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The map label for this gene is msrA [H]

Identifier: 82701461

GI number: 82701461

Start: 352039

End: 353379

Strand: Reverse

Name: msrA [H]

Synonym: Nmul_A0327

Alternate gene names: 82701461

Gene position: 353379-352039 (Counterclockwise)

Preceding gene: 82701462

Following gene: 82701454

Centisome position: 11.1

GC content: 54.44

Gene sequence:

>1341_bases
ATGAAAAGGGTTGTAGCGATGGCAGCGGCCTTGGGCATTATTATGGGTGCATATGCAGTGGAGAAAATCACGATACCTGC
GCAGGCAACGGATTACGTTGTTCTAGGGATGGGGTGCTTCTGGGGTGCGGAGAAGCGCATGGGAGAAATTCCCGGGGTCG
TCGATGTGGAAAGCGGTTATGCAGGCGGTGACCTTCCCGGCGCTGGTTACCAGGACATTTTGAATCATGAAAGAGCGCTT
CGCACCGGCAAAACCACAGGACGCAATCATGCGGAAGTGGTCAAGGTGGTTTTCGATCCGAACAAGGTAACGCTGGAAAC
AGTGCTGGCCAAATTCTGGGAGAGCCATGATCCCACTCAGGGCAATCGCCAGGGGAACGATATCGGCAGTAATTATCGCA
GTGCCATCTATTACCATGACGCGAACCAGAAGGCTATGGGACTGGCAACCCGGACTGCTTATCAGAAAGCACTCGATGCC
GCGGGCTATGACAGAATCACCACCGAGATCCTGCCGCTCAAGAATTACATCACCGCTGAGGAATATCACCAGAACTATCT
GAAAAAGAATCCCGATGGGTATTGCGGTTTGGGTGGTACCGGAGTGAAATACCCCCGGGCAGTCGGGAAAGTTGCACCGA
TGCAGGTACCCCCCATCTCTTCCGGGACTTCTTCGGCTTCGACATCGCCCAAAATGGGCATCGAGCCCCTGAAGAGCGAC
GATCTGAATCCTGTCCGGCAGCTGGTGGCGTTCGAGGCCGAGCATTGCGAATTTTGCGAGCGCTTCGAAAAAGACATAAT
GAGCCACTGGCAAGCGGAAGTGCCGATTGCCAGGACGTTGAACTCGAATCCGCCCAGCGGTTGGGCTCTGGAAAAACCCT
TGTTCGCGGCACCCACCATCGTGCTGTTCAAGAACGGCCGGGAAGTTGCGCGCTATACGGGATACAACGGCGAGAAATCC
AATTTCTGGAAATGGCTCGGCTTTCAACTGCTGTCGCCCGAGCAGCAGAAAATCGCCTTCAAGCGAGGTACCGAACCTCC
TTTTACCGCATCCAATCTGGATGAAAAGCGTCCCGGAAGATTTGTCGACCCTGTCACCGGTGCCACCCTCTTTTACAGCA
ATAGCAAATTTGAAAGCGGAACGGGGTGGCCCAGTTTCTTTGAACCCGTGGAAGGCGCCGTTACCCTGCACGAAGACAAC
TCTCACGGCATGAAACGGATTGAAGTACGGAGCGCAAGCTCCGGCATTCATCTCGGCCATCTATTTCATGACGGACCGCC
TCCGAGCCACAAGCGCTATTGCATCAATGGAAACGTCCTCAAATTCGTCGCGGACCGATGA

Upstream 100 bases:

>100_bases
ATTTATTTTCATTTCAGATTTCAAATTGCACTGGAGTATTGAAAAACGAGATCGAGATCTCACGACCGGGATTTAGGGAT
TTATATAGGGGCATCTTGAA

Downstream 100 bases:

>100_bases
ATCCGACCGGGAACTTAACCAACCCCACACACCCGCCGATTGCCCCCTTTCACGATGAGAACATGCAACTCCTCGTCCTG
GATGTCGCAGGTGATTCGGT

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MKRVVAMAAALGIIMGAYAVEKITIPAQATDYVVLGMGCFWGAEKRMGEIPGVVDVESGYAGGDLPGAGYQDILNHERAL
RTGKTTGRNHAEVVKVVFDPNKVTLETVLAKFWESHDPTQGNRQGNDIGSNYRSAIYYHDANQKAMGLATRTAYQKALDA
AGYDRITTEILPLKNYITAEEYHQNYLKKNPDGYCGLGGTGVKYPRAVGKVAPMQVPPISSGTSSASTSPKMGIEPLKSD
DLNPVRQLVAFEAEHCEFCERFEKDIMSHWQAEVPIARTLNSNPPSGWALEKPLFAAPTIVLFKNGREVARYTGYNGEKS
NFWKWLGFQLLSPEQQKIAFKRGTEPPFTASNLDEKRPGRFVDPVTGATLFYSNSKFESGTGWPSFFEPVEGAVTLHEDN
SHGMKRIEVRSASSGIHLGHLFHDGPPPSHKRYCINGNVLKFVADR

Sequences:

>Translated_446_residues
MKRVVAMAAALGIIMGAYAVEKITIPAQATDYVVLGMGCFWGAEKRMGEIPGVVDVESGYAGGDLPGAGYQDILNHERAL
RTGKTTGRNHAEVVKVVFDPNKVTLETVLAKFWESHDPTQGNRQGNDIGSNYRSAIYYHDANQKAMGLATRTAYQKALDA
AGYDRITTEILPLKNYITAEEYHQNYLKKNPDGYCGLGGTGVKYPRAVGKVAPMQVPPISSGTSSASTSPKMGIEPLKSD
DLNPVRQLVAFEAEHCEFCERFEKDIMSHWQAEVPIARTLNSNPPSGWALEKPLFAAPTIVLFKNGREVARYTGYNGEKS
NFWKWLGFQLLSPEQQKIAFKRGTEPPFTASNLDEKRPGRFVDPVTGATLFYSNSKFESGTGWPSFFEPVEGAVTLHEDN
SHGMKRIEVRSASSGIHLGHLFHDGPPPSHKRYCINGNVLKFVADR
>Mature_446_residues
MKRVVAMAAALGIIMGAYAVEKITIPAQATDYVVLGMGCFWGAEKRMGEIPGVVDVESGYAGGDLPGAGYQDILNHERAL
RTGKTTGRNHAEVVKVVFDPNKVTLETVLAKFWESHDPTQGNRQGNDIGSNYRSAIYYHDANQKAMGLATRTAYQKALDA
AGYDRITTEILPLKNYITAEEYHQNYLKKNPDGYCGLGGTGVKYPRAVGKVAPMQVPPISSGTSSASTSPKMGIEPLKSD
DLNPVRQLVAFEAEHCEFCERFEKDIMSHWQAEVPIARTLNSNPPSGWALEKPLFAAPTIVLFKNGREVARYTGYNGEKS
NFWKWLGFQLLSPEQQKIAFKRGTEPPFTASNLDEKRPGRFVDPVTGATLFYSNSKFESGTGWPSFFEPVEGAVTLHEDN
SHGMKRIEVRSASSGIHLGHLFHDGPPPSHKRYCINGNVLKFVADR

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=183, Percent_Identity=46.448087431694, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI208609995, Length=183, Percent_Identity=46.448087431694, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI208609993, Length=121, Percent_Identity=53.7190082644628, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI301336164, Length=114, Percent_Identity=43.859649122807, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI301336162, Length=114, Percent_Identity=43.859649122807, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI73089054, Length=114, Percent_Identity=43.859649122807, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI37620216, Length=114, Percent_Identity=43.859649122807, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI117606353, Length=120, Percent_Identity=41.6666666666667, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1790665, Length=159, Percent_Identity=44.0251572327044, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1788077, Length=114, Percent_Identity=47.3684210526316, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI115532676, Length=127, Percent_Identity=40.1574803149606, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17553450, Length=127, Percent_Identity=40.1574803149606, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17533973, Length=152, Percent_Identity=31.5789473684211, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320881, Length=165, Percent_Identity=36.3636363636364, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6319816, Length=136, Percent_Identity=33.8235294117647, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI221378664, Length=115, Percent_Identity=43.4782608695652, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI221378662, Length=122, Percent_Identity=40.9836065573771, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24645799, Length=163, Percent_Identity=36.8098159509202, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI45553335, Length=115, Percent_Identity=42.6086956521739, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21356369, Length=115, Percent_Identity=42.6086956521739, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24645801, Length=174, Percent_Identity=35.0574712643678, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24645804, Length=126, Percent_Identity=39.6825396825397, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24664627, Length=158, Percent_Identity=35.4430379746835, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24664631, Length=158, Percent_Identity=35.4430379746835, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45553131, Length=152, Percent_Identity=34.8684210526316, Blast_Score=79, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 49107; Mature: 49107

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVVAMAAALGIIMGAYAVEKITIPAQATDYVVLGMGCFWGAEKRMGEIPGVVDVESGY
CCHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEECHHHHCCHHHHCCCCCEEEECCCC
AGGDLPGAGYQDILNHERALRTGKTTGRNHAEVVKVVFDPNKVTLETVLAKFWESHDPTQ
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEHHHHHHHHHHCCCCCC
GNRQGNDIGSNYRSAIYYHDANQKAMGLATRTAYQKALDAAGYDRITTEILPLKNYITAE
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
EYHQNYLKKNPDGYCGLGGTGVKYPRAVGKVAPMQVPPISSGTSSASTSPKMGIEPLKSD
HHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DLNPVRQLVAFEAEHCEFCERFEKDIMSHWQAEVPIARTLNSNPPSGWALEKPLFAAPTI
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCEE
VLFKNGREVARYTGYNGEKSNFWKWLGFQLLSPEQQKIAFKRGTEPPFTASNLDEKRPGR
EEEECCCCEEHCCCCCCCCCCHHHHHCCEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCC
FVDPVTGATLFYSNSKFESGTGWPSFFEPVEGAVTLHEDNSHGMKRIEVRSASSGIHLGH
CCCCCCCCEEEEECCCCCCCCCCCHHHHCCCCEEEEEECCCCCCEEEEEECCCCCEEEEE
LFHDGPPPSHKRYCINGNVLKFVADR
HCCCCCCCCCCEEEECCCEEEEEECC
>Mature Secondary Structure
MKRVVAMAAALGIIMGAYAVEKITIPAQATDYVVLGMGCFWGAEKRMGEIPGVVDVESGY
CCHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEECHHHHCCHHHHCCCCCEEEECCCC
AGGDLPGAGYQDILNHERALRTGKTTGRNHAEVVKVVFDPNKVTLETVLAKFWESHDPTQ
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEHHHHHHHHHHCCCCCC
GNRQGNDIGSNYRSAIYYHDANQKAMGLATRTAYQKALDAAGYDRITTEILPLKNYITAE
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
EYHQNYLKKNPDGYCGLGGTGVKYPRAVGKVAPMQVPPISSGTSSASTSPKMGIEPLKSD
HHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DLNPVRQLVAFEAEHCEFCERFEKDIMSHWQAEVPIARTLNSNPPSGWALEKPLFAAPTI
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCEE
VLFKNGREVARYTGYNGEKSNFWKWLGFQLLSPEQQKIAFKRGTEPPFTASNLDEKRPGR
EEEECCCCEEHCCCCCCCCCCHHHHHCCEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCC
FVDPVTGATLFYSNSKFESGTGWPSFFEPVEGAVTLHEDNSHGMKRIEVRSASSGIHLGH
CCCCCCCCEEEEECCCCCCCCCCCHHHHCCCCEEEEEECCCCCCEEEEEECCCCCEEEEE
LFHDGPPPSHKRYCINGNVLKFVADR
HCCCCCCCCCCEEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]