/YciO/YrdC/YwlC

Products: NA

Alternate protein names: t(6)A37 threonylcarbamoyladenosine biosynthesis protein YwlC [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MPPALHSEIDAAAALLKKGGVVAFPTETVYGLGAEVSSPSAVARIFEIKKRPLDHPLIVHFADASRLSHWAREVPQQAWR
LAECFWPGPLTLILPRSRHVPEKVTGGQDTVGLRVPDHPVALALLRELGPDRALAAPSANRFGHVSPTTAAHVREEFGDE
LDMVLDGGPCQVGLESTIVGFEGQTAVILRPGGIQLAALAEVLDGNVMLSQEAERSVRVPGALPSHYAPSTPLELLPADP
LWARALELEAKGMRVAVMGWRRREHSLPRHHPENEPVVFSAMPEEPEEYARQLYATLRRFDRGHFDRLLVEKPPETAAWV
AIADRLRRASSRTHPGANAVLRGEQSSSSLTREDENETIYGQTG

Sequences:

>Translated_364_residues
MPPALHSEIDAAAALLKKGGVVAFPTETVYGLGAEVSSPSAVARIFEIKKRPLDHPLIVHFADASRLSHWAREVPQQAWR
LAECFWPGPLTLILPRSRHVPEKVTGGQDTVGLRVPDHPVALALLRELGPDRALAAPSANRFGHVSPTTAAHVREEFGDE
LDMVLDGGPCQVGLESTIVGFEGQTAVILRPGGIQLAALAEVLDGNVMLSQEAERSVRVPGALPSHYAPSTPLELLPADP
LWARALELEAKGMRVAVMGWRRREHSLPRHHPENEPVVFSAMPEEPEEYARQLYATLRRFDRGHFDRLLVEKPPETAAWV
AIADRLRRASSRTHPGANAVLRGEQSSSSLTREDENETIYGQTG
>Mature_363_residues
PPALHSEIDAAAALLKKGGVVAFPTETVYGLGAEVSSPSAVARIFEIKKRPLDHPLIVHFADASRLSHWAREVPQQAWRL
AECFWPGPLTLILPRSRHVPEKVTGGQDTVGLRVPDHPVALALLRELGPDRALAAPSANRFGHVSPTTAAHVREEFGDEL
DMVLDGGPCQVGLESTIVGFEGQTAVILRPGGIQLAALAEVLDGNVMLSQEAERSVRVPGALPSHYAPSTPLELLPADPL
WARALELEAKGMRVAVMGWRRREHSLPRHHPENEPVVFSAMPEEPEEYARQLYATLRRFDRGHFDRLLVEKPPETAAWVA
IADRLRRASSRTHPGANAVLRGEQSSSSLTREDENETIYGQTG

Specific function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (Probable) [H]

COG id: COG0009

COG function: function code J; Putative translation factor (SUA5)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 YrdC-like domain [H]

Homologues:

Organism=Homo sapiens, GI58761510, Length=198, Percent_Identity=31.8181818181818, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI2367210, Length=152, Percent_Identity=35.5263157894737, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI87081864, Length=189, Percent_Identity=30.1587301587302, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17537239, Length=180, Percent_Identity=32.7777777777778, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321269, Length=374, Percent_Identity=31.5508021390374, Blast_Score=150, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR005145
- InterPro:   IPR004388
- InterPro:   IPR006070
- InterPro:   IPR010923 [H]

Pfam domain/function: PF03481 SUA5; PF01300 Sua5_yciO_yrdC [H]

EC number: NA

Molecular weight: Translated: 39784; Mature: 39652

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS51163 YRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPALHSEIDAAAALLKKGGVVAFPTETVYGLGAEVSSPSAVARIFEIKKRPLDHPLIVH
CCCCHHHHHHHHHHHHHCCCEEEECCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEE
FADASRLSHWAREVPQQAWRLAECFWPGPLTLILPRSRHVPEKVTGGQDTVGLRVPDHPV
ECCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHCCCCCCEEEEECCCCHH
ALALLRELGPDRALAAPSANRFGHVSPTTAAHVREEFGDELDMVLDGGPCQVGLESTIVG
HHHHHHHCCCCCEECCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCEECCCCEEEE
FEGQTAVILRPGGIQLAALAEVLDGNVMLSQEAERSVRVPGALPSHYAPSTPLELLPADP
CCCCEEEEECCCCCHHHHHHHHHCCCEEEECCCCCCEECCCCCCCCCCCCCCHHCCCCCH
LWARALELEAKGMRVAVMGWRRREHSLPRHHPENEPVVFSAMPEEPEEYARQLYATLRRF
HHHHHHHHHCCCCEEEEEECHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHH
DRGHFDRLLVEKPPETAAWVAIADRLRRASSRTHPGANAVLRGEQSSSSLTREDENETIY
CCCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCEEE
GQTG
CCCC
>Mature Secondary Structure 
PPALHSEIDAAAALLKKGGVVAFPTETVYGLGAEVSSPSAVARIFEIKKRPLDHPLIVH
CCCHHHHHHHHHHHHHCCCEEEECCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEE
FADASRLSHWAREVPQQAWRLAECFWPGPLTLILPRSRHVPEKVTGGQDTVGLRVPDHPV
ECCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHCCCCCCEEEEECCCCHH
ALALLRELGPDRALAAPSANRFGHVSPTTAAHVREEFGDELDMVLDGGPCQVGLESTIVG
HHHHHHHCCCCCEECCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCEECCCCEEEE
FEGQTAVILRPGGIQLAALAEVLDGNVMLSQEAERSVRVPGALPSHYAPSTPLELLPADP
CCCCEEEEECCCCCHHHHHHHHHCCCEEEECCCCCCEECCCCCCCCCCCCCCHHCCCCCH
LWARALELEAKGMRVAVMGWRRREHSLPRHHPENEPVVFSAMPEEPEEYARQLYATLRRF
HHHHHHHHHCCCCEEEEEECHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHH
DRGHFDRLLVEKPPETAAWVAIADRLRRASSRTHPGANAVLRGEQSSSSLTREDENETIY
CCCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCEEE
GQTG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]