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The map label for this gene is loxA [H]

Identifier: 82701666

GI number: 82701666

Start: 610090

End: 611751

Strand: Reverse

Name: loxA [H]

Synonym: Nmul_A0532

Alternate gene names: 82701666

Gene position: 611751-610090 (Counterclockwise)

Preceding gene: 82701667

Following gene: 82701661

Centisome position: 19.21

GC content: 46.99

Gene sequence:

>1662_bases
GTGTCGAACAAGCTACCGCAGAATGAAGAAAATACAGGTAAAGAAGAGCGGAAGAATTATCTTCTTCAAAGGCAAGCTGA
GTATCAATACGCCTATGAGTATGCCGAGACTATTGCAGTCGCGCGCAAACTGCCATGGCGGGAGATACCGGGCATTGGAT
ATTGGCTCCGTGGGGGAATGAATCTTTTACGGCTGATTCCAAGTTTACCCAGCCTATCGGTTACCTTTTTACGCTACTTG
CTCGGCAAGCCGATGGAAAGTTATCGGGATTATGTTTTTTTTCCGGCGAGTCCTCCAAACCCCGATCTCGTGGATAGCTT
CCAGCAAGACCTGATATTTGGCCTGCAACGCGTCATTGGAGTAAATCCTGTGATGTTGCGCGCTGTAACCCGTCAGAATC
CTCTACCGGAAAAACTGCCGGAAGCAGAAATGCGAAAAATTTTTGAAGAGCAGATTGATGAAATCGATTATATGGCTGCC
ACCGCGCAAAAACGCATATACGTCCTGGACTATGCAGTCCTGGATGTATTGCAGTCAAATCCGGGTTATATCGACGGGCA
AAAACAATATGTCACGACTCCGATCGTCGTGTTGTTTCTGCAACCGGACGGCATGCTGCGGCCGGTTGCCATCCAGCTAT
ACCAGGATGACAGGTCCGATAATCCAATCTATACGTCAAAAGACGGTAATCTCTGGCTGACAGCAAAAATGTTTGCCCAG
GTCGCGGATGGCAACCATCACATCCTGTATACCCATGCAACCCGTATTCATTACGTGATGGAAGCCATTATCATGGCTTC
ACGAAGACAGCTTTATAAATCTCACCCGCTTTACGTTCTATTGAATCCGCATCTTCAGCACACGCTCAATGTCAATCACC
AGCACACTTTCCTGAAAGACCGGAAGGGACGACCCGGCCGGTACGGTGAGTTATTTGCCGGAGACTATGACTCGATGACG
CAATGCATGGCCAATGGCATGACAAGCTTTAATTTTAAAGAATCCGCCTTCTCCGATGATATTGCGAGGCGGGAAGTCGA
TAATCCTGATCTTTTTTATCCCTATCGCGATGATGGCATTTTGTTATGGAATGCGATTCAAAGCTTCAGTAAAGAATATG
TCGATTTATATTACAAATCTGAAGCGGATGTTACTGATGACTATGAAACTCAGGCATGGGCACATGATATCAGTGCGCAG
GATCGGGGCAGGATTCCCGGGTTTCCTGCCCGATTCGAATCCAGGCAAGAGCTGAGCGAGACTCTCGGTCATATCATTTT
TCTATGTACTGCTTTTCATTCCTGCATTCACTTCAACCAATACAAGTATCCGGGATTCGTTCCCAATATGCCGCATTCAG
CTTATGCGCCGCCCCCGGCTGGAAAAAACGCTGAAATTGATGGAGCTGGCTTATTGAAGTTTCTGCCGACCTTTCGAGCC
GCCTATTCGCAAACCTGGACCTATTTTCTGACAAATTTTTGTGTCAACTCGATCGGTCAGTACAACTTAAAGCAATTCGA
TTCTGAAGCACACGAGGTGATAGAGCGGTTTGGGGACAGGCTGGAGGAAATAGAAGAGGAAATCGACCAAAGAAATAGCA
GACGTTCTTTCGCCTATGATCGCATGAATCCAAGATTCATTCCGAACGGTGTAACCATTTAG

Upstream 100 bases:

>100_bases
TTGCAAGCTTCAATACCTCTGTCCAGTGATCAGTGAAAGATAGGGCACATAGAAAGGCTATGGAAACCAGGCGAAAACCT
TATTTTTAAAGGAGTGCCTC

Downstream 100 bases:

>100_bases
TCATTCCTGAAATACGTCTGAAGTTCTTTTCTTATAGGTAGGATTTAGGGGTATACAAGGGGGCTGCGCTTCAGCCACGC
CCGATTTTGGCGTCGGCTGG

Product: arachidonate 15-lipoxygenase

Products: NA

Alternate protein names: 15-LOX [H]

Number of amino acids: Translated: 553; Mature: 552

Protein sequence:

>553_residues
MSNKLPQNEENTGKEERKNYLLQRQAEYQYAYEYAETIAVARKLPWREIPGIGYWLRGGMNLLRLIPSLPSLSVTFLRYL
LGKPMESYRDYVFFPASPPNPDLVDSFQQDLIFGLQRVIGVNPVMLRAVTRQNPLPEKLPEAEMRKIFEEQIDEIDYMAA
TAQKRIYVLDYAVLDVLQSNPGYIDGQKQYVTTPIVVLFLQPDGMLRPVAIQLYQDDRSDNPIYTSKDGNLWLTAKMFAQ
VADGNHHILYTHATRIHYVMEAIIMASRRQLYKSHPLYVLLNPHLQHTLNVNHQHTFLKDRKGRPGRYGELFAGDYDSMT
QCMANGMTSFNFKESAFSDDIARREVDNPDLFYPYRDDGILLWNAIQSFSKEYVDLYYKSEADVTDDYETQAWAHDISAQ
DRGRIPGFPARFESRQELSETLGHIIFLCTAFHSCIHFNQYKYPGFVPNMPHSAYAPPPAGKNAEIDGAGLLKFLPTFRA
AYSQTWTYFLTNFCVNSIGQYNLKQFDSEAHEVIERFGDRLEEIEEEIDQRNSRRSFAYDRMNPRFIPNGVTI

Sequences:

>Translated_553_residues
MSNKLPQNEENTGKEERKNYLLQRQAEYQYAYEYAETIAVARKLPWREIPGIGYWLRGGMNLLRLIPSLPSLSVTFLRYL
LGKPMESYRDYVFFPASPPNPDLVDSFQQDLIFGLQRVIGVNPVMLRAVTRQNPLPEKLPEAEMRKIFEEQIDEIDYMAA
TAQKRIYVLDYAVLDVLQSNPGYIDGQKQYVTTPIVVLFLQPDGMLRPVAIQLYQDDRSDNPIYTSKDGNLWLTAKMFAQ
VADGNHHILYTHATRIHYVMEAIIMASRRQLYKSHPLYVLLNPHLQHTLNVNHQHTFLKDRKGRPGRYGELFAGDYDSMT
QCMANGMTSFNFKESAFSDDIARREVDNPDLFYPYRDDGILLWNAIQSFSKEYVDLYYKSEADVTDDYETQAWAHDISAQ
DRGRIPGFPARFESRQELSETLGHIIFLCTAFHSCIHFNQYKYPGFVPNMPHSAYAPPPAGKNAEIDGAGLLKFLPTFRA
AYSQTWTYFLTNFCVNSIGQYNLKQFDSEAHEVIERFGDRLEEIEEEIDQRNSRRSFAYDRMNPRFIPNGVTI
>Mature_552_residues
SNKLPQNEENTGKEERKNYLLQRQAEYQYAYEYAETIAVARKLPWREIPGIGYWLRGGMNLLRLIPSLPSLSVTFLRYLL
GKPMESYRDYVFFPASPPNPDLVDSFQQDLIFGLQRVIGVNPVMLRAVTRQNPLPEKLPEAEMRKIFEEQIDEIDYMAAT
AQKRIYVLDYAVLDVLQSNPGYIDGQKQYVTTPIVVLFLQPDGMLRPVAIQLYQDDRSDNPIYTSKDGNLWLTAKMFAQV
ADGNHHILYTHATRIHYVMEAIIMASRRQLYKSHPLYVLLNPHLQHTLNVNHQHTFLKDRKGRPGRYGELFAGDYDSMTQ
CMANGMTSFNFKESAFSDDIARREVDNPDLFYPYRDDGILLWNAIQSFSKEYVDLYYKSEADVTDDYETQAWAHDISAQD
RGRIPGFPARFESRQELSETLGHIIFLCTAFHSCIHFNQYKYPGFVPNMPHSAYAPPPAGKNAEIDGAGLLKFLPTFRAA
YSQTWTYFLTNFCVNSIGQYNLKQFDSEAHEVIERFGDRLEEIEEEIDQRNSRRSFAYDRMNPRFIPNGVTI

Specific function: Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid (HpETE) which is rapidly reduced to hydroxyeicosatetraenoic acid (HETE). Could act on exogenous human-derived substrates to potentially modulate the local inflammatory responses during P.a

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasm. Secreted, extracellular space. Note=Periplasmic with some activity further secreted to the extracellular milieu [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoxygenase domain [H]

Homologues:

Organism=Homo sapiens, GI4502057, Length=464, Percent_Identity=31.25, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI182765464, Length=469, Percent_Identity=33.2622601279318, Blast_Score=207, Evalue=3e-53,
Organism=Homo sapiens, GI260166612, Length=469, Percent_Identity=33.2622601279318, Blast_Score=207, Evalue=3e-53,
Organism=Homo sapiens, GI40316937, Length=473, Percent_Identity=29.3868921775898, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI85067501, Length=470, Percent_Identity=28.936170212766, Blast_Score=189, Evalue=6e-48,
Organism=Homo sapiens, GI4502053, Length=466, Percent_Identity=27.8969957081545, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI154426292, Length=462, Percent_Identity=28.1385281385281, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI85067499, Length=469, Percent_Identity=26.865671641791, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI85067503, Length=467, Percent_Identity=23.982869379015, Blast_Score=118, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000907
- InterPro:   IPR013819
- InterPro:   IPR020834
- InterPro:   IPR020833 [H]

Pfam domain/function: PF00305 Lipoxygenase [H]

EC number: =1.13.11.33 [H]

Molecular weight: Translated: 64071; Mature: 63940

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00081 LIPOXYGENASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKLPQNEENTGKEERKNYLLQRQAEYQYAYEYAETIAVARKLPWREIPGIGYWLRGGM
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHH
NLLRLIPSLPSLSVTFLRYLLGKPMESYRDYVFFPASPPNPDLVDSFQQDLIFGLQRVIG
HHHHHHCCCCCHHHHHHHHHHCCCHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHC
VNPVMLRAVTRQNPLPEKLPEAEMRKIFEEQIDEIDYMAATAQKRIYVLDYAVLDVLQSN
CCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHHHHHHHCC
PGYIDGQKQYVTTPIVVLFLQPDGMLRPVAIQLYQDDRSDNPIYTSKDGNLWLTAKMFAQ
CCEECCCCEEEECEEEEEEECCCCCCCCEEEEEEECCCCCCCEEECCCCCEEEEHHHHHH
VADGNHHILYTHATRIHYVMEAIIMASRRQLYKSHPLYVLLNPHLQHTLNVNHQHTFLKD
HCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHCCCCCCHHHHHH
RKGRPGRYGELFAGDYDSMTQCMANGMTSFNFKESAFSDDIARREVDNPDLFYPYRDDGI
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCE
LLWNAIQSFSKEYVDLYYKSEADVTDDYETQAWAHDISAQDRGRIPGFPARFESRQELSE
EEHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHCCHHHHHH
TLGHIIFLCTAFHSCIHFNQYKYPGFVPNMPHSAYAPPPAGKNAEIDGAGLLKFLPTFRA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
AYSQTWTYFLTNFCVNSIGQYNLKQFDSEAHEVIERFGDRLEEIEEEIDQRNSRRSFAYD
HHHHHHHHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
RMNPRFIPNGVTI
CCCCEECCCCCCC
>Mature Secondary Structure 
SNKLPQNEENTGKEERKNYLLQRQAEYQYAYEYAETIAVARKLPWREIPGIGYWLRGGM
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHH
NLLRLIPSLPSLSVTFLRYLLGKPMESYRDYVFFPASPPNPDLVDSFQQDLIFGLQRVIG
HHHHHHCCCCCHHHHHHHHHHCCCHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHC
VNPVMLRAVTRQNPLPEKLPEAEMRKIFEEQIDEIDYMAATAQKRIYVLDYAVLDVLQSN
CCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEHHHHHHHHHCC
PGYIDGQKQYVTTPIVVLFLQPDGMLRPVAIQLYQDDRSDNPIYTSKDGNLWLTAKMFAQ
CCEECCCCEEEECEEEEEEECCCCCCCCEEEEEEECCCCCCCEEECCCCCEEEEHHHHHH
VADGNHHILYTHATRIHYVMEAIIMASRRQLYKSHPLYVLLNPHLQHTLNVNHQHTFLKD
HCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHCCCCCCHHHHHH
RKGRPGRYGELFAGDYDSMTQCMANGMTSFNFKESAFSDDIARREVDNPDLFYPYRDDGI
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCE
LLWNAIQSFSKEYVDLYYKSEADVTDDYETQAWAHDISAQDRGRIPGFPARFESRQELSE
EEHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHCCHHHHHH
TLGHIIFLCTAFHSCIHFNQYKYPGFVPNMPHSAYAPPPAGKNAEIDGAGLLKFLPTFRA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
AYSQTWTYFLTNFCVNSIGQYNLKQFDSEAHEVIERFGDRLEEIEEEIDQRNSRRSFAYD
HHHHHHHHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
RMNPRFIPNGVTI
CCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]