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The map label for this gene is rppH

Identifier: 82701583

GI number: 82701583

Start: 498462

End: 499025

Strand: Reverse

Name: rppH

Synonym: Nmul_A0449

Alternate gene names: 82701583

Gene position: 499025-498462 (Counterclockwise)

Preceding gene: 82701585

Following gene: 82701582

Centisome position: 15.67

GC content: 53.19

Gene sequence:

>564_bases
ATGATCGACCGTAATGGATATCGCTCAAATGTAGGAATCATTCTACTCAATTCGAAGAACGAGGTTTTTTGGGGCAAGCG
CATCAGACAGGACTCCTGGCAATTTCCTCAGGGAGGTATCAAGCCCGGCGAAAGTCCGGAACAAGCAATGTATCGTGAAT
TGACCGAAGAAGTAGGCTTACGGCCTTGGCACGTGCAAATCCTCGGCCGCACACGCGACTGGCTCCGATACGATGTACCT
GCCCAATGGATTAAACGCGACTGGCGAGGAAATTACCGGGGGCAGAAACAGATCTGGTATCTGCTGCGCTTGCTGGGAAG
CGATTGCGACGTTTCGCTCCACACCAGCGGACGTCCTGAATTTGACGCATGGCGGTGGAATCAGTACTGGGTAGAGTTGG
AGTCGGTAGTCGAGTTTAAACGCCAGGTTTACCGCCAGGCACTGACGGAACTGGCACGTCTGCTGAATCGTCCACCTGTT
CCCTTCGGGTATAGCGGATATGAAAAATACGACTATTCCGCCAGCGGGCCCCTTACAGGCAGCACCGCCAAGCAGTCTGA
ATAA

Upstream 100 bases:

>100_bases
GCCACTCCTCCCGATGCCCCCCGACCAGCGACAGCTTTCAATCCGGCACGAAATGTGGAAAAATCTAATCCTATCGTGAA
GGATCAAACGGGTGAATCAT

Downstream 100 bases:

>100_bases
GCAATCGCATTGCAAAAACGCGCTCGTTACAGTACCACCGCCACAGGTGCCGCTGCCGCCGCAGGGGAACTGATGCGTAT
CAGGCAGCTGACAGCAAAGC

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MIDRNGYRSNVGIILLNSKNEVFWGKRIRQDSWQFPQGGIKPGESPEQAMYRELTEEVGLRPWHVQILGRTRDWLRYDVP
AQWIKRDWRGNYRGQKQIWYLLRLLGSDCDVSLHTSGRPEFDAWRWNQYWVELESVVEFKRQVYRQALTELARLLNRPPV
PFGYSGYEKYDYSASGPLTGSTAKQSE

Sequences:

>Translated_187_residues
MIDRNGYRSNVGIILLNSKNEVFWGKRIRQDSWQFPQGGIKPGESPEQAMYRELTEEVGLRPWHVQILGRTRDWLRYDVP
AQWIKRDWRGNYRGQKQIWYLLRLLGSDCDVSLHTSGRPEFDAWRWNQYWVELESVVEFKRQVYRQALTELARLLNRPPV
PFGYSGYEKYDYSASGPLTGSTAKQSE
>Mature_187_residues
MIDRNGYRSNVGIILLNSKNEVFWGKRIRQDSWQFPQGGIKPGESPEQAMYRELTEEVGLRPWHVQILGRTRDWLRYDVP
AQWIKRDWRGNYRGQKQIWYLLRLLGSDCDVSLHTSGRPEFDAWRWNQYWVELESVVEFKRQVYRQALTELARLLNRPPV
PFGYSGYEKYDYSASGPLTGSTAKQSE

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1789194, Length=173, Percent_Identity=49.7109826589595, Blast_Score=174, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPPH_NITMU (Q2YBW4)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_411149.1
- ProteinModelPortal:   Q2YBW4
- STRING:   Q2YBW4
- GeneID:   3785917
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A0449
- eggNOG:   COG0494
- HOGENOM:   HBG302451
- OMA:   GQKQIWY
- PhylomeDB:   Q2YBW4
- ProtClustDB:   PRK00714
- BioCyc:   NMUL323848:NMUL_A0449-MONOMER
- HAMAP:   MF_00298
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR00502

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.- [C]

Molecular weight: Translated: 22134; Mature: 22134

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX; PS00659 GLYCOSYL_HYDROL_F5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDRNGYRSNVGIILLNSKNEVFWGKRIRQDSWQFPQGGIKPGESPEQAMYRELTEEVGL
CCCCCCCCCCCEEEEECCCCCEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
RPWHVQILGRTRDWLRYDVPAQWIKRDWRGNYRGQKQIWYLLRLLGSDCDVSLHTSGRPE
CCEEEEEECCCCHHHEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCC
FDAWRWNQYWVELESVVEFKRQVYRQALTELARLLNRPPVPFGYSGYEKYDYSASGPLTG
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
STAKQSE
CCCCCCC
>Mature Secondary Structure
MIDRNGYRSNVGIILLNSKNEVFWGKRIRQDSWQFPQGGIKPGESPEQAMYRELTEEVGL
CCCCCCCCCCCEEEEECCCCCEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
RPWHVQILGRTRDWLRYDVPAQWIKRDWRGNYRGQKQIWYLLRLLGSDCDVSLHTSGRPE
CCEEEEEECCCCHHHEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCC
FDAWRWNQYWVELESVVEFKRQVYRQALTELARLLNRPPVPFGYSGYEKYDYSASGPLTG
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
STAKQSE
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA