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The map label for this gene is tkt1 [H]

Identifier: 82701522

GI number: 82701522

Start: 427023

End: 429038

Strand: Reverse

Name: tkt1 [H]

Synonym: Nmul_A0388

Alternate gene names: 82701522

Gene position: 429038-427023 (Counterclockwise)

Preceding gene: 82701523

Following gene: 82701521

Centisome position: 13.47

GC content: 56.94

Gene sequence:

>2016_bases
ATGGGAACATTTCGAGATTTTGAAGCGCCGGTATTCAAGAACCTGACCAGCGCCATCCGTGCACTGGCGATGGATGCCGT
GCAAAAAGCCAACTCGGGCCATCCGGGAATGCCTATGGGCATGGCTGAGATCGCTGAGGTATTGTGGATACATCACCTAC
GCCATAATCCGGCAAATCCGAAGTGGGCCGACCGTGACCGCTTCGTTTTGTCCAATGGGCACGGATCCATGCTCATTTAC
GCCCTGCTGCACCTCACGGGCTACGATTTGCCGATGGAGGAAATCAAGCGTTTCCGTCAGCTTCATTCCAAGACTCCCGG
CCATCCGGAATATGGTTATACACCCGGCGTCGAGACGACCACAGGTCCGCTGGGCCAGGGGATCACCAATGCTGTGGGAA
TGGCTCTGGCAGAGAAAATACTTGCCTCGGAATTCAACCGTCCCGGCTTCGATATCGTCAATCACCATACCTATGTATTC
CTGGGCGATGGCTGCCTGATGGAGGGTATTTCCCATGAGGCCTGCTCGCTTGCAGGCACATTGGGGCTGGGCAAGCTGAT
CTGTTTTTATGACGACAACGGCATTTCCATCGATGGGCATGTGGAGGGATGGTTCACAGACGACACGCCCAAACGCTTCG
AAGCCTATGGTTGGCATGTTGTGCCGAATGTCAACGGACATGATCCGGTAGCGATAGAGGCCGCCATCGAAGCTGCCAAG
CAGGCCGTGGACAAACCTTCCATGATCTGCTGCAAGACCGTGATCGGAATGGGCTCGCCCAACAAGGCAAATACTCACGA
GGTGCACGGCGCGGCGCTGGGGGACTTGGAAATAGCCGCTGCGCGCCCGCATATCGGGTGGAATCACCTGCCATTCGAGA
TCCCCGAGGATGTCTACCAGAACTGGGATGCGCGCGCAAAAGGACAAAAGCTGGAAGACGGCTGGAATCGCAAGTTCGCA
GAGTACGCTGCGAAATATCCGACTGAAGCGGCCGAATTCAGTCGGCGGATGGCAGGTGAACTGCCGGAGGGGTGGCAGGA
GCACGTGGATGGCCTGGTTGCACGTGTTCATGCAAAGGAAGAAACCATTGCAAGCCGCAAGGCATCGCAGAATGCGATTG
AAGGACTGGCACCCAAGTTGCCGGAACTGGTCGGCGGCTCGGCAGATCTGGCCGGATCGAACCTTACCCTCTGGTCGGGT
TCAAAAGGCATCGCCCGGCAGGATGGCGGCAACTACGTATATTACGGCGTGCGCGAATTCGGCATGAGCGCCATCATGAA
CGGGCTGGCGCTGCATGGCGGAATCATTCCTTACGGCGCCACTTTCCTCATGTTCTCAGAATATGCGCGGAATGCGCTTC
GCATGGCCGCCCTGATGAAAATACGCTGCCTGTTCGTATTCACCCATGATTCCATCGGTTTGGGCGAAGATGGTCCTACC
CACCAGCCGGTGGAACAGACCGCCACATTGCGCTACATCCCCAACATGGATGTGTGGCGTCCGTGCGATACGGTCGAGTC
GACCGTCGCCTGGGCACGGGCAATCGAGCGCAAGGATGGCCCCTCCACACTGATTTTCAGCCGCCAGAACCTTCCCTTTC
AGAAACGCGAAGGGAATACGATCAAGCTGATCGATAAGGGCGGCTATATCCTGTCGGAAGCCTCCGACAATCAACCGCGG
GCAGTCATCATTGCCACAGGTTCGGAAGTCGGCCTGGCGATGATGGCGCAAAAAGCGCTGGCCGAAACGGGAATTCATGT
GCGCGTCGTTTCGATGCCCTGCACGAACGTATTCGATCGCCAGGATGTCGATTATAAAAGCAGCGTGCTCCCCAAGGGTA
TAGGGCGCGTGGCGGTGGAAGCAGGCGTGACGGATTACTGGCGCAAGTATGTAGGCCTGGAGGGAGCAGTGGTCGGTATC
GATACCTTCGGCGAGTCCGCGCCGGCTGGAGAGCTGTTCAAGCACTTCGGCATCACCGTAGAGAATGTGATAAAGGCGGT
AAACAGCGTCATTTAA

Upstream 100 bases:

>100_bases
ATCCTATCTTAAGAGATAATAATGGTTTTGCCGACCCGCACCGCTATTTGAGCGGTGTTTTTGTGTGCGTATAAATTGTT
GAGCTAGGGAGTTCATGTTC

Downstream 100 bases:

>100_bases
TTCTGACCAATTGCCAGCCGAAACGCGGAGAAAATTTTCTCCGCGTCCGAGGTTCTTTTTTTATCCAAGGAGTGTAAAAC
ATGACAATCAAGGTCGGTAT

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 671; Mature: 670

Protein sequence:

>671_residues
MGTFRDFEAPVFKNLTSAIRALAMDAVQKANSGHPGMPMGMAEIAEVLWIHHLRHNPANPKWADRDRFVLSNGHGSMLIY
ALLHLTGYDLPMEEIKRFRQLHSKTPGHPEYGYTPGVETTTGPLGQGITNAVGMALAEKILASEFNRPGFDIVNHHTYVF
LGDGCLMEGISHEACSLAGTLGLGKLICFYDDNGISIDGHVEGWFTDDTPKRFEAYGWHVVPNVNGHDPVAIEAAIEAAK
QAVDKPSMICCKTVIGMGSPNKANTHEVHGAALGDLEIAAARPHIGWNHLPFEIPEDVYQNWDARAKGQKLEDGWNRKFA
EYAAKYPTEAAEFSRRMAGELPEGWQEHVDGLVARVHAKEETIASRKASQNAIEGLAPKLPELVGGSADLAGSNLTLWSG
SKGIARQDGGNYVYYGVREFGMSAIMNGLALHGGIIPYGATFLMFSEYARNALRMAALMKIRCLFVFTHDSIGLGEDGPT
HQPVEQTATLRYIPNMDVWRPCDTVESTVAWARAIERKDGPSTLIFSRQNLPFQKREGNTIKLIDKGGYILSEASDNQPR
AVIIATGSEVGLAMMAQKALAETGIHVRVVSMPCTNVFDRQDVDYKSSVLPKGIGRVAVEAGVTDYWRKYVGLEGAVVGI
DTFGESAPAGELFKHFGITVENVIKAVNSVI

Sequences:

>Translated_671_residues
MGTFRDFEAPVFKNLTSAIRALAMDAVQKANSGHPGMPMGMAEIAEVLWIHHLRHNPANPKWADRDRFVLSNGHGSMLIY
ALLHLTGYDLPMEEIKRFRQLHSKTPGHPEYGYTPGVETTTGPLGQGITNAVGMALAEKILASEFNRPGFDIVNHHTYVF
LGDGCLMEGISHEACSLAGTLGLGKLICFYDDNGISIDGHVEGWFTDDTPKRFEAYGWHVVPNVNGHDPVAIEAAIEAAK
QAVDKPSMICCKTVIGMGSPNKANTHEVHGAALGDLEIAAARPHIGWNHLPFEIPEDVYQNWDARAKGQKLEDGWNRKFA
EYAAKYPTEAAEFSRRMAGELPEGWQEHVDGLVARVHAKEETIASRKASQNAIEGLAPKLPELVGGSADLAGSNLTLWSG
SKGIARQDGGNYVYYGVREFGMSAIMNGLALHGGIIPYGATFLMFSEYARNALRMAALMKIRCLFVFTHDSIGLGEDGPT
HQPVEQTATLRYIPNMDVWRPCDTVESTVAWARAIERKDGPSTLIFSRQNLPFQKREGNTIKLIDKGGYILSEASDNQPR
AVIIATGSEVGLAMMAQKALAETGIHVRVVSMPCTNVFDRQDVDYKSSVLPKGIGRVAVEAGVTDYWRKYVGLEGAVVGI
DTFGESAPAGELFKHFGITVENVIKAVNSVI
>Mature_670_residues
GTFRDFEAPVFKNLTSAIRALAMDAVQKANSGHPGMPMGMAEIAEVLWIHHLRHNPANPKWADRDRFVLSNGHGSMLIYA
LLHLTGYDLPMEEIKRFRQLHSKTPGHPEYGYTPGVETTTGPLGQGITNAVGMALAEKILASEFNRPGFDIVNHHTYVFL
GDGCLMEGISHEACSLAGTLGLGKLICFYDDNGISIDGHVEGWFTDDTPKRFEAYGWHVVPNVNGHDPVAIEAAIEAAKQ
AVDKPSMICCKTVIGMGSPNKANTHEVHGAALGDLEIAAARPHIGWNHLPFEIPEDVYQNWDARAKGQKLEDGWNRKFAE
YAAKYPTEAAEFSRRMAGELPEGWQEHVDGLVARVHAKEETIASRKASQNAIEGLAPKLPELVGGSADLAGSNLTLWSGS
KGIARQDGGNYVYYGVREFGMSAIMNGLALHGGIIPYGATFLMFSEYARNALRMAALMKIRCLFVFTHDSIGLGEDGPTH
QPVEQTATLRYIPNMDVWRPCDTVESTVAWARAIERKDGPSTLIFSRQNLPFQKREGNTIKLIDKGGYILSEASDNQPRA
VIIATGSEVGLAMMAQKALAETGIHVRVVSMPCTNVFDRQDVDYKSSVLPKGIGRVAVEAGVTDYWRKYVGLEGAVVGID
TFGESAPAGELFKHFGITVENVIKAVNSVI

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=678, Percent_Identity=26.5486725663717, Blast_Score=170, Evalue=5e-42,
Organism=Homo sapiens, GI4507521, Length=678, Percent_Identity=26.5486725663717, Blast_Score=170, Evalue=5e-42,
Organism=Homo sapiens, GI133778974, Length=682, Percent_Identity=24.4868035190616, Blast_Score=134, Evalue=3e-31,
Organism=Escherichia coli, GI48994911, Length=660, Percent_Identity=66.6666666666667, Blast_Score=943, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=660, Percent_Identity=62.5757575757576, Blast_Score=884, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=674, Percent_Identity=24.4807121661721, Blast_Score=160, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6325331, Length=686, Percent_Identity=47.5218658892128, Blast_Score=600, Evalue=1e-172,
Organism=Saccharomyces cerevisiae, GI6319593, Length=683, Percent_Identity=44.8023426061493, Blast_Score=559, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24666278, Length=677, Percent_Identity=24.6676514032496, Blast_Score=147, Evalue=3e-35,
Organism=Drosophila melanogaster, GI45551847, Length=268, Percent_Identity=32.8358208955224, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI45550715, Length=268, Percent_Identity=32.8358208955224, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24645119, Length=233, Percent_Identity=32.618025751073, Blast_Score=103, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 73182; Mature: 73051

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTFRDFEAPVFKNLTSAIRALAMDAVQKANSGHPGMPMGMAEIAEVLWIHHLRHNPANP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
KWADRDRFVLSNGHGSMLIYALLHLTGYDLPMEEIKRFRQLHSKTPGHPEYGYTPGVETT
CCCCCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
TGPLGQGITNAVGMALAEKILASEFNRPGFDIVNHHTYVFLGDGCLMEGISHEACSLAGT
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEEECCCHHHHCCCHHHHHHHHH
LGLGKLICFYDDNGISIDGHVEGWFTDDTPKRFEAYGWHVVPNVNGHDPVAIEAAIEAAK
CCCCEEEEEECCCCEEECCCEEEEECCCCCHHHHHCCCEEECCCCCCCCCHHHHHHHHHH
QAVDKPSMICCKTVIGMGSPNKANTHEVHGAALGDLEIAAARPHIGWNHLPFEIPEDVYQ
HHCCCCHHHHHHHHHCCCCCCCCCCCEECCCEECCEEEEECCCCCCCCCCCCCCCHHHHC
NWDARAKGQKLEDGWNRKFAEYAAKYPTEAAEFSRRMAGELPEGWQEHVDGLVARVHAKE
CCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
ETIASRKASQNAIEGLAPKLPELVGGSADLAGSNLTLWSGSKGIARQDGGNYVYYGVREF
HHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCEEEECHHHH
GMSAIMNGLALHGGIIPYGATFLMFSEYARNALRMAALMKIRCLFVFTHDSIGLGEDGPT
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCC
HQPVEQTATLRYIPNMDVWRPCDTVESTVAWARAIERKDGPSTLIFSRQNLPFQKREGNT
CCCHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCE
IKLIDKGGYILSEASDNQPRAVIIATGSEVGLAMMAQKALAETGIHVRVVSMPCTNVFDR
EEEEECCCEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCC
QDVDYKSSVLPKGIGRVAVEAGVTDYWRKYVGLEGAVVGIDTFGESAPAGELFKHFGITV
CCCCHHHHCCCCCHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCH
ENVIKAVNSVI
HHHHHHHHHCC
>Mature Secondary Structure 
GTFRDFEAPVFKNLTSAIRALAMDAVQKANSGHPGMPMGMAEIAEVLWIHHLRHNPANP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
KWADRDRFVLSNGHGSMLIYALLHLTGYDLPMEEIKRFRQLHSKTPGHPEYGYTPGVETT
CCCCCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
TGPLGQGITNAVGMALAEKILASEFNRPGFDIVNHHTYVFLGDGCLMEGISHEACSLAGT
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEEECCCHHHHCCCHHHHHHHHH
LGLGKLICFYDDNGISIDGHVEGWFTDDTPKRFEAYGWHVVPNVNGHDPVAIEAAIEAAK
CCCCEEEEEECCCCEEECCCEEEEECCCCCHHHHHCCCEEECCCCCCCCCHHHHHHHHHH
QAVDKPSMICCKTVIGMGSPNKANTHEVHGAALGDLEIAAARPHIGWNHLPFEIPEDVYQ
HHCCCCHHHHHHHHHCCCCCCCCCCCEECCCEECCEEEEECCCCCCCCCCCCCCCHHHHC
NWDARAKGQKLEDGWNRKFAEYAAKYPTEAAEFSRRMAGELPEGWQEHVDGLVARVHAKE
CCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
ETIASRKASQNAIEGLAPKLPELVGGSADLAGSNLTLWSGSKGIARQDGGNYVYYGVREF
HHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCEEEECHHHH
GMSAIMNGLALHGGIIPYGATFLMFSEYARNALRMAALMKIRCLFVFTHDSIGLGEDGPT
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCC
HQPVEQTATLRYIPNMDVWRPCDTVESTVAWARAIERKDGPSTLIFSRQNLPFQKREGNT
CCCHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCE
IKLIDKGGYILSEASDNQPRAVIIATGSEVGLAMMAQKALAETGIHVRVVSMPCTNVFDR
EEEEECCCEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCC
QDVDYKSSVLPKGIGRVAVEAGVTDYWRKYVGLEGAVVGIDTFGESAPAGELFKHFGITV
CCCCHHHHCCCCCHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCH
ENVIKAVNSVI
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]