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The map label for this gene is ppx [H]

Identifier: 82701568

GI number: 82701568

Start: 481487

End: 483010

Strand: Reverse

Name: ppx [H]

Synonym: Nmul_A0434

Alternate gene names: 82701568

Gene position: 483010-481487 (Counterclockwise)

Preceding gene: 82701569

Following gene: 82701567

Centisome position: 15.17

GC content: 56.5

Gene sequence:

>1524_bases
ATGCCCGAATACTCCACACTTGCGGCGGTAGATCTCGGTTCCAACAGCTTTCGTTTGCAAGTCGCGCGAGTGGAAGGCAG
ACAGCTTTATCCGCTGGACAATCTGCGTGAAATGGTTCGTCTTGCCGCTGGTCTTACTCGCGACAAGCGCCTGGATGAAG
ATTCCCAGGCACGCGCCCTGGCCTGTCTCACGCGTTTCAGTGAACGCCTGCGCGGTTTCCCTCCTCATGCTGTACGTGCG
GTTGCGACCAACACTCTCAGGGTGGCGAAAAATGCGGCTGTATTTCTCAAAAAAGCCGAGGCAGCGATGGGTTTTCCCAT
TGAAGTCATCTCGGGCCACGAAGAGGCGCGCCTCATCTATCTGGGCGTTGCGCACGGCCTTCCTGCTTCTCCTGACGCTC
GCCTGGTAATGGACATCGGGGGCGGCTCTACTGAATTTATCATTGGCCGCAGGCTGAAGCCGGTCAAGCTGGAAAGCCTC
TATATGGGTTGCGTCAGCTATAGCCTGCGCTTTTTTCCAGGCGGCAGGATCAGCAGGGAGGCAATGAACCGTGCCGAACT
ATCGGCCCGCAGCGAGATTCAGGCGATCGCAAAGGAATTTTCCAGTGAACACTGGCAGCTCGCATATGGATCCTCCGGTA
CGGCACGCGCGTTAGGCGATATCATCCAGTTGAACCAGCTCGGCAGTGGAAGCGGCAACGGAGAGATTACGCGGGAAGGG
CTGGAAAATTTTCGTAATCATCTGCTCAAGGTGGACGATATCAAAAAACTCGACCTCGCGGGTATCAAGACCGATCGGGC
GCCTGTCATAGCCGGCGGTTTCGCCATCATGTCCGCCGCGTTCGCGGAGCTGGGAATTTCCCGGATGGCGCAAGGCATGG
GTGCCTTACGTCAGGGCGTGCTGTACGATCTGCTGGGGCGCTTCCATAAGCATGATATGCGCGAAGTAACGGTCAGGCAG
TTCATGCGCCGGTACCATGTGGATGGCGCGCAGGCGGGGCGGGTGGAATCGACTGCACTTTTGCTCGGAGAACAGTTGCT
GGCGGCCTTTCCCTGTGAGGGAGAAGAACATCTGCAAGTTCTCTCATGGGCTGCCCGGCTGCATGAAGTAGGTATTTCGG
TCGCCCACTCCGGTTACCACAAGCATTCTGCATATATCCTGGGTAATGCCGATATGCCGGGTTTTTCCCAAAGGGAGCAG
GAGCGCTTAAGCATGCTTGTGCTCGCCCACCGGGGCGATATCGGCAAAGCGCGTGGAAACATGATAGAGCGGGCTGATTT
CGCCCTGCTGTTTGCGCTTCGCCTCGCGGCATTGTTTCATCGCAGCCGCTGTGAGACGGCACTTCCGAGGCTCGAGGTCA
GCCTTCGAGGCAAGGAATTCAGTTTATATCTTGAAAGAAAGTGGCTGGAAGGCAATCCCTTGACATATAACGCGTTGCTT
GGCGAAATTGAACAGTGGGATGCCCTTGGTTTTCGTTTTGGCATGGCCGGAGCCGACGGAAGCAAGTTGTCCGCATCTGT
ATAA

Upstream 100 bases:

>100_bases
GGTAAAGGGTAGGGATGTGCGTCACGTCACCGTTGAAGAAATCGAGCGCGAAATACGGGAGTAGGTCCTCCCGTCGCCTG
GAAGCCTCCCAACAGACCTC

Downstream 100 bases:

>100_bases
AACCCTCATCCGGATGCCGTGATATCCCCTTCCAAAAAGAGATCCAAGAAAGCAGGCCTGCCGCCGGGCATGCCGGTGCA
TATCGGGGCAAAGAAAAACG

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MPEYSTLAAVDLGSNSFRLQVARVEGRQLYPLDNLREMVRLAAGLTRDKRLDEDSQARALACLTRFSERLRGFPPHAVRA
VATNTLRVAKNAAVFLKKAEAAMGFPIEVISGHEEARLIYLGVAHGLPASPDARLVMDIGGGSTEFIIGRRLKPVKLESL
YMGCVSYSLRFFPGGRISREAMNRAELSARSEIQAIAKEFSSEHWQLAYGSSGTARALGDIIQLNQLGSGSGNGEITREG
LENFRNHLLKVDDIKKLDLAGIKTDRAPVIAGGFAIMSAAFAELGISRMAQGMGALRQGVLYDLLGRFHKHDMREVTVRQ
FMRRYHVDGAQAGRVESTALLLGEQLLAAFPCEGEEHLQVLSWAARLHEVGISVAHSGYHKHSAYILGNADMPGFSQREQ
ERLSMLVLAHRGDIGKARGNMIERADFALLFALRLAALFHRSRCETALPRLEVSLRGKEFSLYLERKWLEGNPLTYNALL
GEIEQWDALGFRFGMAGADGSKLSASV

Sequences:

>Translated_507_residues
MPEYSTLAAVDLGSNSFRLQVARVEGRQLYPLDNLREMVRLAAGLTRDKRLDEDSQARALACLTRFSERLRGFPPHAVRA
VATNTLRVAKNAAVFLKKAEAAMGFPIEVISGHEEARLIYLGVAHGLPASPDARLVMDIGGGSTEFIIGRRLKPVKLESL
YMGCVSYSLRFFPGGRISREAMNRAELSARSEIQAIAKEFSSEHWQLAYGSSGTARALGDIIQLNQLGSGSGNGEITREG
LENFRNHLLKVDDIKKLDLAGIKTDRAPVIAGGFAIMSAAFAELGISRMAQGMGALRQGVLYDLLGRFHKHDMREVTVRQ
FMRRYHVDGAQAGRVESTALLLGEQLLAAFPCEGEEHLQVLSWAARLHEVGISVAHSGYHKHSAYILGNADMPGFSQREQ
ERLSMLVLAHRGDIGKARGNMIERADFALLFALRLAALFHRSRCETALPRLEVSLRGKEFSLYLERKWLEGNPLTYNALL
GEIEQWDALGFRFGMAGADGSKLSASV
>Mature_506_residues
PEYSTLAAVDLGSNSFRLQVARVEGRQLYPLDNLREMVRLAAGLTRDKRLDEDSQARALACLTRFSERLRGFPPHAVRAV
ATNTLRVAKNAAVFLKKAEAAMGFPIEVISGHEEARLIYLGVAHGLPASPDARLVMDIGGGSTEFIIGRRLKPVKLESLY
MGCVSYSLRFFPGGRISREAMNRAELSARSEIQAIAKEFSSEHWQLAYGSSGTARALGDIIQLNQLGSGSGNGEITREGL
ENFRNHLLKVDDIKKLDLAGIKTDRAPVIAGGFAIMSAAFAELGISRMAQGMGALRQGVLYDLLGRFHKHDMREVTVRQF
MRRYHVDGAQAGRVESTALLLGEQLLAAFPCEGEEHLQVLSWAARLHEVGISVAHSGYHKHSAYILGNADMPGFSQREQE
RLSMLVLAHRGDIGKARGNMIERADFALLFALRLAALFHRSRCETALPRLEVSLRGKEFSLYLERKWLEGNPLTYNALLG
EIEQWDALGFRFGMAGADGSKLSASV

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=511, Percent_Identity=38.9432485322896, Blast_Score=337, Evalue=8e-94,
Organism=Escherichia coli, GI48994966, Length=493, Percent_Identity=35.2941176470588, Blast_Score=283, Evalue=1e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 55805; Mature: 55674

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEYSTLAAVDLGSNSFRLQVARVEGRQLYPLDNLREMVRLAAGLTRDKRLDEDSQARAL
CCCCCCEEEEEECCCCEEEEEEEECCCEECCHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
ACLTRFSERLRGFPPHAVRAVATNTLRVAKNAAVFLKKAEAAMGFPIEVISGHEEARLIY
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCEEEE
LGVAHGLPASPDARLVMDIGGGSTEFIIGRRLKPVKLESLYMGCVSYSLRFFPGGRISRE
EEEECCCCCCCCCEEEEEECCCCEEEEECCCCCCEEHHHHHHHHHHHHHEECCCCCCCHH
AMNRAELSARSEIQAIAKEFSSEHWQLAYGSSGTARALGDIIQLNQLGSGSGNGEITREG
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEHHH
LENFRNHLLKVDDIKKLDLAGIKTDRAPVIAGGFAIMSAAFAELGISRMAQGMGALRQGV
HHHHHHHCEECCCCCHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYDLLGRFHKHDMREVTVRQFMRRYHVDGAQAGRVESTALLLGEQLLAAFPCEGEEHLQV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHH
LSWAARLHEVGISVAHSGYHKHSAYILGNADMPGFSQREQERLSMLVLAHRGDIGKARGN
HHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHEEECCCCCHHHCC
MIERADFALLFALRLAALFHRSRCETALPRLEVSLRGKEFSLYLERKWLEGNPLTYNALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEEEEECCCCCEEHHHHH
GEIEQWDALGFRFGMAGADGSKLSASV
HHHHHHHHHHHEEECCCCCCCCCCCCC
>Mature Secondary Structure 
PEYSTLAAVDLGSNSFRLQVARVEGRQLYPLDNLREMVRLAAGLTRDKRLDEDSQARAL
CCCCCEEEEEECCCCEEEEEEEECCCEECCHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
ACLTRFSERLRGFPPHAVRAVATNTLRVAKNAAVFLKKAEAAMGFPIEVISGHEEARLIY
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCEEEE
LGVAHGLPASPDARLVMDIGGGSTEFIIGRRLKPVKLESLYMGCVSYSLRFFPGGRISRE
EEEECCCCCCCCCEEEEEECCCCEEEEECCCCCCEEHHHHHHHHHHHHHEECCCCCCCHH
AMNRAELSARSEIQAIAKEFSSEHWQLAYGSSGTARALGDIIQLNQLGSGSGNGEITREG
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEHHH
LENFRNHLLKVDDIKKLDLAGIKTDRAPVIAGGFAIMSAAFAELGISRMAQGMGALRQGV
HHHHHHHCEECCCCCHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYDLLGRFHKHDMREVTVRQFMRRYHVDGAQAGRVESTALLLGEQLLAAFPCEGEEHLQV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHH
LSWAARLHEVGISVAHSGYHKHSAYILGNADMPGFSQREQERLSMLVLAHRGDIGKARGN
HHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHEEECCCCCHHHCC
MIERADFALLFALRLAALFHRSRCETALPRLEVSLRGKEFSLYLERKWLEGNPLTYNALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEEEEEECCCCCEEHHHHH
GEIEQWDALGFRFGMAGADGSKLSASV
HHHHHHHHHHHEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]