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The map label for this gene is proC [H]

Identifier: 82701715

GI number: 82701715

Start: 665449

End: 666264

Strand: Reverse

Name: proC [H]

Synonym: Nmul_A0581

Alternate gene names: 82701715

Gene position: 666264-665449 (Counterclockwise)

Preceding gene: 82701716

Following gene: 82701714

Centisome position: 20.92

GC content: 59.07

Gene sequence:

>816_bases
ATGAATATTACATTCATTGGTGGCGGCAACATGGCTTGCGCTTTGATCGGCGGGCTGCTGCAACAGGATTATTCACCGGC
GCAGATACGGGTAGTGGAGATCAACGCTGAAACACGCGAGAGACTCCGGCATGAATTTGGCGTGGGGACGGTCGCGGAAC
TTGCGCGGGGCATGATCGAAGAGAGGGAGATAATCGTGCTCGCCGTAAAGCCGCAGCAGCTCTCCATCGTGGCACGCGCG
CTCGCGCCGCTGCTCGAGCGGAACCTTGTCATCTCGATTGCCGCCGGTATCCGGGCAAATGCTCTTTCACAATGGCTCGG
CGGCTATCTTCGCATCGTGCGCGCCATGCCCAATACGCCCGCGCTGATTGGCTCCGCGGTTACAGGGCTCTATGCCATGG
CAGGCGTGAACGATGAGGAAAAACGTGAGGCGGAAACCATACTCCGCGCGGTCGGCACTGTGCTATGGGTTGAAAGCGAA
GAACTGCTGGATGCAGTGACTGCCACCTCGGGCAGTGGTCCTGCTTATGTATTCTACTTCATCGAAGCCATGCAGAAGGC
AGGACAGGAACTGGGGCTGGATGCGGACCAGGCGCGCAAACTGAGCATTGAAACCTTTCTTGGAGCCGCCAGGCTCGCGA
ACGAGAGCATGGATGAGGCGAGTGTCCTGCGCGCGCGGGTCACATCGCCCGGCGGCACGACGGAACGCGCGATAAGGTCG
CTGGAAAATGACGATGTCAAAATCGGAATCATCCGGGCAATCCGTACCGCATATCAGCGGTCACGCGAGATGGGCGACGA
ACTCGGCCGTACATGA

Upstream 100 bases:

>100_bases
CAGCCTTGCCGGAAATGTGGTACAAATATCGAACAGATCAGGCAGGGGCAGCGTTCGAGCTTTTATTGCCCGCGTTGCCA
GAAATAAATTCACTGGATAC

Downstream 100 bases:

>100_bases
CAGAATAGAGAATAACCATGCGCAAGTGGCGCAGTAAACGGATAATACTTTCATGATCAGTCAAATGCTCATATTCCTGC
TCGATACCCTGCTGGGATTG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MNITFIGGGNMACALIGGLLQQDYSPAQIRVVEINAETRERLRHEFGVGTVAELARGMIEEREIIVLAVKPQQLSIVARA
LAPLLERNLVISIAAGIRANALSQWLGGYLRIVRAMPNTPALIGSAVTGLYAMAGVNDEEKREAETILRAVGTVLWVESE
ELLDAVTATSGSGPAYVFYFIEAMQKAGQELGLDADQARKLSIETFLGAARLANESMDEASVLRARVTSPGGTTERAIRS
LENDDVKIGIIRAIRTAYQRSREMGDELGRT

Sequences:

>Translated_271_residues
MNITFIGGGNMACALIGGLLQQDYSPAQIRVVEINAETRERLRHEFGVGTVAELARGMIEEREIIVLAVKPQQLSIVARA
LAPLLERNLVISIAAGIRANALSQWLGGYLRIVRAMPNTPALIGSAVTGLYAMAGVNDEEKREAETILRAVGTVLWVESE
ELLDAVTATSGSGPAYVFYFIEAMQKAGQELGLDADQARKLSIETFLGAARLANESMDEASVLRARVTSPGGTTERAIRS
LENDDVKIGIIRAIRTAYQRSREMGDELGRT
>Mature_271_residues
MNITFIGGGNMACALIGGLLQQDYSPAQIRVVEINAETRERLRHEFGVGTVAELARGMIEEREIIVLAVKPQQLSIVARA
LAPLLERNLVISIAAGIRANALSQWLGGYLRIVRAMPNTPALIGSAVTGLYAMAGVNDEEKREAETILRAVGTVLWVESE
ELLDAVTATSGSGPAYVFYFIEAMQKAGQELGLDADQARKLSIETFLGAARLANESMDEASVLRARVTSPGGTTERAIRS
LENDDVKIGIIRAIRTAYQRSREMGDELGRT

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=275, Percent_Identity=31.6363636363636, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI24797095, Length=275, Percent_Identity=31.6363636363636, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI21361454, Length=275, Percent_Identity=31.2727272727273, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI198041662, Length=264, Percent_Identity=26.8939393939394, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI1786585, Length=265, Percent_Identity=35.4716981132075, Blast_Score=148, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17569021, Length=275, Percent_Identity=34.1818181818182, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17540664, Length=284, Percent_Identity=28.8732394366197, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320861, Length=210, Percent_Identity=30.4761904761905, Blast_Score=102, Evalue=6e-23,
Organism=Drosophila melanogaster, GI21358587, Length=265, Percent_Identity=32.8301886792453, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24648116, Length=277, Percent_Identity=32.129963898917, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=34.9112426035503, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29299; Mature: 29299

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNITFIGGGNMACALIGGLLQQDYSPAQIRVVEINAETRERLRHEFGVGTVAELARGMIE
CEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHCCCHHHHHHHHHHC
EREIIVLAVKPQQLSIVARALAPLLERNLVISIAAGIRANALSQWLGGYLRIVRAMPNTP
CCCEEEEEECCHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCC
ALIGSAVTGLYAMAGVNDEEKREAETILRAVGTVLWVESEELLDAVTATSGSGPAYVFYF
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEECHHHHHHHHHCCCCCCCCHHHHH
IEAMQKAGQELGLDADQARKLSIETFLGAARLANESMDEASVLRARVTSPGGTTERAIRS
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHH
LENDDVKIGIIRAIRTAYQRSREMGDELGRT
CCCCCEEHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNITFIGGGNMACALIGGLLQQDYSPAQIRVVEINAETRERLRHEFGVGTVAELARGMIE
CEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHCCCHHHHHHHHHHC
EREIIVLAVKPQQLSIVARALAPLLERNLVISIAAGIRANALSQWLGGYLRIVRAMPNTP
CCCEEEEEECCHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCC
ALIGSAVTGLYAMAGVNDEEKREAETILRAVGTVLWVESEELLDAVTATSGSGPAYVFYF
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEECHHHHHHHHHCCCCCCCCHHHHH
IEAMQKAGQELGLDADQARKLSIETFLGAARLANESMDEASVLRARVTSPGGTTERAIRS
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHH
LENDDVKIGIIRAIRTAYQRSREMGDELGRT
CCCCCEEHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]