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The map label for this gene is fabG [C]

Identifier: 82701546

GI number: 82701546

Start: 456518

End: 457354

Strand: Direct

Name: fabG [C]

Synonym: Nmul_A0412

Alternate gene names: 82701546

Gene position: 456518-457354 (Clockwise)

Preceding gene: 82701545

Following gene: 82701550

Centisome position: 14.34

GC content: 53.41

Gene sequence:

>837_bases
ATGAATCAAGCCTATAAAGGAACACCCTTCGACCTCTCTGGACGGGTGGTGCTCATTAGCGGCGCTACCGGACTTCTCGG
CACGGAATTCGCCCTCGCAGCCGCGTCGGCCGGTGCGAATCTGGTATTGGGGGATCTGGACGGGGGCAGGCTGGAATTAC
TGAAAAGTGAGATAGCATCGGCGTATCCCGACACGCAAAGCTGGGCTCAGGTGTTGGATGTTACCCGCGCGGATTCCTGT
CGGTCTATAGCGCAGTCATGCGAAACCCGGTTCGGTCGCATCAATGCCGTGGTCCACAGTGCCGCGATCGACCCGAAATT
CGAGCAAGGTTCCGATACGTCGCATTTTTCAAAATTCACCGAGTTTCCGGGAGAGCTCTGGCAATCCTCTCTTGATGTCA
ATTTAACCGGCGCTTTCCATCTCGCTCAGGCCACCTGCAGGGTGATGGAAAAAACGGGCAAGGGATCCATTGTTTTTCTG
GGCTCAAATTACGGGCTCGTGGGTCCGGATCAGCGCATCTACAAAAAGGCAGGGCAGGAGGAACAGACCTATAAACCTGC
GGTGTATTCAGTGTGCAAGGCGGGTCTGCTGGGATTGACAAAATTTCTGGCTGCCTACTATATGAACACATCCATCCGTG
TAAATATGCTCACGCCCAGCGGCGTCTGGAATCAGCATGGCTCCGAATTTGTCGATAATTATTCGTCGCGAACCATACTG
GGGCGCATGTCGGAAAAAAATGAATACCGGGGAGCGATCATTTTTCTGGTCTCGGATGCATCCAGTTATATGACGGGCGC
AAATCTGGTCATCGATGGGGGATGGACAGCATTATGA

Upstream 100 bases:

>100_bases
GGGGATCAATCCCGCGCGTGACTTTACGAGACGGCATCGAGGTGTTGAAAACCGCCTTAGCGGTTAAAAAATCTCTTCAA
ACCCATCGGAAGGTTGCGCT

Downstream 100 bases:

>100_bases
TTCCTCATCACCCCTGTGTCTGAAACTGCTCCCGGAGCAATTCACAGAATTTACCGGATCACGGATTCTCAGGACCCTGC
AAGCAGAATGGAAGTTTATA

Product: Short-chain dehydrogenase/reductase SDR

Products: 3-dehydro-2-deoxy-D-gluconate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MNQAYKGTPFDLSGRVVLISGATGLLGTEFALAAASAGANLVLGDLDGGRLELLKSEIASAYPDTQSWAQVLDVTRADSC
RSIAQSCETRFGRINAVVHSAAIDPKFEQGSDTSHFSKFTEFPGELWQSSLDVNLTGAFHLAQATCRVMEKTGKGSIVFL
GSNYGLVGPDQRIYKKAGQEEQTYKPAVYSVCKAGLLGLTKFLAAYYMNTSIRVNMLTPSGVWNQHGSEFVDNYSSRTIL
GRMSEKNEYRGAIIFLVSDASSYMTGANLVIDGGWTAL

Sequences:

>Translated_278_residues
MNQAYKGTPFDLSGRVVLISGATGLLGTEFALAAASAGANLVLGDLDGGRLELLKSEIASAYPDTQSWAQVLDVTRADSC
RSIAQSCETRFGRINAVVHSAAIDPKFEQGSDTSHFSKFTEFPGELWQSSLDVNLTGAFHLAQATCRVMEKTGKGSIVFL
GSNYGLVGPDQRIYKKAGQEEQTYKPAVYSVCKAGLLGLTKFLAAYYMNTSIRVNMLTPSGVWNQHGSEFVDNYSSRTIL
GRMSEKNEYRGAIIFLVSDASSYMTGANLVIDGGWTAL
>Mature_278_residues
MNQAYKGTPFDLSGRVVLISGATGLLGTEFALAAASAGANLVLGDLDGGRLELLKSEIASAYPDTQSWAQVLDVTRADSC
RSIAQSCETRFGRINAVVHSAAIDPKFEQGSDTSHFSKFTEFPGELWQSSLDVNLTGAFHLAQATCRVMEKTGKGSIVFL
GSNYGLVGPDQRIYKKAGQEEQTYKPAVYSVCKAGLLGLTKFLAAYYMNTSIRVNMLTPSGVWNQHGSEFVDNYSSRTIL
GRMSEKNEYRGAIIFLVSDASSYMTGANLVIDGGWTAL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI66933014, Length=275, Percent_Identity=25.0909090909091, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI40254992, Length=204, Percent_Identity=30.3921568627451, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI19923817, Length=279, Percent_Identity=24.7311827956989, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI4504505, Length=276, Percent_Identity=27.536231884058, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI32483357, Length=272, Percent_Identity=26.1029411764706, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI59889578, Length=254, Percent_Identity=25.9842519685039, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI15277342, Length=274, Percent_Identity=25.5474452554745, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787335, Length=270, Percent_Identity=25.5555555555556, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI87082160, Length=275, Percent_Identity=26.9090909090909, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790717, Length=271, Percent_Identity=25.4612546125461, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082100, Length=277, Percent_Identity=28.158844765343, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1789208, Length=277, Percent_Identity=22.7436823104693, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787526, Length=212, Percent_Identity=25.4716981132075, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786812, Length=281, Percent_Identity=26.3345195729537, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787905, Length=268, Percent_Identity=23.5074626865672, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=271, Percent_Identity=27.6752767527675, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17560676, Length=291, Percent_Identity=27.1477663230241, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17560150, Length=280, Percent_Identity=26.7857142857143, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17561402, Length=279, Percent_Identity=23.6559139784946, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17555706, Length=268, Percent_Identity=24.6268656716418, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562990, Length=280, Percent_Identity=25.3571428571429, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=211, Percent_Identity=33.175355450237, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6324126, Length=275, Percent_Identity=22.9090909090909, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355319, Length=277, Percent_Identity=25.6317689530686, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24644339, Length=284, Percent_Identity=27.112676056338, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.125

Molecular weight: Translated: 29960; Mature: 29960

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQAYKGTPFDLSGRVVLISGATGLLGTEFALAAASAGANLVLGDLDGGRLELLKSEIAS
CCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHH
AYPDTQSWAQVLDVTRADSCRSIAQSCETRFGRINAVVHSAAIDPKFEQGSDTSHFSKFT
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
EFPGELWQSSLDVNLTGAFHLAQATCRVMEKTGKGSIVFLGSNYGLVGPDQRIYKKAGQE
HCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHCCCC
EQTYKPAVYSVCKAGLLGLTKFLAAYYMNTSIRVNMLTPSGVWNQHGSEFVDNYSSRTIL
CHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHCCCCCEEE
GRMSEKNEYRGAIIFLVSDASSYMTGANLVIDGGWTAL
EECCCCCCCCCEEEEEEECCCHHCCCCCEEEECCCCCC
>Mature Secondary Structure
MNQAYKGTPFDLSGRVVLISGATGLLGTEFALAAASAGANLVLGDLDGGRLELLKSEIAS
CCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHH
AYPDTQSWAQVLDVTRADSCRSIAQSCETRFGRINAVVHSAAIDPKFEQGSDTSHFSKFT
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
EFPGELWQSSLDVNLTGAFHLAQATCRVMEKTGKGSIVFLGSNYGLVGPDQRIYKKAGQE
HCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHCCCC
EQTYKPAVYSVCKAGLLGLTKFLAAYYMNTSIRVNMLTPSGVWNQHGSEFVDNYSSRTIL
CHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHCCCCCEEE
GRMSEKNEYRGAIIFLVSDASSYMTGANLVIDGGWTAL
EECCCCCCCCCEEEEEEECCCHHCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-deoxy-D-gluconate; NAD+

Specific reaction: 2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]